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The map label for this gene is fmt

Identifier: 120613321

GI number: 120613321

Start: 5233772

End: 5234761

Strand: Direct

Name: fmt

Synonym: Aave_4690

Alternate gene names: 120613321

Gene position: 5233772-5234761 (Clockwise)

Preceding gene: 120613320

Following gene: 120613322

Centisome position: 97.78

GC content: 74.65

Gene sequence:

>990_bases
ATGAAGATCATTTTCGCGGGCACGCCCGAGTTCGCCCGGGTGGCCCTGGAGCGCCTGCTCGCCGCAGGCGCCGAAGTCCC
CCTCGTGCTCACCCAGCCCGACCGGCCCGCCGGCCGGGGCATGAAGCTGCAGGCGTCCCCCGTCAAGCAGTGCGCCCTCG
CCCACGGCATCGCCGTGGCGCAGCCGCGCGGGCTGCGGCTGGACGGCAGATATGCCGAGGACGCCGCCGCCGCGCGCGCC
GCGCTGGAGGCGGCCGGGGCCGACGCCATGGTGGTCGCGGCCTACGGCCTGATCCTGCCGCAGTGGGTGCTGGACCTGCC
CCGGCTGGGCTGCCTGAACATCCATGCGAGCCTGCTGCCGCGCTGGCGCGGGGCGGCGCCCATCCACCGCGCCATCGAGG
CGGGCGACGCCGAGACGGGCGTGACCATCATGCAGATGGATGCCGGCCTGGACACGGGGGCCATGCTGCTCATCGAAAAA
ACCGCCATCGCGCCGCGCGAGACCACGGCCACGCTGCACGACCGGCTGGCCGACCTGGGCGGCCGGCTGATCGTGGAGGC
CATGGAGCTGGCCGCCTGCGGCGGGCTGGCGGCCACGCCCCAGCCGGCCGAAGGCGTGACCTACGCGCACAAGATCGAGA
AGGCCGAGAGCGCGATCGACTGGAAGCTGCCCGCCGCGGCCATCGACCGGCGCGTGCGCGCTTTCGATCCGTTCCCGGGC
GCCTCGACGCAATGCAGCGCCGAGACCATCAAGGTCTGGGGGTGCGAGCCGCTTCAGGTGCCCCCGCCGGAGGGCGCGCA
GCCCGGAGAGATCCTGCAGGTCGATGATGCCGGCGTGGACGTGGCCTGCGGAGGCCCGGACGGAGCGGCCGGCGTGCTGC
GCCTCACGGTGCTGCAGCGCGCGGGCGGCAAGCGCCTGCCGGTGGGCGACTTCCTGCGAGGCCATCCGCTGGCGCCGGGC
ATGGTGCTCGGCGGCGGGGCCGGTGCATGA

Upstream 100 bases:

>100_bases
GCGGTACGCAAGGTGATGTTCACCGACGAGCCCGATCCGCGCGAGTGGCGCCATTTCTGACCGACCGGCGCCCCCGCGGG
GAGCGCTTTTTTCCGCTGCC

Downstream 100 bases:

>100_bases
GCATGGCGGAGGACGCATCCGCTGGCGAACCGGCCGGCACCGTGCCGCGTTCGGCGGGGGAGATGGTGCGGCATCCGTTT
TTCCGCACCGGCATGACGGA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKIIFAGTPEFARVALERLLAAGAEVPLVLTQPDRPAGRGMKLQASPVKQCALAHGIAVAQPRGLRLDGRYAEDAAAARA
ALEAAGADAMVVAAYGLILPQWVLDLPRLGCLNIHASLLPRWRGAAPIHRAIEAGDAETGVTIMQMDAGLDTGAMLLIEK
TAIAPRETTATLHDRLADLGGRLIVEAMELAACGGLAATPQPAEGVTYAHKIEKAESAIDWKLPAAAIDRRVRAFDPFPG
ASTQCSAETIKVWGCEPLQVPPPEGAQPGEILQVDDAGVDVACGGPDGAAGVLRLTVLQRAGGKRLPVGDFLRGHPLAPG
MVLGGGAGA

Sequences:

>Translated_329_residues
MKIIFAGTPEFARVALERLLAAGAEVPLVLTQPDRPAGRGMKLQASPVKQCALAHGIAVAQPRGLRLDGRYAEDAAAARA
ALEAAGADAMVVAAYGLILPQWVLDLPRLGCLNIHASLLPRWRGAAPIHRAIEAGDAETGVTIMQMDAGLDTGAMLLIEK
TAIAPRETTATLHDRLADLGGRLIVEAMELAACGGLAATPQPAEGVTYAHKIEKAESAIDWKLPAAAIDRRVRAFDPFPG
ASTQCSAETIKVWGCEPLQVPPPEGAQPGEILQVDDAGVDVACGGPDGAAGVLRLTVLQRAGGKRLPVGDFLRGHPLAPG
MVLGGGAGA
>Mature_329_residues
MKIIFAGTPEFARVALERLLAAGAEVPLVLTQPDRPAGRGMKLQASPVKQCALAHGIAVAQPRGLRLDGRYAEDAAAARA
ALEAAGADAMVVAAYGLILPQWVLDLPRLGCLNIHASLLPRWRGAAPIHRAIEAGDAETGVTIMQMDAGLDTGAMLLIEK
TAIAPRETTATLHDRLADLGGRLIVEAMELAACGGLAATPQPAEGVTYAHKIEKAESAIDWKLPAAAIDRRVRAFDPFPG
ASTQCSAETIKVWGCEPLQVPPPEGAQPGEILQVDDAGVDVACGGPDGAAGVLRLTVLQRAGGKRLPVGDFLRGHPLAPG
MVLGGGAGA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=317, Percent_Identity=29.6529968454259, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI21614513, Length=324, Percent_Identity=30.8641975308642, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI164663775, Length=261, Percent_Identity=32.9501915708812, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI1789683, Length=322, Percent_Identity=46.8944099378882, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1788589, Length=294, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI133930964, Length=271, Percent_Identity=29.8892988929889, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI45550868, Length=233, Percent_Identity=32.618025751073, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI28571984, Length=233, Percent_Identity=32.618025751073, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585660, Length=249, Percent_Identity=29.3172690763052, Blast_Score=78, Evalue=8e-15,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_ACIAC (A1TW87)

Other databases:

- EMBL:   CP000512
- RefSeq:   YP_972999.1
- ProteinModelPortal:   A1TW87
- SMR:   A1TW87
- STRING:   A1TW87
- GeneID:   4669864
- GenomeReviews:   CP000512_GR
- KEGG:   aav:Aave_4690
- NMPDR:   fig|397945.5.peg.4045
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   A1TW87
- ProtClustDB:   CLSK963445
- BioCyc:   AAVE397945:AAVE_4690-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33979; Mature: 33979

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIFAGTPEFARVALERLLAAGAEVPLVLTQPDRPAGRGMKLQASPVKQCALAHGIAVA
CEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCHHHHHHHHHCEEEC
QPRGLRLDGRYAEDAAAARAALEAAGADAMVVAAYGLILPQWVLDLPRLGCLNIHASLLP
CCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCC
RWRGAAPIHRAIEAGDAETGVTIMQMDAGLDTGAMLLIEKTAIAPRETTATLHDRLADLG
CCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHC
GRLIVEAMELAACGGLAATPQPAEGVTYAHKIEKAESAIDWKLPAAAIDRRVRAFDPFPG
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCHHHHCCCCCC
ASTQCSAETIKVWGCEPLQVPPPEGAQPGEILQVDDAGVDVACGGPDGAAGVLRLTVLQR
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
AGGKRLPVGDFLRGHPLAPGMVLGGGAGA
CCCCCCCHHHHHCCCCCCCCEEECCCCCC
>Mature Secondary Structure
MKIIFAGTPEFARVALERLLAAGAEVPLVLTQPDRPAGRGMKLQASPVKQCALAHGIAVA
CEEEEECCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCEEEECCHHHHHHHHHCEEEC
QPRGLRLDGRYAEDAAAARAALEAAGADAMVVAAYGLILPQWVLDLPRLGCLNIHASLLP
CCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCC
RWRGAAPIHRAIEAGDAETGVTIMQMDAGLDTGAMLLIEKTAIAPRETTATLHDRLADLG
CCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHC
GRLIVEAMELAACGGLAATPQPAEGVTYAHKIEKAESAIDWKLPAAAIDRRVRAFDPFPG
CHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHCHHHHCCCCCC
ASTQCSAETIKVWGCEPLQVPPPEGAQPGEILQVDDAGVDVACGGPDGAAGVLRLTVLQR
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHH
AGGKRLPVGDFLRGHPLAPGMVLGGGAGA
CCCCCCCHHHHHCCCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA