Click here to switch to the map view.

The map label for this gene is copR [H]

Identifier: 120611665

GI number: 120611665

Start: 3310459

End: 3311151

Strand: Direct

Name: copR [H]

Synonym: Aave_3002

Alternate gene names: 120611665

Gene position: 3310459-3311151 (Clockwise)

Preceding gene: 120611664

Following gene: 120611666

Centisome position: 61.85

GC content: 70.42

Gene sequence:

>693_bases
ATGAGCACCGCGCAGATCCTGGTCGTGGAGGACGATCCCCGCGTTGCCGATTTCCTGCAGCGTGGCCTGCGCGCGGAAGG
CTACGGCGTGCAGATGGCGCGCACCGGTCCCGAAGGGCTCGCGCTCGCCCGCGCCGGGGAGGCGGCGCTGGTGATCCTCG
ACGTGATGCTGCCCGGCATGACCGGGCTGGACCTGTGCCAGTCGCTGCGGGCCGAAGGCGGCCAGGTGCCGGTGCTGATG
CTCACGGCCCTGAGCAGCATCGAGGACAAGGTCGCCGGATTGAAGCTCGGCGCGGACGACTACCTCACCAAGCCGTTCGC
CTTCGAGGAACTGCTGGCGCGCATCGAGGCGCTGCTGCGGCGCGGGCGCGAGCAGCGCCCCCGGGCGACCACGCTGCAGG
TGGCGGACCTGGTACTCGACCTGGAACGCATGCAGGCCAGCCGCGCGGGGCGCCCGATCGCGCTCACCGCCAAGGAGCTG
GCCTTCCTGGAGCTGCTCATGAGCGCCCCGGGCCGGCTCTGCAGCCGCGAGCGCATCCTCTCCAACGTGTGGGGCATGCA
CGAGGACCCACTGACCAATGTGGTGGATGTCTATGTGCGCCGCCTGCGCAGCAAGATCGATGAAGGGCACCCGCTCGCGC
TGCTCAAGACCGTGCGCGGGTTGGGCTACCGCCTGGACGACGGCGAGACGTAG

Upstream 100 bases:

>100_bases
CCCGCGGCACCCTCGTCGGCATCCACCTGCCGGCCGCATGCGTGGCCGGCGTGCACGCGTCCCCGGCGCCTGCGAGCGCC
GCACGGGCGGAGGACGGCCG

Downstream 100 bases:

>100_bases
GCGCGCGAGGCACGCCTCATCTGCCGGAGCCGGCGTGCTCGGCCGGCACGTTCATGCAGCGTTCATGTGCGCGTCAGCCG
GGCTTCATCGCGCGGCAACG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 230; Mature: 229

Protein sequence:

>230_residues
MSTAQILVVEDDPRVADFLQRGLRAEGYGVQMARTGPEGLALARAGEAALVILDVMLPGMTGLDLCQSLRAEGGQVPVLM
LTALSSIEDKVAGLKLGADDYLTKPFAFEELLARIEALLRRGREQRPRATTLQVADLVLDLERMQASRAGRPIALTAKEL
AFLELLMSAPGRLCSRERILSNVWGMHEDPLTNVVDVYVRRLRSKIDEGHPLALLKTVRGLGYRLDDGET

Sequences:

>Translated_230_residues
MSTAQILVVEDDPRVADFLQRGLRAEGYGVQMARTGPEGLALARAGEAALVILDVMLPGMTGLDLCQSLRAEGGQVPVLM
LTALSSIEDKVAGLKLGADDYLTKPFAFEELLARIEALLRRGREQRPRATTLQVADLVLDLERMQASRAGRPIALTAKEL
AFLELLMSAPGRLCSRERILSNVWGMHEDPLTNVVDVYVRRLRSKIDEGHPLALLKTVRGLGYRLDDGET
>Mature_229_residues
STAQILVVEDDPRVADFLQRGLRAEGYGVQMARTGPEGLALARAGEAALVILDVMLPGMTGLDLCQSLRAEGGQVPVLML
TALSSIEDKVAGLKLGADDYLTKPFAFEELLARIEALLRRGREQRPRATTLQVADLVLDLERMQASRAGRPIALTAKELA
FLELLMSAPGRLCSRERILSNVWGMHEDPLTNVVDVYVRRLRSKIDEGHPLALLKTVRGLGYRLDDGET

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=45.8149779735683, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=43.4389140271493, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=39.8190045248869, Blast_Score=147, Evalue=4e-37,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=40.625, Blast_Score=144, Evalue=4e-36,
Organism=Escherichia coli, GI1790860, Length=226, Percent_Identity=36.283185840708, Blast_Score=141, Evalue=3e-35,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=33.6283185840708, Blast_Score=138, Evalue=4e-34,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=35.9649122807018, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.5555555555556, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=40.3508771929825, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=33.7899543378995, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=35.2422907488987, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=33.0357142857143, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1790863, Length=234, Percent_Identity=33.7606837606838, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=29.6943231441048, Blast_Score=80, Evalue=9e-17,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=41.2280701754386, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1790299, Length=148, Percent_Identity=29.7297297297297, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1788905, Length=119, Percent_Identity=35.2941176470588, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1787487, Length=101, Percent_Identity=34.6534653465347, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788191, Length=117, Percent_Identity=35.042735042735, Blast_Score=60, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25188; Mature: 25057

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTAQILVVEDDPRVADFLQRGLRAEGYGVQMARTGPEGLALARAGEAALVILDVMLPGM
CCCEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHHCCC
TGLDLCQSLRAEGGQVPVLMLTALSSIEDKVAGLKLGADDYLTKPFAFEELLARIEALLR
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCEEECCHHHHCCCHHHHHHHHHHHHHHH
RGREQRPRATTLQVADLVLDLERMQASRAGRPIALTAKELAFLELLMSAPGRLCSRERIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHH
SNVWGMHEDPLTNVVDVYVRRLRSKIDEGHPLALLKTVRGLGYRLDDGET
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
STAQILVVEDDPRVADFLQRGLRAEGYGVQMARTGPEGLALARAGEAALVILDVMLPGM
CCEEEEEECCCCHHHHHHHHCCCCCCCCEEEECCCCCHHHHHCCCCHHHHHHHHHHCCC
TGLDLCQSLRAEGGQVPVLMLTALSSIEDKVAGLKLGADDYLTKPFAFEELLARIEALLR
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCEEECCHHHHCCCHHHHHHHHHHHHHHH
RGREQRPRATTLQVADLVLDLERMQASRAGRPIALTAKELAFLELLMSAPGRLCSRERIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCHHHHHHHHH
SNVWGMHEDPLTNVVDVYVRRLRSKIDEGHPLALLKTVRGLGYRLDDGET
HHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]