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The map label for this gene is arsB [H]

Identifier: 120611511

GI number: 120611511

Start: 3137947

End: 3139221

Strand: Reverse

Name: arsB [H]

Synonym: Aave_2847

Alternate gene names: 120611511

Gene position: 3139221-3137947 (Counterclockwise)

Preceding gene: 120611513

Following gene: 120611510

Centisome position: 58.65

GC content: 72.08

Gene sequence:

>1275_bases
ATGCTGACAATCGCCCATCCCGGGTGGACCTGGGGCGTGATCGCCGTCGCCACCGCCGCCGTCATCCTGCGGCCCGCGCG
CATTCCCGAGGCCGTGTGGGCCGTGGGCGGTGCCCTCGTGCTCGCCGTGTCCGGCATGCTGCCCTGGGCGGAGGCATGGA
AGGGCGTGCTGCGTGGGCACGACGTGTATCTGTTCCTGGCAGGCATGATGCTGCTGTCGGAAATGGCACGCCGCGAAGGG
GTGTTCGACTGGCTGGCCGTCGAGGCGGCACGCCGGGCGCGAGGCTCCGGCGAGCGTCTCTTCGCATGGGTTTTCGGGGT
CGGCACGCTCGTGACCGCGACGCTGTCCAACGATGCCACGGCCGTCGTCCTCACGCCGGCCGTGATCGCCGTGGCTCGGA
CCGTGGGGGCGGCCCCGTTGCCCTACCTGCTGATCTGCGCCTTCGTGGCCAACGCGGCCAGCTTTCTGCTGCCGATTTCC
AATCCGGCCAACCTGGTTCTTTGGGGCGGTGGGCGGATGCCGTCGCTGCCCCATTGGCTGGCGCTGTTCGGCCTGCCGTC
CGTCGCGGCGATCGGCTGCACCTACTGGGTACTGAAATGGCGTGTCCGGCAGGACATCGCCCGGCCCGTGGCCGCCGAGG
TGCCCGCCCGCCCGCTCGGCGCCGGCGGTCGCCTGGCGGCTGCAGGACTCGCCGTGTCGGCGGTGGTGCTCGTGGGGTGC
GCATGGTGGCGGATTCCGCTGGGAGCTCCGACGCTGGGGGCGGCGCTGCTCACGCTGGTACTGCTGCGCGCGGGCTGCGG
GCACCAGGTGGGGCCGGTGCTGAAGTCGGTGTCCTGGGGTGTACTGCCTCTGGTGGCCGGGCTGTTCGTCTTCGTGCAAG
CGCTGGAAGTCACCGGGGTGGTGGGGCACCTGGCCCGCATGCTGGCCGGGGCCGCGGCGGCCGCGCCCCTGGCTGCGGGT
CCGGCGCTCGGGGCGCTGCTGGGTTTCGGCGCCAACCTGGTGAACAACCTGCCCGCCGGCCTGCTGGCCGGTGCCGCGCT
GGAGGCTGCCCATGCCGCAGAGCCGCTGCGTGCCGCCGCGCTCATCGGTGTCGATCTCGGCCCCAATCTCTCCATTACCG
GCTCGCTCGCGACCCTCCTGTGGCTGGCGGCGTTGCGGCGTGAAGGCATCGAGGTGAGCGCGGTGCAGTTCCTGAAGTTC
GGCACCTGGGTGATGCCTCCCGCGCTCGCGGCGGCGCTCCTGGTGCTGATGGGCATGTCGGCTGCCGGCCTGTGA

Upstream 100 bases:

>100_bases
GAATCCGCGTCCGGCAGGCGGCACCGCCCCTGCGAGAGAGAACCATACAACAGCGCGCGCCGGGGCTGTCCTGGCCGCGC
ACAGAAAGGAACCGCTTTCC

Downstream 100 bases:

>100_bases
CGTCTCCAGCCCCGCCGAGGAACCTCCTGCGCACGGCAGGTGCTGATGAAAGCTATGGAGGTAGGGCGCATGATTGTTAC
AAAAAAGCCTAAACGGCTCC

Product: arsenical pump membrane protein

Products: ADP; phosphate; arsenite [Periplasm] [C]

Alternate protein names: Arsenic efflux pump protein [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MLTIAHPGWTWGVIAVATAAVILRPARIPEAVWAVGGALVLAVSGMLPWAEAWKGVLRGHDVYLFLAGMMLLSEMARREG
VFDWLAVEAARRARGSGERLFAWVFGVGTLVTATLSNDATAVVLTPAVIAVARTVGAAPLPYLLICAFVANAASFLLPIS
NPANLVLWGGGRMPSLPHWLALFGLPSVAAIGCTYWVLKWRVRQDIARPVAAEVPARPLGAGGRLAAAGLAVSAVVLVGC
AWWRIPLGAPTLGAALLTLVLLRAGCGHQVGPVLKSVSWGVLPLVAGLFVFVQALEVTGVVGHLARMLAGAAAAAPLAAG
PALGALLGFGANLVNNLPAGLLAGAALEAAHAAEPLRAAALIGVDLGPNLSITGSLATLLWLAALRREGIEVSAVQFLKF
GTWVMPPALAAALLVLMGMSAAGL

Sequences:

>Translated_424_residues
MLTIAHPGWTWGVIAVATAAVILRPARIPEAVWAVGGALVLAVSGMLPWAEAWKGVLRGHDVYLFLAGMMLLSEMARREG
VFDWLAVEAARRARGSGERLFAWVFGVGTLVTATLSNDATAVVLTPAVIAVARTVGAAPLPYLLICAFVANAASFLLPIS
NPANLVLWGGGRMPSLPHWLALFGLPSVAAIGCTYWVLKWRVRQDIARPVAAEVPARPLGAGGRLAAAGLAVSAVVLVGC
AWWRIPLGAPTLGAALLTLVLLRAGCGHQVGPVLKSVSWGVLPLVAGLFVFVQALEVTGVVGHLARMLAGAAAAAPLAAG
PALGALLGFGANLVNNLPAGLLAGAALEAAHAAEPLRAAALIGVDLGPNLSITGSLATLLWLAALRREGIEVSAVQFLKF
GTWVMPPALAAALLVLMGMSAAGL
>Mature_424_residues
MLTIAHPGWTWGVIAVATAAVILRPARIPEAVWAVGGALVLAVSGMLPWAEAWKGVLRGHDVYLFLAGMMLLSEMARREG
VFDWLAVEAARRARGSGERLFAWVFGVGTLVTATLSNDATAVVLTPAVIAVARTVGAAPLPYLLICAFVANAASFLLPIS
NPANLVLWGGGRMPSLPHWLALFGLPSVAAIGCTYWVLKWRVRQDIARPVAAEVPARPLGAGGRLAAAGLAVSAVVLVGC
AWWRIPLGAPTLGAALLTLVLLRAGCGHQVGPVLKSVSWGVLPLVAGLFVFVQALEVTGVVGHLARMLAGAAAAAPLAAG
PALGALLGFGANLVNNLPAGLLAGAALEAAHAAEPLRAAALIGVDLGPNLSITGSLATLLWLAALRREGIEVSAVQFLKF
GTWVMPPALAAALLVLMGMSAAGL

Specific function: Involved in arsenical resistance. Thought to form the channel of an arsenite pump [H]

COG id: COG1055

COG function: function code P; Na+/H+ antiporter NhaD and related arsenite permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsB family [H]

Homologues:

Organism=Escherichia coli, GI87082277, Length=360, Percent_Identity=28.0555555555556, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000802 [H]

Pfam domain/function: PF02040 ArsB [H]

EC number: NA

Molecular weight: Translated: 43410; Mature: 43410

Theoretical pI: Translated: 10.59; Mature: 10.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTIAHPGWTWGVIAVATAAVILRPARIPEAVWAVGGALVLAVSGMLPWAEAWKGVLRGH
CEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
DVYLFLAGMMLLSEMARREGVFDWLAVEAARRARGSGERLFAWVFGVGTLVTATLSNDAT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCE
AVVLTPAVIAVARTVGAAPLPYLLICAFVANAASFLLPISNPANLVLWGGGRMPSLPHWL
EEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEEECCCCCCCCHHHH
ALFGLPSVAAIGCTYWVLKWRVRQDIARPVAAEVPARPLGAGGRLAAAGLAVSAVVLVGC
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
AWWRIPLGAPTLGAALLTLVLLRAGCGHQVGPVLKSVSWGVLPLVAGLFVFVQALEVTGV
HHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VGHLARMLAGAAAAAPLAAGPALGALLGFGANLVNNLPAGLLAGAALEAAHAAEPLRAAA
HHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LIGVDLGPNLSITGSLATLLWLAALRREGIEVSAVQFLKFGTWVMPPALAAALLVLMGMS
HEEECCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCH
AAGL
HCCC
>Mature Secondary Structure
MLTIAHPGWTWGVIAVATAAVILRPARIPEAVWAVGGALVLAVSGMLPWAEAWKGVLRGH
CEEECCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCC
DVYLFLAGMMLLSEMARREGVFDWLAVEAARRARGSGERLFAWVFGVGTLVTATLSNDAT
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCE
AVVLTPAVIAVARTVGAAPLPYLLICAFVANAASFLLPISNPANLVLWGGGRMPSLPHWL
EEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHEEEECCCCCCEEEECCCCCCCCHHHH
ALFGLPSVAAIGCTYWVLKWRVRQDIARPVAAEVPARPLGAGGRLAAAGLAVSAVVLVGC
HHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
AWWRIPLGAPTLGAALLTLVLLRAGCGHQVGPVLKSVSWGVLPLVAGLFVFVQALEVTGV
HHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
VGHLARMLAGAAAAAPLAAGPALGALLGFGANLVNNLPAGLLAGAALEAAHAAEPLRAAA
HHHHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
LIGVDLGPNLSITGSLATLLWLAALRREGIEVSAVQFLKFGTWVMPPALAAALLVLMGMS
HEEECCCCCCEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCH
AAGL
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; arsenite [Cytoplasm]; H2O [C]

Specific reaction: ATP + arsenite [Cytoplasm] + H2O = ADP + phosphate + arsenite [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA