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The map label for this gene is hemH [H]

Identifier: 120611663

GI number: 120611663

Start: 3307695

End: 3308759

Strand: Direct

Name: hemH [H]

Synonym: Aave_3000

Alternate gene names: 120611663

Gene position: 3307695-3308759 (Clockwise)

Preceding gene: 120611661

Following gene: 120611664

Centisome position: 61.79

GC content: 71.64

Gene sequence:

>1065_bases
ATGAACGCATCCGCCGCAGACCGCTCCCCGACCGCCCCGATGCCCCGCACCGCCGTGCTGCTGTGCAACCTGGGCACGCC
CGATGCGCCCACCGCGCCCGCGCTGCGCCGCTATCTCGCGCAGTTCCTGTCCGACCCGCGCATCGTGGAGATTCCCCGTG
CCGCGTGGCTGCCCATCCTGCACGGCATCATCCTGCGCATCCGGCCGGCGAAGTCCGCGGCCAAGTACGCCAGCATCTGG
ATGCCCGAGGGTTCGCCCCTGGCCGTGTGGACGGAGCGCCAGGCCACGCTGCTGCGCGGATGGCTGGGCGAGGCGGGGCT
GCGGGTGCAGGTGCGGCATGCGATGCGCTACGGGCAGCCGTCCATCGCCGGCCAGTTGAAGGCCCTGCAGGCCGAAGGCG
TGGACCGCGTGCTGGTGCTGCCGCTCTATCCGCAGTACTCGGGCACGACCACCGCGAGCGTGTCGGACGACGTGTGCGCC
TATGCGCTGCGCACGCGCCGCCTGCCGGAGCTGCGTTTCGTGAACAGCTACCACGACCACCCCGCCTACATCGACGCGCT
GGCACGCAGCGTGCGCGCCCACTGGCAGCGCGAGGGCGGGCCGGCAGAACAGCTGGTGATGAGCTTCCACGGCATTCCGG
AGCGCGCCGTGCGCCTGGGCGACCCCTACCAGCAGGAGTGCCTGGCGACCGCCGCGCTGCTGGCGCAGGCGCTGGGCCTG
GCGGCGGACCGCTACCGGGTGACCTTCCAGTCCCGCTTCGGCAAGGCCAAGTGGCTGGAGCCCTATACCGAACCGACGCT
CATCGAGATGGCCCGTGGCGGCACGCGCAGCGTGGACGTGATGTGCCCGGGGTTCACCAGCGACTGCCTGGAAACGCTGG
AGGAAATCAACCAGGAGGCGCGCGAGGCCTTCCTGCACGCGGGCGGCAAGGAATTCCGCTACATCCCCTGCCTGAACGCG
GACAACGCCTGGATCACCGCGCTGAGCCGGATCGCGCAGGAGCACCTGTCGGGCTGGGATACGGGGGCACCGGGCGGAGC
GGCAGCGCCCGGCCTGGCCCGCTGA

Upstream 100 bases:

>100_bases
GTCGAGATCGAGGGTCATCGCGCGGATGCGGGCGGTATCGAGCATGGTGGCCGAGAATAGCGCAACCATTGCATTTCCCT
TTCCTTTCCTTCCGCTGTCC

Downstream 100 bases:

>100_bases
GCGAGCCGCACCGCGAGGCCCGCGCCATGTTCCGATTGCGCCTGTCCCTGGCTTTCGCCACCCTGGTCGCGCTGGTGTGC
GCGCAGGCGGCCTTCGTCTA

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNASAADRSPTAPMPRTAVLLCNLGTPDAPTAPALRRYLAQFLSDPRIVEIPRAAWLPILHGIILRIRPAKSAAKYASIW
MPEGSPLAVWTERQATLLRGWLGEAGLRVQVRHAMRYGQPSIAGQLKALQAEGVDRVLVLPLYPQYSGTTTASVSDDVCA
YALRTRRLPELRFVNSYHDHPAYIDALARSVRAHWQREGGPAEQLVMSFHGIPERAVRLGDPYQQECLATAALLAQALGL
AADRYRVTFQSRFGKAKWLEPYTEPTLIEMARGGTRSVDVMCPGFTSDCLETLEEINQEAREAFLHAGGKEFRYIPCLNA
DNAWITALSRIAQEHLSGWDTGAPGGAAAPGLAR

Sequences:

>Translated_354_residues
MNASAADRSPTAPMPRTAVLLCNLGTPDAPTAPALRRYLAQFLSDPRIVEIPRAAWLPILHGIILRIRPAKSAAKYASIW
MPEGSPLAVWTERQATLLRGWLGEAGLRVQVRHAMRYGQPSIAGQLKALQAEGVDRVLVLPLYPQYSGTTTASVSDDVCA
YALRTRRLPELRFVNSYHDHPAYIDALARSVRAHWQREGGPAEQLVMSFHGIPERAVRLGDPYQQECLATAALLAQALGL
AADRYRVTFQSRFGKAKWLEPYTEPTLIEMARGGTRSVDVMCPGFTSDCLETLEEINQEAREAFLHAGGKEFRYIPCLNA
DNAWITALSRIAQEHLSGWDTGAPGGAAAPGLAR
>Mature_354_residues
MNASAADRSPTAPMPRTAVLLCNLGTPDAPTAPALRRYLAQFLSDPRIVEIPRAAWLPILHGIILRIRPAKSAAKYASIW
MPEGSPLAVWTERQATLLRGWLGEAGLRVQVRHAMRYGQPSIAGQLKALQAEGVDRVLVLPLYPQYSGTTTASVSDDVCA
YALRTRRLPELRFVNSYHDHPAYIDALARSVRAHWQREGGPAEQLVMSFHGIPERAVRLGDPYQQECLATAALLAQALGL
AADRYRVTFQSRFGKAKWLEPYTEPTLIEMARGGTRSVDVMCPGFTSDCLETLEEINQEAREAFLHAGGKEFRYIPCLNA
DNAWITALSRIAQEHLSGWDTGAPGGAAAPGLAR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=336, Percent_Identity=25.5952380952381, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=25.6797583081571, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1786681, Length=317, Percent_Identity=47.0031545741325, Blast_Score=285, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6324750, Length=349, Percent_Identity=26.3610315186246, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17864156, Length=347, Percent_Identity=25.3602305475504, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24651774, Length=266, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38834; Mature: 38834

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASAADRSPTAPMPRTAVLLCNLGTPDAPTAPALRRYLAQFLSDPRIVEIPRAAWLPIL
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
HGIILRIRPAKSAAKYASIWMPEGSPLAVWTERQATLLRGWLGEAGLRVQVRHAMRYGQP
HHHHHEECCCHHHHHHHEEECCCCCCEEEEECHHHHHHHHHHCCCCCEEEEHHHHHCCCC
SIAGQLKALQAEGVDRVLVLPLYPQYSGTTTASVSDDVCAYALRTRRLPELRFVNSYHDH
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCC
PAYIDALARSVRAHWQREGGPAEQLVMSFHGIPERAVRLGDPYQQECLATAALLAQALGL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHC
AADRYRVTFQSRFGKAKWLEPYTEPTLIEMARGGTRSVDVMCPGFTSDCLETLEEINQEA
CHHHHEEEHHHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
REAFLHAGGKEFRYIPCLNADNAWITALSRIAQEHLSGWDTGAPGGAAAPGLAR
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNASAADRSPTAPMPRTAVLLCNLGTPDAPTAPALRRYLAQFLSDPRIVEIPRAAWLPIL
CCCCCCCCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
HGIILRIRPAKSAAKYASIWMPEGSPLAVWTERQATLLRGWLGEAGLRVQVRHAMRYGQP
HHHHHEECCCHHHHHHHEEECCCCCCEEEEECHHHHHHHHHHCCCCCEEEEHHHHHCCCC
SIAGQLKALQAEGVDRVLVLPLYPQYSGTTTASVSDDVCAYALRTRRLPELRFVNSYHDH
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCC
PAYIDALARSVRAHWQREGGPAEQLVMSFHGIPERAVRLGDPYQQECLATAALLAQALGL
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHC
AADRYRVTFQSRFGKAKWLEPYTEPTLIEMARGGTRSVDVMCPGFTSDCLETLEEINQEA
CHHHHEEEHHHHCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHH
REAFLHAGGKEFRYIPCLNADNAWITALSRIAQEHLSGWDTGAPGGAAAPGLAR
HHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA