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The map label for this gene is mazG

Identifier: 121636950

GI number: 121636950

Start: 1173156

End: 1174133

Strand: Direct

Name: mazG

Synonym: BCG_1078

Alternate gene names: 121636950

Gene position: 1173156-1174133 (Clockwise)

Preceding gene: 121636949

Following gene: 121636951

Centisome position: 26.82

GC content: 62.17

Gene sequence:

>978_bases
ATGATTGTCGTCCTGGTCGACCCCCGGCGTCCGACACTGGTGCCTGTTGAAGCGATCGAGTTCCTGCGCGGCGAGGTGCA
ATACACCGAGGAAATGCCGGTCGCGGTGCCCTGGTCGCTACCAGCGGCTCGTTCGGCGCACGCCGGAAACGACGCGCCGG
TGTTGCTGTCGTCTGACCCCAACCATCCTGCTGTCATTACTCGACTGGCCGCCGGTGCCCGGCTGATCTCGGCACCGGAT
TCTCAGCGTGGCGAACGACTCGTCGACGCCGTCGCGATGATGGACAAGCTGCGCACCGCCGGACCGTGGGAAAGTGAGCA
GACTCACGACTCGCTGCGCAGATACCTGCTGGAGGAGACCTACGAGCTGTTGGACGCGGTCCGCAGCGGCAGTGTTGACC
AGCTGCGCGAAGAGCTTGGTGATCTCTTGCTGCAGGTCCTCTTTCACGCCCGGATCGCTGAGGATGCGTCGCAATCGCCG
TTCACCATCGACGACGTCGCCGACACACTGATGCGAAAGCTCGGCAATCGGGCGCCAGGAGTACTTGCGGGCGAATCGAT
TTCGCTCGAAGATCAACTGGCGCAATGGGAGGCAGCCAAGGCCTCGGAAAAGGCGCGAAAGTCGGTAGCCGACGATGTCC
ATACGGGCCAGCCGGCATTAGCGCTGGCGCAGAAGGTTATTCAGCGTGCCCAAAAGGCTGGGCTGCCCGCTCACCTGATC
CCCGATGAGATCACTTCTGTTTCGGTTTCAGCTGACGTAGATGCGGAAAACACGCTGCGCACTGCCGTTTTGGACTTTAT
TGACAGGCTGCGCTGTGCCGAGCGGGCAATTGCCGTCGCACGCCGGGGCAGCAACGTTGCCGAGCAGCTCGATGTGACGC
CGCTGGGTGTGATCACCGAGCAGGAGTGGCTCGCGCATTGGCCAACTGCTGTCAACGATTCCCGCGGCGGGTCCAAGAAA
CGTAAAGGCATGCGATAA

Upstream 100 bases:

>100_bases
TCGCTGGGAAACCGCGCCAGCATATTGGTATAACGAACCCTAGCCCGCCAGGCGAAGACGGCCGTGGTCGCAACACGACG
ATTAAGGAGCGACAACCGTG

Downstream 100 bases:

>100_bases
CCGCCCCGAGTGCGACGGGGTAGTCAACAAACCCATGGGACGATGATCGTGACGGAAGCCGGTATAGGTGCCCTACGAGG
GAGAGTTGTGTCGCCGAGAC

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPD
SQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSP
FTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKK
RKGMR

Sequences:

>Translated_325_residues
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPD
SQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSP
FTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKK
RKGMR
>Mature_325_residues
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDPNHPAVITRLAAGARLISAPD
SQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEETYELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSP
FTIDDVADTLMRKLGNRAPGVLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITEQEWLAHWPTAVNDSRGGSKK
RKGMR

Specific function: Required to maintain the full capacity of the mycobacteria to respond to oxidative stress via the degradation of the oxidation-induced damaged nucleotides. It hydrolyzes all canonical (d)NTPs, as well as the mutagenic dUTP and 8-oxo-7,8- dihydro-2'-deoxyg

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family

Homologues:

Organism=Escherichia coli, GI1789144, Length=152, Percent_Identity=39.4736842105263, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MAZG_MYCTU (P96379)

Other databases:

- EMBL:   BX842575
- PIR:   H70622
- RefSeq:   NP_215537.1
- ProteinModelPortal:   P96379
- SMR:   P96379
- EnsemblBacteria:   EBMYCT00000000313
- GeneID:   886052
- GenomeReviews:   AL123456_GR
- KEGG:   mtu:Rv1021
- TubercuList:   Rv1021
- GeneTree:   EBGT00050000016580
- HOGENOM:   HBG616899
- OMA:   IAVPWSL
- ProtClustDB:   PRK12334
- InterPro:   IPR004518

Pfam domain/function: PF03819 MazG

EC number: =3.6.1.8

Molecular weight: Translated: 35414; Mature: 35414

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDP
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEEEECCC
NHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEET
CCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
VLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITE
CHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEECC
QEWLAHWPTAVNDSRGGSKKRKGMR
HHHHHHCCCCCCCCCCCCHHCCCCC
>Mature Secondary Structure
MIVVLVDPRRPTLVPVEAIEFLRGEVQYTEEMPVAVPWSLPAARSAHAGNDAPVLLSSDP
CEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCCCEEEECCC
NHPAVITRLAAGARLISAPDSQRGERLVDAVAMMDKLRTAGPWESEQTHDSLRRYLLEET
CCHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHH
YELLDAVRSGSVDQLREELGDLLLQVLFHARIAEDASQSPFTIDDVADTLMRKLGNRAPG
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
VLAGESISLEDQLAQWEAAKASEKARKSVADDVHTGQPALALAQKVIQRAQKAGLPAHLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
PDEITSVSVSADVDAENTLRTAVLDFIDRLRCAERAIAVARRGSNVAEQLDVTPLGVITE
CHHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEECC
QEWLAHWPTAVNDSRGGSKKRKGMR
HHHHHHCCCCCCCCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230