| Definition | Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome. |
|---|---|
| Accession | NC_008769 |
| Length | 4,374,522 |
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The map label for this gene is ephD [H]
Identifier: 121637768
GI number: 121637768
Start: 2113065
End: 2113925
Strand: Reverse
Name: ephD [H]
Synonym: BCG_1901c
Alternate gene names: 121637768
Gene position: 2113925-2113065 (Counterclockwise)
Preceding gene: 121637772
Following gene: 121637767
Centisome position: 48.32
GC content: 63.07
Gene sequence:
>861_bases GTGCCAGGCAGGACATCCATCGGCGTCAAGATCCGGGACAAGGTCCAGGACAAAGTAATCGCCATCACCGGCGGCGCCCG GGGGATCGGATTGGCCACAGCGGCCGCGCTGCACAACTTGGGAGCCAAGGTCGCTATCGGCGACATCGATGAGGCGATGG CGAAAGAGTCGGGTGCCGATCTCGACCTCGACATGTACGGCAAACTCGATGTCACCGACCCGGATTCGTTTTCGGGATTC CTCGACGCCGTCGAGCGCCAACTCGGCCCGATCGACGTGCTGGTCAACAACGCCGGCATCATGCCCGTGGGGCGGATTGT CGACGAACCAGACCCGGTAACCCGCCGAATCCTGGACATCAACGTCTACGGGGTGATCTTGGGTAGCAAGCTGGCGGCGC AGCGGATGGTCCCGCGCGGGCGGGGACACGTTATCAATGTCGCCTCGCTTGCCGGGGAAATCTACGCCGTAGGCGTGGCC ACTTACTGTGCCAGCAAGCACGCGGTGGTCGCGTTCACCGATTCGGCCAGGCTTGAATACCGTTCGGCCGGCGTGAAGTT CTCGATGGTGTTGCCGTCGTTTGTCAACACCGAGCTCATTGCGGGCACCGGTGGGATCAAAGGATTCAAGAACGCCGAGC CGGCCGATATCGCCGACGCGATCGTCGGGCTGATTGTTCATCCCAAACCGCGGGTGCGGGTCACGAAAGCGGCTGGCTCG ATGATCGTGGCACAGCGGTTCATGCCGCGCCAGGTTTCCGAGGGCTTGAACCGACTCCTCGGCGGCGAGCATGTCTTCAC CGACGATGTCGACATGGAGAAGCGCAGGACCTACGAGGCTCGGGCTCGCGGCGAGGAGTGA
Upstream 100 bases:
>100_bases TGCACACCGTAGCTGTTTCATCGGCGTTCGCGGCTACCGTGACTACACGGGCGCGACCGCATTGGACGGCGGCTAAGGCC CGCCGAGCGAAGGGACGACA
Downstream 100 bases:
>100_bases CCGTTGCGCCGCGCCGGCTGGCGTGGACCAACGCGCGTCAGAGCTACCCTGTGCGGGTGGCGCATGTGTTGTCGGTCAAC CTGGCTCGTGTTCGGGCGAA
Product: short chain dehydrogenase
Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]
Alternate protein names: NA
Number of amino acids: Translated: 286; Mature: 285
Protein sequence:
>286_residues MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVAIGDIDEAMAKESGADLDLDMYGKLDVTDPDSFSGF LDAVERQLGPIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVA TYCASKHAVVAFTDSARLEYRSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVRVTKAAGS MIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARARGEE
Sequences:
>Translated_286_residues MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVAIGDIDEAMAKESGADLDLDMYGKLDVTDPDSFSGF LDAVERQLGPIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVA TYCASKHAVVAFTDSARLEYRSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVRVTKAAGS MIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARARGEE >Mature_285_residues PGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVAIGDIDEAMAKESGADLDLDMYGKLDVTDPDSFSGFL DAVERQLGPIDVLVNNAGIMPVGRIVDEPDPVTRRILDINVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVAT YCASKHAVVAFTDSARLEYRSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVRVTKAAGSM IVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARARGEE
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI40807363, Length=278, Percent_Identity=27.6978417266187, Blast_Score=106, Evalue=3e-23, Organism=Homo sapiens, GI142976729, Length=250, Percent_Identity=25.6, Blast_Score=94, Evalue=1e-19, Organism=Homo sapiens, GI31542939, Length=197, Percent_Identity=34.5177664974619, Blast_Score=93, Evalue=3e-19, Organism=Homo sapiens, GI210032110, Length=255, Percent_Identity=24.3137254901961, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI20149619, Length=195, Percent_Identity=27.1794871794872, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI150247226, Length=207, Percent_Identity=33.8164251207729, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI40254992, Length=219, Percent_Identity=29.6803652968037, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI224922801, Length=171, Percent_Identity=35.0877192982456, Blast_Score=79, Evalue=3e-15, Organism=Homo sapiens, GI19743808, Length=209, Percent_Identity=31.5789473684211, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI7706318, Length=199, Percent_Identity=28.1407035175879, Blast_Score=79, Evalue=4e-15, Organism=Homo sapiens, GI109715829, Length=238, Percent_Identity=26.0504201680672, Blast_Score=79, Evalue=5e-15, Organism=Homo sapiens, GI25282469, Length=210, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=6e-15, Organism=Homo sapiens, GI15277342, Length=203, Percent_Identity=28.0788177339901, Blast_Score=79, Evalue=7e-15, Organism=Homo sapiens, GI157739938, Length=198, Percent_Identity=31.3131313131313, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI210032112, Length=251, Percent_Identity=22.7091633466135, Blast_Score=73, Evalue=2e-13, Organism=Homo sapiens, GI59889578, Length=165, Percent_Identity=31.5151515151515, Blast_Score=72, Evalue=4e-13, Organism=Homo sapiens, GI40548397, Length=201, Percent_Identity=32.3383084577114, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI214010158, Length=201, Percent_Identity=32.3383084577114, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI214010156, Length=201, Percent_Identity=32.3383084577114, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI22758144, Length=201, Percent_Identity=32.3383084577114, Blast_Score=71, Evalue=1e-12, Organism=Homo sapiens, GI32483357, Length=207, Percent_Identity=29.951690821256, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI4503817, Length=182, Percent_Identity=24.7252747252747, Blast_Score=69, Evalue=6e-12, Organism=Homo sapiens, GI22507405, Length=192, Percent_Identity=30.7291666666667, Blast_Score=68, Evalue=1e-11, Organism=Homo sapiens, GI7705925, Length=185, Percent_Identity=28.6486486486486, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI310128830, Length=263, Percent_Identity=22.8136882129278, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI310115468, Length=263, Percent_Identity=22.8136882129278, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI4758504, Length=203, Percent_Identity=31.0344827586207, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=32.6315789473684, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI1790717, Length=186, Percent_Identity=31.1827956989247, Blast_Score=88, Evalue=7e-19, Organism=Escherichia coli, GI87082100, Length=195, Percent_Identity=29.7435897435897, Blast_Score=81, Evalue=9e-17, Organism=Escherichia coli, GI2367175, Length=224, Percent_Identity=29.9107142857143, Blast_Score=79, Evalue=4e-16, Organism=Escherichia coli, GI87082160, Length=200, Percent_Identity=28, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI1786701, Length=268, Percent_Identity=27.2388059701493, Blast_Score=72, Evalue=4e-14, Organism=Escherichia coli, GI1788459, Length=190, Percent_Identity=30, Blast_Score=64, Evalue=1e-11, Organism=Caenorhabditis elegans, GI193203115, Length=279, Percent_Identity=27.9569892473118, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI193203117, Length=272, Percent_Identity=28.3088235294118, Blast_Score=105, Evalue=2e-23, Organism=Caenorhabditis elegans, GI17564282, Length=271, Percent_Identity=27.3062730627306, Blast_Score=101, Evalue=4e-22, Organism=Caenorhabditis elegans, GI17567345, Length=271, Percent_Identity=25.4612546125461, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17508895, Length=244, Percent_Identity=29.0983606557377, Blast_Score=88, Evalue=4e-18, Organism=Caenorhabditis elegans, GI17555706, Length=225, Percent_Identity=26.2222222222222, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17570069, Length=191, Percent_Identity=26.7015706806283, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI25147288, Length=187, Percent_Identity=29.9465240641711, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI71994604, Length=188, Percent_Identity=28.7234042553192, Blast_Score=72, Evalue=4e-13, Organism=Caenorhabditis elegans, GI71994600, Length=191, Percent_Identity=27.7486910994764, Blast_Score=70, Evalue=1e-12, Organism=Caenorhabditis elegans, GI32563809, Length=201, Percent_Identity=29.3532338308458, Blast_Score=68, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17507613, Length=201, Percent_Identity=29.3532338308458, Blast_Score=67, Evalue=7e-12, Organism=Caenorhabditis elegans, GI71997402, Length=191, Percent_Identity=24.6073298429319, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17561402, Length=194, Percent_Identity=27.8350515463918, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17562908, Length=192, Percent_Identity=30.2083333333333, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17562906, Length=192, Percent_Identity=32.8125, Blast_Score=65, Evalue=5e-11, Organism=Caenorhabditis elegans, GI17544670, Length=282, Percent_Identity=25.886524822695, Blast_Score=64, Evalue=7e-11, Organism=Saccharomyces cerevisiae, GI6323882, Length=261, Percent_Identity=30.2681992337165, Blast_Score=81, Evalue=2e-16, Organism=Saccharomyces cerevisiae, GI6320089, Length=186, Percent_Identity=27.4193548387097, Blast_Score=69, Evalue=7e-13, Organism=Saccharomyces cerevisiae, GI6322861, Length=203, Percent_Identity=27.0935960591133, Blast_Score=65, Evalue=9e-12, Organism=Drosophila melanogaster, GI281364494, Length=242, Percent_Identity=30.1652892561983, Blast_Score=90, Evalue=2e-18, Organism=Drosophila melanogaster, GI21358495, Length=244, Percent_Identity=27.4590163934426, Blast_Score=89, Evalue=2e-18, Organism=Drosophila melanogaster, GI21355631, Length=264, Percent_Identity=29.1666666666667, Blast_Score=89, Evalue=5e-18, Organism=Drosophila melanogaster, GI281364892, Length=199, Percent_Identity=29.6482412060301, Blast_Score=88, Evalue=5e-18, Organism=Drosophila melanogaster, GI116007236, Length=241, Percent_Identity=28.6307053941909, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI24641232, Length=239, Percent_Identity=32.6359832635983, Blast_Score=86, Evalue=3e-17, Organism=Drosophila melanogaster, GI221510726, Length=205, Percent_Identity=27.3170731707317, Blast_Score=85, Evalue=5e-17, Organism=Drosophila melanogaster, GI24581726, Length=220, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI28571387, Length=240, Percent_Identity=30.8333333333333, Blast_Score=80, Evalue=2e-15, Organism=Drosophila melanogaster, GI116007234, Length=234, Percent_Identity=29.0598290598291, Blast_Score=79, Evalue=4e-15, Organism=Drosophila melanogaster, GI21357041, Length=189, Percent_Identity=31.2169312169312, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI24640492, Length=195, Percent_Identity=26.6666666666667, Blast_Score=76, Evalue=3e-14, Organism=Drosophila melanogaster, GI24639444, Length=189, Percent_Identity=28.5714285714286, Blast_Score=76, Evalue=3e-14, Organism=Drosophila melanogaster, GI28571526, Length=191, Percent_Identity=32.4607329842932, Blast_Score=76, Evalue=3e-14, Organism=Drosophila melanogaster, GI24580925, Length=226, Percent_Identity=28.3185840707965, Blast_Score=75, Evalue=4e-14, Organism=Drosophila melanogaster, GI21356301, Length=226, Percent_Identity=26.5486725663717, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24663911, Length=244, Percent_Identity=31.5573770491803, Blast_Score=74, Evalue=8e-14, Organism=Drosophila melanogaster, GI116007238, Length=222, Percent_Identity=26.1261261261261, Blast_Score=74, Evalue=1e-13, Organism=Drosophila melanogaster, GI17737361, Length=200, Percent_Identity=29, Blast_Score=73, Evalue=3e-13, Organism=Drosophila melanogaster, GI24641388, Length=239, Percent_Identity=31.7991631799163, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI24648693, Length=242, Percent_Identity=31.404958677686, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21355889, Length=242, Percent_Identity=31.404958677686, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI24649181, Length=191, Percent_Identity=27.7486910994764, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI23397609, Length=191, Percent_Identity=32.4607329842932, Blast_Score=72, Evalue=6e-13, Organism=Drosophila melanogaster, GI116007232, Length=197, Percent_Identity=28.9340101522843, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24644339, Length=194, Percent_Identity=30.4123711340206, Blast_Score=69, Evalue=3e-12, Organism=Drosophila melanogaster, GI21355319, Length=189, Percent_Identity=26.984126984127, Blast_Score=66, Evalue=3e-11, Organism=Drosophila melanogaster, GI24648944, Length=220, Percent_Identity=23.6363636363636, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR000073 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00561 Abhydrolase_1; PF00106 adh_short [H]
EC number: 1.1.1.100 [C]
Molecular weight: Translated: 30405; Mature: 30274
Theoretical pI: Translated: 7.71; Mature: 7.71
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.1 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.8 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MPGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVAIGDIDEAMAKESGAD CCCCCEECEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHCCCC LDLDMYGKLDVTDPDSFSGFLDAVERQLGPIDVLVNNAGIMPVGRIVDEPDPVTRRILDI CCEEECCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHCCCCCHHHHEEEEE NVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVATYCASKHAVVAFTDSARLEY EEEEEEECCHHHHHHCCCCCCCCEEEHHHHCCHHHEEHHHHHHCCCCEEEEEECCCCEEE RSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVRVTKAAGS CCCCEEEEEECCHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEECCCCC MIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARARGEE HHHHHHHCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCC >Mature Secondary Structure PGRTSIGVKIRDKVQDKVIAITGGARGIGLATAAALHNLGAKVAIGDIDEAMAKESGAD CCCCEECEEECCCCCCEEEEEECCCCCCHHHHHHHHHHCCCEEEECCHHHHHHHHCCCC LDLDMYGKLDVTDPDSFSGFLDAVERQLGPIDVLVNNAGIMPVGRIVDEPDPVTRRILDI CCEEECCEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCHHHCCCCCHHHHEEEEE NVYGVILGSKLAAQRMVPRGRGHVINVASLAGEIYAVGVATYCASKHAVVAFTDSARLEY EEEEEEECCHHHHHHCCCCCCCCEEEHHHHCCHHHEEHHHHHHCCCCEEEEEECCCCEEE RSAGVKFSMVLPSFVNTELIAGTGGIKGFKNAEPADIADAIVGLIVHPKPRVRVTKAAGS CCCCEEEEEECCHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEEECCCCC MIVAQRFMPRQVSEGLNRLLGGEHVFTDDVDMEKRRTYEARARGEE HHHHHHHCHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NADPH [C]
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]
Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]
General reaction: Redox reaction [C]
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 12788972 [H]