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The map label for this gene is serA [H]

Identifier: 120611817

GI number: 120611817

Start: 3487320

End: 3488336

Strand: Direct

Name: serA [H]

Synonym: Aave_3158

Alternate gene names: 120611817

Gene position: 3487320-3488336 (Clockwise)

Preceding gene: 120611815

Following gene: 120611822

Centisome position: 65.15

GC content: 68.73

Gene sequence:

>1017_bases
ATGGACTCCATGAACATTGTCATCCTCGACGACTACCAGGACGCCGTCCGCAAGCTCCATTGCGCAGCGCGTCTCGATGC
CTATTCCGCCAAGGTCTACACCAATACCGTCAAAGGCCTCGGCCAGCTCTCCGTGCGGCTGCGCGATGCCGACATCATCG
TGCTCATCCGCGAGCGCACCCAGATCACGCGCCAGCTCGTGGAGAAGCTGCCGCGGCTGAAGCTCATCGCGCAGACCGGC
AAGGTGGGCCCGCACGTGGACGTGGCCGCCTGCACCGAGCGCGGCGTCGCGGTGGCCGAGGGCGTGGGCTCGCCCGTCGC
GCCGGCCGAACTGACCTGGGCGCTGATCATGGCGGCCATGCGGCGCCTGCCGCAGTACATCTCCAACCTGAAGCACGGCG
CCTGGCAGCAGTCGGGCCTGCGCGCGGCCTCCATGCCACCCAACTTCGGCATCGGTACGGTGCTGCGCGGCAAGACGCTG
GGCATCTGGGGCTACGGGCGCATCGGCCAGATCGTGGCAGGCTACGGCCGCGCGTTCGGCATGAACGTGCGCGTCTGGGG
CCGCGAGGCCTCGCGCGCCCAGGCCCTGAGCGACGGCCTGCAGGTGGCGACCACGCGCGAGGAGTTCTTCTCGCAGTGCG
ACGTGGTGTCGCTGCACCTGCGGCTCAACGACGAGACGCGCGGCATCGTGCGCCTGGAAGACCTCTCCGGCATGAAGCCC
AACGCACTGCTGGTGAACACCTCGCGCGCGGAGCTGATCGAGCCGGATGCGCTGATCGCCGCCCTGAACCGCGGGCGCCC
CGGCATGGCGGCGGTGGACGTGTTCGAGAGCGAGCCCATCCTGCAGGGCCACGCGTTGCTGCGCCTGGAGAACTGCATCT
GCACGCCGCACATCGGCTACGTGGAGCAGGACAGCTACGAGCTGTACTTCGGGGCGGCGTTCGACAACGTGATCAACTAC
ATCCGGGGCACGCCGACGAACATCGTGAACCCGGGCGCGCTGCAGGTGCGGCGCTGA

Upstream 100 bases:

>100_bases
GCACGCCGCCCCTGGCCGGCGCAGCACTTCCTTTTCCGCACATCATCGCTTTTTCGTGCCGGCCCGCGCGGCGCTCGCGC
GGGGTCACGGCCTGCGGCCC

Downstream 100 bases:

>100_bases
GAGGCCGCTGCCCCGGGGCCCGTGCGGCGAACGGGGCAGGTTTCATGGGAGCAGGCCCGTACACAGGTCGCTGAGCCGCG
ACAACGTCATGAGTTGGTTG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 338; Mature: 338

Protein sequence:

>338_residues
MDSMNIVILDDYQDAVRKLHCAARLDAYSAKVYTNTVKGLGQLSVRLRDADIIVLIRERTQITRQLVEKLPRLKLIAQTG
KVGPHVDVAACTERGVAVAEGVGSPVAPAELTWALIMAAMRRLPQYISNLKHGAWQQSGLRAASMPPNFGIGTVLRGKTL
GIWGYGRIGQIVAGYGRAFGMNVRVWGREASRAQALSDGLQVATTREEFFSQCDVVSLHLRLNDETRGIVRLEDLSGMKP
NALLVNTSRAELIEPDALIAALNRGRPGMAAVDVFESEPILQGHALLRLENCICTPHIGYVEQDSYELYFGAAFDNVINY
IRGTPTNIVNPGALQVRR

Sequences:

>Translated_338_residues
MDSMNIVILDDYQDAVRKLHCAARLDAYSAKVYTNTVKGLGQLSVRLRDADIIVLIRERTQITRQLVEKLPRLKLIAQTG
KVGPHVDVAACTERGVAVAEGVGSPVAPAELTWALIMAAMRRLPQYISNLKHGAWQQSGLRAASMPPNFGIGTVLRGKTL
GIWGYGRIGQIVAGYGRAFGMNVRVWGREASRAQALSDGLQVATTREEFFSQCDVVSLHLRLNDETRGIVRLEDLSGMKP
NALLVNTSRAELIEPDALIAALNRGRPGMAAVDVFESEPILQGHALLRLENCICTPHIGYVEQDSYELYFGAAFDNVINY
IRGTPTNIVNPGALQVRR
>Mature_338_residues
MDSMNIVILDDYQDAVRKLHCAARLDAYSAKVYTNTVKGLGQLSVRLRDADIIVLIRERTQITRQLVEKLPRLKLIAQTG
KVGPHVDVAACTERGVAVAEGVGSPVAPAELTWALIMAAMRRLPQYISNLKHGAWQQSGLRAASMPPNFGIGTVLRGKTL
GIWGYGRIGQIVAGYGRAFGMNVRVWGREASRAQALSDGLQVATTREEFFSQCDVVSLHLRLNDETRGIVRLEDLSGMKP
NALLVNTSRAELIEPDALIAALNRGRPGMAAVDVFESEPILQGHALLRLENCICTPHIGYVEQDSYELYFGAAFDNVINY
IRGTPTNIVNPGALQVRR

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=295, Percent_Identity=29.8305084745763, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI61743967, Length=262, Percent_Identity=33.206106870229, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4557497, Length=262, Percent_Identity=33.206106870229, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI145580578, Length=257, Percent_Identity=33.852140077821, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4557499, Length=257, Percent_Identity=33.852140077821, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI6912396, Length=217, Percent_Identity=30.4147465437788, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI145580575, Length=257, Percent_Identity=33.852140077821, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI87082289, Length=288, Percent_Identity=30.5555555555556, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1789279, Length=300, Percent_Identity=31.3333333333333, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1787645, Length=285, Percent_Identity=27.719298245614, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI87081824, Length=146, Percent_Identity=32.8767123287671, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=334, Percent_Identity=28.4431137724551, Blast_Score=117, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=31.7829457364341, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320925, Length=260, Percent_Identity=30, Blast_Score=97, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=312, Percent_Identity=26.9230769230769, Blast_Score=94, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324055, Length=226, Percent_Identity=29.2035398230088, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=270, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24646446, Length=250, Percent_Identity=34.8, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646448, Length=250, Percent_Identity=34.8, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646452, Length=250, Percent_Identity=34.8, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646450, Length=250, Percent_Identity=34.8, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI62472511, Length=250, Percent_Identity=34.8, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28574286, Length=257, Percent_Identity=27.6264591439689, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI19921140, Length=290, Percent_Identity=28.6206896551724, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571528, Length=242, Percent_Identity=28.5123966942149, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI45551003, Length=260, Percent_Identity=25.3846153846154, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45552429, Length=260, Percent_Identity=25.3846153846154, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24585514, Length=260, Percent_Identity=25.3846153846154, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=260, Percent_Identity=25.3846153846154, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=260, Percent_Identity=25.3846153846154, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585516, Length=242, Percent_Identity=24.7933884297521, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 37044; Mature: 37044

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSMNIVILDDYQDAVRKLHCAARLDAYSAKVYTNTVKGLGQLSVRLRDADIIVLIRERT
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEEEECCCEEEEEECHH
QITRQLVEKLPRLKLIAQTGKVGPHVDVAACTERGVAVAEGVGSPVAPAELTWALIMAAM
HHHHHHHHHCCCEEEEHHCCCCCCCCCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHH
RRLPQYISNLKHGAWQQSGLRAASMPPNFGIGTVLRGKTLGIWGYGRIGQIVAGYGRAFG
HHHHHHHHHHCCCCHHHCCCEECCCCCCCCCCEEECCCEEEEECCCHHHHHHHHCCHHCC
MNVRVWGREASRAQALSDGLQVATTREEFFSQCDVVSLHLRLNDETRGIVRLEDLSGMKP
CEEEEECCCHHHHHHHHCCCEEEECHHHHHCCCCEEEEEEEECCCCCCEEEECCCCCCCC
NALLVNTSRAELIEPDALIAALNRGRPGMAAVDVFESEPILQGHALLRLENCICTPHIGY
CEEEEECCHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHEEECCEECCCCCCC
VEQDSYELYFGAAFDNVINYIRGTPTNIVNPGALQVRR
EECCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MDSMNIVILDDYQDAVRKLHCAARLDAYSAKVYTNTVKGLGQLSVRLRDADIIVLIRERT
CCCCEEEEEECHHHHHHHHHHHHHHHHHHHHEEHHHHHCCCEEEEEEECCCEEEEEECHH
QITRQLVEKLPRLKLIAQTGKVGPHVDVAACTERGVAVAEGVGSPVAPAELTWALIMAAM
HHHHHHHHHCCCEEEEHHCCCCCCCCCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHHH
RRLPQYISNLKHGAWQQSGLRAASMPPNFGIGTVLRGKTLGIWGYGRIGQIVAGYGRAFG
HHHHHHHHHHCCCCHHHCCCEECCCCCCCCCCEEECCCEEEEECCCHHHHHHHHCCHHCC
MNVRVWGREASRAQALSDGLQVATTREEFFSQCDVVSLHLRLNDETRGIVRLEDLSGMKP
CEEEEECCCHHHHHHHHCCCEEEECHHHHHCCCCEEEEEEEECCCCCCEEEECCCCCCCC
NALLVNTSRAELIEPDALIAALNRGRPGMAAVDVFESEPILQGHALLRLENCICTPHIGY
CEEEEECCHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHEEECCEECCCCCCC
VEQDSYELYFGAAFDNVINYIRGTPTNIVNPGALQVRR
EECCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]