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The map label for this gene is bclA [H]

Identifier: 120611834

GI number: 120611834

Start: 3503405

End: 3505024

Strand: Reverse

Name: bclA [H]

Synonym: Aave_3175

Alternate gene names: 120611834

Gene position: 3505024-3503405 (Counterclockwise)

Preceding gene: 120611835

Following gene: 120611833

Centisome position: 65.48

GC content: 71.48

Gene sequence:

>1620_bases
ATGCATGCCAGCGCCCACGTCGATACCTTCGCGCGCGACCGCCTTCCTCCGGCCGCGCAGCAGCCCGAGTACCTGTTCGA
ACTGCCGGAACTGCAGTTCCCCGAGCGCCTGAACTGCGCCGATCCGCTGCTGGACGTGCACGTGCGCGAAGGGCGGGGCG
GGCGGTTGTGCATCCGGGCACCGGGCGGCGTCGCCTGGACCTATGCCGACCTGCAGGACAAGGCCCACCGCATCGCCAAC
GTGCTGGTGCACCGCATGGGCCTGCAGCCCGGCAACCGCGTGCTGCTGCGCGCGCCCAACAACCCCATGCTCGCGGCCTG
CTGGTTCGCGGTGATGAAGGCTGGCGGCATCGCGGTGGCCACCATGCCGCTGCTGCGCGCCAAGGAGCTGAAGGCGATCA
TCGACATCGCCCAGGTCACGCATGCGCTGTGCGACGCGTCGCTGGCCGAGGAACTGGCGCTCGCCGCGCAGGAGCCCGGT
TCGCCGCTGCGCGCGGTGCGCCACTTCCACGATGCCGGGCCTGAAGGGCTGGAGGCGCTGATGGCCGGGGCCTCGGCCGG
GTTCACCAACGTCGATACCGCGTCCGACGACTGCTGCCTGCTGGGCTTCACCTCCGGCACCACGGGGGTGCCCAAGGCGA
CGATGCACTACCACCGCGACGTGATGGCCATCTGCCACTGCTGGCCGCCGCATGTGCTGCGTCCGCGCGCGGACGACGTC
TTCATCGGCAGCCCGCCGCTGGCCTTCACCTTCGGGCTGGGCGGGCTGCTGCTCTTTCCGCTGCACATCGGCGCCTCCAC
GGTGCTGCTGGAAAAGGCCGGGCCCCCGCAGTTGCTGGAGGCCATCCAGCAGTTCGGCGCGACGGTGCTCTTCACGGCGC
CCACGTCCTACCGCACGCTGGCGGCCGACGGCGCGCTGCTGCGCGGCACGCCGCTGCGCAAGTGCGTGTCCGCCGGCGAG
GCGCTGCCCGCCTCCACGCGCGCGCTCTGGAAGGAGGCGACCGGCATCGAACTGATCGATGGCATCGGCGCCACGGAGAT
GCTGCACATCTTCATCTCCCACGACGAGGCGGGCGCGCGGCCCGGCGCGACGGGCAGGCCCGTGCCGGGCTACCGGGCCC
GCGTGGTGGACGAGGCGGGCCGGGAGGTACCGCCGGGCACCGTGGGCCGGCTGGCGGTGCGGGGACCGACCGGCTGCCGC
TACCTCGCGGACGAGCGGCAGCGGGCCTACGTGCAGGACGGCTGGAACCTGACCGGCGACGCCTACCTGATGGATGCGGA
CGGCTACTTCTTCTACCAGGCGCGCACCGACGACATGATCGTCTCGGCCGGCTACAACATCGCCGCGCCCGAGGTGGAGG
AGGCGCTGCTGGCCCACCCCGCGGTGGCGGAATGCGCCGTGATCGGCGTGCCGGACGCGCAGCGCGGCCAGATCGTCAAG
GCCTTCGTGGTGCTGCGCCCCGGCACCGCGGCGGACGACGGCACCGTGCAGGCATTGCAGGATTTCGTCAAGCGCACGGT
CGCTCCGTACAAATACCCCCGCGCCGTGGAATTCACCGATCGGCTTCCGCGCACGCAAACGGGGAAGCTGCAGCGCTTTA
AGCTACATGCCCCGGCATGA

Upstream 100 bases:

>100_bases
GTTGCCGGGGCCGCCGCCGGCTGACGCCGCGCCTTGTGCACGACGGCCCTTTTGCACGACGGCTCATCGATCCGGAACCG
GAAAGGACAAGGAAGACGCC

Downstream 100 bases:

>100_bases
TGCCGGCGCGCGCGCCACCGGGCCGCGCGCTTTCCTCCCTTCCATCCACCGCCTGCCGCCTAGTGCCAAGGAGCCCTCGA
TGCCATTCCTCCCGTCCCGC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Benzoyl-CoA synthetase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHASAHVDTFARDRLPPAAQQPEYLFELPELQFPERLNCADPLLDVHVREGRGGRLCIRAPGGVAWTYADLQDKAHRIAN
VLVHRMGLQPGNRVLLRAPNNPMLAACWFAVMKAGGIAVATMPLLRAKELKAIIDIAQVTHALCDASLAEELALAAQEPG
SPLRAVRHFHDAGPEGLEALMAGASAGFTNVDTASDDCCLLGFTSGTTGVPKATMHYHRDVMAICHCWPPHVLRPRADDV
FIGSPPLAFTFGLGGLLLFPLHIGASTVLLEKAGPPQLLEAIQQFGATVLFTAPTSYRTLAADGALLRGTPLRKCVSAGE
ALPASTRALWKEATGIELIDGIGATEMLHIFISHDEAGARPGATGRPVPGYRARVVDEAGREVPPGTVGRLAVRGPTGCR
YLADERQRAYVQDGWNLTGDAYLMDADGYFFYQARTDDMIVSAGYNIAAPEVEEALLAHPAVAECAVIGVPDAQRGQIVK
AFVVLRPGTAADDGTVQALQDFVKRTVAPYKYPRAVEFTDRLPRTQTGKLQRFKLHAPA

Sequences:

>Translated_539_residues
MHASAHVDTFARDRLPPAAQQPEYLFELPELQFPERLNCADPLLDVHVREGRGGRLCIRAPGGVAWTYADLQDKAHRIAN
VLVHRMGLQPGNRVLLRAPNNPMLAACWFAVMKAGGIAVATMPLLRAKELKAIIDIAQVTHALCDASLAEELALAAQEPG
SPLRAVRHFHDAGPEGLEALMAGASAGFTNVDTASDDCCLLGFTSGTTGVPKATMHYHRDVMAICHCWPPHVLRPRADDV
FIGSPPLAFTFGLGGLLLFPLHIGASTVLLEKAGPPQLLEAIQQFGATVLFTAPTSYRTLAADGALLRGTPLRKCVSAGE
ALPASTRALWKEATGIELIDGIGATEMLHIFISHDEAGARPGATGRPVPGYRARVVDEAGREVPPGTVGRLAVRGPTGCR
YLADERQRAYVQDGWNLTGDAYLMDADGYFFYQARTDDMIVSAGYNIAAPEVEEALLAHPAVAECAVIGVPDAQRGQIVK
AFVVLRPGTAADDGTVQALQDFVKRTVAPYKYPRAVEFTDRLPRTQTGKLQRFKLHAPA
>Mature_539_residues
MHASAHVDTFARDRLPPAAQQPEYLFELPELQFPERLNCADPLLDVHVREGRGGRLCIRAPGGVAWTYADLQDKAHRIAN
VLVHRMGLQPGNRVLLRAPNNPMLAACWFAVMKAGGIAVATMPLLRAKELKAIIDIAQVTHALCDASLAEELALAAQEPG
SPLRAVRHFHDAGPEGLEALMAGASAGFTNVDTASDDCCLLGFTSGTTGVPKATMHYHRDVMAICHCWPPHVLRPRADDV
FIGSPPLAFTFGLGGLLLFPLHIGASTVLLEKAGPPQLLEAIQQFGATVLFTAPTSYRTLAADGALLRGTPLRKCVSAGE
ALPASTRALWKEATGIELIDGIGATEMLHIFISHDEAGARPGATGRPVPGYRARVVDEAGREVPPGTVGRLAVRGPTGCR
YLADERQRAYVQDGWNLTGDAYLMDADGYFFYQARTDDMIVSAGYNIAAPEVEEALLAHPAVAECAVIGVPDAQRGQIVK
AFVVLRPGTAADDGTVQALQDFVKRTVAPYKYPRAVEFTDRLPRTQTGKLQRFKLHAPA

Specific function: Catalyzes the ligation of benzoate and CoA to form benzoyl-CoA at the expense of ATP. The enzyme also ligates 2- aminobenzoate and CoA. The enzyme shows activity toward a number of benzoate derivates [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Partially Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily [H]

Homologues:

Organism=Homo sapiens, GI38505220, Length=531, Percent_Identity=32.9566854990584, Blast_Score=245, Evalue=9e-65,
Organism=Homo sapiens, GI42544132, Length=536, Percent_Identity=31.5298507462687, Blast_Score=243, Evalue=3e-64,
Organism=Homo sapiens, GI115511026, Length=531, Percent_Identity=30.6967984934087, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI122937307, Length=532, Percent_Identity=30.8270676691729, Blast_Score=215, Evalue=8e-56,
Organism=Homo sapiens, GI58082049, Length=527, Percent_Identity=29.7912713472486, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI157311624, Length=527, Percent_Identity=29.6015180265655, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI157311622, Length=527, Percent_Identity=29.6015180265655, Blast_Score=212, Evalue=7e-55,
Organism=Homo sapiens, GI187761345, Length=523, Percent_Identity=29.6367112810707, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI187761343, Length=523, Percent_Identity=29.6367112810707, Blast_Score=173, Evalue=5e-43,
Organism=Homo sapiens, GI13375727, Length=551, Percent_Identity=25.4083484573503, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI28416953, Length=540, Percent_Identity=26.8518518518519, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI156151445, Length=533, Percent_Identity=26.6416510318949, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI8923896, Length=531, Percent_Identity=25.2354048964218, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI42544134, Length=375, Percent_Identity=25.3333333333333, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI253970489, Length=544, Percent_Identity=24.6323529411765, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI195947378, Length=401, Percent_Identity=24.4389027431421, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1788107, Length=524, Percent_Identity=28.6259541984733, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI145693145, Length=493, Percent_Identity=29.8174442190669, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI221142682, Length=520, Percent_Identity=27.8846153846154, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790505, Length=544, Percent_Identity=25.7352941176471, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786810, Length=520, Percent_Identity=26.3461538461538, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1786529, Length=525, Percent_Identity=27.2380952380952, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1789201, Length=559, Percent_Identity=25.4025044722719, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1786801, Length=512, Percent_Identity=24.0234375, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17557194, Length=507, Percent_Identity=27.6134122287968, Blast_Score=151, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17538037, Length=500, Percent_Identity=27.2, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71994703, Length=518, Percent_Identity=26.0617760617761, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI71994694, Length=518, Percent_Identity=26.0617760617761, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71994690, Length=518, Percent_Identity=26.0617760617761, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17558820, Length=487, Percent_Identity=24.0246406570842, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17559526, Length=360, Percent_Identity=31.3888888888889, Blast_Score=123, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71982997, Length=554, Percent_Identity=24.7292418772563, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI71983001, Length=554, Percent_Identity=24.7292418772563, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17560308, Length=525, Percent_Identity=26.0952380952381, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=513, Percent_Identity=26.3157894736842, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI32563687, Length=478, Percent_Identity=24.6861924686192, Blast_Score=116, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71996755, Length=478, Percent_Identity=22.8033472803347, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560140, Length=489, Percent_Identity=24.9488752556237, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=349, Percent_Identity=27.5071633237822, Blast_Score=91, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319264, Length=558, Percent_Identity=26.1648745519713, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319699, Length=351, Percent_Identity=27.3504273504274, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323182, Length=520, Percent_Identity=25.5769230769231, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24581924, Length=512, Percent_Identity=27.9296875, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI18859661, Length=495, Percent_Identity=25.4545454545455, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24667955, Length=554, Percent_Identity=24.5487364620939, Blast_Score=122, Evalue=5e-28,
Organism=Drosophila melanogaster, GI62472339, Length=519, Percent_Identity=24.4701348747592, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24667959, Length=358, Percent_Identity=26.2569832402235, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI21355225, Length=565, Percent_Identity=24.4247787610619, Blast_Score=113, Evalue=4e-25,
Organism=Drosophila melanogaster, GI21355181, Length=497, Percent_Identity=24.5472837022133, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19922652, Length=497, Percent_Identity=24.1448692152917, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24648260, Length=482, Percent_Identity=24.4813278008299, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24656500, Length=501, Percent_Identity=22.3552894211577, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24653035, Length=482, Percent_Identity=23.4439834024896, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21356947, Length=496, Percent_Identity=25, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24648257, Length=340, Percent_Identity=25.5882352941176, Blast_Score=82, Evalue=1e-15,
Organism=Drosophila melanogaster, GI161076582, Length=489, Percent_Identity=23.1083844580777, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI20130357, Length=353, Percent_Identity=25.2124645892351, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358303, Length=462, Percent_Identity=21.2121212121212, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI281365686, Length=178, Percent_Identity=28.0898876404494, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000873
- InterPro:   IPR011957 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.25 [H]

Molecular weight: Translated: 57896; Mature: 57896

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHASAHVDTFARDRLPPAAQQPEYLFELPELQFPERLNCADPLLDVHVREGRGGRLCIRA
CCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEC
PGGVAWTYADLQDKAHRIANVLVHRMGLQPGNRVLLRAPNNPMLAACWFAVMKAGGIAVA
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEE
TMPLLRAKELKAIIDIAQVTHALCDASLAEELALAAQEPGSPLRAVRHFHDAGPEGLEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
MAGASAGFTNVDTASDDCCLLGFTSGTTGVPKATMHYHRDVMAICHCWPPHVLRPRADDV
HHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
FIGSPPLAFTFGLGGLLLFPLHIGASTVLLEKAGPPQLLEAIQQFGATVLFTAPTSYRTL
EECCCCCEEHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCEEE
AADGALLRGTPLRKCVSAGEALPASTRALWKEATGIELIDGIGATEMLHIFISHDEAGAR
ECCCCEECCCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCCCEEEEEEECCCCCCC
PGATGRPVPGYRARVVDEAGREVPPGTVGRLAVRGPTGCRYLADERQRAYVQDGWNLTGD
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
AYLMDADGYFFYQARTDDMIVSAGYNIAAPEVEEALLAHPAVAECAVIGVPDAQRGQIVK
EEEEECCCEEEEEECCCCEEEECCCCCCCCHHHHHHHCCCCHHHEEEEECCCCCCCCEEE
AFVVLRPGTAADDGTVQALQDFVKRTVAPYKYPRAVEFTDRLPRTQTGKLQRFKLHAPA
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECHHHCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MHASAHVDTFARDRLPPAAQQPEYLFELPELQFPERLNCADPLLDVHVREGRGGRLCIRA
CCCCCCCHHHHHHCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEC
PGGVAWTYADLQDKAHRIANVLVHRMGLQPGNRVLLRAPNNPMLAACWFAVMKAGGIAVA
CCCEEEEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEE
TMPLLRAKELKAIIDIAQVTHALCDASLAEELALAAQEPGSPLRAVRHFHDAGPEGLEAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHH
MAGASAGFTNVDTASDDCCLLGFTSGTTGVPKATMHYHRDVMAICHCWPPHVLRPRADDV
HHCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCE
FIGSPPLAFTFGLGGLLLFPLHIGASTVLLEKAGPPQLLEAIQQFGATVLFTAPTSYRTL
EECCCCCEEHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCEEEEECCCCCEEE
AADGALLRGTPLRKCVSAGEALPASTRALWKEATGIELIDGIGATEMLHIFISHDEAGAR
ECCCCEECCCHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCCCEEEEEEECCCCCCC
PGATGRPVPGYRARVVDEAGREVPPGTVGRLAVRGPTGCRYLADERQRAYVQDGWNLTGD
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCC
AYLMDADGYFFYQARTDDMIVSAGYNIAAPEVEEALLAHPAVAECAVIGVPDAQRGQIVK
EEEEECCCEEEEEECCCCEEEECCCCCCCCHHHHHHHCCCCHHHEEEEECCCCCCCCEEE
AFVVLRPGTAADDGTVQALQDFVKRTVAPYKYPRAVEFTDRLPRTQTGKLQRFKLHAPA
EEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEECHHHCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12897012 [H]