BacMap

Definition	Mycobacterium bovis BCG str. Pasteur 1173P2, complete genome.
Accession	NC_008769
Length	4,374,522

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The map label for this gene is fadD36 [H]

Identifier: 121637122

GI number: 121637122

Start: 1365530

End: 1366951

Strand: Direct

Name: fadD36 [H]

Synonym: BCG_1253

Alternate gene names: 121637122

Gene position: 1365530-1366951 (Clockwise)

Preceding gene: 121637121

Following gene: 121637124

Centisome position: 31.22

GC content: 68.35

Gene sequence:

>1422_bases
GTGCTGCTGGCCTCCCTGAATCCTGCTGTCGTCTCCGCCGCCGATATCGCGGACGCGGTCCGCATCGACGGCGACGTGCT
GAGCCGTAGCGACCTGGTCGGCGCGGCAACGTCGGTGGCCGAGCGGGTCGCCGGTGCGCACCGGGTCGCCGTGCTGGCCA
CGCCGACCGCGTCGACGGTGCTGGCGATCACCGGCTGCCTGATCGCCGGCGTGCCGGTTGTGCCGGTACCCGCCGATGTG
GGCGTCACCGAACGCCGGCACATGCTCACCGACTCCGGCGTCCAGGCATGGCTGGGCCCGTTGCCCGACGACCCAGCGGG
GCTGCCACACATCCCGGTGCGCACGCACGCGCGGTCCTGGCACCGTTATCCGGAGCCCTCACCCGGGGCCATCGCCATGG
TGGTCTACACGTCCGGCACCACCGGGCCGCCCAAAGGCGTGCAGCTGAGCCGGCGGGCGATCGCCGCCGACCTCGATGCA
TTGGCAGAGGCCTGGCAGTGGACGGCCGAGGACGTGCTGGTCCACGGTCTGCCGCTGTATCACGTTCACGGCCTGGTGCT
GGGCTTGCTCGGGTCGCTGCGGTTCGGAAATCGCTTCGTGCACACCGGTAAACCAACGCCGGCCGGCTACGCCCAGGCCT
GTTATGAAGCGCACGGCACGTTGTTTTTTGGGGTGCCGACGGTGTGGTCACGAGTGGCGGCCGACCAAGCTGCCGCCGGG
GCGCTCAAACCGGCGCGGCTGCTGGTGTCCGGGAGTGCGGCACTACCCGTGCCGGTGTTCGACAAGCTGGTGCAGCTCAC
CGGGCACCGGCCCGTCGAACGCTACGGTGCTTCGGAGTCGCTGATCACCCTATCGACGCGGGCTGACGGTGAGCGTCGCC
CGGGCTGGGTCGGCCTGCCGCTGGCCGGTGTGCAGACCCGACTGGTGGACGACGATGGCGGTGAGGTCCCGCACGACGGG
GAAACCGTTGGAAAGCTTCAGGTTCGCGGTCCGACCCTGTTCGACGGCTACCTGAATCAACCCGATGCCACCGCCGCGGC
GTTCGACGCCGACAGCTGGTACCGCACCGGCGACGTCGCGGTGGTCGACGGCAGTGGGATGCACCGCATCGTGGGACGCG
AGTCGGTCGACTTGATCAAGTCGGGTGGATACCGGGTCGGCGCCGGTGAAATTGAAACGGTGCTGCTCGGGCATCCGGAC
GTGGCGGAGGCGGCAGTCGTCGGGGTGCCCGACGATGATCTAGGCCAGCGGATCGTTGCCTACGTAGTCGGCTCAGCGAA
TGTCGATGCGGACGGGCTTATCAACTTTGTTGCCCAACAACTTTCGGTGCACAAGCGCCCGCGCGAGGTGCGTATCGTAG
ATGCGCTGCCGCGCAACGCGTTGGGGAAAGTGCTCAAGAAGCAGTTGCTGTCAGAAGGCTGA

Upstream 100 bases:

>100_bases
GTTTCCGCGACCGGATACACCGGCAGAGGCGGTCAGCACCCCCCAGACGCGACCGGCCTGACGGGGCAGGCGATCACGGC
GCCGGGGTAGCCTCGCTCAC

Downstream 100 bases:

>100_bases
GCTACGGCGAATTATCGTGTACCGCTGGACAGTTACGCTGGCACACTGTTACTCCGACGGCCCGGTGAGCTTAGCGCATG
GGCCTTGTTGCCGCGCCACT

Product: acyl-CoA synthetase

Products: NA

Alternate protein names: Long-chain acyl-CoA synthetase [H]

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAGAHRVAVLATPTASTVLAITGCLIAGVPVVPVPADV
GVTERRHMLTDSGVQAWLGPLPDDPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDA
LAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAG
ALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPGWVGLPLAGVQTRLVDDDGGEVPHDG
ETVGKLQVRGPTLFDGYLNQPDATAAAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHPD
VAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPRNALGKVLKKQLLSEG

Sequences:

>Translated_473_residues
MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAGAHRVAVLATPTASTVLAITGCLIAGVPVVPVPADV
GVTERRHMLTDSGVQAWLGPLPDDPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDA
LAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAG
ALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPGWVGLPLAGVQTRLVDDDGGEVPHDG
ETVGKLQVRGPTLFDGYLNQPDATAAAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHPD
VAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPRNALGKVLKKQLLSEG
>Mature_473_residues
MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAGAHRVAVLATPTASTVLAITGCLIAGVPVVPVPADV
GVTERRHMLTDSGVQAWLGPLPDDPAGLPHIPVRTHARSWHRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDA
LAEAWQWTAEDVLVHGLPLYHVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAG
ALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPGWVGLPLAGVQTRLVDDDGGEVPHDG
ETVGKLQVRGPTLFDGYLNQPDATAAAFDADSWYRTGDVAVVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHPD
VAEAAVVGVPDDDLGQRIVAYVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPRNALGKVLKKQLLSEG

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=375, Percent_Identity=39.2, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI187761343, Length=375, Percent_Identity=39.2, Blast_Score=235, Evalue=8e-62,
Organism=Homo sapiens, GI156151445, Length=350, Percent_Identity=29.4285714285714, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI122937307, Length=349, Percent_Identity=27.7936962750716, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI157311624, Length=469, Percent_Identity=24.5202558635394, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI157311622, Length=469, Percent_Identity=24.5202558635394, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI42544132, Length=372, Percent_Identity=26.6129032258064, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI38505220, Length=412, Percent_Identity=27.1844660194175, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI58082049, Length=380, Percent_Identity=27.3684210526316, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI115511026, Length=378, Percent_Identity=28.042328042328, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI40807491, Length=352, Percent_Identity=26.4204545454545, Blast_Score=100, Evalue=5e-21,
Organism=Homo sapiens, GI57165410, Length=343, Percent_Identity=26.530612244898, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI57165412, Length=343, Percent_Identity=26.2390670553936, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI28416953, Length=380, Percent_Identity=25.5263157894737, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI13236579, Length=380, Percent_Identity=24.2105263157895, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1788107, Length=364, Percent_Identity=32.967032967033, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI145693145, Length=343, Percent_Identity=30.9037900874636, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI1786810, Length=357, Percent_Identity=31.0924369747899, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI221142682, Length=354, Percent_Identity=25.7062146892655, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1789201, Length=355, Percent_Identity=28.169014084507, Blast_Score=102, Evalue=8e-23,
Organism=Escherichia coli, GI1790505, Length=363, Percent_Identity=28.099173553719, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786801, Length=301, Percent_Identity=29.5681063122924, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1788595, Length=468, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786529, Length=379, Percent_Identity=28.4960422163588, Blast_Score=69, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17558820, Length=492, Percent_Identity=30.2845528455285, Blast_Score=214, Evalue=8e-56,
Organism=Caenorhabditis elegans, GI32563687, Length=466, Percent_Identity=29.6137339055794, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17557194, Length=384, Percent_Identity=29.9479166666667, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17531443, Length=357, Percent_Identity=29.6918767507003, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17559526, Length=397, Percent_Identity=28.2115869017632, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17538037, Length=384, Percent_Identity=28.3854166666667, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71994703, Length=361, Percent_Identity=28.2548476454294, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71994694, Length=361, Percent_Identity=28.2548476454294, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71994690, Length=308, Percent_Identity=30.5194805194805, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17560308, Length=355, Percent_Identity=30.1408450704225, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71996755, Length=356, Percent_Identity=28.0898876404494, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17560140, Length=365, Percent_Identity=26.5753424657534, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17556552, Length=360, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI25141359, Length=446, Percent_Identity=21.9730941704036, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=351, Percent_Identity=24.2165242165242, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17510401, Length=187, Percent_Identity=29.4117647058824, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=342, Percent_Identity=30.9941520467836, Blast_Score=153, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6320852, Length=407, Percent_Identity=25.3071253071253, Blast_Score=93, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6319264, Length=376, Percent_Identity=27.1276595744681, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6323182, Length=373, Percent_Identity=26.0053619302949, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355181, Length=348, Percent_Identity=31.8965517241379, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI18859661, Length=357, Percent_Identity=28.0112044817927, Blast_Score=131, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24581924, Length=358, Percent_Identity=29.608938547486, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI221329755, Length=392, Percent_Identity=24.7448979591837, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI19922652, Length=352, Percent_Identity=28.9772727272727, Blast_Score=108, Evalue=9e-24,
Organism=Drosophila melanogaster, GI24656500, Length=356, Percent_Identity=29.4943820224719, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24648260, Length=507, Percent_Identity=25.4437869822485, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24653035, Length=342, Percent_Identity=26.6081871345029, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI21356947, Length=354, Percent_Identity=25.1412429378531, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281366413, Length=354, Percent_Identity=28.5310734463277, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666501, Length=354, Percent_Identity=28.5310734463277, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24666497, Length=354, Percent_Identity=28.5310734463277, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24648257, Length=388, Percent_Identity=26.8041237113402, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI161076582, Length=349, Percent_Identity=24.9283667621776, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI21356441, Length=347, Percent_Identity=25.6484149855908, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24667959, Length=188, Percent_Identity=28.7234042553192, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI62472339, Length=188, Percent_Identity=28.7234042553192, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667955, Length=188, Percent_Identity=28.7234042553192, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI20130353, Length=365, Percent_Identity=24.3835616438356, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI28573631, Length=365, Percent_Identity=24.3835616438356, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI281365686, Length=316, Percent_Identity=21.5189873417722, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21358303, Length=210, Percent_Identity=24.7619047619048, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24648253, Length=339, Percent_Identity=23.0088495575221, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24648255, Length=339, Percent_Identity=23.3038348082596, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020459
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.3 [H]

Molecular weight: Translated: 49521; Mature: 49521

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAGAHRVAVLATPTASTV
CEEECCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
LAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWLGPLPDDPAGLPHIPVRTHARSW
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHH
HRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLY
CCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHH
HVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAG
HHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHC
ALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPGWVGLP
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCCEEECC
LAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATAAAFDADSWYRTGDVA
CCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCEEECCCCCEECCCEE
VVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHPDVAEAAVVGVPDDDLGQRIVA
EECCCCCEEHHCCCHHHHHHCCCEEECCCCEEEEEECCCCHHCEEEEECCCHHHHHHEEH
YVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPRNALGKVLKKQLLSEG
HEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLLASLNPAVVSAADIADAVRIDGDVLSRSDLVGAATSVAERVAGAHRVAVLATPTASTV
CEEECCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHCCCEEEEEEECCCHHHH
LAITGCLIAGVPVVPVPADVGVTERRHMLTDSGVQAWLGPLPDDPAGLPHIPVRTHARSW
HHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHH
HRYPEPSPGAIAMVVYTSGTTGPPKGVQLSRRAIAADLDALAEAWQWTAEDVLVHGLPLY
CCCCCCCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCHHH
HVHGLVLGLLGSLRFGNRFVHTGKPTPAGYAQACYEAHGTLFFGVPTVWSRVAADQAAAG
HHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHC
ALKPARLLVSGSAALPVPVFDKLVQLTGHRPVERYGASESLITLSTRADGERRPGWVGLP
CCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHCCCCCEEEEEECCCCCCCCCEEECC
LAGVQTRLVDDDGGEVPHDGETVGKLQVRGPTLFDGYLNQPDATAAAFDADSWYRTGDVA
CCCCEEEEECCCCCCCCCCCCCEEEEEECCCEEECCCCCCCCCCCEEECCCCCEECCCEE
VVDGSGMHRIVGRESVDLIKSGGYRVGAGEIETVLLGHPDVAEAAVVGVPDDDLGQRIVA
EECCCCCEEHHCCCHHHHHHCCCEEECCCCEEEEEECCCCHHCEEEEECCCHHHHHHEEH
YVVGSANVDADGLINFVAQQLSVHKRPREVRIVDALPRNALGKVLKKQLLSEG
HEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]