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The map label for this gene is fadA [H]

Identifier: 120611543

GI number: 120611543

Start: 3169226

End: 3170401

Strand: Reverse

Name: fadA [H]

Synonym: Aave_2879

Alternate gene names: 120611543

Gene position: 3170401-3169226 (Counterclockwise)

Preceding gene: 120611544

Following gene: 120611542

Centisome position: 59.23

GC content: 68.03

Gene sequence:

>1176_bases
ATGACCTCCGCAGTGATCGTTTCCACCGCCCGCACGCCGCTCGCCAAGAGCTGGAAGGGCTCTTTCAACATGACCCACGG
CGCCACGCTCGGTGGCCATGCGGTGCAGCACGCCGTGCAGCGCGCCGGCATCGACGGCGCTGAAGTCGACGACGTCATCA
TGGGCTGCGCCAACCCCGAAGGCGCGACCGGCGCGAACATCGCGCGCCAGATCGCCCTGCGCGCCGGCCTGCCCGTCACC
ACCTCGGGCATGACCGTCAACCGCTTCTGCTCCTCGGGCCTGCAGACCATCGCGCTGGCTGCGCAGCGCATCATCGCGGG
CGAGGCCGACGTGTTCGTCGCCGGCGGCGTCGAGAGCATCTCCTGCGTGCAGCAGGAGATGAACCTGCACATGCTGCGCG
ACCTCGAACTGGCCAAGGCCAAGCCCGAGATCTACTGGAGCATGCTGGAAACCGCCGAACAGGTCGCCAAGCGCTACCAC
ATCAGCCGCGACGCCATGGACGAATATGGCGCCGCCAGCCAGCAGAAGGCCTGCGCCGCACAGGCCGCCGGCAAGTTCGA
CGACGAGATCGCGCCCATCACCGTCACGGCCGGCGTGGCCGACAAGACCCTCGGCCTGATCACCAAGCAGGTCACGGTGA
GCAAGGATGAAGGCACGCGCGAAGGCACGACCAAGGAAGGCATCAGCGGCATCAAGCCCGCGCTGCCCGGCGGTGTGATT
TCCGCCGGCAACGCGAGCCAGTTCTCCGATGGCGCGGGTGCCTGCGTCATCACGAGCGAAGACTATGCGAGCCGCAAGGG
CCTTAAGCCCCTGGGCCGCTTCCTCGGCTTCGCCGTGGCAGGCTGCGAGCCGGACGAGATGGGCATCGGCCCCGTCTTCG
CCGTGCCCAAGGTGCTCAAGAAGCTGGGCCTGACGGTGCAGGACATCGACCTCTGGGAGTTGAACGAAGCCTTTGCCGTG
CAGGTGCTGTACTGCCGCGACAAGCTCGGCATTCCGGCCGACCGCCTGAACGTGAACGGCGGCGCCATCGCCCTCGGCCA
TCCCTACGGCGTGAGCGGCCAGCGCCTCACGGGCCATGCGCTCATCGAAGGCCGCCGCCGCGGCGCCAAGCGCGTCTGCG
TCACGATGTGCATCGGCGGCGGCATGGGTGCAGCCGGCGTGTTCGAAGTGTTCTGA

Upstream 100 bases:

>100_bases
TGGGAGCCCGCGCCGCTGCTCTCCCGCCTCGCAGCCGAGGGCAAGGCCTTCGCCTGACCCGCGCCGTCCGCATGTTTGCA
AAGAACCAGGGAATCCGCAC

Downstream 100 bases:

>100_bases
GCGCGCCATGTCCCGCAGCCTGGAAGAGGGCGCGGCAACGCCCCGCAGCGAGTCCGAATGGCTCGCCTATGGCCGCGACG
TGCTGGCCCGGCAGCCCTTC

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase [H]

Number of amino acids: Translated: 391; Mature: 390

Protein sequence:

>391_residues
MTSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVQHAVQRAGIDGAEVDDVIMGCANPEGATGANIARQIALRAGLPVT
TSGMTVNRFCSSGLQTIALAAQRIIAGEADVFVAGGVESISCVQQEMNLHMLRDLELAKAKPEIYWSMLETAEQVAKRYH
ISRDAMDEYGAASQQKACAAQAAGKFDDEIAPITVTAGVADKTLGLITKQVTVSKDEGTREGTTKEGISGIKPALPGGVI
SAGNASQFSDGAGACVITSEDYASRKGLKPLGRFLGFAVAGCEPDEMGIGPVFAVPKVLKKLGLTVQDIDLWELNEAFAV
QVLYCRDKLGIPADRLNVNGGAIALGHPYGVSGQRLTGHALIEGRRRGAKRVCVTMCIGGGMGAAGVFEVF

Sequences:

>Translated_391_residues
MTSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVQHAVQRAGIDGAEVDDVIMGCANPEGATGANIARQIALRAGLPVT
TSGMTVNRFCSSGLQTIALAAQRIIAGEADVFVAGGVESISCVQQEMNLHMLRDLELAKAKPEIYWSMLETAEQVAKRYH
ISRDAMDEYGAASQQKACAAQAAGKFDDEIAPITVTAGVADKTLGLITKQVTVSKDEGTREGTTKEGISGIKPALPGGVI
SAGNASQFSDGAGACVITSEDYASRKGLKPLGRFLGFAVAGCEPDEMGIGPVFAVPKVLKKLGLTVQDIDLWELNEAFAV
QVLYCRDKLGIPADRLNVNGGAIALGHPYGVSGQRLTGHALIEGRRRGAKRVCVTMCIGGGMGAAGVFEVF
>Mature_390_residues
TSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVQHAVQRAGIDGAEVDDVIMGCANPEGATGANIARQIALRAGLPVTT
SGMTVNRFCSSGLQTIALAAQRIIAGEADVFVAGGVESISCVQQEMNLHMLRDLELAKAKPEIYWSMLETAEQVAKRYHI
SRDAMDEYGAASQQKACAAQAAGKFDDEIAPITVTAGVADKTLGLITKQVTVSKDEGTREGTTKEGISGIKPALPGGVIS
AGNASQFSDGAGACVITSEDYASRKGLKPLGRFLGFAVAGCEPDEMGIGPVFAVPKVLKKLGLTVQDIDLWELNEAFAVQ
VLYCRDKLGIPADRLNVNGGAIALGHPYGVSGQRLTGHALIEGRRRGAKRVCVTMCIGGGMGAAGVFEVF

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=396, Percent_Identity=38.3838383838384, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI4501853, Length=388, Percent_Identity=41.2371134020619, Blast_Score=251, Evalue=8e-67,
Organism=Homo sapiens, GI4557237, Length=401, Percent_Identity=37.1571072319202, Blast_Score=231, Evalue=8e-61,
Organism=Homo sapiens, GI148539872, Length=394, Percent_Identity=35.5329949238579, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI4504327, Length=436, Percent_Identity=32.1100917431193, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI194353979, Length=386, Percent_Identity=31.8652849740933, Blast_Score=148, Evalue=7e-36,
Organism=Escherichia coli, GI1787663, Length=410, Percent_Identity=40.4878048780488, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1788554, Length=404, Percent_Identity=41.3366336633663, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI87082165, Length=406, Percent_Identity=37.6847290640394, Blast_Score=231, Evalue=4e-62,
Organism=Escherichia coli, GI48994986, Length=398, Percent_Identity=38.9447236180905, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1788683, Length=412, Percent_Identity=29.6116504854369, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI133906874, Length=401, Percent_Identity=38.1546134663342, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI17535921, Length=399, Percent_Identity=36.8421052631579, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI25147385, Length=398, Percent_Identity=32.9145728643216, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17551802, Length=438, Percent_Identity=28.9954337899543, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17535917, Length=375, Percent_Identity=30.1333333333333, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6322031, Length=393, Percent_Identity=38.676844783715, Blast_Score=233, Evalue=3e-62,
Organism=Saccharomyces cerevisiae, GI6325229, Length=407, Percent_Identity=34.3980343980344, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24655093, Length=403, Percent_Identity=41.439205955335, Blast_Score=277, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17648125, Length=398, Percent_Identity=38.9447236180905, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI24640423, Length=394, Percent_Identity=35.7868020304569, Blast_Score=218, Evalue=8e-57,
Organism=Drosophila melanogaster, GI17137578, Length=435, Percent_Identity=31.9540229885057, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 40718; Mature: 40587

Theoretical pI: Translated: 7.12; Mature: 7.12

Prosite motif: PS00098 THIOLASE_1 ; PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVQHAVQRAGIDGAEVDDVIMGCANPE
CCCEEEEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
GATGANIARQIALRAGLPVTTSGMTVNRFCSSGLQTIALAAQRIIAGEADVFVAGGVESI
CCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNLHMLRDLELAKAKPEIYWSMLETAEQVAKRYHISRDAMDEYGAASQQKACAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHH
QAAGKFDDEIAPITVTAGVADKTLGLITKQVTVSKDEGTREGTTKEGISGIKPALPGGVI
HHCCCCCCCCCCEEEECCCCHHHHHHHHHEEEEECCCCCCCCCCHHHHCCCCCCCCCCEE
SAGNASQFSDGAGACVITSEDYASRKGLKPLGRFLGFAVAGCEPDEMGIGPVFAVPKVLK
ECCCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
KLGLTVQDIDLWELNEAFAVQVLYCRDKLGIPADRLNVNGGAIALGHPYGVSGQRLTGHA
HHCCEEEECCCEECCHHHEEEEEEECCCCCCCHHHEECCCCEEEECCCCCCCCCCEECHH
LIEGRRRGAKRVCVTMCIGGGMGAAGVFEVF
HHHHHHCCHHHEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure 
TSAVIVSTARTPLAKSWKGSFNMTHGATLGGHAVQHAVQRAGIDGAEVDDVIMGCANPE
CCEEEEECCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHCCCCCC
GATGANIARQIALRAGLPVTTSGMTVNRFCSSGLQTIALAAQRIIAGEADVFVAGGVESI
CCCHHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
SCVQQEMNLHMLRDLELAKAKPEIYWSMLETAEQVAKRYHISRDAMDEYGAASQQKACAA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHH
QAAGKFDDEIAPITVTAGVADKTLGLITKQVTVSKDEGTREGTTKEGISGIKPALPGGVI
HHCCCCCCCCCCEEEECCCCHHHHHHHHHEEEEECCCCCCCCCCHHHHCCCCCCCCCCEE
SAGNASQFSDGAGACVITSEDYASRKGLKPLGRFLGFAVAGCEPDEMGIGPVFAVPKVLK
ECCCCCCCCCCCCEEEEECCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
KLGLTVQDIDLWELNEAFAVQVLYCRDKLGIPADRLNVNGGAIALGHPYGVSGQRLTGHA
HHCCEEEECCCEECCHHHEEEEEEECCCCCCCHHHEECCCCEEEECCCCCCCCCCEECHH
LIEGRRRGAKRVCVTMCIGGGMGAAGVFEVF
HHHHHHCCHHHEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]