Click here to switch to the map view.

The map label for this gene is livM [H]

Identifier: 120611596

GI number: 120611596

Start: 3221166

End: 3222488

Strand: Reverse

Name: livM [H]

Synonym: Aave_2932

Alternate gene names: 120611596

Gene position: 3222488-3221166 (Counterclockwise)

Preceding gene: 120611597

Following gene: 120611595

Centisome position: 60.2

GC content: 66.97

Gene sequence:

>1323_bases
ATGGCCATGCATCCAACTTCCGGGGTCTATCGTTTCCGGCCGCTCGACATCGGCCGCGCCGTGGTCTGGGGCCTGTTCGC
GCTGGCGCTCATCGTGGCGCCGATGCTGTTCACCAGCAGCCTGGCGCTCACCATGCTCTCGCAGATCGGCTACCTCATCA
TCATCTGCCTGTCCTACAACATCCTGCTGGGGCAGGGCGGCATGCTGAGTTTCGGGCATGCCGTCTATACGGGCCTGGGC
TCCTTCATGGCCGTGCACGCCATGAACTGGGCCGGCAAGGGCGCGCTGCCCGTGCCGCTGGTCCTCATCCCGCTGGTAGG
CGGCCTGGCCGGCATGTTCTTCGCGGTGCTGCTGGGCTTCGTCACCACGAAGAAGTCCGGCACCACGTTCGCGATGATCA
CGCTGGGCATCGGCGAGCTCGTGGCCTCCATGGCGCTGATGTTCCCCGAGGTGTTCGGGGGCGAGGGCGGCATCACGACC
GACCGCGTCTACGGCAAGGGGTTCTTCGGCATCACCTTCGGCCCGGCCATCCAGGTGTACTACCTGATCGCCGCCTACTG
CTTCGTCTGCACGGCGCTCATGTTCGCCTTCACCGGCACGCCGCTCGGCCGCATGCTGAACGCGGTGCGCGACAACCCGG
AGCGCGTGGAGTTCATCGGCTACAACACCCAGCGCGTGCGCTATTACGCCTTCATCATCTCCGGCTTCTTCGCCGGCATC
GGCGGCGCGCTGGCGGCGATCAATTTCGAGATCGTCACCGCGGCCGACAGCGTGAGCGTGATGCGCTCGGGCTCCTACCT
GCTGTTCACCTTCCTCGGCGGCGCCACCTTCTTCTTCGGGCCCATCATCGGCGCGGTGCTGCTGGTCTTCGCCTCCGTGC
TGCTGTCGGAACTCTCCAAGGCCTGGCTGCTGTACCTGGGCCTGGTGTTCCTGTTCATGGTCATGTACGCCCCCGGTGGC
ATCGCCAGCCTGATCATGATGAACCTGCGCGTTGCGCGCCATGGGCGGCTCAAGCCGTTGTTGCCGGGCTACCTCGCGCT
CGCCTGCTCCGCGCTCATCGCGGTCGCGGGCGCCGCCGCGATGATCGAGATGACCTACCACCTGCAGCTCAACGCGGCGC
TCGGGCCGCAGATCGGATTCCTGGGCATGACCCTCGATGCGCGCAGTACCGCGACCTGGATCGGCGCCGGCATCGTGTTC
GCCGTGGGGCTGGGCCTGTTCGAGGTGTGCCGCAGGCGCTTCGCCCTGGCCTGGGGAGCCACCCAGGAGGGCATCGAACG
AGACCTGCGGTCGGGCCTTTCCGGCCGGGGAGACCGCGCATGA

Upstream 100 bases:

>100_bases
ACCATCTCGCAGGTCGCGCCGATCCTGCCGTACCTTTTCCTCGTGCTGATCCTGATCTTCCGTCCCAAGGGACTGCTCGG
AACGCGGGAGGACTGACACC

Downstream 100 bases:

>100_bases
CGGCCGTGAACCACCATCCTGCAGCCCCTGCGCTGGAACTGCGCGACCTGCGCAAGCGCTTCGGCAAGACGGAGATCATC
CGCGGCGCCAACCTGTCGGT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MAMHPTSGVYRFRPLDIGRAVVWGLFALALIVAPMLFTSSLALTMLSQIGYLIIICLSYNILLGQGGMLSFGHAVYTGLG
SFMAVHAMNWAGKGALPVPLVLIPLVGGLAGMFFAVLLGFVTTKKSGTTFAMITLGIGELVASMALMFPEVFGGEGGITT
DRVYGKGFFGITFGPAIQVYYLIAAYCFVCTALMFAFTGTPLGRMLNAVRDNPERVEFIGYNTQRVRYYAFIISGFFAGI
GGALAAINFEIVTAADSVSVMRSGSYLLFTFLGGATFFFGPIIGAVLLVFASVLLSELSKAWLLYLGLVFLFMVMYAPGG
IASLIMMNLRVARHGRLKPLLPGYLALACSALIAVAGAAAMIEMTYHLQLNAALGPQIGFLGMTLDARSTATWIGAGIVF
AVGLGLFEVCRRRFALAWGATQEGIERDLRSGLSGRGDRA

Sequences:

>Translated_440_residues
MAMHPTSGVYRFRPLDIGRAVVWGLFALALIVAPMLFTSSLALTMLSQIGYLIIICLSYNILLGQGGMLSFGHAVYTGLG
SFMAVHAMNWAGKGALPVPLVLIPLVGGLAGMFFAVLLGFVTTKKSGTTFAMITLGIGELVASMALMFPEVFGGEGGITT
DRVYGKGFFGITFGPAIQVYYLIAAYCFVCTALMFAFTGTPLGRMLNAVRDNPERVEFIGYNTQRVRYYAFIISGFFAGI
GGALAAINFEIVTAADSVSVMRSGSYLLFTFLGGATFFFGPIIGAVLLVFASVLLSELSKAWLLYLGLVFLFMVMYAPGG
IASLIMMNLRVARHGRLKPLLPGYLALACSALIAVAGAAAMIEMTYHLQLNAALGPQIGFLGMTLDARSTATWIGAGIVF
AVGLGLFEVCRRRFALAWGATQEGIERDLRSGLSGRGDRA
>Mature_439_residues
AMHPTSGVYRFRPLDIGRAVVWGLFALALIVAPMLFTSSLALTMLSQIGYLIIICLSYNILLGQGGMLSFGHAVYTGLGS
FMAVHAMNWAGKGALPVPLVLIPLVGGLAGMFFAVLLGFVTTKKSGTTFAMITLGIGELVASMALMFPEVFGGEGGITTD
RVYGKGFFGITFGPAIQVYYLIAAYCFVCTALMFAFTGTPLGRMLNAVRDNPERVEFIGYNTQRVRYYAFIISGFFAGIG
GALAAINFEIVTAADSVSVMRSGSYLLFTFLGGATFFFGPIIGAVLLVFASVLLSELSKAWLLYLGLVFLFMVMYAPGGI
ASLIMMNLRVARHGRLKPLLPGYLALACSALIAVAGAAAMIEMTYHLQLNAALGPQIGFLGMTLDARSTATWIGAGIVFA
VGLGLFEVCRRRFALAWGATQEGIERDLRSGLSGRGDRA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=305, Percent_Identity=26.5573770491803, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 46852; Mature: 46720

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMHPTSGVYRFRPLDIGRAVVWGLFALALIVAPMLFTSSLALTMLSQIGYLIIICLSYN
CCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLGQGGMLSFGHAVYTGLGSFMAVHAMNWAGKGALPVPLVLIPLVGGLAGMFFAVLLGF
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VTTKKSGTTFAMITLGIGELVASMALMFPEVFGGEGGITTDRVYGKGFFGITFGPAIQVY
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEHHHHHHHH
YLIAAYCFVCTALMFAFTGTPLGRMLNAVRDNPERVEFIGYNTQRVRYYAFIISGFFAGI
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
GGALAAINFEIVTAADSVSVMRSGSYLLFTFLGGATFFFGPIIGAVLLVFASVLLSELSK
HHHHHHEEEEEEECCHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLLYLGLVFLFMVMYAPGGIASLIMMNLRVARHGRLKPLLPGYLALACSALIAVAGAAA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
MIEMTYHLQLNAALGPQIGFLGMTLDARSTATWIGAGIVFAVGLGLFEVCRRRFALAWGA
HHEEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TQEGIERDLRSGLSGRGDRA
CHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AMHPTSGVYRFRPLDIGRAVVWGLFALALIVAPMLFTSSLALTMLSQIGYLIIICLSYN
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILLGQGGMLSFGHAVYTGLGSFMAVHAMNWAGKGALPVPLVLIPLVGGLAGMFFAVLLGF
HHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VTTKKSGTTFAMITLGIGELVASMALMFPEVFGGEGGITTDRVYGKGFFGITFGPAIQVY
HHCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEECCCEEEEEHHHHHHHH
YLIAAYCFVCTALMFAFTGTPLGRMLNAVRDNPERVEFIGYNTQRVRYYAFIISGFFAGI
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
GGALAAINFEIVTAADSVSVMRSGSYLLFTFLGGATFFFGPIIGAVLLVFASVLLSELSK
HHHHHHEEEEEEECCHHHHHHHCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AWLLYLGLVFLFMVMYAPGGIASLIMMNLRVARHGRLKPLLPGYLALACSALIAVAGAAA
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHH
MIEMTYHLQLNAALGPQIGFLGMTLDARSTATWIGAGIVFAVGLGLFEVCRRRFALAWGA
HHEEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TQEGIERDLRSGLSGRGDRA
CHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]