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The map label for this gene is ilvI [H]

Identifier: 120611772

GI number: 120611772

Start: 3436459

End: 3438264

Strand: Reverse

Name: ilvI [H]

Synonym: Aave_3112

Alternate gene names: 120611772

Gene position: 3438264-3436459 (Counterclockwise)

Preceding gene: 120611779

Following gene: 120611771

Centisome position: 64.23

GC content: 65.78

Gene sequence:

>1806_bases
ATGGAAATCTCCAGGGCCGAGCTCTCTTCGGCATCCACCGCCGCGCAGGCGGGCGGAACCCACGCCACCGGCACCTCCGC
TGCTCCCCAGGACCTCATGGGGGCCGAGATCCTCATCAAGGCATTGCAGGCCGAAGGCGTGCAGTACATGTGGGGCTACC
CGGGCGGGGCGGTGCTCTACATCTACGACGCCCTCTACAAGCAGGACACCATCCAGCACGTGCTGGTACGGCACGAGCAG
GCGGCCGTGCACGCGGCGGACGGCTATGCGCGCGCCACGGGCGACGTGGGCGTGGCGCTGGTGACCTCCGGCCCGGGCCT
CACCAACGCGGTGACCGGCATCGCGACGGCCTACATGGATTCGATTCCCATGGTCATCATCTCCGGCCAGGTGCCCACGC
CGGCGATCGGCCTGGATGCCTTCCAGGAATGCGACACCGTGGGCATCACGCGGCCCATCGTCAAGCACAACTTCCTGGTC
AAGGACACGCGCGACCTGGCTGAGACCCTGAAGAAGGCCTTCCACATCGCCCGCACCGGCCGTCCCGGTCCCGTGGTGGT
GGACATCCCGAAGGATGTGTCTTTCAAGAAGGTTCCCTACCACGGCTATCCGCAGAGCGTGGAAATGCGCTCGTACAACC
CGGTCCGCCGCGGGCATGGCGGACAGATCCGCAAGGCGCTGCAACTGCTGCTGTCCGCCAAGCGCCCCTACATCTATACC
GGCGGCGGCGTGCTGCTGGGCAACGCCACGCAGGAGCTGCGCACGCTGGTGGACATGCTGGGCTATCCGGTCACCAACAC
GCTCATGGGGCTGGGCGCCTATCCGGCGAGTTCGCCCAAGTTCCTGGGCATGCTGGGCATGCACGGCACGATCGAGGCCA
ACAACGCCATGCAGAACTGCGACGTGCTGCTGGCCGTGGGCGCGCGCTTCGACGACCGCGTGATCGGCAACCCCAGGCAC
TTCGCGCAGAACGACCGCAAGATCATCCACGTGGACATCGACCCGTCGAGCATCTCCAAGCGCGTGAAGGTGGACGTGCC
GATCGTGGGCGACGTCAAGGACGTGCTCACCGAGCTGATCTCGATGATCCGCGAATCCACGGTGCGGCCCGATGCTGGCG
CGCTGGCGTCCTGGTGGGACACGATCGAAGGCTGGCGCCGCCGCGACTGCCTCAAGTACGACCGGGGCAACCAGGAGGTC
ATCAAGCCGCAGTTCGTGGTCGAGACCCTCTGGAACATGACCCGGGACGCGGACACCTACATCACGTCCGACGTCGGCCA
GCACCAGATGTGGGCCGCCCAGTATTACCGCTTCGACGAGCCGCGCCGCTGGATCAATTCCGGCGGGCTGGGCACGATGG
GCGTGGGCATCCCCTATGCCATGGGCATCAAGCTGGCGAAGCCGCAGAGCGAGGTGTTCTGCATCACGGGCGAAGGCTCG
GTGCAGATGAACATCCAGGAACTCTCGACCTGCCTGCAGTACAACACGCCGATCAAGATCTGCTCGCTCAACAACCGCTA
CCTCGGCATGGTGCGGCAGTGGCAGGAGATCGAGTATTCCGGCCGCTACAGCCACAGCTACATGGATGCGCTGCCGAACT
TCGTGAAGCTCGCCGAGGCCTACGGTCACGTCGGCATGCTCATCGAGCGCCCGCAGGACGTGGAGCCCGCGCTGCGCGAG
GCCCGCAGGCTCAAGGACCGGACCGTCTTCCTCGACTTCCGCACCGATCCCACGGAGAACGTGTTCCCGATGGTGCAGGC
CGGCAAGGGCATCACGGAAATGCTGCTCGGCTCGGAGGATCTCTGA

Upstream 100 bases:

>100_bases
TTTCGCCCATGTCCGAGGCCTCAAGTTCCACGCTGGTTCCACAAGAACCCTGCAAGGAGCACCCTAGGTTTTTCGTCAGA
GAAATTCACAAAGGTTGATC

Downstream 100 bases:

>100_bases
GCCTTTGAGCGCCGCAGGGGCCGGCTCCCGCCCTGTCGCGCCGTCCTCGCGGGCGGCGCCTTTCGACGAATCTATTGTCT
GCCGAGCCTGGGGCTTACCG

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS-III; ALS-III; Acetohydroxy-acid synthase III large subunit [H]

Number of amino acids: Translated: 601; Mature: 601

Protein sequence:

>601_residues
MEISRAELSSASTAAQAGGTHATGTSAAPQDLMGAEILIKALQAEGVQYMWGYPGGAVLYIYDALYKQDTIQHVLVRHEQ
AAVHAADGYARATGDVGVALVTSGPGLTNAVTGIATAYMDSIPMVIISGQVPTPAIGLDAFQECDTVGITRPIVKHNFLV
KDTRDLAETLKKAFHIARTGRPGPVVVDIPKDVSFKKVPYHGYPQSVEMRSYNPVRRGHGGQIRKALQLLLSAKRPYIYT
GGGVLLGNATQELRTLVDMLGYPVTNTLMGLGAYPASSPKFLGMLGMHGTIEANNAMQNCDVLLAVGARFDDRVIGNPRH
FAQNDRKIIHVDIDPSSISKRVKVDVPIVGDVKDVLTELISMIRESTVRPDAGALASWWDTIEGWRRRDCLKYDRGNQEV
IKPQFVVETLWNMTRDADTYITSDVGQHQMWAAQYYRFDEPRRWINSGGLGTMGVGIPYAMGIKLAKPQSEVFCITGEGS
VQMNIQELSTCLQYNTPIKICSLNNRYLGMVRQWQEIEYSGRYSHSYMDALPNFVKLAEAYGHVGMLIERPQDVEPALRE
ARRLKDRTVFLDFRTDPTENVFPMVQAGKGITEMLLGSEDL

Sequences:

>Translated_601_residues
MEISRAELSSASTAAQAGGTHATGTSAAPQDLMGAEILIKALQAEGVQYMWGYPGGAVLYIYDALYKQDTIQHVLVRHEQ
AAVHAADGYARATGDVGVALVTSGPGLTNAVTGIATAYMDSIPMVIISGQVPTPAIGLDAFQECDTVGITRPIVKHNFLV
KDTRDLAETLKKAFHIARTGRPGPVVVDIPKDVSFKKVPYHGYPQSVEMRSYNPVRRGHGGQIRKALQLLLSAKRPYIYT
GGGVLLGNATQELRTLVDMLGYPVTNTLMGLGAYPASSPKFLGMLGMHGTIEANNAMQNCDVLLAVGARFDDRVIGNPRH
FAQNDRKIIHVDIDPSSISKRVKVDVPIVGDVKDVLTELISMIRESTVRPDAGALASWWDTIEGWRRRDCLKYDRGNQEV
IKPQFVVETLWNMTRDADTYITSDVGQHQMWAAQYYRFDEPRRWINSGGLGTMGVGIPYAMGIKLAKPQSEVFCITGEGS
VQMNIQELSTCLQYNTPIKICSLNNRYLGMVRQWQEIEYSGRYSHSYMDALPNFVKLAEAYGHVGMLIERPQDVEPALRE
ARRLKDRTVFLDFRTDPTENVFPMVQAGKGITEMLLGSEDL
>Mature_601_residues
MEISRAELSSASTAAQAGGTHATGTSAAPQDLMGAEILIKALQAEGVQYMWGYPGGAVLYIYDALYKQDTIQHVLVRHEQ
AAVHAADGYARATGDVGVALVTSGPGLTNAVTGIATAYMDSIPMVIISGQVPTPAIGLDAFQECDTVGITRPIVKHNFLV
KDTRDLAETLKKAFHIARTGRPGPVVVDIPKDVSFKKVPYHGYPQSVEMRSYNPVRRGHGGQIRKALQLLLSAKRPYIYT
GGGVLLGNATQELRTLVDMLGYPVTNTLMGLGAYPASSPKFLGMLGMHGTIEANNAMQNCDVLLAVGARFDDRVIGNPRH
FAQNDRKIIHVDIDPSSISKRVKVDVPIVGDVKDVLTELISMIRESTVRPDAGALASWWDTIEGWRRRDCLKYDRGNQEV
IKPQFVVETLWNMTRDADTYITSDVGQHQMWAAQYYRFDEPRRWINSGGLGTMGVGIPYAMGIKLAKPQSEVFCITGEGS
VQMNIQELSTCLQYNTPIKICSLNNRYLGMVRQWQEIEYSGRYSHSYMDALPNFVKLAEAYGHVGMLIERPQDVEPALRE
ARRLKDRTVFLDFRTDPTENVFPMVQAGKGITEMLLGSEDL

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=571, Percent_Identity=25.569176882662, Blast_Score=170, Evalue=5e-42,
Organism=Homo sapiens, GI21361361, Length=569, Percent_Identity=26.3620386643234, Blast_Score=167, Evalue=4e-41,
Organism=Escherichia coli, GI87081685, Length=573, Percent_Identity=57.9406631762653, Blast_Score=690, Evalue=0.0,
Organism=Escherichia coli, GI1790104, Length=575, Percent_Identity=40, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1786717, Length=537, Percent_Identity=33.8919925512104, Blast_Score=296, Evalue=3e-81,
Organism=Escherichia coli, GI1787096, Length=571, Percent_Identity=27.84588441331, Blast_Score=209, Evalue=6e-55,
Organism=Escherichia coli, GI1788716, Length=555, Percent_Identity=25.045045045045, Blast_Score=154, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17542570, Length=510, Percent_Identity=27.6470588235294, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17531301, Length=556, Percent_Identity=25.8992805755396, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17531299, Length=556, Percent_Identity=25.8992805755396, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323755, Length=583, Percent_Identity=42.0240137221269, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320816, Length=479, Percent_Identity=24.8434237995825, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321524, Length=492, Percent_Identity=22.9674796747967, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19922626, Length=576, Percent_Identity=26.0416666666667, Blast_Score=179, Evalue=4e-45,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 66230; Mature: 66230

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEISRAELSSASTAAQAGGTHATGTSAAPQDLMGAEILIKALQAEGVQYMWGYPGGAVLY
CCCCHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEE
IYDALYKQDTIQHVLVRHEQAAVHAADGYARATGDVGVALVTSGPGLTNAVTGIATAYMD
EEHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHC
SIPMVIISGQVPTPAIGLDAFQECDTVGITRPIVKHNFLVKDTRDLAETLKKAFHIARTG
CCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHCCEEEECHHHHHHHHHHHHHHHCCC
RPGPVVVDIPKDVSFKKVPYHGYPQSVEMRSYNPVRRGHGGQIRKALQLLLSAKRPYIYT
CCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEE
GGGVLLGNATQELRTLVDMLGYPVTNTLMGLGAYPASSPKFLGMLGMHGTIEANNAMQNC
CCCEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEECCCCEEECCCCHHCC
DVLLAVGARFDDRVIGNPRHFAQNDRKIIHVDIDPSSISKRVKVDVPIVGDVKDVLTELI
CEEEEECCCCCCCCCCCCHHHCCCCCEEEEEECCHHHCCCEEEEECCEECCHHHHHHHHH
SMIRESTVRPDAGALASWWDTIEGWRRRDCLKYDRGNQEVIKPQFVVETLWNMTRDADTY
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCCCCHH
ITSDVGQHQMWAAQYYRFDEPRRWINSGGLGTMGVGIPYAMGIKLAKPQSEVFCITGEGS
EECCCCCHHHHHHHHHCCCCHHHHHCCCCCCEECCCCHHHHCEEEECCCCCEEEEECCCC
VQMNIQELSTCLQYNTPIKICSLNNRYLGMVRQWQEIEYSGRYSHSYMDALPNFVKLAEA
EEEEHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YGHVGMLIERPQDVEPALREARRLKDRTVFLDFRTDPTENVFPMVQAGKGITEMLLGSED
HCCCCEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCHHHHHCCCCC
L
C
>Mature Secondary Structure
MEISRAELSSASTAAQAGGTHATGTSAAPQDLMGAEILIKALQAEGVQYMWGYPGGAVLY
CCCCHHHHCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCEEEE
IYDALYKQDTIQHVLVRHEQAAVHAADGYARATGDVGVALVTSGPGLTNAVTGIATAYMD
EEHHHHHHHHHHHHHHHHHHHHEEECCCCEEECCCCCEEEEECCCCHHHHHHHHHHHHHC
SIPMVIISGQVPTPAIGLDAFQECDTVGITRPIVKHNFLVKDTRDLAETLKKAFHIARTG
CCCEEEEECCCCCCCCCCHHHHHCCCCCCCCHHHHCCEEEECHHHHHHHHHHHHHHHCCC
RPGPVVVDIPKDVSFKKVPYHGYPQSVEMRSYNPVRRGHGGQIRKALQLLLSAKRPYIYT
CCCCEEEECCCCCCEEECCCCCCCCCCCCCCCCCHHCCCCHHHHHHHHHHHHCCCCEEEE
GGGVLLGNATQELRTLVDMLGYPVTNTLMGLGAYPASSPKFLGMLGMHGTIEANNAMQNC
CCCEEECCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEECCCCEEECCCCHHCC
DVLLAVGARFDDRVIGNPRHFAQNDRKIIHVDIDPSSISKRVKVDVPIVGDVKDVLTELI
CEEEEECCCCCCCCCCCCHHHCCCCCEEEEEECCHHHCCCEEEEECCEECCHHHHHHHHH
SMIRESTVRPDAGALASWWDTIEGWRRRDCLKYDRGNQEVIKPQFVVETLWNMTRDADTY
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHCCCCCHH
ITSDVGQHQMWAAQYYRFDEPRRWINSGGLGTMGVGIPYAMGIKLAKPQSEVFCITGEGS
EECCCCCHHHHHHHHHCCCCHHHHHCCCCCCEECCCCHHHHCEEEECCCCCEEEEECCCC
VQMNIQELSTCLQYNTPIKICSLNNRYLGMVRQWQEIEYSGRYSHSYMDALPNFVKLAEA
EEEEHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
YGHVGMLIERPQDVEPALREARRLKDRTVFLDFRTDPTENVFPMVQAGKGITEMLLGSED
HCCCCEEECCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCHHHHHCCCCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6308579; 1630901; 9278503; 3891724; 9298646 [H]