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The map label for this gene is mdmC [H]

Identifier: 121636099

GI number: 121636099

Start: 248604

End: 249266

Strand: Direct

Name: mdmC [H]

Synonym: BCG_0224

Alternate gene names: 121636099

Gene position: 248604-249266 (Clockwise)

Preceding gene: 121636098

Following gene: 121636100

Centisome position: 5.68

GC content: 66.97

Gene sequence:

>663_bases
TTGGGCATGGACCAGCAACCCAACCCGCCCGACGTCGACGCATTTTTGGACAGCACACTGGTCGGCGACGATCCGGCGTT
AGCCGCGGCATTGGCGGCCAGCGACGCGGCCGAGTTACCCCGCATCGCGGTGTCGGCACAGCAGGGCAAGTTCCTGTGCC
TGCTGGCCGGTGCCATCCAGGCGCGCCGCGTCCTCGAGATCGGCACACTCGGTGGCTTCAGCACCATTTGGCTGGCGCGT
GGCGCGGGCCCACAGGGACGGGTGGTCACGCTGGAATACCAGCCCAAGCACGCTGAGGTCGCCCGGGTGAACCTGCAGCG
AGCGGGCGTCGCCGATCGGGTGGAGGTGGTCGTCGGTCCGGCGCTGGACACGTTGCCGACGTTGGCCGGTGGCCCGTTCG
ACCTGGTGTTCATCGACGCCGACAAAGAGAACAACGTCGTATATATTCAGTGGGCGATCCGGTTGGCCCGGCGCGGCGCA
GTGATCGTGGTGGACAACGTTATTCGTGGCGGCGGGATTCTTGCTGAGTCCGACGATGCCGACGCAGTGGCGGCACGTCG
GACGCTGCAAATGATGGGTGAGCACCCCGGCCTAGACGCCACGGCGATCCAGACCGTCGGGCGCAAGGGCTGGGACGGTT
TCGCCCTCGCTTTGGTGCGGTAG

Upstream 100 bases:

>100_bases
ACAGCTACTTAAATATATACCCTATACGGGTATCTGGTAAACCCCCAGGCCGGTGGGCGGTTGCCTGCTGGCGCGCGACG
GTCGGTGGTCGCGCTAGCGT

Downstream 100 bases:

>100_bases
CCGCTGGTCCGGCGCCCAATTTTCGTTGCTGGCATCCCGAAAACGGGCGTAATCTTGGAGCAGATGGATGGGTGGCAGCG
AGCCCAAAAGTTTTGCTGCA

Product: putative o-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLAR
GAGPQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVVYIQWAIRLARRGA
VIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR

Sequences:

>Translated_220_residues
MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLAR
GAGPQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVVYIQWAIRLARRGA
VIVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR
>Mature_219_residues
GMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCLLAGAIQARRVLEIGTLGGFSTIWLARG
AGPQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGPALDTLPTLAGGPFDLVFIDADKENNVVYIQWAIRLARRGAV
IVVDNVIRGGGILAESDDADAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=135, Percent_Identity=34.0740740740741, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23126; Mature: 22995

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCLLAGAIQ
CCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCHHHCCEEEEECCCCCEEEEEECHHH
ARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGP
HHHEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEEHHHCCCCCEEEEEECC
ALDTLPTLAGGPFDLVFIDADKENNVVYIQWAIRLARRGAVIVVDNVIRGGGILAESDDA
CHHHHHHCCCCCEEEEEEECCCCCCEEEEEEHHHHHHCCCEEEEECEECCCCEEECCCCC
DAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEEC
>Mature Secondary Structure 
GMDQQPNPPDVDAFLDSTLVGDDPALAAALAASDAAELPRIAVSAQQGKFLCLLAGAIQ
CCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHCCHHHCCEEEEECCCCCEEEEEECHHH
ARRVLEIGTLGGFSTIWLARGAGPQGRVVTLEYQPKHAEVARVNLQRAGVADRVEVVVGP
HHHEEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEEEHHHCCCCCEEEEEECC
ALDTLPTLAGGPFDLVFIDADKENNVVYIQWAIRLARRGAVIVVDNVIRGGGILAESDDA
CHHHHHHCCCCCEEEEEEECCCCCCEEEEEEHHHHHHCCCEEEEECEECCCCEEECCCCC
DAVAARRTLQMMGEHPGLDATAIQTVGRKGWDGFALALVR
HHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]