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The map label for this gene is cbl [H]

Identifier: 120611702

GI number: 120611702

Start: 3349508

End: 3350437

Strand: Reverse

Name: cbl [H]

Synonym: Aave_3039

Alternate gene names: 120611702

Gene position: 3350437-3349508 (Counterclockwise)

Preceding gene: 120611703

Following gene: 120611700

Centisome position: 62.59

GC content: 70.0

Gene sequence:

>930_bases
ATGAATTTCCAGCAACTGCGTTCCGTGCGCGAGGCCGTGCGCACGGGTTTCAACCTCACCGACGTGGCCCGCATCCTCCA
CACGTCCCAGCCCGGCGTGAGCCGGCAGATCCGCGAGCTTGAGGAGGAACTGGGCCTGGAGATCTTCGTGCGCGCGGGCA
AGCGGCTCACGGGGCTCACCCCGCCGGGATCCACGCTGCTGCCCATCGTCGAGCGACTGATGCTGGAGGCGGAGAACCTG
CGGCGCGCCGGGCACGACTTCCGCGCCAGCGGGGAAGGGCGCCTGTCCATCGCGGCCACGCACTCGCAGGCACGCTATGC
CCTGCCGCAGGTGGTGCGCGATTTCCGGGCGCTGTTCCCGCAGGTCACCCTGCACCTGCACCAGGGCTCGCCCCGGCAGG
TGGCCGAGATGCTGCTCTCGGGCGAGGCCGACATCGGCGTCGCCACGGAGGCGCTGGCGGGCTATGGCGAACTGGTCACG
CTGCCCTGCTACCGCTGGTCCCACAGCATCGTGGTGCCGCCGGGCCACCCGCTGCTCGACCTGCCCGAGCCGCCCACCCT
GCGGCAATTGGCGCGCTTTCCCATCATCACCTACGAGCTGGGCTACACCGGACGCGCCCACATCGACGAGGCCTTCGCCC
GCGAAGGACTGCAGCCGGACGTGGTGCTCACCGCCATGGACGCGGACGTGATCAAGACCTATGTGGAACTGGACATGGGG
GTGGGCATCGTCGCCTCCATCGCGCTGGACCCGGAGCGCGACCGCCACCTGCGCATGATCGATGCGCGCCATCTGTTCGA
AGTCAACCTCACCCGCCTGGGGTTGCGGCGCGGCAGCTGGCTGCGCGGCTACGCCTACCGCTTCATCGAGGCCTTCGTTC
CCACCCTGACGCGCGAAGCGGTGGACGAGGCGCTGCGCGCCGCGCGCTGA

Upstream 100 bases:

>100_bases
AGCGCACCGCTGCCGGCCCTGGCGCCCGCGCGTTGATCCCCCACGCGTTGACCCCCGTACGGTTATCGGCCGCATAACAA
CAGGAAAGCCCGGCGAACCC

Downstream 100 bases:

>100_bases
CCGGGGATCGCCGCGGCTGCAGCACCTAGCCCTTGCGCCGGGCGAGGATCCACCGGGCCAGGGTCCGCGCTTCTTCTTCC
CCGATGCGCGGGTGCCGCGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNFQQLRSVREAVRTGFNLTDVARILHTSQPGVSRQIRELEEELGLEIFVRAGKRLTGLTPPGSTLLPIVERLMLEAENL
RRAGHDFRASGEGRLSIAATHSQARYALPQVVRDFRALFPQVTLHLHQGSPRQVAEMLLSGEADIGVATEALAGYGELVT
LPCYRWSHSIVVPPGHPLLDLPEPPTLRQLARFPIITYELGYTGRAHIDEAFAREGLQPDVVLTAMDADVIKTYVELDMG
VGIVASIALDPERDRHLRMIDARHLFEVNLTRLGLRRGSWLRGYAYRFIEAFVPTLTREAVDEALRAAR

Sequences:

>Translated_309_residues
MNFQQLRSVREAVRTGFNLTDVARILHTSQPGVSRQIRELEEELGLEIFVRAGKRLTGLTPPGSTLLPIVERLMLEAENL
RRAGHDFRASGEGRLSIAATHSQARYALPQVVRDFRALFPQVTLHLHQGSPRQVAEMLLSGEADIGVATEALAGYGELVT
LPCYRWSHSIVVPPGHPLLDLPEPPTLRQLARFPIITYELGYTGRAHIDEAFAREGLQPDVVLTAMDADVIKTYVELDMG
VGIVASIALDPERDRHLRMIDARHLFEVNLTRLGLRRGSWLRGYAYRFIEAFVPTLTREAVDEALRAAR
>Mature_309_residues
MNFQQLRSVREAVRTGFNLTDVARILHTSQPGVSRQIRELEEELGLEIFVRAGKRLTGLTPPGSTLLPIVERLMLEAENL
RRAGHDFRASGEGRLSIAATHSQARYALPQVVRDFRALFPQVTLHLHQGSPRQVAEMLLSGEADIGVATEALAGYGELVT
LPCYRWSHSIVVPPGHPLLDLPEPPTLRQLARFPIITYELGYTGRAHIDEAFAREGLQPDVVLTAMDADVIKTYVELDMG
VGIVASIALDPERDRHLRMIDARHLFEVNLTRLGLRRGSWLRGYAYRFIEAFVPTLTREAVDEALRAAR

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=301, Percent_Identity=52.4916943521595, Blast_Score=319, Evalue=2e-88,
Organism=Escherichia coli, GI1787530, Length=305, Percent_Identity=47.2131147540984, Blast_Score=304, Evalue=5e-84,
Organism=Escherichia coli, GI157672245, Length=226, Percent_Identity=33.6283185840708, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788887, Length=235, Percent_Identity=30.6382978723404, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1789204, Length=171, Percent_Identity=33.9181286549708, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788481, Length=245, Percent_Identity=26.9387755102041, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI145693105, Length=136, Percent_Identity=27.2058823529412, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787601, Length=185, Percent_Identity=31.3513513513514, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790399, Length=234, Percent_Identity=24.3589743589744, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788297, Length=153, Percent_Identity=28.7581699346405, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI87082132, Length=147, Percent_Identity=28.5714285714286, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081904, Length=234, Percent_Identity=27.7777777777778, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34552; Mature: 34552

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS50931 HTH_LYSR ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLRSVREAVRTGFNLTDVARILHTSQPGVSRQIRELEEELGLEIFVRAGKRLTGLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCC
PPGSTLLPIVERLMLEAENLRRAGHDFRASGEGRLSIAATHSQARYALPQVVRDFRALFP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
QVTLHLHQGSPRQVAEMLLSGEADIGVATEALAGYGELVTLPCYRWSHSIVVPPGHPLLD
HHEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEECEEECCCEEECCCCCCCCC
LPEPPTLRQLARFPIITYELGYTGRAHIDEAFAREGLQPDVVLTAMDADVIKTYVELDMG
CCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCC
VGIVASIALDPERDRHLRMIDARHLFEVNLTRLGLRRGSWLRGYAYRFIEAFVPTLTREA
CCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VDEALRAAR
HHHHHHHCC
>Mature Secondary Structure
MNFQQLRSVREAVRTGFNLTDVARILHTSQPGVSRQIRELEEELGLEIFVRAGKRLTGLT
CCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCCCCCCC
PPGSTLLPIVERLMLEAENLRRAGHDFRASGEGRLSIAATHSQARYALPQVVRDFRALFP
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHH
QVTLHLHQGSPRQVAEMLLSGEADIGVATEALAGYGELVTLPCYRWSHSIVVPPGHPLLD
HHEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEECEEECCCEEECCCCCCCCC
LPEPPTLRQLARFPIITYELGYTGRAHIDEAFAREGLQPDVVLTAMDADVIKTYVELDMG
CCCCCHHHHHHHCCEEEEECCCCCCHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHCC
VGIVASIALDPERDRHLRMIDARHLFEVNLTRLGLRRGSWLRGYAYRFIEAFVPTLTREA
CCEEEEEEECCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
VDEALRAAR
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]