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The map label for this gene is metC [H]

Identifier: 120611684

GI number: 120611684

Start: 3329962

End: 3331203

Strand: Reverse

Name: metC [H]

Synonym: Aave_3021

Alternate gene names: 120611684

Gene position: 3331203-3329962 (Counterclockwise)

Preceding gene: 120611685

Following gene: 120611682

Centisome position: 62.23

GC content: 71.5

Gene sequence:

>1242_bases
ATGACTTCCTCCGCATCCGACGCCACGCCGGGCTCCGGGCCCGACACCCGCCTGATCCACCATGCCTATGCGCCACCCGA
GGGTTTTTGCGCCCCTCAGCCGGCGGTGCACAAGGCGTCCACCGTCATCTTCCCGGATGTCGCCGCGATGCGGGCGCGCG
AGTGGAAGGACAAGACCGGCTACACCTACGGCCTGCACGGCACGCCCACGACCTACATCCTCGAGGAACGCCTCTGCGAA
CTGGAAGGCGGCCTGCAGTGCGTGCTGATGCCCAGCGGACTCGCGGCCATCGCCAACGTGGCGCTGGCTTTGCTGCGCAG
CGGCGACGAGGTGCTGATCCCGGACAACGCCTACGGACCCAACAAGGCGCTGGCCGAGGTGGAACTGGCGCACTACGGCA
TCCGCCATGCGTACTACGATCCGCTGGATCCCGCCGACCTGGCGGCCCGCATCACGCCCGACACCCGGCTGGTGTGGCTG
GAAGCCCCGGGCTCCGTCACGCTGGAGTTCCCGGACTTGGCCGAACAGGTGCGCATCTGCCGCGAGCGCGGCGTGACCAG
CGCGCTCGACAATACCTGGGGCGCGGGTATCGCCTTCCGGCCCTTCGACCTGCTCGGCGACGGCCGGCTGGGCGTGGACA
TCTCGGTCCATGCCCTGACCAAGTACCCCAGCGGCGGTGGCGACGTGCTCATGGGCAGCGCGATCACCCGCGACCCGGCC
CTGCACCTGCGCATCAAGCTCACCCACATGCGCCTGGGCCTGGGCGTGGGCGCCAACGATGCCGAGGCGGTCCTGCGTTC
GCTGCCCAGCGTCGGATTGCGGTACCGCGCGCATGACGCGGCTGCGCGCGAATTGGCCGCCTGGATGGGCGGGCAGCCCG
CCGTCGCCCAGGTGCTGCACCCCGCGCTGCCGGGTTCGCCGGGGCACGCGCACTGGGCCGCTCTCTGCGCGCGCGGCGCG
GGGCAGGGCGCCGCGGCCGGCCTGTTCAGCGTGGTCATCGACGAGCGCCATGGCCAGGACCGGGTCGATGCCTTCTGCGA
CGGCCTGCGGCTCTTCAAGCTCGGCTACAGCTGGGGCGGGCCCATGAGCCTGGTGGTGCCTTACGAGCTGCGGACGATGC
GCGCGCGGCCCACGGCGCACGTGCGGCCCGGCACCGTGGTGCGCTTTTCCGTGGGGCTGGAGAACGTGGAAGACCTGCGC
AGCGACCTCGCGCAGTCGCTCGCCGCCGCGTTTCCGGCCTGA

Upstream 100 bases:

>100_bases
GGCGTGAACTCGGTGGTGAACCAGCTGACGGTCACCCCGGGCACGACGGGCTGAAACGGGGCCGGTCCCCGGCCGAGGCG
GGCGGCGATACCATCGCCGC

Downstream 100 bases:

>100_bases
CGGGCGGGACGCTCCCGCCGGGCCGCGGGCTGTCCGGCGCGCCATGGCGGCGTGCCATGCCAGGGCGGGGCAAGGGGTCT
TGCCGGGCGTGCTGCTACAT

Product: Cys/Met metabolism pyridoxal-phosphate-dependent enzyme

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MTSSASDATPGSGPDTRLIHHAYAPPEGFCAPQPAVHKASTVIFPDVAAMRAREWKDKTGYTYGLHGTPTTYILEERLCE
LEGGLQCVLMPSGLAAIANVALALLRSGDEVLIPDNAYGPNKALAEVELAHYGIRHAYYDPLDPADLAARITPDTRLVWL
EAPGSVTLEFPDLAEQVRICRERGVTSALDNTWGAGIAFRPFDLLGDGRLGVDISVHALTKYPSGGGDVLMGSAITRDPA
LHLRIKLTHMRLGLGVGANDAEAVLRSLPSVGLRYRAHDAAARELAAWMGGQPAVAQVLHPALPGSPGHAHWAALCARGA
GQGAAAGLFSVVIDERHGQDRVDAFCDGLRLFKLGYSWGGPMSLVVPYELRTMRARPTAHVRPGTVVRFSVGLENVEDLR
SDLAQSLAAAFPA

Sequences:

>Translated_413_residues
MTSSASDATPGSGPDTRLIHHAYAPPEGFCAPQPAVHKASTVIFPDVAAMRAREWKDKTGYTYGLHGTPTTYILEERLCE
LEGGLQCVLMPSGLAAIANVALALLRSGDEVLIPDNAYGPNKALAEVELAHYGIRHAYYDPLDPADLAARITPDTRLVWL
EAPGSVTLEFPDLAEQVRICRERGVTSALDNTWGAGIAFRPFDLLGDGRLGVDISVHALTKYPSGGGDVLMGSAITRDPA
LHLRIKLTHMRLGLGVGANDAEAVLRSLPSVGLRYRAHDAAARELAAWMGGQPAVAQVLHPALPGSPGHAHWAALCARGA
GQGAAAGLFSVVIDERHGQDRVDAFCDGLRLFKLGYSWGGPMSLVVPYELRTMRARPTAHVRPGTVVRFSVGLENVEDLR
SDLAQSLAAAFPA
>Mature_412_residues
TSSASDATPGSGPDTRLIHHAYAPPEGFCAPQPAVHKASTVIFPDVAAMRAREWKDKTGYTYGLHGTPTTYILEERLCEL
EGGLQCVLMPSGLAAIANVALALLRSGDEVLIPDNAYGPNKALAEVELAHYGIRHAYYDPLDPADLAARITPDTRLVWLE
APGSVTLEFPDLAEQVRICRERGVTSALDNTWGAGIAFRPFDLLGDGRLGVDISVHALTKYPSGGGDVLMGSAITRDPAL
HLRIKLTHMRLGLGVGANDAEAVLRSLPSVGLRYRAHDAAARELAAWMGGQPAVAQVLHPALPGSPGHAHWAALCARGAG
QGAAAGLFSVVIDERHGQDRVDAFCDGLRLFKLGYSWGGPMSLVVPYELRTMRARPTAHVRPGTVVRFSVGLENVEDLRS
DLAQSLAAAFPA

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=361, Percent_Identity=30.1939058171745, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI299473759, Length=360, Percent_Identity=26.9444444444444, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI25453487, Length=359, Percent_Identity=26.7409470752089, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1789383, Length=394, Percent_Identity=34.010152284264, Blast_Score=238, Evalue=5e-64,
Organism=Escherichia coli, GI1790375, Length=390, Percent_Identity=30.2564102564103, Blast_Score=139, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17560056, Length=359, Percent_Identity=30.08356545961, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17538055, Length=361, Percent_Identity=29.6398891966759, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI71980708, Length=381, Percent_Identity=27.2965879265092, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6321170, Length=348, Percent_Identity=33.0459770114943, Blast_Score=193, Evalue=5e-50,
Organism=Saccharomyces cerevisiae, GI6319307, Length=360, Percent_Identity=27.5, Blast_Score=105, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323333, Length=399, Percent_Identity=24.3107769423559, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI19922554, Length=364, Percent_Identity=32.4175824175824, Blast_Score=154, Evalue=2e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 43949; Mature: 43817

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSSASDATPGSGPDTRLIHHAYAPPEGFCAPQPAVHKASTVIFPDVAAMRAREWKDKTG
CCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHCCCEEECCCHHHHHHHHCCCCCC
YTYGLHGTPTTYILEERLCELEGGLQCVLMPSGLAAIANVALALLRSGDEVLIPDNAYGP
EEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCC
NKALAEVELAHYGIRHAYYDPLDPADLAARITPDTRLVWLEAPGSVTLEFPDLAEQVRIC
CHHHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCEEEEEECCCCEEEECHHHHHHHHHH
RERGVTSALDNTWGAGIAFRPFDLLGDGRLGVDISVHALTKYPSGGGDVLMGSAITRDPA
HHCCCHHHHHCCCCCCEEECCHHCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCCCC
LHLRIKLTHMRLGLGVGANDAEAVLRSLPSVGLRYRAHDAAARELAAWMGGQPAVAQVLH
EEEEEEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHH
PALPGSPGHAHWAALCARGAGQGAAAGLFSVVIDERHGQDRVDAFCDGLRLFKLGYSWGG
HCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHEEECCCCHHHHHHHHCCCEEEEECCCCCC
PMSLVVPYELRTMRARPTAHVRPGTVVRFSVGLENVEDLRSDLAQSLAAAFPA
CEEEEEEHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSSASDATPGSGPDTRLIHHAYAPPEGFCAPQPAVHKASTVIFPDVAAMRAREWKDKTG
CCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHCCCEEECCCHHHHHHHHCCCCCC
YTYGLHGTPTTYILEERLCELEGGLQCVLMPSGLAAIANVALALLRSGDEVLIPDNAYGP
EEEECCCCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHCCCEEEECCCCCCC
NKALAEVELAHYGIRHAYYDPLDPADLAARITPDTRLVWLEAPGSVTLEFPDLAEQVRIC
CHHHHHHHHHHHHHHHHCCCCCCHHHHEEEECCCCEEEEEECCCCEEEECHHHHHHHHHH
RERGVTSALDNTWGAGIAFRPFDLLGDGRLGVDISVHALTKYPSGGGDVLMGSAITRDPA
HHCCCHHHHHCCCCCCEEECCHHCCCCCCCCEEEEEEEEEECCCCCCCEEECCCCCCCCC
LHLRIKLTHMRLGLGVGANDAEAVLRSLPSVGLRYRAHDAAARELAAWMGGQPAVAQVLH
EEEEEEEEEEEEECCCCCCHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHH
PALPGSPGHAHWAALCARGAGQGAAAGLFSVVIDERHGQDRVDAFCDGLRLFKLGYSWGG
HCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHEEECCCCHHHHHHHHCCCEEEEECCCCCC
PMSLVVPYELRTMRARPTAHVRPGTVVRFSVGLENVEDLRSDLAQSLAAAFPA
CEEEEEEHHHHHHCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]