Click here to switch to the map view.

The map label for this gene is pkn1 [H]

Identifier: 121636634

GI number: 121636634

Start: 840208

End: 841107

Strand: Direct

Name: pkn1 [H]

Synonym: BCG_0762

Alternate gene names: 121636634

Gene position: 840208-841107 (Clockwise)

Preceding gene: 121636633

Following gene: 121636635

Centisome position: 19.21

GC content: 67.0

Gene sequence:

>900_bases
GTGCTGACCGAGTTGGTTGACCTGCCCGGCGGATCGTTCCGCATGGGCTCGACGCGCTTCTACCCCGAAGAAGCGCCGAT
TCATACCGTGACCGTGCGCGCCTTTGCGGTAGAGCGACACCCGGTGACCAACGCGCAATTTGCCGAATTCGTCTCCGCGA
CAGGCTATGTGACGGTTGCAGAACAACCCCTTGACCCCGGGCTCTACCCAGGAGTGGACGCAGCAGACCTGTGTCCCGGT
GCGATGGTGTTTTGTCCGACGGCCGGGCCGGTCGACCTGCGTGACTGGCGGCAATGGTGGGACTGGGTACCTGGCGCCTG
CTGGCGCCATCCGTTTGGCCGGGACAGCGATATCGCCGACCGAGCCGGCCACCCGGTCGTACAGGTGGCCTATCCGGACG
CCGTGGCCTACGCACGATGGGCTGGTCGACGCCTACCGACCGAGGCCGAGTGGGAGTACGCGGCCCGTGGCGGAACCACG
GCAACCTATGCGTGGGGCGACCAGGAGAAGCCGGGGGGCATGCTCATGGCGAACACCTGGCAGGGCCGGTTTCCTTACCG
CAACGACGGTGCATTGGGCTGGGTGGGAACCTCCCCGGTGGGCAGGTTTCCGGCCAACGGGTTTGGCTTGCTCGACATGA
TCGGAAACGTTTGGGAGTGGACCACCACCGAGTTCTATCCACACCATCGCATCGATCCACCCTCGACGGCCTGCTGCGCA
CCGGTCAAGCTCGCTACAGCCGCCGACCCGACGATCAGCCAGACCCTCAAGGGCGGCTCGCACCTGTGCGCGCCGGAGTA
CTGCCACCGCTACCGCCCGGCGGCGCGCTCGCCGCAGTCGCAGGACACCGCGACCACCCATATCGGGTTCCGGTGCGTGG
CCGACCCGGTGTCCGGGTAG

Upstream 100 bases:

>100_bases
GACCGTTCGAAGATGTGGAATCCGATCTTGCGCTTGCTTTTTCGCGTGACTGAGCGGTCTGCTGTGACGCGGGACGGCGT
GGTCGGCATACGCTGAAGTC

Downstream 100 bases:

>100_bases
TGCCAACTTCGCATGAGGAACTGCACACCCAGCAGGGCGTCAGTCGGCGCGACGAGTCACTCCCGGGGGCTACGCATGAA
TTCGACTACCGGAGCGGGCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNAQFAEFVSATGYVTVAEQPLDPGLYPGVDAADLCPG
AMVFCPTAGPVDLRDWRQWWDWVPGACWRHPFGRDSDIADRAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTT
ATYAWGDQEKPGGMLMANTWQGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTTTEFYPHHRIDPPSTACCA
PVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVADPVSG

Sequences:

>Translated_299_residues
MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNAQFAEFVSATGYVTVAEQPLDPGLYPGVDAADLCPG
AMVFCPTAGPVDLRDWRQWWDWVPGACWRHPFGRDSDIADRAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTT
ATYAWGDQEKPGGMLMANTWQGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTTTEFYPHHRIDPPSTACCA
PVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVADPVSG
>Mature_299_residues
MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNAQFAEFVSATGYVTVAEQPLDPGLYPGVDAADLCPG
AMVFCPTAGPVDLRDWRQWWDWVPGACWRHPFGRDSDIADRAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTT
ATYAWGDQEKPGGMLMANTWQGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTTTEFYPHHRIDPPSTACCA
PVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVADPVSG

Specific function: Together with the serine/threonine kinase pknD, may play a role in the specific interactions with host proteins during intracellular growth [H]

COG id: COG1262

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 protein kinase domain [H]

Homologues:

Organism=Homo sapiens, GI38202250, Length=297, Percent_Identity=40.7407407407407, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI257470975, Length=298, Percent_Identity=39.9328859060403, Blast_Score=204, Evalue=6e-53,
Organism=Homo sapiens, GI257470977, Length=297, Percent_Identity=39.3939393939394, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI194248088, Length=299, Percent_Identity=35.7859531772575, Blast_Score=155, Evalue=4e-38,
Organism=Homo sapiens, GI194248087, Length=299, Percent_Identity=34.1137123745819, Blast_Score=141, Evalue=6e-34,
Organism=Homo sapiens, GI226437577, Length=199, Percent_Identity=40.2010050251256, Blast_Score=127, Evalue=9e-30,
Organism=Homo sapiens, GI194248090, Length=229, Percent_Identity=36.2445414847162, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI20130397, Length=302, Percent_Identity=38.0794701986755, Blast_Score=189, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016187
- InterPro:   IPR011009
- InterPro:   IPR000719
- InterPro:   IPR017442
- InterPro:   IPR005532 [H]

Pfam domain/function: PF03781 DUF323; PF00069 Pkinase [H]

EC number: =2.7.11.1 [H]

Molecular weight: Translated: 32744; Mature: 32744

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNAQFAEFVSATGYVTVA
CCCCEEECCCCCEECCCCEECCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHCCCEEEEE
EQPLDPGLYPGVDAADLCPGAMVFCPTAGPVDLRDWRQWWDWVPGACWRHPFGRDSDIAD
CCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCHHH
RAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTTATYAWGDQEKPGGMLMANTW
HCCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCEEEEECC
QGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTTTEFYPHHRIDPPSTACCA
CCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCC
PVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVADPVSG
CEEEECCCCCHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECEEEECCCCCC
>Mature Secondary Structure
MLTELVDLPGGSFRMGSTRFYPEEAPIHTVTVRAFAVERHPVTNAQFAEFVSATGYVTVA
CCCCEEECCCCCEECCCCEECCCCCCEEEEEEEEEEEECCCCCCHHHHHHHHCCCEEEEE
EQPLDPGLYPGVDAADLCPGAMVFCPTAGPVDLRDWRQWWDWVPGACWRHPFGRDSDIAD
CCCCCCCCCCCCCHHHHCCCCEEEECCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCCHHH
RAGHPVVQVAYPDAVAYARWAGRRLPTEAEWEYAARGGTTATYAWGDQEKPGGMLMANTW
HCCCCEEEEECCCHHHHHHHHCCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCEEEEECC
QGRFPYRNDGALGWVGTSPVGRFPANGFGLLDMIGNVWEWTTTEFYPHHRIDPPSTACCA
CCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCHHCCCCCCCCCCCCCCCCCCCCCC
PVKLATAADPTISQTLKGGSHLCAPEYCHRYRPAARSPQSQDTATTHIGFRCVADPVSG
CEEEECCCCCHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCCCCEEEEECEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12682364 [H]