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The map label for this gene is mscL [H]

Identifier: 121636912

GI number: 121636912

Start: 1131514

End: 1131969

Strand: Reverse

Name: mscL [H]

Synonym: BCG_1040c

Alternate gene names: 121636912

Gene position: 1131969-1131514 (Counterclockwise)

Preceding gene: 121636916

Following gene: 121636907

Centisome position: 25.88

GC content: 59.87

Gene sequence:

>456_bases
ATGCTCAAAGGATTCAAGGAGTTTCTCGCGCGGGGTAATATCGTCGACCTGGCTGTCGCGGTGGTAATCGGCACAGCGTT
CACGGCGTTGGTCACCAAGTTCACCGACAGCATCATTACGCCGCTGATCAACCGGATCGGCGTCAACGCACAGTCCGACG
TCGGCATCTTGCGGATCGGTATCGGCGGTGGTCAGACCATTGACTTGAACGTCTTGTTGTCGGCAGCGATCAACTTTTTC
CTGATCGCGTTCGCGGTGTACTTCCTAGTCGTGCTGCCCTACAACACACTACGCAAGAAGGGGGAGGTCGAGCAGCCGGG
CGACACCCAAGTCGTGCTGCTCACCGAAATCCGCGATCTGCTCGCGCAAACGAACGGGGACTCGCCGGGGAGGCACGGCG
GCCGTGGGACACCATCGCCAACCGACGGGCCTCTCGCGAGCACAGAATCGCAATAG

Upstream 100 bases:

>100_bases
ACGGCGATCCCAGCGTCGTGGCCATTGACACCACCTGGTCTAGTTTTTCTAGGTGTTCCACTCGCGGACTGCCGGCCGCC
GACTGCAGAAAGGACATCGC

Downstream 100 bases:

>100_bases
CCCGACACTCGATCCGGATTCAGATCTCCAAGCTCGACAACTGCCCGATGATCTGTGCCGCTAGCGGATTCAGCGTCGCC
ATTCCATCGCGCACCGCATA

Product: large-conductance mechanosensitive channel

Products: non-specific ion/solute [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINRIGVNAQSDVGILRIGIGGGQTIDLNVLLSAAINFF
LIAFAVYFLVVLPYNTLRKKGEVEQPGDTQVVLLTEIRDLLAQTNGDSPGRHGGRGTPSPTDGPLASTESQ

Sequences:

>Translated_151_residues
MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINRIGVNAQSDVGILRIGIGGGQTIDLNVLLSAAINFF
LIAFAVYFLVVLPYNTLRKKGEVEQPGDTQVVLLTEIRDLLAQTNGDSPGRHGGRGTPSPTDGPLASTESQ
>Mature_151_residues
MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINRIGVNAQSDVGILRIGIGGGQTIDLNVLLSAAINFF
LIAFAVYFLVVLPYNTLRKKGEVEQPGDTQVVLLTEIRDLLAQTNGDSPGRHGGRGTPSPTDGPLASTESQ

Specific function: Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell [H]

COG id: COG1970

COG function: function code M; Large-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscL family [H]

Homologues:

Organism=Escherichia coli, GI1789686, Length=134, Percent_Identity=36.5671641791045, Blast_Score=70, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019823
- InterPro:   IPR001185
- InterPro:   IPR015089 [H]

Pfam domain/function: PF01741 MscL [H]

EC number: NA

Molecular weight: Translated: 15981; Mature: 15981

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS01327 MSCL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINRIGVNAQSDVGILRIG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
IGGGQTIDLNVLLSAAINFFLIAFAVYFLVVLPYNTLRKKGEVEQPGDTQVVLLTEIRDL
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCEEEEHHHHHHH
LAQTNGDSPGRHGGRGTPSPTDGPLASTESQ
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLKGFKEFLARGNIVDLAVAVVIGTAFTALVTKFTDSIITPLINRIGVNAQSDVGILRIG
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
IGGGQTIDLNVLLSAAINFFLIAFAVYFLVVLPYNTLRKKGEVEQPGDTQVVLLTEIRDL
CCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCCCCCCCCCEEEEHHHHHHH
LAQTNGDSPGRHGGRGTPSPTDGPLASTESQ
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: non-specific ion/solute [Cytoplasm] [C]

Specific reaction: non-specific ion/solute [Cytoplasm] = non-specific ion/solute [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]