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The map label for this gene is nanT [H]

Identifier: 121637808

GI number: 121637808

Start: 2150036

End: 2151304

Strand: Reverse

Name: nanT [H]

Synonym: BCG_1941c

Alternate gene names: 121637808

Gene position: 2151304-2150036 (Counterclockwise)

Preceding gene: 121637811

Following gene: 121637806

Centisome position: 49.18

GC content: 60.84

Gene sequence:

>1269_bases
GTGGCAGCACCGCGGTTGACCGGCGACCAGCGAAACGCTTTTATGGCATCTTTCTTGGGTTGGACGATGGATGCGTTCGA
TTACTTTCTCGTGGTGCTGGTCTATGCCGACATCGCAACGACCTTCCACCACACCAAGACCGACGTCGCGTTTCTCACCA
CCGCCACCCTGGCCATGCGCCCCGTGGGTGCGTTGCTGTTCGGGCTATGGGCCGACCGGGTGGGCCGGCGGGTCCCGCTG
ATGGTCGACGTGTCGTTCTATTCGGTGATCGGATTTCTGTGCGCATTCGCACCCAACTTCACCGTGCTGGTGATCCTGCG
ACTGCTCTACGGCATTGGCATGGGCGGAGAGTGGGGGCTGGGTGCCGCGCTGTCCATGGAGAAGGTTCCAGCCGAGCGGC
GTGGCGTCTTCTCCGGGCTGCTGCAGGAGGGCTACGCGTTCGGCTATCTGCTGGCCAGTGTGGCAGCGCTGGTGGTGATG
AACTGGCTAGGGCTGTCGTGGCGGTGGTTGTTCGGCCTAAGCATCATCCCGGCTCTGATCAGCTTGATCATCCGGTACCG
GGTAAAGGAATCCGAAGTCTGGGAAGCCGCGCAGGACCGCATGCGGCTCACCAAGACCCGAATCCGCGATGTCCTGGGTA
ACCCCGCAATTGTGCGCCGGTTTGTCTACCTAGTGCTGTTGATGACCGCCTTCAACTGGATGAGCCACGGCACCCAGGAT
GTCTACCCGACCTTCCTGACCGCGACTACCGATCATGGTGCCGGTTTGTCCAGCCTGACCGCCAGGTGGATAGTGGTGAT
CTACAACATCGGCGCCATCATCGGCGGTCTGGCGTTCGGCACGTTGTCCCAGCGGTTCAGCCGCCGTTACACCATCGTTT
TCTGTGCGGCGCTGGGACTGCCGATCGTGCCGCTGTTCGCTTACTCGCGCACTGCGGCGATGTTGTGCCTGGGTTCGTTT
TTGATGCAAGTCTTCGTACAGGGTGCCTGGGGTGTGATCCCCGCGCATCTGACCGAGATGTCGCCAGACGCTATCCGGGG
CGTCTACCCCGGCGTAACCTACCAGCTCGGTAATCTGCTGGCGGCGTTCAACCTTCCTATTCAAGAGCGTCTGGCCGAAT
CCCATGGCTACCCCTTCGCCTTGGCCGCGACGATCGTGCCCGTGCTATTGGTCGTAGCGGTGCTGACGGCGATTGGCAAG
GATGCCACCGGAATCCGCTTTGGTACTACGGAAACTGCTTTTCTTGTTCGTCATCGAAATCGACATTAG

Upstream 100 bases:

>100_bases
AAAGGCACCATTGCCCGATCCTGCCACGGACATGCGAGCCGCCGCTGTTCGCCATGTCCCCGGACTCGCGGTGCCGCGCC
CGGTACGCCACGATGCAGAC

Downstream 100 bases:

>100_bases
CGCGGTGTCTTCTCGTCGAACTTTGTCGCGCTGCTGTCGATTTCGCCGTCGCTAGGGTGAGCCCGGGATACCGCTCAGGG
TGCGCCGCAGCAGGTGCATC

Product: putative sialic acid-transport integral membrane protein nanT

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHTKTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPL
MVDVSFYSVIGFLCAFAPNFTVLVILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVM
NWLGLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFVYLVLLMTAFNWMSHGTQD
VYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGTLSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSF
LMQVFVQGAWGVIPAHLTEMSPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIGK
DATGIRFGTTETAFLVRHRNRH

Sequences:

>Translated_422_residues
MAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHTKTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPL
MVDVSFYSVIGFLCAFAPNFTVLVILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVM
NWLGLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFVYLVLLMTAFNWMSHGTQD
VYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGTLSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSF
LMQVFVQGAWGVIPAHLTEMSPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIGK
DATGIRFGTTETAFLVRHRNRH
>Mature_421_residues
AAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHTKTDVAFLTTATLAMRPVGALLFGLWADRVGRRVPLM
VDVSFYSVIGFLCAFAPNFTVLVILRLLYGIGMGGEWGLGAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVMN
WLGLSWRWLFGLSIIPALISLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFVYLVLLMTAFNWMSHGTQDV
YPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGTLSQRFSRRYTIVFCAALGLPIVPLFAYSRTAAMLCLGSFL
MQVFVQGAWGVIPAHLTEMSPDAIRGVYPGVTYQLGNLLAAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIGKD
ATGIRFGTTETAFLVRHRNRH

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=200, Percent_Identity=29, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI87082231, Length=452, Percent_Identity=28.0973451327434, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI87082404, Length=352, Percent_Identity=24.4318181818182, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788292, Length=334, Percent_Identity=28.4431137724551, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790550, Length=437, Percent_Identity=23.3409610983982, Blast_Score=79, Evalue=7e-16,
Organism=Escherichia coli, GI1786229, Length=200, Percent_Identity=26.5, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082159, Length=139, Percent_Identity=32.3741007194245, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789941, Length=461, Percent_Identity=26.0303687635575, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322632, Length=439, Percent_Identity=28.9293849658314, Blast_Score=144, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46453; Mature: 46322

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHTKTDVAFLTTATLAMR
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
PVGALLFGLWADRVGRRVPLMVDVSFYSVIGFLCAFAPNFTVLVILRLLYGIGMGGEWGL
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
GAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVMNWLGLSWRWLFGLSIIPALI
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFVYLVLLMTAFNWMSHGTQD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGTLSQRFSRRYTIVFCAALGL
CCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
PIVPLFAYSRTAAMLCLGSFLMQVFVQGAWGVIPAHLTEMSPDAIRGVYPGVTYQLGNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHH
AAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIGKDATGIRFGTTETAFLVRHRN
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHCCC
RH
CC
>Mature Secondary Structure 
AAPRLTGDQRNAFMASFLGWTMDAFDYFLVVLVYADIATTFHHTKTDVAFLTTATLAMR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
PVGALLFGLWADRVGRRVPLMVDVSFYSVIGFLCAFAPNFTVLVILRLLYGIGMGGEWGL
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCC
GAALSMEKVPAERRGVFSGLLQEGYAFGYLLASVAALVVMNWLGLSWRWLFGLSIIPALI
CHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
SLIIRYRVKESEVWEAAQDRMRLTKTRIRDVLGNPAIVRRFVYLVLLMTAFNWMSHGTQD
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCC
VYPTFLTATTDHGAGLSSLTARWIVVIYNIGAIIGGLAFGTLSQRFSRRYTIVFCAALGL
CCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCC
PIVPLFAYSRTAAMLCLGSFLMQVFVQGAWGVIPAHLTEMSPDAIRGVYPGVTYQLGNLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCHHHHHCCCCHHHHHHHHH
AAFNLPIQERLAESHGYPFALAATIVPVLLVVAVLTAIGKDATGIRFGTTETAFLVRHRN
HHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCHHHHHHHCCC
RH
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]