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The map label for this gene is pleC [H]

Identifier: 120611637

GI number: 120611637

Start: 3263638

End: 3264534

Strand: Direct

Name: pleC [H]

Synonym: Aave_2974

Alternate gene names: 120611637

Gene position: 3263638-3264534 (Clockwise)

Preceding gene: 120611636

Following gene: 120611638

Centisome position: 60.97

GC content: 68.45

Gene sequence:

>897_bases
ATGACATCCGAGCAAGACCAGGCGGCAGCCACCTCTGCCGAGGCGCTGCGCGCCGCGCTGGCGGCCAGCCAGCAGGAAAT
CGAACTGCTGCGCGCGGAGCTGGAGGAAACCAACCGCGGCGTGGTGGCGCTCTATTCGGAACTGGACGCACAGGCCGAGC
AGCTGCGCAAGGCCACCGAGATGAAGAGCCGGTTCCTGGCGTACATGAGCCACGAATTCCGCACGCCGATCAGTTCCATC
CGCAGCATTGCCCGGCTGCTGGCCGACCACGTGGACGGCCCGCTGAACGCCGAGCAGTCGCGGCAGGTGGCCTTCATCCA
GGCCACTGCCATGGAGTTCTCCGACATGGTGGACGACCTGCTCGACCTCGCGAAGATCGAGGCCGGCCGCGTCGATATCT
CGCCCGCCTGGTTCGAGATGGTGGACCTGTTCCAGGCCCTGCGCGGCATGTTCAAGCCGGTCGCCACCAACCCCGATCTC
AACCTGGTGTTCGAGGAGCCCCGCAACCTTCCGCCGCTCTTCACGGACGACCGCAAGCTGTCGCAGATCCTGCGCAACTT
CATCTCCAACGCGCTCAAGTTCACGCCGCGCGGCGAAGTCCGCGTGTCCGCGCAGGCCTGCGACGGAGACCGCGTGCGCT
TCTCGGTGGCCGACACGGGCATCGGCATCGCCCCCGAGTTCCACGCCAGCGTGTTCGAGGATTTCTCGCAGGTCGGCTCG
CCCCTGCAGAAGCGCCTGCGCGGCACCGGCCTGGGCCTGGCGCTGTGCCGCCAGCTCGCCGAACTGCTCGGCGGTGCCGT
GGAGCTGCAGAGCGTGCCCGGCGAAGGATCGGTGTTCTCCGTGACGCTGCCCGTGCGCCTGCCGGAGCCGGCGCCTGCCA
CCGGGATCGCGGAGTGA

Upstream 100 bases:

>100_bases
GCCGCCGTGCTGCTGCGCGACCACCACCGGGCCCGCGACGATGCCACCGTCGTCGTGGTCCAGCGCACGGGTTGAGCCCG
CGTACCCGAGGAACCGCACG

Downstream 100 bases:

>100_bases
CGCATATGCTCGACGTCGGAGCCATCCACGCGACCATCGAACGCTCGGCCCACACCGTGCTGGTGGTGGACGACAACCCG
GTCACCCGCTATTCCACCGC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 298; Mature: 297

Protein sequence:

>298_residues
MTSEQDQAAATSAEALRAALAASQQEIELLRAELEETNRGVVALYSELDAQAEQLRKATEMKSRFLAYMSHEFRTPISSI
RSIARLLADHVDGPLNAEQSRQVAFIQATAMEFSDMVDDLLDLAKIEAGRVDISPAWFEMVDLFQALRGMFKPVATNPDL
NLVFEEPRNLPPLFTDDRKLSQILRNFISNALKFTPRGEVRVSAQACDGDRVRFSVADTGIGIAPEFHASVFEDFSQVGS
PLQKRLRGTGLGLALCRQLAELLGGAVELQSVPGEGSVFSVTLPVRLPEPAPATGIAE

Sequences:

>Translated_298_residues
MTSEQDQAAATSAEALRAALAASQQEIELLRAELEETNRGVVALYSELDAQAEQLRKATEMKSRFLAYMSHEFRTPISSI
RSIARLLADHVDGPLNAEQSRQVAFIQATAMEFSDMVDDLLDLAKIEAGRVDISPAWFEMVDLFQALRGMFKPVATNPDL
NLVFEEPRNLPPLFTDDRKLSQILRNFISNALKFTPRGEVRVSAQACDGDRVRFSVADTGIGIAPEFHASVFEDFSQVGS
PLQKRLRGTGLGLALCRQLAELLGGAVELQSVPGEGSVFSVTLPVRLPEPAPATGIAE
>Mature_297_residues
TSEQDQAAATSAEALRAALAASQQEIELLRAELEETNRGVVALYSELDAQAEQLRKATEMKSRFLAYMSHEFRTPISSIR
SIARLLADHVDGPLNAEQSRQVAFIQATAMEFSDMVDDLLDLAKIEAGRVDISPAWFEMVDLFQALRGMFKPVATNPDLN
LVFEEPRNLPPLFTDDRKLSQILRNFISNALKFTPRGEVRVSAQACDGDRVRFSVADTGIGIAPEFHASVFEDFSQVGSP
LQKRLRGTGLGLALCRQLAELLGGAVELQSVPGEGSVFSVTLPVRLPEPAPATGIAE

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=31.2252964426877, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI145693157, Length=245, Percent_Identity=33.469387755102, Blast_Score=130, Evalue=7e-32,
Organism=Escherichia coli, GI48994928, Length=231, Percent_Identity=34.1991341991342, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI87081816, Length=268, Percent_Identity=36.9402985074627, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1789149, Length=272, Percent_Identity=29.4117647058824, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1786912, Length=241, Percent_Identity=28.2157676348548, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082128, Length=239, Percent_Identity=27.6150627615063, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1788393, Length=243, Percent_Identity=27.9835390946502, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1790436, Length=230, Percent_Identity=29.5652173913043, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788549, Length=254, Percent_Identity=22.0472440944882, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786600, Length=242, Percent_Identity=28.5123966942149, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790300, Length=246, Percent_Identity=28.8617886178862, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790346, Length=259, Percent_Identity=24.3243243243243, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=26.4462809917355, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787894, Length=247, Percent_Identity=23.4817813765182, Blast_Score=61, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=74, Percent_Identity=45.945945945946, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 32544; Mature: 32413

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSEQDQAAATSAEALRAALAASQQEIELLRAELEETNRGVVALYSELDAQAEQLRKATE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHH
MKSRFLAYMSHEFRTPISSIRSIARLLADHVDGPLNAEQSRQVAFIQATAMEFSDMVDDL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LDLAKIEAGRVDISPAWFEMVDLFQALRGMFKPVATNPDLNLVFEEPRNLPPLFTDDRKL
HHHHHHCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHH
SQILRNFISNALKFTPRGEVRVSAQACDGDRVRFSVADTGIGIAPEFHASVFEDFSQVGS
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
PLQKRLRGTGLGLALCRQLAELLGGAVELQSVPGEGSVFSVTLPVRLPEPAPATGIAE
HHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
TSEQDQAAATSAEALRAALAASQQEIELLRAELEETNRGVVALYSELDAQAEQLRKATE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHH
MKSRFLAYMSHEFRTPISSIRSIARLLADHVDGPLNAEQSRQVAFIQATAMEFSDMVDDL
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LDLAKIEAGRVDISPAWFEMVDLFQALRGMFKPVATNPDLNLVFEEPRNLPPLFTDDRKL
HHHHHHCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCHHH
SQILRNFISNALKFTPRGEVRVSAQACDGDRVRFSVADTGIGIAPEFHASVFEDFSQVGS
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
PLQKRLRGTGLGLALCRQLAELLGGAVELQSVPGEGSVFSVTLPVRLPEPAPATGIAE
HHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]