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The map label for this gene is hemB [H]

Identifier: 121636430

GI number: 121636430

Start: 635400

End: 636389

Strand: Direct

Name: hemB [H]

Synonym: BCG_0555

Alternate gene names: 121636430

Gene position: 635400-636389 (Clockwise)

Preceding gene: 121636429

Following gene: 121636431

Centisome position: 14.53

GC content: 67.27

Gene sequence:

>990_bases
ATGAGCATGAGTTCCTATCCGCGGCAGCGACCGCGCCGGCTCCGCTCCACCGTCGCGATGCGCCGTCTGGTTGCGCAAAC
CTCGTTGGAGCCAAGGCATTTGGTGCTGCCGATGTTCGTTGCCGACGGCATTGACGAGCCGCGGCCGATTACCTCCATGC
CGGGCGTGGTACAGCACACCCGGGATTCGCTACGTAGGGCCGCGGCAGCCGCGGTGGCCGCCGGCGTGGGTGGGCTGATG
CTTTTCGGCGTGCCGCGCGACCAGGACAAGGACGGTGTCGGTTCGGCGGGCATCGACCCCGACGGGATCCTCAACGTCGC
CCTTCGCGATCTGGCCAAGGACCTGGGTGAGGCCACGGTGTTGATGGCCGACACCTGTCTGGACGAGTTCACCGACCACG
GGCACTGCGGTGTGCTCGATGACCGGGGCCGGGTCGATAACGACGCCACCGTGGCCCGCTATGTGGAACTGGCTGTGGCG
CAAGCGGAATCGGGCGCCCACGTGGTCGGACCCAGTGGGATGATGGATGGCCAGGTAGCCGCGATCCGGGACGGTTTGGA
CGCCGCCGGCTACATCGATGTGGTGATCTTGGCCTACGCCGCGAAGTTTGCTTCGGCGTTCTACGGCCCGTTCCGCGAGG
CGGTGAGCTCTAGCCTGTCCGGGGATCGGCGCACCTACCAGCAGGAGCCGGGCAACGCCGCCGAGGCGCTGCGTGAGATC
GAGCTCGATCTCGACGGAGGCGCCGACATTGTGATGGTCAAACCCGCGATGGGCTACCTCGATGTGGTGGCGGCCGCGGC
GGACGTCTCGCCGGTCCCGGTGGCCGCCTATCAGGTCTCGGGAGAGTACGCGATGATTCGTGCGGCGGCGGCCAATAATT
GGATCGATGAGCGTGCCGCGGTGCTAGAGTCGCTGACCGGTATCCGGCGTGCCGGCGCCGACATCGTGCTCACCTACTGG
GCGGTAGACGCGGCGGGCTGGCTTACGTGA

Upstream 100 bases:

>100_bases
AGCCGCAGGCGCTAGTGGCCCACCCTCGTCAGGTGAGCGTGCGTGTCTGTACACCGACACGCCGACCGAGCTGGCATTTT
GCGTACGCTCGCGGCTACGA

Downstream 100 bases:

>100_bases
CGGAGGCCTGACATGACACCAACCGGGGATACCAAGCCCAAGTTGTTGTTCTACGAACCCGGCGCGAGCTGGTACTGGGT
GCTGACTGGTCCGCTTGCGG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 329; Mature: 328

Protein sequence:

>329_residues
MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLM
LFGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVA
QAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREI
ELDLDGGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYW
AVDAAGWLT

Sequences:

>Translated_329_residues
MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLM
LFGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVA
QAESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREI
ELDLDGGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYW
AVDAAGWLT
>Mature_328_residues
SMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHTRDSLRRAAAAAVAAGVGGLML
FGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATVLMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVAQ
AESGAHVVGPSGMMDGQVAAIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREIE
LDLDGGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAAVLESLTGIRRAGADIVLTYWA
VDAAGWLT

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=308, Percent_Identity=43.1818181818182, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI87081728, Length=317, Percent_Identity=47.6340694006309, Blast_Score=275, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6321398, Length=339, Percent_Identity=36.5781710914454, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI21358291, Length=318, Percent_Identity=40.251572327044, Blast_Score=218, Evalue=5e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 34800; Mature: 34669

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHT
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCCCCCCCHHHHHH
RDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATV
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHEE
LMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVAQAESGAHVVGPSGMMDGQVA
HHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHH
AIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHH
ELDLDGGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAA
HEECCCCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEHHHCCHHHHHHH
VLESLTGIRRAGADIVLTYWAVDAAGWLT
HHHHHHHHHHCCCCEEEEEEEHHHCCCCC
>Mature Secondary Structure 
SMSSYPRQRPRRLRSTVAMRRLVAQTSLEPRHLVLPMFVADGIDEPRPITSMPGVVQHT
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCCCCCCCHHHHHH
RDSLRRAAAAAVAAGVGGLMLFGVPRDQDKDGVGSAGIDPDGILNVALRDLAKDLGEATV
HHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCHHEE
LMADTCLDEFTDHGHCGVLDDRGRVDNDATVARYVELAVAQAESGAHVVGPSGMMDGQVA
HHHHHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCCHH
AIRDGLDAAGYIDVVILAYAAKFASAFYGPFREAVSSSLSGDRRTYQQEPGNAAEALREI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHH
ELDLDGGADIVMVKPAMGYLDVVAAAADVSPVPVAAYQVSGEYAMIRAAAANNWIDERAA
HEECCCCCCEEEECCCCHHHHHHHHHCCCCCCCEEEEEECCCEEEEEEHHHCCHHHHHHH
VLESLTGIRRAGADIVLTYWAVDAAGWLT
HHHHHHHHHHCCCCEEEEEEEHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]