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The map label for this gene is gpwA [H]

Identifier: 120613298

GI number: 120613298

Start: 5212467

End: 5213066

Strand: Direct

Name: gpwA [H]

Synonym: Aave_4667

Alternate gene names: 120613298

Gene position: 5212467-5213066 (Clockwise)

Preceding gene: 120613297

Following gene: 120613300

Centisome position: 97.38

GC content: 65.0

Gene sequence:

>600_bases
ATGCCCCGCCTGACCGCCCCGCTGATCCTCGCACTCGCGGCATCCTCCGCAGTGCTGCCCGCAGCCTCGCAATCCACGCC
CGCCGCCCCGGCAGAGCCCGCGAAACCGGCCCCGGCATGCCCCGCCACACTGCGCCACACCATGCCCCGCCTGCAGGACG
AAGCACCCCAGGATCTGTGCCAATACAGGGGCCAGGTGCTGCTGGTAGTCAACACCGCCAGTTACTGCGGATTCACCGGG
CAATACGAGGGACTGGAGGCGCTGCACGCCCGTTACAAGACGCAAGGTTTCGCAGTGCTGGGCTTTCCGTCGAACGATTT
CGCCCAGGAAACCGGCAGCAATGCGCAAATCGCTGACTTCTGCAGCAACACTTTCGGCGTGCGCTTTCCCATGTTCGCCA
AGAGCAGCGTCAAGGGCGGCGGCGCCTCGCCGTTCTATCGCGAACTCGCTGCACAAGCGGGAGAGGCGCCGCGCTGGAAC
TTCCACAAGTACCTGCTCGACAGGAAAGGCAGGGTGGTGGCGAGCTTCGGCAGTTCCGTCGCCCCGGACGACCCAAAAAT
CGTCCGCGCGGTCGAGCAGCAGCTGAAGCTTTTTCGCTAA

Upstream 100 bases:

>100_bases
TCGTTTGAGCAAAGCCCCGCTTGCCCCGCGGGCGGCTCTGGACTACCGTCGCGGTCGGCCACGCCCCGGCCACCAGGACG
TTGAACTCGGGAGAACCACC

Downstream 100 bases:

>100_bases
ATTGCAACGTTTTTCGGTGTCATATTCCGAACAACGGAAAGCTTACATTTTTTGATGTTTTTGGAGCCTCGAACGCTGGA
ACTTTGCCGGATTGGCACTA

Product: glutathione peroxidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 199; Mature: 198

Protein sequence:

>199_residues
MPRLTAPLILALAASSAVLPAASQSTPAAPAEPAKPAPACPATLRHTMPRLQDEAPQDLCQYRGQVLLVVNTASYCGFTG
QYEGLEALHARYKTQGFAVLGFPSNDFAQETGSNAQIADFCSNTFGVRFPMFAKSSVKGGGASPFYRELAAQAGEAPRWN
FHKYLLDRKGRVVASFGSSVAPDDPKIVRAVEQQLKLFR

Sequences:

>Translated_199_residues
MPRLTAPLILALAASSAVLPAASQSTPAAPAEPAKPAPACPATLRHTMPRLQDEAPQDLCQYRGQVLLVVNTASYCGFTG
QYEGLEALHARYKTQGFAVLGFPSNDFAQETGSNAQIADFCSNTFGVRFPMFAKSSVKGGGASPFYRELAAQAGEAPRWN
FHKYLLDRKGRVVASFGSSVAPDDPKIVRAVEQQLKLFR
>Mature_198_residues
PRLTAPLILALAASSAVLPAASQSTPAAPAEPAKPAPACPATLRHTMPRLQDEAPQDLCQYRGQVLLVVNTASYCGFTGQ
YEGLEALHARYKTQGFAVLGFPSNDFAQETGSNAQIADFCSNTFGVRFPMFAKSSVKGGGASPFYRELAAQAGEAPRWNF
HKYLLDRKGRVVASFGSSVAPDDPKIVRAVEQQLKLFR

Specific function: Not Essential For B12 Transport; However, It Is An Auxiliary Component Of The Transport System. [C]

COG id: COG0386

COG function: function code O; Glutathione peroxidase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutathione peroxidase family [H]

Homologues:

Organism=Homo sapiens, GI15618997, Length=145, Percent_Identity=43.448275862069, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI192455698, Length=140, Percent_Identity=37.1428571428571, Blast_Score=95, Evalue=4e-20,
Organism=Homo sapiens, GI75709200, Length=151, Percent_Identity=37.0860927152318, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI90903240, Length=133, Percent_Identity=40.6015037593985, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI90903238, Length=115, Percent_Identity=40.8695652173913, Blast_Score=78, Evalue=5e-15,
Organism=Escherichia coli, GI1788003, Length=162, Percent_Identity=39.5061728395062, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17506887, Length=132, Percent_Identity=37.8787878787879, Blast_Score=93, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17535473, Length=134, Percent_Identity=37.3134328358209, Blast_Score=91, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI193210707, Length=148, Percent_Identity=35.1351351351351, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71993584, Length=130, Percent_Identity=35.3846153846154, Blast_Score=87, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17550320, Length=141, Percent_Identity=28.3687943262411, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322228, Length=142, Percent_Identity=43.6619718309859, Blast_Score=127, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6319721, Length=128, Percent_Identity=44.53125, Blast_Score=119, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6322826, Length=126, Percent_Identity=37.3015873015873, Blast_Score=100, Evalue=2e-22,
Organism=Drosophila melanogaster, GI85726443, Length=140, Percent_Identity=35.7142857142857, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24656772, Length=200, Percent_Identity=29.5, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24656777, Length=145, Percent_Identity=33.1034482758621, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24656767, Length=145, Percent_Identity=33.1034482758621, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000889
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00255 GSHPx [H]

EC number: =1.11.1.9 [H]

Molecular weight: Translated: 21361; Mature: 21230

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: PS00460 GLUTATHIONE_PEROXID_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLTAPLILALAASSAVLPAASQSTPAAPAEPAKPAPACPATLRHTMPRLQDEAPQDLC
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
QYRGQVLLVVNTASYCGFTGQYEGLEALHARYKTQGFAVLGFPSNDFAQETGSNAQIADF
HHCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCHHHHH
CSNTFGVRFPMFAKSSVKGGGASPFYRELAAQAGEAPRWNFHKYLLDRKGRVVASFGSSV
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCCC
APDDPKIVRAVEQQLKLFR
CCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PRLTAPLILALAASSAVLPAASQSTPAAPAEPAKPAPACPATLRHTMPRLQDEAPQDLC
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHH
QYRGQVLLVVNTASYCGFTGQYEGLEALHARYKTQGFAVLGFPSNDFAQETGSNAQIADF
HHCCCEEEEEECHHHCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHCCCCCHHHHH
CSNTFGVRFPMFAKSSVKGGGASPFYRELAAQAGEAPRWNFHKYLLDRKGRVVASFGSSV
HCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEECCCCC
APDDPKIVRAVEQQLKLFR
CCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA