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The map label for this gene is lrp [H]

Identifier: 120611804

GI number: 120611804

Start: 3469853

End: 3470311

Strand: Reverse

Name: lrp [H]

Synonym: Aave_3144

Alternate gene names: 120611804

Gene position: 3470311-3469853 (Counterclockwise)

Preceding gene: 120611813

Following gene: 120611798

Centisome position: 64.83

GC content: 66.67

Gene sequence:

>459_bases
ATGGATCGTATCGACCGGAAAATCCTCGCCGTGCTCCAGGCCGACGCGCGCGCCAGCCTGCAGGACATCGGCCAGGCCGT
GGGCCTGAGCCCGTCGCCCTGCTGGGCGCGCATCCGCCGCATGGAGGAATCCGGCGTGATCGAGGGCTACACGGTGCGCC
TCAACGCCCAGGCGCTGGACCTGGCCGATACCGTGCTCGTGCAGGTCACGCTCGACAGCCATTCCGACAACACCCTGGAG
AAGTTCGGCGAAACGCTCGCGAGCATCCCCGAGGTGGTGGAGGCGCACCTGGTGTCGGGCGACTACGACTACCTGCTGCG
CGTGGTGGTGAAGGACACGCGCGACTACGAGCGCCTGTTGCGCGAGAAGCTCTACAAGATCAAGGGCATCCGCCACAGCC
GCTCGAGTTTCGTGCTGCGCACGCTCAAGAAAGCGGATCTGCCCCTGCGCGCGGACTGA

Upstream 100 bases:

>100_bases
GTGCCGCCTGGGCTGCCGATGGTTTTTCCGTATTTCCAGCAAATGGCGCAGTACGAAGAAAAATATTCTGCGATCTGGCG
AATATCTGCACAATCCTTCC

Downstream 100 bases:

>100_bases
GCGGCAGCGCAGGAGCGGTCCCCGCCGCAGCGCAGCGATGGGTTTGCTCCGTCAGCCCAGCAGCAGCGCGTCGTCCGCCA
GCTGCTCGCCGCGCACCTTC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MDRIDRKILAVLQADARASLQDIGQAVGLSPSPCWARIRRMEESGVIEGYTVRLNAQALDLADTVLVQVTLDSHSDNTLE
KFGETLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLLREKLYKIKGIRHSRSSFVLRTLKKADLPLRAD

Sequences:

>Translated_152_residues
MDRIDRKILAVLQADARASLQDIGQAVGLSPSPCWARIRRMEESGVIEGYTVRLNAQALDLADTVLVQVTLDSHSDNTLE
KFGETLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLLREKLYKIKGIRHSRSSFVLRTLKKADLPLRAD
>Mature_152_residues
MDRIDRKILAVLQADARASLQDIGQAVGLSPSPCWARIRRMEESGVIEGYTVRLNAQALDLADTVLVQVTLDSHSDNTLE
KFGETLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLLREKLYKIKGIRHSRSSFVLRTLKKADLPLRAD

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=146, Percent_Identity=41.7808219178082, Blast_Score=129, Evalue=9e-32,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=34, Blast_Score=105, Evalue=1e-24,
Organism=Escherichia coli, GI1790182, Length=143, Percent_Identity=25.8741258741259, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17149; Mature: 17149

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRIDRKILAVLQADARASLQDIGQAVGLSPSPCWARIRRMEESGVIEGYTVRLNAQALD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHH
LADTVLVQVTLDSHSDNTLEKFGETLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLL
HHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
REKLYKIKGIRHSRSSFVLRTLKKADLPLRAD
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDRIDRKILAVLQADARASLQDIGQAVGLSPSPCWARIRRMEESGVIEGYTVRLNAQALD
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCHHHH
LADTVLVQVTLDSHSDNTLEKFGETLASIPEVVEAHLVSGDYDYLLRVVVKDTRDYERLL
HHCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHHHHHH
REKLYKIKGIRHSRSSFVLRTLKKADLPLRAD
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]