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The map label for this gene is fabG2 [H]

Identifier: 120611531

GI number: 120611531

Start: 3158278

End: 3159036

Strand: Direct

Name: fabG2 [H]

Synonym: Aave_2867

Alternate gene names: 120611531

Gene position: 3158278-3159036 (Clockwise)

Preceding gene: 120611530

Following gene: 120611538

Centisome position: 59.0

GC content: 70.62

Gene sequence:

>759_bases
ATGGACATTCAGGGCAAGGTTTTCATCGTCACCGGCGGCGCATCGGGCCTGGGCGAAGGCACGGCGCGCATGCTCGCCGC
CGCGGGCGGGCGCGTGGTCATCGCGGACATGCAGGCGGACAAGGGCGAAGCCGTGGCGCGCGATATCGGCGGCACCTTCG
TGCGCTGCGACGTGACGAGCGAGGCCGACGGCCAGGCGGTGGTGGCGCAGGCCGTCGCGCAAGGCAAGCTGATGGGCCTG
GTCAACTGCGCCGGCATCGCCCCCGCCGAGAAGACCGTGGGCAAGAACGGCGCCCATGGGCTGGCGCTGTTCGCCAAGAC
GGTGACGGTGAACCTGATCGGCAGTTTCAACATGATCCGCCTCGCGGCCGAGGCCATGGCCCGCAACGAGCCCGAGCCCA
CCGGCGAGCGCGGCGTGCTGATTTCCACGGCCAGCGTGGCGGCCTATGACGGCCAGATCGGCCAGGCGGCCTATTCCGCG
TCGAAGGGCGGCATCGTGGGGATGACGCTGCCCATCGCGCGCGACCTGGCGCGCAACGGCATCCGCAACATGACGATCGC
GCCCGGCATCTTCGGCACGCCGATGCTGTTCGGCATGCCGCAGGAGGTGCAGGACGCGCTGGCGGCGGGGGTGCCCTTCC
CGAGCCGCCTCGGCACGCCGGAAGACTATGCCCGCCTGGCCCGCCACATCTTCGAGAACGACATGCTCAACGGCGAGGTG
ATCCGGCTGGACGGCGCCATCCGGCTCGCACCGCGCTGA

Upstream 100 bases:

>100_bases
AGGAAAGCCCGGTCCGCCGGGCTTTCGTTCGTCCGCAGACTGCATTTCTTCGACCATAATTGACGTTTACGTCAACGTCA
TATCATCAGGAGACAGTTCC

Downstream 100 bases:

>100_bases
AGGGGCTGCGCGGGGTCCCGCTGCGCGCCGTCTGACCGTGGTTGCCCGTTCCCCATGCCCCGGCAACCGCCAGGGCAACA
CCGGGTGCGGGAGTCAGGCC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MDIQGKVFIVTGGASGLGEGTARMLAAAGGRVVIADMQADKGEAVARDIGGTFVRCDVTSEADGQAVVAQAVAQGKLMGL
VNCAGIAPAEKTVGKNGAHGLALFAKTVTVNLIGSFNMIRLAAEAMARNEPEPTGERGVLISTASVAAYDGQIGQAAYSA
SKGGIVGMTLPIARDLARNGIRNMTIAPGIFGTPMLFGMPQEVQDALAAGVPFPSRLGTPEDYARLARHIFENDMLNGEV
IRLDGAIRLAPR

Sequences:

>Translated_252_residues
MDIQGKVFIVTGGASGLGEGTARMLAAAGGRVVIADMQADKGEAVARDIGGTFVRCDVTSEADGQAVVAQAVAQGKLMGL
VNCAGIAPAEKTVGKNGAHGLALFAKTVTVNLIGSFNMIRLAAEAMARNEPEPTGERGVLISTASVAAYDGQIGQAAYSA
SKGGIVGMTLPIARDLARNGIRNMTIAPGIFGTPMLFGMPQEVQDALAAGVPFPSRLGTPEDYARLARHIFENDMLNGEV
IRLDGAIRLAPR
>Mature_252_residues
MDIQGKVFIVTGGASGLGEGTARMLAAAGGRVVIADMQADKGEAVARDIGGTFVRCDVTSEADGQAVVAQAVAQGKLMGL
VNCAGIAPAEKTVGKNGAHGLALFAKTVTVNLIGSFNMIRLAAEAMARNEPEPTGERGVLISTASVAAYDGQIGQAAYSA
SKGGIVGMTLPIARDLARNGIRNMTIAPGIFGTPMLFGMPQEVQDALAAGVPFPSRLGTPEDYARLARHIFENDMLNGEV
IRLDGAIRLAPR

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=56.4705882352941, Blast_Score=261, Evalue=4e-70,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=53.3333333333333, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI15277342, Length=240, Percent_Identity=31.6666666666667, Blast_Score=99, Evalue=5e-21,
Organism=Homo sapiens, GI40254992, Length=253, Percent_Identity=30.4347826086957, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI59889578, Length=194, Percent_Identity=29.8969072164948, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=26.8199233716475, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=28.0632411067194, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI33667109, Length=194, Percent_Identity=30.4123711340206, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI4504505, Length=220, Percent_Identity=30.4545454545455, Blast_Score=65, Evalue=5e-11,
Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=29.0196078431373, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=26.3779527559055, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1787905, Length=237, Percent_Identity=30.8016877637131, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789057, Length=203, Percent_Identity=32.512315270936, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082100, Length=265, Percent_Identity=27.1698113207547, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=52.6104417670683, Blast_Score=243, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI25147288, Length=227, Percent_Identity=30.3964757709251, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17555706, Length=228, Percent_Identity=32.4561403508772, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=273, Percent_Identity=27.1062271062271, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI72000259, Length=242, Percent_Identity=28.5123966942149, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561402, Length=259, Percent_Identity=29.7297297297297, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=246, Percent_Identity=28.0487804878049, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=201, Percent_Identity=29.3532338308458, Blast_Score=67, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320089, Length=215, Percent_Identity=26.9767441860465, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=54.7244094488189, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24639444, Length=255, Percent_Identity=29.4117647058824, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357041, Length=234, Percent_Identity=29.0598290598291, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28571526, Length=234, Percent_Identity=29.9145299145299, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=29.4354838709677, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24644339, Length=236, Percent_Identity=27.5423728813559, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 25921; Mature: 25921

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQGKVFIVTGGASGLGEGTARMLAAAGGRVVIADMQADKGEAVARDIGGTFVRCDVTS
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCCEEEEEEECC
EADGQAVVAQAVAQGKLMGLVNCAGIAPAEKTVGKNGAHGLALFAKTVTVNLIGSFNMIR
CCCCHHHHHHHHHHCHHEEEEECCCCCCCHHHCCCCCCCHHEEEEEEEEEEECCCCHHHH
LAAEAMARNEPEPTGERGVLISTASVAAYDGQIGQAAYSASKGGIVGMTLPIARDLARNG
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHCC
IRNMTIAPGIFGTPMLFGMPQEVQDALAAGVPFPSRLGTPEDYARLARHIFENDMLNGEV
CCCCEECCCCCCCHHHCCCCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHCCCCCCEE
IRLDGAIRLAPR
EEECCEEEECCC
>Mature Secondary Structure
MDIQGKVFIVTGGASGLGEGTARMLAAAGGRVVIADMQADKGEAVARDIGGTFVRCDVTS
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCCCCCHHHHHHCCCEEEEEEECC
EADGQAVVAQAVAQGKLMGLVNCAGIAPAEKTVGKNGAHGLALFAKTVTVNLIGSFNMIR
CCCCHHHHHHHHHHCHHEEEEECCCCCCCHHHCCCCCCCHHEEEEEEEEEEECCCCHHHH
LAAEAMARNEPEPTGERGVLISTASVAAYDGQIGQAAYSASKGGIVGMTLPIARDLARNG
HHHHHHHCCCCCCCCCCEEEEEECEEEEECCCCCHHHHCCCCCCEEEEEHHHHHHHHHCC
IRNMTIAPGIFGTPMLFGMPQEVQDALAAGVPFPSRLGTPEDYARLARHIFENDMLNGEV
CCCCEECCCCCCCHHHCCCCHHHHHHHHHCCCCCHHCCCHHHHHHHHHHHHHCCCCCCEE
IRLDGAIRLAPR
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]