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The map label for this gene is uvrY [H]

Identifier: 120613018

GI number: 120613018

Start: 4874913

End: 4875542

Strand: Direct

Name: uvrY [H]

Synonym: Aave_4382

Alternate gene names: 120613018

Gene position: 4874913-4875542 (Clockwise)

Preceding gene: 120613017

Following gene: 120613032

Centisome position: 91.07

GC content: 66.03

Gene sequence:

>630_bases
ATGATCCACGTCGTGCTGTGCGACGACCATGCCGTGCTGCGGCGCGGCATCCGCGACACGCTCACCGAAGCGCCGGACAT
CCAGGTGACCGGGGAGGCCGGCGGCTATTCGGAGCTGCGCGAGATCCTGCGCAAGGCACCCTGCGATGTGCTGCTGCTGG
ACCTGAACATGCCGGGCCGCAGCGGGCTGGAGGTGTTGAGCAGCCTGAAGGAAACGGATTCGGCCATCAAGGTACTCGTG
GTGTCGATGTATCCCGAGGACCAGTACGCCCTGCGCTGCCTCCGGGCGGGGGCGCAGGGCTATGCCAACAAGGCCGGCGA
TCCCATGGAGCTGATCGAGGCCGTCCGCACCGTGATGAAGGGCCGCAAGTACCTGACGCCCGAGGTGGCGCAGATGCTCG
CGGACAGCCTGGCGCAACCCGCGCCCGAACTTCCCCACGAGGCCCTGTCCGAGCGCGAACTCCAGACGCTGGTGAAGATC
GCGTCCGGCAAGCGGCTTTCGGACATCGCGGAAGAGCTCATGCTGAGTCCGAAGACCGTGAGCGTGTACCGCTCGCGCGT
GCTGGAGAAGCTCAAGCTCAGCAACAACGCCGAACTGACGGTGTACGCCATCCGCAACCAGCTGGTGTGA

Upstream 100 bases:

>100_bases
TGGACATCAGCAGCCAGCCGGGACGCGGCACCTCGGTCATCGTGTCGATCCCGCTGGAGCCGCAGGACAGCCAGGGCGCC
GAGGACCCAGGAGAATTGCC

Downstream 100 bases:

>100_bases
CGCCCCGCCGTCCGGTTACCGCTGCGAGGCGAAGAGGTCGATGGATTGCTGCATGAGGGTGAGCACCGGTTGCTCGAGCA
TGGGCAGCGTGGCGGCGATC

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MIHVVLCDDHAVLRRGIRDTLTEAPDIQVTGEAGGYSELREILRKAPCDVLLLDLNMPGRSGLEVLSSLKETDSAIKVLV
VSMYPEDQYALRCLRAGAQGYANKAGDPMELIEAVRTVMKGRKYLTPEVAQMLADSLAQPAPELPHEALSERELQTLVKI
ASGKRLSDIAEELMLSPKTVSVYRSRVLEKLKLSNNAELTVYAIRNQLV

Sequences:

>Translated_209_residues
MIHVVLCDDHAVLRRGIRDTLTEAPDIQVTGEAGGYSELREILRKAPCDVLLLDLNMPGRSGLEVLSSLKETDSAIKVLV
VSMYPEDQYALRCLRAGAQGYANKAGDPMELIEAVRTVMKGRKYLTPEVAQMLADSLAQPAPELPHEALSERELQTLVKI
ASGKRLSDIAEELMLSPKTVSVYRSRVLEKLKLSNNAELTVYAIRNQLV
>Mature_209_residues
MIHVVLCDDHAVLRRGIRDTLTEAPDIQVTGEAGGYSELREILRKAPCDVLLLDLNMPGRSGLEVLSSLKETDSAIKVLV
VSMYPEDQYALRCLRAGAQGYANKAGDPMELIEAVRTVMKGRKYLTPEVAQMLADSLAQPAPELPHEALSERELQTLVKI
ASGKRLSDIAEELMLSPKTVSVYRSRVLEKLKLSNNAELTVYAIRNQLV

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=209, Percent_Identity=38.2775119617225, Blast_Score=158, Evalue=2e-40,
Organism=Escherichia coli, GI1790102, Length=199, Percent_Identity=39.6984924623116, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788521, Length=208, Percent_Identity=36.0576923076923, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI1786747, Length=200, Percent_Identity=30.5, Blast_Score=109, Evalue=1e-25,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=29.8076923076923, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=34.0659340659341, Blast_Score=80, Evalue=8e-17,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=28.4313725490196, Blast_Score=75, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23070; Mature: 23070

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHVVLCDDHAVLRRGIRDTLTEAPDIQVTGEAGGYSELREILRKAPCDVLLLDLNMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCC
SGLEVLSSLKETDSAIKVLVVSMYPEDQYALRCLRAGAQGYANKAGDPMELIEAVRTVMK
HHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GRKYLTPEVAQMLADSLAQPAPELPHEALSERELQTLVKIASGKRLSDIAEELMLSPKTV
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
SVYRSRVLEKLKLSNNAELTVYAIRNQLV
HHHHHHHHHHHHCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MIHVVLCDDHAVLRRGIRDTLTEAPDIQVTGEAGGYSELREILRKAPCDVLLLDLNMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCC
SGLEVLSSLKETDSAIKVLVVSMYPEDQYALRCLRAGAQGYANKAGDPMELIEAVRTVMK
HHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GRKYLTPEVAQMLADSLAQPAPELPHEALSERELQTLVKIASGKRLSDIAEELMLSPKTV
CCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCHH
SVYRSRVLEKLKLSNNAELTVYAIRNQLV
HHHHHHHHHHHHCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]