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The map label for this gene is fkpA [H]

Identifier: 120611808

GI number: 120611808

Start: 3475678

End: 3476139

Strand: Direct

Name: fkpA [H]

Synonym: Aave_3148

Alternate gene names: 120611808

Gene position: 3475678-3476139 (Clockwise)

Preceding gene: 120611807

Following gene: 120611809

Centisome position: 64.93

GC content: 71.21

Gene sequence:

>462_bases
GTGAAGAAGACCTTGCTGCCCGCTCTCGCCGCCGTCCTGCTGGCCGGTACCGCCTGCGCCCAGAAGCCGACTGCCGCGCC
CGCTGCACCGGCCGCTTCGGCCGCTCCGGCCGCCGCCGCACCGGCACCCGTGACCACCGCCAGCGGCCTGGTGTACGAGT
CGCTCAAGGAAGGCACGGGCGAATCGCCCAAGGCCACCGACGTCGTGAAAGTGCACTACCGCGGCACGTTCCTGGACGGC
AAGGAGTTCGACAGCTCCTACAAGCGCGGCGAGCCCACCGAATTCCCGCTCAACCGCGTGATCCCCTGCTGGACCGAAGG
CGTGCAGCGCATGAAGCCGGGTGGCAAGGCCCGCCTCACCTGCCCGCCCGCCATCGCCTACGGCGCGGCTGGCGCGGGCG
GCGTGATTCCGCCCAACGCCACGCTGCGCTTCGAGGTCGAACTGGTTTCCGTGCGCCGCTGA

Upstream 100 bases:

>100_bases
TTCGCCTGAGCCCGCGCGTGGCCGTGCCTGGGCGCGCCGGCAGCGATGCCCGGCGGCGCGGGCCGGCTACCATCGCGTCT
TTTGACCGGAGACCCGAACC

Downstream 100 bases:

>100_bases
GCGGAGCGCGGACCTGCCGGGCGGCTTCAGGGGCGTACACTGGCAGGCTCGCCCGCGGCACCGCCGCGTTCCGCACACCG
CCCCGGCGTGAACCGCCGGG

Product: FKBP-type peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MKKTLLPALAAVLLAGTACAQKPTAAPAAPAASAAPAAAAPAPVTTASGLVYESLKEGTGESPKATDVVKVHYRGTFLDG
KEFDSSYKRGEPTEFPLNRVIPCWTEGVQRMKPGGKARLTCPPAIAYGAAGAGGVIPPNATLRFEVELVSVRR

Sequences:

>Translated_153_residues
MKKTLLPALAAVLLAGTACAQKPTAAPAAPAASAAPAAAAPAPVTTASGLVYESLKEGTGESPKATDVVKVHYRGTFLDG
KEFDSSYKRGEPTEFPLNRVIPCWTEGVQRMKPGGKARLTCPPAIAYGAAGAGGVIPPNATLRFEVELVSVRR
>Mature_153_residues
MKKTLLPALAAVLLAGTACAQKPTAAPAAPAASAAPAAAAPAPVTTASGLVYESLKEGTGESPKATDVVKVHYRGTFLDG
KEFDSSYKRGEPTEFPLNRVIPCWTEGVQRMKPGGKARLTCPPAIAYGAAGAGGVIPPNATLRFEVELVSVRR

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. FkpA probably acts in the folding of extracytoplasmic proteins [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=45.2830188679245, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=46.2264150943396, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=46.2264150943396, Blast_Score=89, Evalue=1e-18,
Organism=Homo sapiens, GI224809329, Length=98, Percent_Identity=47.9591836734694, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI224809327, Length=98, Percent_Identity=47.9591836734694, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI4758384, Length=98, Percent_Identity=47.9591836734694, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI4503729, Length=131, Percent_Identity=41.2213740458015, Blast_Score=86, Evalue=1e-17,
Organism=Homo sapiens, GI224809331, Length=94, Percent_Identity=47.8723404255319, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI206725530, Length=89, Percent_Identity=43.8202247191011, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI17149844, Length=89, Percent_Identity=43.8202247191011, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI17149842, Length=89, Percent_Identity=43.8202247191011, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI192448443, Length=87, Percent_Identity=43.6781609195402, Blast_Score=70, Evalue=6e-13,
Organism=Homo sapiens, GI4503727, Length=108, Percent_Identity=41.6666666666667, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI33469985, Length=90, Percent_Identity=41.1111111111111, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1789745, Length=108, Percent_Identity=56.4814814814815, Blast_Score=122, Evalue=8e-30,
Organism=Escherichia coli, GI87082390, Length=107, Percent_Identity=51.4018691588785, Blast_Score=113, Evalue=5e-27,
Organism=Caenorhabditis elegans, GI17540882, Length=99, Percent_Identity=41.4141414141414, Blast_Score=79, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI71993519, Length=107, Percent_Identity=41.1214953271028, Blast_Score=71, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17561782, Length=96, Percent_Identity=46.875, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=89, Percent_Identity=52.8089887640449, Blast_Score=87, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=92, Percent_Identity=46.7391304347826, Blast_Score=84, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=50.9615384615385, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363946, Length=94, Percent_Identity=46.8085106382979, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17352457, Length=94, Percent_Identity=46.8085106382979, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24655568, Length=91, Percent_Identity=49.4505494505495, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24647110, Length=124, Percent_Identity=43.5483870967742, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356629, Length=98, Percent_Identity=50, Blast_Score=78, Evalue=3e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15730; Mature: 15730

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKTLLPALAAVLLAGTACAQKPTAAPAAPAASAAPAAAAPAPVTTASGLVYESLKEGTG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
ESPKATDVVKVHYRGTFLDGKEFDSSYKRGEPTEFPLNRVIPCWTEGVQRMKPGGKARLT
CCCCCCCEEEEEECCEECCCHHHCCHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEEEE
CPPAIAYGAAGAGGVIPPNATLRFEVELVSVRR
CCCHHHCCCCCCCCCCCCCCEEEEEEEEEEECC
>Mature Secondary Structure
MKKTLLPALAAVLLAGTACAQKPTAAPAAPAASAAPAAAAPAPVTTASGLVYESLKEGTG
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
ESPKATDVVKVHYRGTFLDGKEFDSSYKRGEPTEFPLNRVIPCWTEGVQRMKPGGKARLT
CCCCCCCEEEEEECCEECCCHHHCCHHCCCCCCCCCHHHCCCHHHHHHHHHCCCCCEEEE
CPPAIAYGAAGAGGVIPPNATLRFEVELVSVRR
CCCHHHCCCCCCCCCCCCCCEEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9171380 [H]