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The map label for this gene is era

Identifier: 121638243

GI number: 121638243

Start: 2610793

End: 2611695

Strand: Reverse

Name: era

Synonym: BCG_2378c

Alternate gene names: 121638243

Gene position: 2611695-2610793 (Counterclockwise)

Preceding gene: 121638244

Following gene: 121638241

Centisome position: 59.7

GC content: 63.12

Gene sequence:

>903_bases
ATGACCGAATTCCATTCTGGCTTTGTGTGTTTGGTCGGCCGGCCGAACACCGGCAAGTCCACGCTGACCAATGCGCTGGT
CGGGGCGAAAGTGGCAATCACGTCGACGCGCCCGCAGACCACCAGGCACGCTATTCGTGGGATCGTGCATAGCGACGACT
TCCAGATCATCCTCGTCGACACTCCCGGTCTGCACCGGCCGCGCACTCTGCTGGGCAAGCGGCTCAACGACTTGGTCCGC
GAAACCTACGCGGCGGTCGACGTCATCGGGCTATGCATCCCCGCCGACGAGGCGATCGGTCCGGGAGACCGGTGGATTGT
CGAGCAGCTTCGTTCGACCGGCCCTGCCAATACGACACTGGTGGTCATCGTCACCAAGATTGACAAGGTGCCGAAAGAAA
AAGTGGTCGCCCAGCTGGTAGCGGTCAGCGAACTCGTCACGAATGCGGCCGAGATTGTCCCGGTTTCGGCGATGACCGGC
GACCGGGTAGACCTGTTGATCGACGTACTGGCCGCGGCATTGCCGGCCGGCCCCGCGTATTACCCCGACGGTGAGTTGAC
TGACGAACCCGAGGAGGTTCTGATGGCCGAGCTCATCCGCGAGGCGGCCCTTCAGGGCGTGCGCGATGAGCTGCCCCATT
CGCTGGCGGTGGTGATTGACGAGGTCAGTCCACGTGAGGGGCGTGACGACCTGATCGACGTACACGCCGCGCTGTACGTC
GAGCGAGATAGTCAGAAGGGCATCGTCATCGGCAAGGGTGGTGCCCGGCTGCGGGAGGTGGGTACCGCGGCCCGTAGCCA
GATCGAAAACCTGCTGGGCACCAAGGTCTATCTCGACTTGCGGGTCAAGGTCGCCAAGAACTGGCAGCGCGACCCCAAAC
AGCTTGGCCGACTGGGGTTTTAG

Upstream 100 bases:

>100_bases
ACCGATCGGGCAGGTAACCCGCTATGACGCCGAACGTGCATTCACGGCGGAAAAAAGCGGGAAAAGTCTCCCTGTGTTCA
CGTTCGGCGAGGAAACCGGC

Downstream 100 bases:

>100_bases
CTCGTCCACCACACCTGCGGCTGCTTGGTCGCCCAGCCACTGACGGCTTCCAACTCGGCGGCCAGCGAGATCAGCATGCC
CTCGCTGTTGGCCGGTCCCA

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVDTPGLHRPRTLLGKRLNDLVR
ETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTG
DRVDLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYV
ERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF

Sequences:

>Translated_300_residues
MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVDTPGLHRPRTLLGKRLNDLVR
ETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTG
DRVDLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYV
ERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
>Mature_299_residues
TEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVDTPGLHRPRTLLGKRLNDLVRE
TYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTLVVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTGD
RVDLLIDVLAAALPAGPAYYPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYVE
RDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Escherichia coli, GI1788919, Length=298, Percent_Identity=33.2214765100671, Blast_Score=168, Evalue=4e-43,
Organism=Drosophila melanogaster, GI24646434, Length=318, Percent_Identity=22.9559748427673, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_MYCBO (P0A563)

Other databases:

- EMBL:   BX248342
- RefSeq:   NP_856034.1
- ProteinModelPortal:   P0A563
- SMR:   P0A563
- EnsemblBacteria:   EBMYCT00000017378
- GeneID:   1094373
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb2385c
- GeneTree:   EBGT00050000017254
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- BioCyc:   MBOV233413:MB2385C-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PRINTS:   PR00326
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 32461; Mature: 32330

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVD
CCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCEECCCEEEEEEE
TPGLHRPRTLLGKRLNDLVRETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCCCCEE
VVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAY
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCC
YPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHEEE
ERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
EECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEHHCCCCCHHHHCCCCC
>Mature Secondary Structure 
TEFHSGFVCLVGRPNTGKSTLTNALVGAKVAITSTRPQTTRHAIRGIVHSDDFQIILVD
CCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCHHHHHHHHHCEECCCEEEEEEE
TPGLHRPRTLLGKRLNDLVRETYAAVDVIGLCIPADEAIGPGDRWIVEQLRSTGPANTTL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHHHHHHCCCCCCCEE
VVIVTKIDKVPKEKVVAQLVAVSELVTNAAEIVPVSAMTGDRVDLLIDVLAAALPAGPAY
EEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHHHHCCCCCCC
YPDGELTDEPEEVLMAELIREAALQGVRDELPHSLAVVIDEVSPREGRDDLIDVHAALYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHEEE
ERDSQKGIVIGKGGARLREVGTAARSQIENLLGTKVYLDLRVKVAKNWQRDPKQLGRLGF
EECCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972