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The map label for this gene is accD2 [H]

Identifier: 121636900

GI number: 121636900

Start: 1116232

End: 1117821

Strand: Reverse

Name: accD2 [H]

Synonym: BCG_1028c

Alternate gene names: 121636900

Gene position: 1117821-1116232 (Counterclockwise)

Preceding gene: 121636901

Following gene: 121636899

Centisome position: 25.55

GC content: 66.1

Gene sequence:

>1590_bases
GTGCTGCAATCCACACTGGACCCGAACGCTTCCGCCTACGACGAGGCGGCCGCGACGATGAGCGGCAAGCTCGACGAGAT
CAACGCCGAACTGGCCAAGGCGCTCGCCGGCGGTGGCCCCAAATACGTCGACCGGCACCACGCCCGCGGCAAGCTGACAC
CACGGGAACGCATCGAGCTGCTCGTCGACCCGGACTCCCCGTTCCTGGAGCTGAGCCCGCTGGCCGCCTACGGCAGCAAC
TTCCAGATCGGCGCCAGCCTGGTCACCGGCATCGGCGCGGTCTGCGGCGTGGAATGCATGATCGTCGCCAACGACCCGAC
GGTCAAGGGCGGCACCAGCAATCCGTGGACGCTTCGAAAGATACTGCGGGCCAACCAGATCGCCTTCGAAAACCGGCTTC
CCGTCATTTCGCTGGTGGAATCCGGCGGGGCCGATCTGCCCACCCAGAAAGAGATTTTCATCCCCGGCGGACAGATGTTC
CGCGACCTGACCCGGCTGTCGGCGGCCGGGATCCCGACCATTGCGCTGGTTTTCGGCAACTCCACCGCGGGCGGTGCCTA
CGTCCCCGGCATGTCCGATCACGTGGTGATGATCAAGGAACGCTCCAAGGTGTTTTTGGCCGGCCCGCCGCTAGTGAAGA
TGGCCACCGGCGAAGAGTCCGACGACGAGTCGCTGGGCGGCGCCGAAATGCACGCCCGCATATCGGGTTTGGCCGACTAT
TTTGCGCTCGACGAGCTCGACGCGATCCGCATCGGACGCCGCATCGTGGCGCGACTGAACTGGATCAAACAGGGACCCGC
ACCCGCTCCGGTGACCGAGCCGCTGTTCGACGCCGAGGAGCTAATCGGCATCGTGCCCCCGGATCTGCGCATCCCATTCG
ACCCGCGCGAGGTGATCGCCCGCATCGTCGATGGCTCCGAGTTCGACGAATTCAAGCCGCTGTACGGGTCGTCTCTGGTG
ACCGGCTGGGCTCGGTTGCACGGCTATCCGCTGGGCATCCTGGCCAACGCCCGCGGCGTGCTGTTCAGCGAGGAATCACA
GAAGGCCACCCAGTTCATCCAGCTGGCCAACCGGGCCGACACGCCGCTGTTGTTCTTACACAACACCACCGGCTACATGG
TGGGCAAGGACTACGAGGAAGGCGGGATGATCAAGCATGGCTCGATGATGATCAACGCCGTGTCCAACTCGACCGTCCCG
CACATCTCGCTGCTGATCGGCGCGTCCTACGGCGCCGGGCACTACGGCATGTGCGGGCGCGCCTACGACCCGCGCTTCCT
ATTCGCCTGGCCCAGCGCCAAGTCCGCGGTGATGGGCGGCGCCCAGCTGTCGGGCGTGCTGTCCATCGTGGCCCGGGCGG
CAGCCGAAGCCCGCGGGCAGCAAGTCGACGAAGCCGCCGACGCGGCGATGCGGGCCGCCGTCGAGGGCCAGATCGAAGCC
GAGTCGCTACCGTTGGTGCTGTCCGGGATGCTTTACGACGACGGGGTGATCGACCCGCGCGACACCCGCACCGTGCTGGG
AATGTGTTTGTCCGCCATCGCCAATGGCCCGATCAAGGGGACGTCGAACTTCGGCGTCTTCCGGATGTGA

Upstream 100 bases:

>100_bases
AACGCCAATACCGGGACATGCGAATCCTCGGTATCGGAGGCGGCACCACCGAAATACTGACCGCTTTGGCCGCCAAAACC
CTGGGGTATCAATCGTGACC

Downstream 100 bases:

>100_bases
TGCTGATGGGAATCACTCGAGTATTGGTTGCTAACCGCGGCGAGATCGCCCGGCGGGTGTTCGCCACCTGCCGCCGGCTG
GGGCTCGGCACCGTCGCCGT

Product: putative acetyl-/propionyl-coa carboxylase subunit beta accD2

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 529; Mature: 529

Protein sequence:

>529_residues
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAYGSN
FQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLV
TGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVP
HISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM

Sequences:

>Translated_529_residues
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAYGSN
FQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLV
TGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVP
HISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM
>Mature_529_residues
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGKLTPRERIELLVDPDSPFLELSPLAAYGSN
FQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRKILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMF
RDLTRLSAAGIPTIALVFGNSTAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIARIVDGSEFDEFKPLYGSSLV
TGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRADTPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVP
HISLLIGASYGAGHYGMCGRAYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI11545863, Length=531, Percent_Identity=49.7175141242938, Blast_Score=495, Evalue=1e-140,
Organism=Homo sapiens, GI119943100, Length=511, Percent_Identity=31.3111545988258, Blast_Score=215, Evalue=1e-55,
Organism=Homo sapiens, GI295821216, Length=531, Percent_Identity=30.3201506591337, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI310133460, Length=138, Percent_Identity=47.8260869565217, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17552936, Length=535, Percent_Identity=46.9158878504673, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI25147362, Length=510, Percent_Identity=30.5882352941176, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI25147359, Length=513, Percent_Identity=30.4093567251462, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24586065, Length=552, Percent_Identity=47.2826086956522, Blast_Score=513, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 56271; Mature: 56271

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGKLTPRERIEL
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHCEEE
LVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK
EECCCCCCEEECCHHHCCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHH
ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGN
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECC
STAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
CCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHH
RIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRAD
HHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHCCC
TPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGR
CCEEEEECCCCEEECCCCCCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCC
AYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
CCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM
CCCCEEEECEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC
>Mature Secondary Structure
MLQSTLDPNASAYDEAAATMSGKLDEINAELAKALAGGGPKYVDRHHARGKLTPRERIEL
CCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCHHHCEEE
LVDPDSPFLELSPLAAYGSNFQIGASLVTGIGAVCGVECMIVANDPTVKGGTSNPWTLRK
EECCCCCCEEECCHHHCCCCCEEHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCHHHHH
ILRANQIAFENRLPVISLVESGGADLPTQKEIFIPGGQMFRDLTRLSAAGIPTIALVFGN
HHHHHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCHHHHHHHHHHHHCCCCEEEEEECC
STAGGAYVPGMSDHVVMIKERSKVFLAGPPLVKMATGEESDDESLGGAEMHARISGLADY
CCCCCEECCCCCCCEEEEEECCEEEEECCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
FALDELDAIRIGRRIVARLNWIKQGPAPAPVTEPLFDAEELIGIVPPDLRIPFDPREVIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHH
RIVDGSEFDEFKPLYGSSLVTGWARLHGYPLGILANARGVLFSEESQKATQFIQLANRAD
HHHCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCCEEEECCHHHHHHHHHHHHCCC
TPLLFLHNTTGYMVGKDYEEGGMIKHGSMMINAVSNSTVPHISLLIGASYGAGHYGMCGR
CCEEEEECCCCEEECCCCCCCCEEEECCEEEEECCCCCCCEEEEEEECCCCCCCCCCCCC
AYDPRFLFAWPSAKSAVMGGAQLSGVLSIVARAAAEARGQQVDEAADAAMRAAVEGQIEA
CCCCEEEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCC
ESLPLVLSGMLYDDGVIDPRDTRTVLGMCLSAIANGPIKGTSNFGVFRM
CCCCEEEECEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]