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The map label for this gene is cysNC [H]

Identifier: 120611718

GI number: 120611718

Start: 3366106

End: 3367476

Strand: Direct

Name: cysNC [H]

Synonym: Aave_3056

Alternate gene names: 120611718

Gene position: 3366106-3367476 (Clockwise)

Preceding gene: 120611717

Following gene: 120611719

Centisome position: 62.89

GC content: 72.5

Gene sequence:

>1371_bases
ATGACTAACACGACTGATTCGATGGCTGCCAAGGCAGCCACTACCACTTCGGCAGGCCGGGACGACCACGAAGCGGCGTT
GCGCTTCATCACCTGCGGCAGCGTGGACGACGGCAAGAGCACGCTGATCGGGCGCCTGCTGGTGGACAGCCGCGCCGTGC
TGCAGGACCACCTGGCCGGGGTGACGCGCGGCGGCGAGACCGACCTGGCGCTGCTCACCGACGGCCTCTCGGCCGAGCGC
GAGCAGGGCATCACCATCGACGTGGCCTACCGCTATTTCGCGACCGAGACGCGCAAGTTCATCATCGGCGACGCACCGGG
CCACGAGCAGTACACCCGCAACATGGTCACGGCCGCCTCCAGCGCCGACGCGGCCGTGGTGCTGGTCGATGCCACCAAGC
TCGACTGGCGCGACCCGCAGCTCGCGCTGCTGCCGCAGACCCGCCGCCACTCCCTGCTGGTGCACCTGCTGCGCGTGCAT
TCGCTGGTGTTCGCCGTGAACAAGCTCGACGCGGTGGACGACCCCGCCCTCGCCTGGCGCCACATCCGGGCCGCGCTGGA
AGCCTTCGCCCGGACGGCCGGCATCGCCGTGCGCGCCACCGTGCCCGTGTCCGCGCTCAAGGGCTGGAACGTGGTCGATG
CGCAGCCCGGCTGGTGCGGCTACGAAGGCCCGGGCCTGCTGCAGATCCTGGAGCAGCTGCCCCACACGCCCGCAGACACC
GGACTGGCGCTGGCCTTCCCGGTGCAGTGGGTGGAGAAATTCTCGTCTTCGGCGGACACCACGCAGGGCCGCCGCGTGTT
CTGGGGCCGCGTCGCCGCGGGCCAGGTCGCGCCCGGCACGGAAGTGCAGGTGTTCCCGAGCGGCCAGCTCGCCCGCGTGG
CGCAGGTGCTCGACCACGCCCGCCGACCGCACACCGTGCAGGCCGGCACCAGCGCGGGCATCATCCTCGACCGCGAGGTG
GACGTCTCGCGCGGCGACTGGATCCTGGCCGCGCCCACCCCCGCGGCAGCGGCCGCCGCGGACGATTTCGACACCCCGGC
GCCGGTGCCCGCCTGGCCGGCGCGCCGCGAGATCCGCGCCACCGTGGCCTGGATGGACGACGAGCCCCTGGTGGCCGGCC
GCGTGTACTGGGCGCTGCACGGCCACCGCTGGGTCAAGGCCAAGGCGCAGCGCGTGGTGCACCGCCTGAATATCCACACG
CTGGCCGAGGAAGACGCCGCGCAGCTGGAGCCCAACGCCATCGGCCACGTGGAACTGCTGCTGCAGGAGGCCCTGCCCGC
CGCGCCGTTCGGCCAGGCCCGGGTACTGGGTTCCCTGATCCTCGTGGACACCGCGAGCCACCGCACCGCCGCGGCCGTGC
TGGTGAACTGA

Upstream 100 bases:

>100_bases
AGGGGGACACCGCCAGTGCGGCGGGGCGGCCCTTGCACGGCGGTTCTCGCCTGGGCCGCGTCCATTTTTAACGCCCCGCG
TGGGCGACTGAAAGAGTTGG

Downstream 100 bases:

>100_bases
ACCGGCCCGCTTCCCCCGCCGCCCCTTCCTGCGACAGCGCAAGGGGCGCAGGGACACTCCGGCCCGAACCGCCCTAAAAT
TGCGGGTTACCCCCGACCCA

Product: sulfate adenylyltransferase subunit 1

Products: NA

Alternate protein names: Sulfate adenylyltransferase subunit 1; ATP-sulfurylase large subunit; Sulfate adenylate transferase; SAT; Adenylyl-sulfate kinase; APS kinase; ATP adenosine-5'-phosphosulfate 3'-phosphotransferase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MTNTTDSMAAKAATTTSAGRDDHEAALRFITCGSVDDGKSTLIGRLLVDSRAVLQDHLAGVTRGGETDLALLTDGLSAER
EQGITIDVAYRYFATETRKFIIGDAPGHEQYTRNMVTAASSADAAVVLVDATKLDWRDPQLALLPQTRRHSLLVHLLRVH
SLVFAVNKLDAVDDPALAWRHIRAALEAFARTAGIAVRATVPVSALKGWNVVDAQPGWCGYEGPGLLQILEQLPHTPADT
GLALAFPVQWVEKFSSSADTTQGRRVFWGRVAAGQVAPGTEVQVFPSGQLARVAQVLDHARRPHTVQAGTSAGIILDREV
DVSRGDWILAAPTPAAAAAADDFDTPAPVPAWPARREIRATVAWMDDEPLVAGRVYWALHGHRWVKAKAQRVVHRLNIHT
LAEEDAAQLEPNAIGHVELLLQEALPAAPFGQARVLGSLILVDTASHRTAAAVLVN

Sequences:

>Translated_456_residues
MTNTTDSMAAKAATTTSAGRDDHEAALRFITCGSVDDGKSTLIGRLLVDSRAVLQDHLAGVTRGGETDLALLTDGLSAER
EQGITIDVAYRYFATETRKFIIGDAPGHEQYTRNMVTAASSADAAVVLVDATKLDWRDPQLALLPQTRRHSLLVHLLRVH
SLVFAVNKLDAVDDPALAWRHIRAALEAFARTAGIAVRATVPVSALKGWNVVDAQPGWCGYEGPGLLQILEQLPHTPADT
GLALAFPVQWVEKFSSSADTTQGRRVFWGRVAAGQVAPGTEVQVFPSGQLARVAQVLDHARRPHTVQAGTSAGIILDREV
DVSRGDWILAAPTPAAAAAADDFDTPAPVPAWPARREIRATVAWMDDEPLVAGRVYWALHGHRWVKAKAQRVVHRLNIHT
LAEEDAAQLEPNAIGHVELLLQEALPAAPFGQARVLGSLILVDTASHRTAAAVLVN
>Mature_455_residues
TNTTDSMAAKAATTTSAGRDDHEAALRFITCGSVDDGKSTLIGRLLVDSRAVLQDHLAGVTRGGETDLALLTDGLSAERE
QGITIDVAYRYFATETRKFIIGDAPGHEQYTRNMVTAASSADAAVVLVDATKLDWRDPQLALLPQTRRHSLLVHLLRVHS
LVFAVNKLDAVDDPALAWRHIRAALEAFARTAGIAVRATVPVSALKGWNVVDAQPGWCGYEGPGLLQILEQLPHTPADTG
LALAFPVQWVEKFSSSADTTQGRRVFWGRVAAGQVAPGTEVQVFPSGQLARVAQVLDHARRPHTVQAGTSAGIILDREVD
VSRGDWILAAPTPAAAAAADDFDTPAPVPAWPARREIRATVAWMDDEPLVAGRVYWALHGHRWVKAKAQRVVHRLNIHTL
AEEDAAQLEPNAIGHVELLLQEALPAAPFGQARVLGSLILVDTASHRTAAAVLVN

Specific function: APS kinase catalyzes the synthesis of activated sulfate [H]

COG id: COG2895

COG function: function code P; GTPases - Sulfate adenylate transferase subunit 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the APS kinase family [H]

Homologues:

Organism=Homo sapiens, GI4503475, Length=299, Percent_Identity=32.1070234113712, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4503471, Length=297, Percent_Identity=31.3131313131313, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI223555963, Length=295, Percent_Identity=28.4745762711864, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI5729864, Length=288, Percent_Identity=28.8194444444444, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI194097354, Length=318, Percent_Identity=27.9874213836478, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI194018520, Length=318, Percent_Identity=27.9874213836478, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI46094014, Length=350, Percent_Identity=26.5714285714286, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI194018522, Length=318, Percent_Identity=27.9874213836478, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI34147630, Length=163, Percent_Identity=32.5153374233129, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789108, Length=444, Percent_Identity=39.4144144144144, Blast_Score=285, Evalue=5e-78,
Organism=Escherichia coli, GI1790412, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789737, Length=140, Percent_Identity=32.8571428571429, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115532067, Length=285, Percent_Identity=33.6842105263158, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI115532065, Length=285, Percent_Identity=33.6842105263158, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI32566629, Length=345, Percent_Identity=30.4347826086957, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17552884, Length=325, Percent_Identity=30.7692307692308, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17569207, Length=325, Percent_Identity=30.7692307692308, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI32566303, Length=323, Percent_Identity=27.5541795665635, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI32566301, Length=143, Percent_Identity=37.0629370629371, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25141371, Length=306, Percent_Identity=24.8366013071895, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6322937, Length=320, Percent_Identity=30, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6325337, Length=300, Percent_Identity=31.3333333333333, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6319594, Length=300, Percent_Identity=31.3333333333333, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320377, Length=333, Percent_Identity=27.027027027027, Blast_Score=102, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6324761, Length=340, Percent_Identity=28.5294117647059, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI45553807, Length=297, Percent_Identity=31.986531986532, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI45553816, Length=297, Percent_Identity=31.986531986532, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24651721, Length=297, Percent_Identity=31.986531986532, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17864154, Length=297, Percent_Identity=31.986531986532, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24652838, Length=297, Percent_Identity=31.986531986532, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI17137572, Length=297, Percent_Identity=31.986531986532, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45550900, Length=310, Percent_Identity=30.6451612903226, Blast_Score=109, Evalue=4e-24,
Organism=Drosophila melanogaster, GI17137380, Length=326, Percent_Identity=27.3006134969325, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI281363316, Length=331, Percent_Identity=27.4924471299094, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17864358, Length=331, Percent_Identity=27.4924471299094, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921738, Length=162, Percent_Identity=33.3333333333333, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002891
- InterPro:   IPR000795
- InterPro:   IPR011779
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF01583 APS_kinase; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: =2.7.7.4; =2.7.1.25 [H]

Molecular weight: Translated: 48976; Mature: 48845

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTDSMAAKAATTTSAGRDDHEAALRFITCGSVDDGKSTLIGRLLVDSRAVLQDHLAG
CCCCCHHHHHHHHCCCCCCCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTRGGETDLALLTDGLSAEREQGITIDVAYRYFATETRKFIIGDAPGHEQYTRNMVTAAS
CCCCCCCCEEEEECCCCCHHHCCCEEEEEEEEHHCCCCEEEEECCCCHHHHHHHHHHCCC
SADAAVVLVDATKLDWRDPQLALLPQTRRHSLLVHLLRVHSLVFAVNKLDAVDDPALAWR
CCCEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
HIRAALEAFARTAGIAVRATVPVSALKGWNVVDAQPGWCGYEGPGLLQILEQLPHTPADT
HHHHHHHHHHHHCCEEEEEECCHHHHCCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
GLALAFPVQWVEKFSSSADTTQGRRVFWGRVAAGQVAPGTEVQVFPSGQLARVAQVLDHA
CEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHH
RRPHTVQAGTSAGIILDREVDVSRGDWILAAPTPAAAAAADDFDTPAPVPAWPARREIRA
CCCCEEECCCCCCEEEECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCEEEE
TVAWMDDEPLVAGRVYWALHGHRWVKAKAQRVVHRLNIHTLAEEDAAQLEPNAIGHVELL
EEEEECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
LQEALPAAPFGQARVLGSLILVDTASHRTAAAVLVN
HHHHCCCCCCCHHHHHCEEEEEECCCCCEEEEEEEC
>Mature Secondary Structure 
TNTTDSMAAKAATTTSAGRDDHEAALRFITCGSVDDGKSTLIGRLLVDSRAVLQDHLAG
CCCCHHHHHHHHCCCCCCCCCHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
VTRGGETDLALLTDGLSAEREQGITIDVAYRYFATETRKFIIGDAPGHEQYTRNMVTAAS
CCCCCCCCEEEEECCCCCHHHCCCEEEEEEEEHHCCCCEEEEECCCCHHHHHHHHHHCCC
SADAAVVLVDATKLDWRDPQLALLPQTRRHSLLVHLLRVHSLVFAVNKLDAVDDPALAWR
CCCEEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
HIRAALEAFARTAGIAVRATVPVSALKGWNVVDAQPGWCGYEGPGLLQILEQLPHTPADT
HHHHHHHHHHHHCCEEEEEECCHHHHCCCCEEECCCCCCCCCCCHHHHHHHHCCCCCCCC
GLALAFPVQWVEKFSSSADTTQGRRVFWGRVAAGQVAPGTEVQVFPSGQLARVAQVLDHA
CEEEEHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHH
RRPHTVQAGTSAGIILDREVDVSRGDWILAAPTPAAAAAADDFDTPAPVPAWPARREIRA
CCCCEEECCCCCCEEEECCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCCCCCCEEEE
TVAWMDDEPLVAGRVYWALHGHRWVKAKAQRVVHRLNIHTLAEEDAAQLEPNAIGHVELL
EEEEECCCCEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCHHHHHH
LQEALPAAPFGQARVLGSLILVDTASHRTAAAVLVN
HHHHCCCCCCCHHHHHCEEEEEECCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10910347 [H]