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The map label for this gene is zwf2

Identifier: 121637377

GI number: 121637377

Start: 1650230

End: 1651774

Strand: Reverse

Name: zwf2

Synonym: BCG_1508c

Alternate gene names: 121637377

Gene position: 1651774-1650230 (Counterclockwise)

Preceding gene: 121637378

Following gene: 121637376

Centisome position: 37.76

GC content: 65.89

Gene sequence:

>1545_bases
ATGAAACCGGCCCACGCCGCGGCGTCGTGGCGCAACCCGCTACGAGACAAGCGGGACAAGCGATTACCCAGAATCGCCGG
CCCGTGCGGCATGGTGATTTTCGGCGTCACCGGCGACCTGGCCCGCAAGAAGGTGATGCCGGCCGTCTACGATTTGGCCA
ACCGCGGCCTGCTGCCGCCCACATTCTCGCTGGTGGGGTTTGCCCGCCGAGACTGGAGCACCCAGGATTTCGGTCAAGTG
GTGTACAACGCCGTCCAAGAGCACTGCCGAACACCGTTTCGGCAACAGAACTGGGACCGGCTGGCCGAGGGATTCCGTTT
TGTGCCAGGCACTTTCGACGACGACGACGCGTTCGCCCAACTCGCCGAGACGCTGGAGAAGCTCGACGCCGAGCGCGGCA
CCGGCGGCAACCACGCCTTCTACCTGGCGATCCCGCCCAAATCCTTCCCGGTGGTGTGTGAGCAGCTGCACAAGTCCGGC
CTGGCCCGCCCGCAAGGCGACCGGTGGAGCCGAGTCGTGATAGAGAAGCCGTTCGGCCACGACCTGGCCAGCGCACGCGA
GCTGAACAAGGCGGTCAACGCGGTCTTCCCGGAGGAAGCGGTCTTCCGCATCGACCACTACCTGGGCAAAGAGACGGTGC
AGAACATCCTGGCGCTGCGGTTCGCCAACCAGCTGTTCGACCCGATCTGGAATGCGCACTACGTCGACCACGTACAGATC
ACCATGGCCGAAGACATCGGCCTGGGCGGGCGCGCGGGCTATTACGACGGCATCGGCGCGGCCCGCGATGTCATCCAGAA
CCATCTCATGCAGCTGCTGGCGCTGACCGCGATGGAGGAGCCGGTCAGCTTCCACCCGGCAGCGTTGCAGGCCGAGAAGA
TCAAGGTGCTCTCGGCCACCCGCCTTGCCGAGCCACTCGACCAGACCACCAGCCGCGGCCAGTACGCCGCCGGCTGGCAA
GGCGGGGAGAAGGTGGTTGGGCTGCTCGACGAGGAGGGGTTCGCCGAGGACTCCACCACCGAAACCTTCGCCGCTATCAC
CCTGGAAGTCGATACGCGCCGGTGGGCCGGCGTGCCGTTCTATCTGCGAACGGGAAAACGATTGGGCCGCCGGGTGACCG
AGATCGCTCTGGTCTTCAGGCGGGCGCCGCATCTGCCGTTCGACGCCACCATGACCGACGAGCTGGGCACCAACGCGATG
GTCATCCGCGTGCAGCCCGACGAAGGTGTCACATTGCGGTTCGGCTCCAAGGTGCCGGGCACCGCCATGGAAGTCCGCGA
CGTCAACATGGACTTCTCCTACGGCTCGGCATTCGCCGAAGATTCACCGGAGGCCTACGAGCGGCTCATCCTCGACGTCC
TGCTCGGCGAGCCCTCGCTGTTTCCGGTCAACGCGGAGGTCGAACTGGCGTGGGAGATCCTCGATCCAGCGTTGGAACAT
TGGGCGGCACACGGGACGCCCGACGCCTACGAGGCAGGTACCTGGGGTCCGGAATCATCCTTGGAGATGCTGCGCCGCAC
CGGCCGGGAATGGCGGCGGCCATAG

Upstream 100 bases:

>100_bases
ACGTGTTTGCCGTCCTCGAGGAGGAAGGCGTGCGGAAGTTCGAGGCCTCCTGGAACGAGCTACTCCAGGAAACCCGGGCG
CATCTCGACACCGCTGCCCA

Downstream 100 bases:

>100_bases
TGATCCGCGCCGGCGACGATGCAGAGCGAAGCGATGAGGAGGAGCGGCGCAGATGATTGTCGACTTGCCCGACACCACCA
CCACCGCGGTCAACAAGAAG

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQV
VYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSG
LARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQI
TMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQ
GGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAM
VIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEH
WAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP

Sequences:

>Translated_514_residues
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQV
VYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSG
LARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQI
TMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQ
GGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAM
VIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEH
WAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP
>Mature_514_residues
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPPTFSLVGFARRDWSTQDFGQV
VYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQLAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSG
LARPQGDRWSRVVIEKPFGHDLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQI
TMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSATRLAEPLDQTTSRGQYAAGWQ
GGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPFYLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAM
VIRVQPDEGVTLRFGSKVPGTAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEH
WAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI109389365, Length=487, Percent_Identity=36.9609856262834, Blast_Score=314, Evalue=2e-85,
Organism=Homo sapiens, GI108773793, Length=487, Percent_Identity=36.9609856262834, Blast_Score=314, Evalue=2e-85,
Organism=Homo sapiens, GI52145310, Length=524, Percent_Identity=28.4351145038168, Blast_Score=168, Evalue=1e-41,
Organism=Escherichia coli, GI1788158, Length=497, Percent_Identity=41.6498993963783, Blast_Score=381, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17538218, Length=501, Percent_Identity=37.125748502994, Blast_Score=344, Evalue=6e-95,
Organism=Saccharomyces cerevisiae, GI6324088, Length=484, Percent_Identity=38.0165289256198, Blast_Score=327, Evalue=3e-90,
Organism=Drosophila melanogaster, GI24643350, Length=482, Percent_Identity=35.8921161825726, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI24643352, Length=482, Percent_Identity=35.8921161825726, Blast_Score=301, Evalue=7e-82,
Organism=Drosophila melanogaster, GI221513548, Length=488, Percent_Identity=27.6639344262295, Blast_Score=191, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PD_MYCBO (P0A585)

Other databases:

- EMBL:   BX248339
- RefSeq:   NP_855134.1
- ProteinModelPortal:   P0A585
- SMR:   P0A585
- EnsemblBacteria:   EBMYCT00000015099
- GeneID:   1092339
- GenomeReviews:   BX248333_GR
- KEGG:   mbo:Mb1482c
- GeneTree:   EBGT00050000015853
- HOGENOM:   HBG322449
- OMA:   SRRWAGV
- ProtClustDB:   PRK05722
- BioCyc:   MBOV233413:MB1482C-MONOMER
- BRENDA:   1.1.1.49
- GO:   GO:0005488
- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR23429
- PIRSF:   PIRSF000110
- PRINTS:   PR00079
- TIGRFAMs:   TIGR00871

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N

EC number: =1.1.1.49

Molecular weight: Translated: 57344; Mature: 57344

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: ACT_SITE 268-268 BINDING 37-37 BINDING 69-69 BINDING 206-206 BINDING 210-210

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
TFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHCCCEECCCCCCCHHHHHH
LAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGH
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
DLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQI
CHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEECEEEE
TMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSAT
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
RLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPF
HHHHHHHHHHCCCCCCCCCCCCCHHEEEECCCCCCCCCCCCEEEEEEEEECCCHHCCCCH
YLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECCCCEEEEECCCCCC
TAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEH
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
WAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKPAHAAASWRNPLRDKRDKRLPRIAGPCGMVIFGVTGDLARKKVMPAVYDLANRGLLPP
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCCCCC
TFSLVGFARRDWSTQDFGQVVYNAVQEHCRTPFRQQNWDRLAEGFRFVPGTFDDDDAFAQ
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHCCCHHHHHCCCEECCCCCCCHHHHHH
LAETLEKLDAERGTGGNHAFYLAIPPKSFPVVCEQLHKSGLARPQGDRWSRVVIEKPFGH
HHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
DLASARELNKAVNAVFPEEAVFRIDHYLGKETVQNILALRFANQLFDPIWNAHYVDHVQI
CHHHHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEECEEEE
TMAEDIGLGGRAGYYDGIGAARDVIQNHLMQLLALTAMEEPVSFHPAALQAEKIKVLSAT
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHH
RLAEPLDQTTSRGQYAAGWQGGEKVVGLLDEEGFAEDSTTETFAAITLEVDTRRWAGVPF
HHHHHHHHHHCCCCCCCCCCCCCHHEEEECCCCCCCCCCCCEEEEEEEEECCCHHCCCCH
YLRTGKRLGRRVTEIALVFRRAPHLPFDATMTDELGTNAMVIRVQPDEGVTLRFGSKVPG
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCEEEEEEECCCCEEEEECCCCCC
TAMEVRDVNMDFSYGSAFAEDSPEAYERLILDVLLGEPSLFPVNAEVELAWEILDPALEH
CEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHH
WAAHGTPDAYEAGTWGPESSLEMLRRTGREWRRP
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972