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The map label for this gene is bioA [C]

Identifier: 120613372

GI number: 120613372

Start: 5291269

End: 5292636

Strand: Direct

Name: bioA [C]

Synonym: Aave_4744

Alternate gene names: 120613372

Gene position: 5291269-5292636 (Clockwise)

Preceding gene: 120613369

Following gene: 120613373

Centisome position: 98.85

GC content: 68.93

Gene sequence:

>1368_bases
ATGGGCTTTTCCGTCATCGAACCCGCGCCCGGCGCGGACGCCGCCGCCCCCCGCATGGATGCCGCCTGGCTCGAAGCGCA
CTGGATGCCCTTCACGGGCAACCGCAACTTCAAGGCCCGCCCGCGCATGATCGTGGGCGCCCAGGGTGCCTATTACACGG
ATGCCGAAGGCCGCAAGATCTTCGACGGCCTGTCGGGCCTGTGGTGCACTGGCCTGGGGCACGGCCGCAAGGAGATCGCC
GAGGCCATCGGCCGCGCCGCCGCCACGCTGGACTATTCGCCCGCGTTCCAGTTCGGCCATCCCGCCTCGTTCGCGCTGGC
GAACAAGCTCAAGGAACTGACGCCCGAAGGGCTCGACTACGTGTTCTTCACCGGGTCGGGCTCCGAATCCGCCGACACGT
CCCTGAAGATGGCGCGCGCCTACTGGCGCGCCAAGGGCCAGGCGAGCAAGACACGCCTGATCGGCCGCGAGAAGGGCTAC
CACGGCGTGAACTTCGGGGGCATCTCGGTGGGCGGCATCGTGGGCAACCGCAAGACCTTCGGCCAGGGCGTGGAGGCGGA
CCACATCCCGCACACGCAGCCGCCCGCGGGCACCTTCCAGCGCGGCATGGCCGAGGACGGCGGCCGCGCGCTGGCCGACC
GGCTGCTGGACGTGATCGCCCTGCACGACGCCTCCAACATCGCCGCGGTGATCGTCGAGCCGTTCTCGGGCTCGGCCGGC
GTGGTGATCCCGCCCAAGGGCTACCTGGAGCGCATCCGCGAGATCTGCACGCAGAACAACATCCTGCTGATCTTCGACGA
GGTCATCACGGGCTTCGGCCGCTGCGGCGCGTGGACCGGGGCCGAGGCCTTCGGCGTGACGCCCGACATCCTGAACTTCG
CCAAGCAGGTGACCAACGGCGCGCAGCCGCTGGGCGGCGTGATGGCCACCAAGGAAATCTACGACACCTTCATCGCTCAG
GGCGGCCCCGAGTACATGCTCGAGTTCCCGCACGGCTACACCTACTCCGCCCATCCGGTCGCGTGCGCAGCCGGCAATGC
GGTGCTCGACATCCTGCAGAAGGAAGACATGCCCGGCCGCGCGCGCGCGCTGGCGCCGGTTTTCGAGAACGCGGTGCATG
GCCTCAAGGGCGCGAAGCACGTGGCGGACATCCGCAACTACGGCCTGGCGGCGGGCATCACCATCGCGGCCGTTCCGGGG
GAGCCCGCGAAGCGCCCCTACGAAATCGCGATGAAGTGCTGGGACAAGGGCTTCTATGTGCGCTACGGCGGCGACACCAT
CCAGCTCGCGCCGCCCTTCATCAGCACCGAGACGGAAATCGACCGCCTGGTCAGTGCCTTGGGCGACGCCCTGCACGAAG
TGGCCTGA

Upstream 100 bases:

>100_bases
GGAAGAATCGGTGCTGATGCAGGGGCGACGGGCTGCCGGGAGAGCGCCGCCGCCACTGCCTGCACGTCTCTTTTTCCACC
CCTTTTCCGAAGGACCGACC

Downstream 100 bases:

>100_bases
CCCCCATGCGCATCGCCATCCTGACCTTCGACGGCTTCAACGACCTGGATTCGCTGGTCGCCTTCGGCATGCTCCACCGC
ATCGCGCTGCGGGGGGATGC

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MGFSVIEPAPGADAAAPRMDAAWLEAHWMPFTGNRNFKARPRMIVGAQGAYYTDAEGRKIFDGLSGLWCTGLGHGRKEIA
EAIGRAAATLDYSPAFQFGHPASFALANKLKELTPEGLDYVFFTGSGSESADTSLKMARAYWRAKGQASKTRLIGREKGY
HGVNFGGISVGGIVGNRKTFGQGVEADHIPHTQPPAGTFQRGMAEDGGRALADRLLDVIALHDASNIAAVIVEPFSGSAG
VVIPPKGYLERIREICTQNNILLIFDEVITGFGRCGAWTGAEAFGVTPDILNFAKQVTNGAQPLGGVMATKEIYDTFIAQ
GGPEYMLEFPHGYTYSAHPVACAAGNAVLDILQKEDMPGRARALAPVFENAVHGLKGAKHVADIRNYGLAAGITIAAVPG
EPAKRPYEIAMKCWDKGFYVRYGGDTIQLAPPFISTETEIDRLVSALGDALHEVA

Sequences:

>Translated_455_residues
MGFSVIEPAPGADAAAPRMDAAWLEAHWMPFTGNRNFKARPRMIVGAQGAYYTDAEGRKIFDGLSGLWCTGLGHGRKEIA
EAIGRAAATLDYSPAFQFGHPASFALANKLKELTPEGLDYVFFTGSGSESADTSLKMARAYWRAKGQASKTRLIGREKGY
HGVNFGGISVGGIVGNRKTFGQGVEADHIPHTQPPAGTFQRGMAEDGGRALADRLLDVIALHDASNIAAVIVEPFSGSAG
VVIPPKGYLERIREICTQNNILLIFDEVITGFGRCGAWTGAEAFGVTPDILNFAKQVTNGAQPLGGVMATKEIYDTFIAQ
GGPEYMLEFPHGYTYSAHPVACAAGNAVLDILQKEDMPGRARALAPVFENAVHGLKGAKHVADIRNYGLAAGITIAAVPG
EPAKRPYEIAMKCWDKGFYVRYGGDTIQLAPPFISTETEIDRLVSALGDALHEVA
>Mature_454_residues
GFSVIEPAPGADAAAPRMDAAWLEAHWMPFTGNRNFKARPRMIVGAQGAYYTDAEGRKIFDGLSGLWCTGLGHGRKEIAE
AIGRAAATLDYSPAFQFGHPASFALANKLKELTPEGLDYVFFTGSGSESADTSLKMARAYWRAKGQASKTRLIGREKGYH
GVNFGGISVGGIVGNRKTFGQGVEADHIPHTQPPAGTFQRGMAEDGGRALADRLLDVIALHDASNIAAVIVEPFSGSAGV
VIPPKGYLERIREICTQNNILLIFDEVITGFGRCGAWTGAEAFGVTPDILNFAKQVTNGAQPLGGVMATKEIYDTFIAQG
GPEYMLEFPHGYTYSAHPVACAAGNAVLDILQKEDMPGRARALAPVFENAVHGLKGAKHVADIRNYGLAAGITIAAVPGE
PAKRPYEIAMKCWDKGFYVRYGGDTIQLAPPFISTETEIDRLVSALGDALHEVA

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=425, Percent_Identity=27.5294117647059, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI37574042, Length=441, Percent_Identity=29.7052154195011, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI226442705, Length=441, Percent_Identity=29.7052154195011, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI226442709, Length=406, Percent_Identity=29.8029556650246, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI13994255, Length=438, Percent_Identity=26.7123287671233, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=28.7009063444109, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI24119277, Length=389, Percent_Identity=28.0205655526992, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786991, Length=444, Percent_Identity=30.4054054054054, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI145693181, Length=403, Percent_Identity=28.0397022332506, Blast_Score=150, Evalue=1e-37,
Organism=Escherichia coli, GI1788044, Length=415, Percent_Identity=28.6746987951807, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=28.3292978208232, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=26.1904761904762, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1787560, Length=437, Percent_Identity=25.858123569794, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786349, Length=352, Percent_Identity=28.125, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=26.1744966442953, Blast_Score=138, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=24.6376811594203, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71992977, Length=443, Percent_Identity=27.9909706546275, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=227, Percent_Identity=29.5154185022026, Blast_Score=101, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=438, Percent_Identity=26.7123287671233, Blast_Score=151, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6324386, Length=428, Percent_Identity=25.2336448598131, Blast_Score=122, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324432, Length=423, Percent_Identity=24.822695035461, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6321456, Length=293, Percent_Identity=22.8668941979522, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI21357415, Length=416, Percent_Identity=28.125, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI21356575, Length=435, Percent_Identity=27.5862068965517, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI28574759, Length=447, Percent_Identity=26.8456375838926, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI161085790, Length=444, Percent_Identity=26.3513513513513, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48531; Mature: 48399

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFSVIEPAPGADAAAPRMDAAWLEAHWMPFTGNRNFKARPRMIVGAQGAYYTDAEGRKI
CCCCCCCCCCCCCCCCCCCCHHHHHEECEEECCCCCCCCCCCEEEECCCCEEECCCCCHH
FDGLSGLWCTGLGHGRKEIAEAIGRAAATLDYSPAFQFGHPASFALANKLKELTPEGLDY
HHCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCE
VFFTGSGSESADTSLKMARAYWRAKGQASKTRLIGREKGYHGVNFGGISVGGIVGNRKTF
EEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEECCEECCCHHH
GQGVEADHIPHTQPPAGTFQRGMAEDGGRALADRLLDVIALHDASNIAAVIVEPFSGSAG
CCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
VVIPPKGYLERIREICTQNNILLIFDEVITGFGRCGAWTGAEAFGVTPDILNFAKQVTNG
EEECCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
AQPLGGVMATKEIYDTFIAQGGPEYMLEFPHGYTYSAHPVACAAGNAVLDILQKEDMPGR
CCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEECCCHHHHHHHHHCCCCCH
ARALAPVFENAVHGLKGAKHVADIRNYGLAAGITIAAVPGEPAKRPYEIAMKCWDKGFYV
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEE
RYGGDTIQLAPPFISTETEIDRLVSALGDALHEVA
EECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GFSVIEPAPGADAAAPRMDAAWLEAHWMPFTGNRNFKARPRMIVGAQGAYYTDAEGRKI
CCCCCCCCCCCCCCCCCCCHHHHHEECEEECCCCCCCCCCCEEEECCCCEEECCCCCHH
FDGLSGLWCTGLGHGRKEIAEAIGRAAATLDYSPAFQFGHPASFALANKLKELTPEGLDY
HHCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCE
VFFTGSGSESADTSLKMARAYWRAKGQASKTRLIGREKGYHGVNFGGISVGGIVGNRKTF
EEEECCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEECCEECCCHHH
GQGVEADHIPHTQPPAGTFQRGMAEDGGRALADRLLDVIALHDASNIAAVIVEPFSGSAG
CCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCC
VVIPPKGYLERIREICTQNNILLIFDEVITGFGRCGAWTGAEAFGVTPDILNFAKQVTNG
EEECCHHHHHHHHHHHCCCCEEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCC
AQPLGGVMATKEIYDTFIAQGGPEYMLEFPHGYTYSAHPVACAAGNAVLDILQKEDMPGR
CCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCEECCCHHHHHHHHHCCCCCH
ARALAPVFENAVHGLKGAKHVADIRNYGLAAGITIAAVPGEPAKRPYEIAMKCWDKGFYV
HHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEE
RYGGDTIQLAPPFISTETEIDRLVSALGDALHEVA
EECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]