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The map label for this gene is apt

Identifier: 120613414

GI number: 120613414

Start: 5341225

End: 5341779

Strand: Direct

Name: apt

Synonym: Aave_4787

Alternate gene names: 120613414

Gene position: 5341225-5341779 (Clockwise)

Preceding gene: 120613413

Following gene: 120613415

Centisome position: 99.78

GC content: 67.39

Gene sequence:

>555_bases
ATGCAAGACCTCAGCGTCAACGAATACCTTCGCCAGTACATCCGCACCGTGCCCGACTGGCCCGCGGCGGGCGTGCAGTT
CCGCGACATCACCCCGCTGCTGCAGGATCCCAAGGTGTTCCGCGTGCTCATCGATGCCTTCGTGCACCGCTACATGGACC
GGGCCCTGCGTCCCGACGTGGTCGCGGGCCTGGATGCGCGCGGCTTCATCCTCGGCGCCGTCGTGGCCTACGAATTGAAC
GTCGGCTTCGTGCCCATCCGCAAGAAGGGCAAGCTGCCTTTCACCACGGTCGAGGAAACCTACGAACTCGAGTACGGCAG
CGCCACGGTCGAGCTGCATGCCGATGCGGTGAAGCCCGGCGACCGGGTGCTGCTGATCGACGACCTCATCGCCACCGGCG
GCACCATGATGGCCGGGCGCAGGCTGCTGGAGCGGCTCGGCGCCACGGTGACCGAAGGCGCCGCCATCGTCGATCTGCCC
GAACTGGGCGGTTCCTCGCGGCTGCGCGAATCCGGGCTGCCGCTCTACACCCTGGTGGACTTCGCGGGGCATTGA

Upstream 100 bases:

>100_bases
GGGCCGGCGCGGCCGGGAACGCCCGGCACAGCGGCAGGCTCTAAACTGCCGCCCTTTCCCGCCGCGCGCGCCGTGGCCCA
TCCCTTTTCCCGCCCCCGCC

Downstream 100 bases:

>100_bases
AGGAGAGCTTCCCCGGAAGGCAGAGCCCGGCACGCCCGGATAGAATGACAATCATTCGCATGGCAAAGGCCTGGTGGAGC
CCTCTGCCGGGCCATCCGTG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MQDLSVNEYLRQYIRTVPDWPAAGVQFRDITPLLQDPKVFRVLIDAFVHRYMDRALRPDVVAGLDARGFILGAVVAYELN
VGFVPIRKKGKLPFTTVEETYELEYGSATVELHADAVKPGDRVLLIDDLIATGGTMMAGRRLLERLGATVTEGAAIVDLP
ELGGSSRLRESGLPLYTLVDFAGH

Sequences:

>Translated_184_residues
MQDLSVNEYLRQYIRTVPDWPAAGVQFRDITPLLQDPKVFRVLIDAFVHRYMDRALRPDVVAGLDARGFILGAVVAYELN
VGFVPIRKKGKLPFTTVEETYELEYGSATVELHADAVKPGDRVLLIDDLIATGGTMMAGRRLLERLGATVTEGAAIVDLP
ELGGSSRLRESGLPLYTLVDFAGH
>Mature_184_residues
MQDLSVNEYLRQYIRTVPDWPAAGVQFRDITPLLQDPKVFRVLIDAFVHRYMDRALRPDVVAGLDARGFILGAVVAYELN
VGFVPIRKKGKLPFTTVEETYELEYGSATVELHADAVKPGDRVLLIDDLIATGGTMMAGRRLLERLGATVTEGAAIVDLP
ELGGSSRLRESGLPLYTLVDFAGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=175, Percent_Identity=45.7142857142857, Blast_Score=150, Evalue=5e-37,
Organism=Homo sapiens, GI71773201, Length=127, Percent_Identity=48.8188976377953, Blast_Score=124, Evalue=7e-29,
Organism=Escherichia coli, GI1786675, Length=177, Percent_Identity=50.8474576271186, Blast_Score=186, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI17509087, Length=172, Percent_Identity=44.1860465116279, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=183, Percent_Identity=37.7049180327869, Blast_Score=119, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320649, Length=182, Percent_Identity=30.7692307692308, Blast_Score=85, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17136334, Length=161, Percent_Identity=41.6149068322981, Blast_Score=130, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_ACIAC (A1TWI0)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_973092.1
- ProteinModelPortal:   A1TWI0
- SMR:   A1TWI0
- STRING:   A1TWI0
- GeneID:   4665130
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4787
- NMPDR:   fig|397945.5.peg.4127
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   A1TWI0
- ProtClustDB:   PRK02304
- BioCyc:   AAVE397945:AAVE_4787-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20271; Mature: 20271

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDLSVNEYLRQYIRTVPDWPAAGVQFRDITPLLQDPKVFRVLIDAFVHRYMDRALRPDV
CCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHHHHHHHCCCHH
VAGLDARGFILGAVVAYELNVGFVPIRKKGKLPFTTVEETYELEYGSATVELHADAVKPG
HHCCCCCHHHHHHHHHHEECCCEEEECCCCCCCCEECCHHEEEECCCEEEEEEECCCCCC
DRVLLIDDLIATGGTMMAGRRLLERLGATVTEGAAIVDLPELGGSSRLRESGLPLYTLVD
CEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCEEEEEC
FAGH
CCCC
>Mature Secondary Structure
MQDLSVNEYLRQYIRTVPDWPAAGVQFRDITPLLQDPKVFRVLIDAFVHRYMDRALRPDV
CCCCCHHHHHHHHHHHCCCCCCCCEEECCCCCCHHCHHHHHHHHHHHHHHHHHHHCCCHH
VAGLDARGFILGAVVAYELNVGFVPIRKKGKLPFTTVEETYELEYGSATVELHADAVKPG
HHCCCCCHHHHHHHHHHEECCCEEEECCCCCCCCEECCHHEEEECCCEEEEEEECCCCCC
DRVLLIDDLIATGGTMMAGRRLLERLGATVTEGAAIVDLPELGGSSRLRESGLPLYTLVD
CEEEEEEHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCEEEEEC
FAGH
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA