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The map label for this gene is edd [H]

Identifier: 120611457

GI number: 120611457

Start: 3065626

End: 3067479

Strand: Reverse

Name: edd [H]

Synonym: Aave_2793

Alternate gene names: 120611457

Gene position: 3067479-3065626 (Counterclockwise)

Preceding gene: 120611458

Following gene: 120611456

Centisome position: 57.31

GC content: 71.63

Gene sequence:

>1854_bases
ATGCCACTCCACGATACCGTCCATTCCGTCACCGAACGCATCCGCGAGCGCAGCGCGCCCACGCGTGCCGCCTACCTCGC
CCAGCTCGATTTCCATGCGCAGCGCGACCGCGGCGCCGACCGCCTGGGCTGCGCCAACGTCGCCCACGCCTTCGCGGGCA
TGCCCGGCAACGACAAGTTCCGCGTCGTCGCCGAGCGCGCGCGCAACATCGGCATCGTCAATGCCTACAACGACATGCTC
TCGGCCCATGCGCCGCTGCGCCATTACCCCGACATGATCAAGGAGGTGGCCCGCCAGCACGGTGCCACGGCCCAGGTGGC
GGGCGGCGTGCCGGCCATGTGCGACGGCGTCACGCAGGGCACGCCGGGCATGGAGCTGTCGCTCTTCAGCCGCGACGTGA
TCGCGATGGCCACGGCCGTTTCGCTCTCGCACGACGTCTATGACGCCGCGCTCATGCTCGGCGTGTGCGACAAGATCGTG
CCCGGCCTGCTGATCGGTGCACTGCACTTCGGCCACCTGCCGACCGTGTTCGTGCCGGCCGGGCCGATGACCTCGGGCCT
TTCGAACAGCGCCAAGGCCAAGGTGCGCGAGCAGGCCGCGCAGGGCCTGGTCGGCCGCGACGAACTGCTGGCCGCCGAAT
CCGCCGCGTATCACAGCGAGGGCACCTGCACCTTCTACGGCACGGCCAACAGCAACCAGATGCTCATGGAAGCCATGGGC
CTGCACGTGCCCGGCACCGCCTTCGTGAACCCCGGCGAGGCGCTGCGTACCGAACTCACGCGTGAGGCCGCCCGCACCGT
GCTCGGCCAGCCGGGTGCGCCGTGCGCGCCCATCGGCCGCATCGTGGACGAGCGCTGCATCGTCAACGCCATGGCGGCGC
TGCTCGCCACGGGCGGCTCCACGAACCACCTGATCCACTGGGTAGCCGTGGCCCGCGCCGCGGGCATCGCCATCGGCTGG
GACGATTTCGCGGCGCTCTCGGCCGTGGTGCCGCTGCTCGCTCGCGTCTATCCCAACGGCAGCGCCGACGTGAACCAGTT
CCAGGCGGCCGGCGGCCCCGGCTACGTGATCCGCGAACTGCTGGACGCCGGCCTGATGCACGAGGACGTACTCACCGTGC
GGCCCGGCGGCCTGCGCGAATACACCCGGCTGCCGGTGGAGGATGCCGCGGCCCCCGGCACCGGCAAACTCTCCTGGGCA
CCCATCGGTGCCAGCGGCGACGACGGCGTGCTGCGCCCCGCGGATGCGCCGTTCAGCCCGGTCGGCGGGCTCAAGTTGCT
CGAAGGCAACCTGGGCCGCAGCGTGATCAAGGTGTCCGCCGTACCCGAAGACCACCACGTGATCGAGGCGCCCGCGCGCG
TCTTCGCCTCGCAGGCCGAACTGCAGCAGGCCTTCCAGGCCGGCGAGCTGGACCGGGCCTGCGAAGCCCACCCGTCGCAC
GGGCTGGTCTGCGTGGTGCGCTGGCAGGGCCCGCGCGCCAACGGCATGCCCGAGCTGCACAAGCTCACGCCGCCGCTGGC
CGTGCTGCAGGGCAAGGGCTACCGCGTGGCGCTGGTCACGGACGGCCGCATGAGCGGCGCCTCCGGCAAGGTGCCGGCCG
CCATCCACGTCTCGCCCGAGGCTCTGGCAGGCGGGCCGCTGGCGCGCGTGCAGAATGGCGACATCGTGCGGCTCGACGCC
GTGGCGGGTACATTGAATGCCCTGGTGGAACCGGCGGAATGGGCGGCCCGCGTGCCGGCCAACCAGCCCGAGGAACTGGC
CCGTGCCGACGGCCACGGCTGGGGCCGCGAACTGTTTGCCGGATTCCGGCGCAATGCGCTCAGCGCGGAAGAGGGAGCCT
GCACATGGCTGTGA

Upstream 100 bases:

>100_bases
GCCGGCACCGTGCTCCGGCCTGGCGGCCGCTCCAGCAGCCCGCGCGCCTTTTCCGCTCCTTTCCACGTCGATCCTGCAAG
GCACCGCCCCACACACCGCC

Downstream 100 bases:

>100_bases
ACGAACGCAATGCTTTGACCGCGCAGGACGTGATGCGCGACGCGCCGGTGATCCCGGTCATCGTGCTGACCGACGTGGCG
CACGCCGTGCCCATGGCGCG

Product: phosphogluconate dehydratase

Products: NA

Alternate protein names: 6-phosphogluconate dehydratase [H]

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MPLHDTVHSVTERIRERSAPTRAAYLAQLDFHAQRDRGADRLGCANVAHAFAGMPGNDKFRVVAERARNIGIVNAYNDML
SAHAPLRHYPDMIKEVARQHGATAQVAGGVPAMCDGVTQGTPGMELSLFSRDVIAMATAVSLSHDVYDAALMLGVCDKIV
PGLLIGALHFGHLPTVFVPAGPMTSGLSNSAKAKVREQAAQGLVGRDELLAAESAAYHSEGTCTFYGTANSNQMLMEAMG
LHVPGTAFVNPGEALRTELTREAARTVLGQPGAPCAPIGRIVDERCIVNAMAALLATGGSTNHLIHWVAVARAAGIAIGW
DDFAALSAVVPLLARVYPNGSADVNQFQAAGGPGYVIRELLDAGLMHEDVLTVRPGGLREYTRLPVEDAAAPGTGKLSWA
PIGASGDDGVLRPADAPFSPVGGLKLLEGNLGRSVIKVSAVPEDHHVIEAPARVFASQAELQQAFQAGELDRACEAHPSH
GLVCVVRWQGPRANGMPELHKLTPPLAVLQGKGYRVALVTDGRMSGASGKVPAAIHVSPEALAGGPLARVQNGDIVRLDA
VAGTLNALVEPAEWAARVPANQPEELARADGHGWGRELFAGFRRNALSAEEGACTWL

Sequences:

>Translated_617_residues
MPLHDTVHSVTERIRERSAPTRAAYLAQLDFHAQRDRGADRLGCANVAHAFAGMPGNDKFRVVAERARNIGIVNAYNDML
SAHAPLRHYPDMIKEVARQHGATAQVAGGVPAMCDGVTQGTPGMELSLFSRDVIAMATAVSLSHDVYDAALMLGVCDKIV
PGLLIGALHFGHLPTVFVPAGPMTSGLSNSAKAKVREQAAQGLVGRDELLAAESAAYHSEGTCTFYGTANSNQMLMEAMG
LHVPGTAFVNPGEALRTELTREAARTVLGQPGAPCAPIGRIVDERCIVNAMAALLATGGSTNHLIHWVAVARAAGIAIGW
DDFAALSAVVPLLARVYPNGSADVNQFQAAGGPGYVIRELLDAGLMHEDVLTVRPGGLREYTRLPVEDAAAPGTGKLSWA
PIGASGDDGVLRPADAPFSPVGGLKLLEGNLGRSVIKVSAVPEDHHVIEAPARVFASQAELQQAFQAGELDRACEAHPSH
GLVCVVRWQGPRANGMPELHKLTPPLAVLQGKGYRVALVTDGRMSGASGKVPAAIHVSPEALAGGPLARVQNGDIVRLDA
VAGTLNALVEPAEWAARVPANQPEELARADGHGWGRELFAGFRRNALSAEEGACTWL
>Mature_616_residues
PLHDTVHSVTERIRERSAPTRAAYLAQLDFHAQRDRGADRLGCANVAHAFAGMPGNDKFRVVAERARNIGIVNAYNDMLS
AHAPLRHYPDMIKEVARQHGATAQVAGGVPAMCDGVTQGTPGMELSLFSRDVIAMATAVSLSHDVYDAALMLGVCDKIVP
GLLIGALHFGHLPTVFVPAGPMTSGLSNSAKAKVREQAAQGLVGRDELLAAESAAYHSEGTCTFYGTANSNQMLMEAMGL
HVPGTAFVNPGEALRTELTREAARTVLGQPGAPCAPIGRIVDERCIVNAMAALLATGGSTNHLIHWVAVARAAGIAIGWD
DFAALSAVVPLLARVYPNGSADVNQFQAAGGPGYVIRELLDAGLMHEDVLTVRPGGLREYTRLPVEDAAAPGTGKLSWAP
IGASGDDGVLRPADAPFSPVGGLKLLEGNLGRSVIKVSAVPEDHHVIEAPARVFASQAELQQAFQAGELDRACEAHPSHG
LVCVVRWQGPRANGMPELHKLTPPLAVLQGKGYRVALVTDGRMSGASGKVPAAIHVSPEALAGGPLARVQNGDIVRLDAV
AGTLNALVEPAEWAARVPANQPEELARADGHGWGRELFAGFRRNALSAEEGACTWL

Specific function: KEY ENZYME IN THE ENTNER-DOUDOROFF PATHWAY. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI1788157, Length=608, Percent_Identity=55.2631578947368, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI48994964, Length=549, Percent_Identity=28.5974499089253, Blast_Score=191, Evalue=2e-49,
Organism=Escherichia coli, GI2367371, Length=467, Percent_Identity=31.9057815845824, Blast_Score=155, Evalue=8e-39,
Organism=Escherichia coli, GI1786464, Length=523, Percent_Identity=31.1663479923518, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6322476, Length=483, Percent_Identity=28.9855072463768, Blast_Score=166, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004786
- InterPro:   IPR015928
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.12 [H]

Molecular weight: Translated: 64740; Mature: 64609

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLHDTVHSVTERIRERSAPTRAAYLAQLDFHAQRDRGADRLGCANVAHAFAGMPGNDKF
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCH
RVVAERARNIGIVNAYNDMLSAHAPLRHYPDMIKEVARQHGATAQVAGGVPAMCDGVTQG
HHHHHHHHCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCC
TPGMELSLFSRDVIAMATAVSLSHDVYDAALMLGVCDKIVPGLLIGALHFGHLPTVFVPA
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTSGLSNSAKAKVREQAAQGLVGRDELLAAESAAYHSEGTCTFYGTANSNQMLMEAMG
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHC
LHVPGTAFVNPGEALRTELTREAARTVLGQPGAPCAPIGRIVDERCIVNAMAALLATGGS
CCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
TNHLIHWVAVARAAGIAIGWDDFAALSAVVPLLARVYPNGSADVNQFQAAGGPGYVIREL
CHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHH
LDAGLMHEDVLTVRPGGLREYTRLPVEDAAAPGTGKLSWAPIGASGDDGVLRPADAPFSP
HHCCCCCCCEEEECCCCCHHHHCCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
VGGLKLLEGNLGRSVIKVSAVPEDHHVIEAPARVFASQAELQQAFQAGELDRACEAHPSH
CCCCEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
GLVCVVRWQGPRANGMPELHKLTPPLAVLQGKGYRVALVTDGRMSGASGKVPAAIHVSPE
CEEEEEEECCCCCCCCCHHHHCCCCHHEECCCCEEEEEEECCCCCCCCCCCCEEEEECHH
ALAGGPLARVQNGDIVRLDAVAGTLNALVEPAEWAARVPANQPEELARADGHGWGRELFA
HHCCCCEEEECCCCEEEEHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHCCCCCHHHHHHH
GFRRNALSAEEGACTWL
HHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
PLHDTVHSVTERIRERSAPTRAAYLAQLDFHAQRDRGADRLGCANVAHAFAGMPGNDKF
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCH
RVVAERARNIGIVNAYNDMLSAHAPLRHYPDMIKEVARQHGATAQVAGGVPAMCDGVTQG
HHHHHHHHCCCEEEHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHCCCCCC
TPGMELSLFSRDVIAMATAVSLSHDVYDAALMLGVCDKIVPGLLIGALHFGHLPTVFVPA
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
GPMTSGLSNSAKAKVREQAAQGLVGRDELLAAESAAYHSEGTCTFYGTANSNQMLMEAMG
CCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHC
LHVPGTAFVNPGEALRTELTREAARTVLGQPGAPCAPIGRIVDERCIVNAMAALLATGGS
CCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCC
TNHLIHWVAVARAAGIAIGWDDFAALSAVVPLLARVYPNGSADVNQFQAAGGPGYVIREL
CHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCHHHHHHH
LDAGLMHEDVLTVRPGGLREYTRLPVEDAAAPGTGKLSWAPIGASGDDGVLRPADAPFSP
HHCCCCCCCEEEECCCCCHHHHCCCHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
VGGLKLLEGNLGRSVIKVSAVPEDHHVIEAPARVFASQAELQQAFQAGELDRACEAHPSH
CCCCEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
GLVCVVRWQGPRANGMPELHKLTPPLAVLQGKGYRVALVTDGRMSGASGKVPAAIHVSPE
CEEEEEEECCCCCCCCCHHHHCCCCHHEECCCCEEEEEEECCCCCCCCCCCCEEEEECHH
ALAGGPLARVQNGDIVRLDAVAGTLNALVEPAEWAARVPANQPEELARADGHGWGRELFA
HHCCCCEEEECCCCEEEEHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHCCCCCHHHHHHH
GFRRNALSAEEGACTWL
HHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]