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The map label for this gene is nrdZ [H]

Identifier: 121636488

GI number: 121636488

Start: 692186

End: 694318

Strand: Direct

Name: nrdZ [H]

Synonym: BCG_0615

Alternate gene names: 121636488

Gene position: 692186-694318 (Clockwise)

Preceding gene: 121636487

Following gene: 121636494

Centisome position: 15.82

GC content: 67.18

Gene sequence:

>2133_bases
GTGGGTGTCAGCTGGCCGGCGAAAGTCCGGCGCCGGGATGGAACGCTGGTGCCGTTCGACATCGCGCGGATCGAAGCAGC
GGTGACGCGGGCAGCGCGCGAGGTGGCTTGCGACGACCCCGATATGCCGGGCACCGTAGCGAAAGCCGTCGCCGACGCAC
TCGGGCGCGGTATCGCTCCCGTTGAGGACATTCAGGACTGCGTGGAGGCCCGGCTGGGGGAAGCCGGTCTGGATGACGTG
GCCCGTGTTTACATCATCTACCGGCAGCGGCGCGCCGAGCTGCGGACGGCTAAGGCCTTGCTCGGCGTGCGGGACGAGTT
AAAGCTGAGCTTGGCGGCCGTGACGGTACTGCGCGAGCGCTATCTGCTGCACGACGAGCAGGGCCGGCCGGCCGAGTCGA
CCGGCGAGCTGATGGACCGATCGGCGCGCTGTGTCGCGGCGGCCGAGGACCAGTATGAGCCGGGCTCGTCGAGGCGGTGG
GCCGAGCGGTTCGCCACGCTATTACGCAACCTGGAATTCCTGCCGAATTCGCCCACGTTGATGAACTCTGGCACCGACCT
GGGACTGCTCGCCGGCTGTTTTGTTCTGCCGATTGAGGATTCGCTGCAATCGATCTTTGCGACGCTGGGACAGGCCGCCG
AGCTGCAGCGGGCTGGAGGCGGCACCGGATATGCGTTCAGCCACCTGCGACCCGCCGGGGATCGGGTGGCCTCCACGGGC
GGCACGGCCAGCGGACCGGTGTCGTTTCTACGGCTGTATGACAGTGCCGCGGGTGTGGTCTCCATGGGCGGTCGCCGGCG
TGGCGCCTGTATGGCTGTGCTTGATGTGTCGCACCCGGATATCTGTGATTTCGTCACCGCCAAGGCCGAATCCCCCAGCG
AGCTCCCGCATTTCAACCTATCGGTTGGTGTGACCGACGCGTTCCTGCGGGCCGTCGAACGCAACGGCCTACACCGGCTG
GTCAATCCGCGAACCGGCAAGATCGTCGCGCGGATGCCCGCCGCCGAGCTGTTCGACGCCATCTGCAAAGCCGCGCACGC
CGGTGGCGATCCCGGGCTGGTGTTTCTCGACACGATCAATAGGGCAAACCCGGTGCCGGGGAGAGGCCGCATCGAGGCGA
CCAACCCGTGCGGGGAGGTCCCACTGCTGCCTTACGAGTCATGTAATCTCGGCTCGATCAACCTCGCCCGGATGCTCGCC
GACGGTCGCGTCGACTGGGACCGGCTCGAGGAGGTCGCCGGTGTGGCGGTGCGGTTCCTTGATGACGTCATCGATGTCAG
CCGCTACCCCTTCCCCGAACTGGGTGAGGCGGCCCGCGCCACCCGCAAGATCGGGCTGGGAGTCATGGGTTTGGCGGAAC
TGCTTGCCGCACTGGGTATTCCGTACGACAGTGAAGAAGCCGTGCGGTTAGCCACCCGGCTCATGCGTCGCATACAGCAG
GCGGCGCACACGGCATCGCGGAGGCTGGCCGAAGAGCGGGGCGCATTCCCGGCGTTCACCGATAGCCGGTTCGCGCGGTC
GGGCCCGAGGCGCAACGCACAGGTCACCTCCGTCGCTCCGACGGGCACCATCTCACTGATCGCCGGAACCACCGCGGGCA
TCGAGCCGATGTTCGCCATCGCGTTCACCCGCGCCATCGTCGGCCGGCATCTGCTGGAGGTCAATCCGTGCTTCGACCGA
CTGGCCCGCGATCGGGGCTTTTATCGTGACGAGCTGATCGCCGAGATCGCTCAGCGTGGCGGAGTCCGTGGCTATCCGCG
GCTGCCTGCTGAGGTGCGGGCCGCGTTCCCGACCGCGGCGGAGATCGCGCCGCAGTGGCATCTGCGCATGCAGGCCGCGG
TGCAGCGCCACGTCGAGGCCGCCGTGTCCAAGACGGTCAACTTGCCCGCCACGGGACGGTCGATGACGTCCGCGCCATCT
ATGTGGCCGCCTGGAAGGCAAAGGTCAAGGGCATCACGGTGTATCGCTACGGCAGCCGGGAAGGACAGGTACTGTCCTAC
GCCGCGCCGAAACCGCTACTGGCGCAGGCTGACACGGAGTTCAGCGGCGGCTGTGCGGGCCGCTCCTGCGAGTTCTGACG
GCGGCTCCCATGGCGCGAGCAGACGCAGAATCGCACAAAATCAGCGATTTTGA

Upstream 100 bases:

>100_bases
AATGCGGCCGACGAGCGGGCGCAGCATCGGTTCGGCGCGGTTCAGTCGGCGATCCTCCATGCCAGGGGAACGTAGGCGAT
TCGCTCAAGCGACGAAGTCG

Downstream 100 bases:

>100_bases
TGCGATTCTGCGTCTGCTCGCGCAGGGATCGCAGGGATCACCCCGGCCGGCTAGCGGTTTAGCCGCTTGGGCCTGGGCCG
CACAAGTGGTCGATGAACCA

Product: putative ribonucleoside-diphosphate reductase large subunit nrdZ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 710; Mature: 709

Protein sequence:

>710_residues
MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDV
ARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRW
AERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRL
VNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA
DGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDR
LARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATGRSMTSAPS
MWPPGRQRSRASRCIATAAGKDRYCPTPRRNRYWRRLTRSSAAAVRAAPASSDGGSHGASRRRIAQNQRF

Sequences:

>Translated_710_residues
MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDV
ARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRW
AERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRL
VNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLA
DGRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDR
LARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATGRSMTSAPS
MWPPGRQRSRASRCIATAAGKDRYCPTPRRNRYWRRLTRSSAAAVRAAPASSDGGSHGASRRRIAQNQRF
>Mature_709_residues
GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAPVEDIQDCVEARLGEAGLDDVA
RVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRERYLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWA
ERFATLLRNLEFLPNSPTLMNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTGG
TASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNLSVGVTDAFLRAVERNGLHRLV
NPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTINRANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLAD
GRVDWDRLEEVAGVAVRFLDDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQA
AHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAIAFTRAIVGRHLLEVNPCFDRL
ARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAAEIAPQWHLRMQAAVQRHVEAAVSKTVNLPATGRSMTSAPSM
WPPGRQRSRASRCIATAAGKDRYCPTPRRNRYWRRLTRSSAAAVRAAPASSDGGSHGASRRRIAQNQRF

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=544, Percent_Identity=27.5735294117647, Blast_Score=207, Evalue=2e-53,
Organism=Escherichia coli, GI1789030, Length=570, Percent_Identity=27.1929824561404, Blast_Score=146, Evalue=5e-36,
Organism=Escherichia coli, GI2367133, Length=555, Percent_Identity=22.7027027027027, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17555242, Length=514, Percent_Identity=27.6264591439689, Blast_Score=189, Evalue=6e-48,
Organism=Saccharomyces cerevisiae, GI6322123, Length=654, Percent_Identity=27.0642201834862, Blast_Score=203, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320914, Length=662, Percent_Identity=27.7945619335347, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI17352481, Length=543, Percent_Identity=25.414364640884, Blast_Score=179, Evalue=5e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 76724; Mature: 76593

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS51161 ATP_CONE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP
CCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL
HHHCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
CCCCCCHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHCCC
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL
CCCCCHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEE
SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN
ECCHHHHHHHHHHHCCHHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCC
RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHH
AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA
HHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHH
EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATGRSMTSAPSMWPPGRQRSRASRCIATAAG
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
KDRYCPTPRRNRYWRRLTRSSAAAVRAAPASSDGGSHGASRRRIAQNQRF
CCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure 
GVSWPAKVRRRDGTLVPFDIARIEAAVTRAAREVACDDPDMPGTVAKAVADALGRGIAP
CCCCCHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCC
VEDIQDCVEARLGEAGLDDVARVYIIYRQRRAELRTAKALLGVRDELKLSLAAVTVLRER
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
YLLHDEQGRPAESTGELMDRSARCVAAAEDQYEPGSSRRWAERFATLLRNLEFLPNSPTL
HHHCCCCCCCCCHHHHHHHCCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
MNSGTDLGLLAGCFVLPIEDSLQSIFATLGQAAELQRAGGGTGYAFSHLRPAGDRVASTG
CCCCCCHHHHHHHHEEECHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHCCC
GTASGPVSFLRLYDSAAGVVSMGGRRRGACMAVLDVSHPDICDFVTAKAESPSELPHFNL
CCCCCHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEE
SVGVTDAFLRAVERNGLHRLVNPRTGKIVARMPAAELFDAICKAAHAGGDPGLVFLDTIN
ECCHHHHHHHHHHHCCHHHHCCCCCCCEEEECCHHHHHHHHHHHHHCCCCCCEEEEECCC
RANPVPGRGRIEATNPCGEVPLLPYESCNLGSINLARMLADGRVDWDRLEEVAGVAVRFL
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHH
DDVIDVSRYPFPELGEAARATRKIGLGVMGLAELLAALGIPYDSEEAVRLATRLMRRIQQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
AAHTASRRLAEERGAFPAFTDSRFARSGPRRNAQVTSVAPTGTISLIAGTTAGIEPMFAI
HHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHH
AFTRAIVGRHLLEVNPCFDRLARDRGFYRDELIAEIAQRGGVRGYPRLPAEVRAAFPTAA
HHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCHH
EIAPQWHLRMQAAVQRHVEAAVSKTVNLPATGRSMTSAPSMWPPGRQRSRASRCIATAAG
HHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
KDRYCPTPRRNRYWRRLTRSSAAAVRAAPASSDGGSHGASRRRIAQNQRF
CCCCCCCCCHHHHHHHHHHHHHHHHEECCCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]