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The map label for this gene is yngE [H]

Identifier: 120610793

GI number: 120610793

Start: 2325804

End: 2327231

Strand: Reverse

Name: yngE [H]

Synonym: Aave_2116

Alternate gene names: 120610793

Gene position: 2327231-2325804 (Counterclockwise)

Preceding gene: 120610800

Following gene: 120610792

Centisome position: 43.48

GC content: 64.57

Gene sequence:

>1428_bases
TTGTCGATTTCCGCAGCCAGAACAAGATCGATTTTCGATACTGGAACATTCACCGAAACGCAACCATCCATTGAAAGCCA
TTTCATCTGCGGCAAGGGCCTCGTCGATTCACGCACCGTTTTCCTGATCATGAACCGGGGCCGTGACTGCGAATTCGACG
ATCGACTGCAACGGAACACCGCGCCGCACATCATCCGCACTGTCGAGCAGGCGGCGCAGGCGGGCGCCCCCCTGCTTTAT
GTGCAGGATCAACTGGGCGATCCGGACCGGGGATTCGATACCACCCGCGTGATCACGGCAGATCTTTCCACCCTGCTGCT
GTCGCCTTCCGGCATGGGGCGGGTCAGCGCGTGCCTGGCCAGGTTCGCGGAGCAGCATCTGATGGTTTCCGCCGTCCTGG
GACCGACCTCCGGCCCTCTCGCGTTGCCGCTCATGCTGGCCGACCTCGTGCTGATGACCCGCAAAGGGGCCCTGTGCATG
GGACGCCCCGACATGGTCCGGGCCATGCTGGGGCAGGAATGCGACCTGCAGTCGCTGGGGGGAGCGCAAGTGCACAGCGA
CGCCGGTTCGGCGCAACTGGTTTTCGACGACGAGCAGGCGCTGTTCGCCTGCGCGCGAAAGCTGATACGCCTGGACAGCC
GGCAGGCACCCAGGAGGCCGGCGAGGGGCCCCAGGCCGCGGCCAATGGACATCGGCAGCCTCATCCCGCACGACCCTGGC
AGACCCTACGACGCGCACGCCCTGGTCGAGGCGGTCGCCGATGCAGGCAGCCTGGTGGAAATCAGCCCCCGCCACGCTCC
CGAGGTCCTGACCGGTTTCGCGACCGTGGGGAAACACCCCATGGCGCTGATCGCCAACAATCCCAGGCACCAGTCGGGCG
CCATCCAGGGGCCATCGGCCAGGAAAATGGTCCGCGCCATCCGCATTGCAGACAAGCTCCGCATTCCCATCGTTTTCTTC
GCGGATGTACCGGGTTTCATGATAGGCAGGGAAGCGGAGCGCAGCGGCATATTCTCCGCAGCGGCCGAACTGTTTTCGGC
GCATGTCCGGAGCACCGTCCCGAAAATCCTCATCGTCGTGCGAAAGGCTTTTACCGGCGGACTGTACGCCATGCACGGCC
CCGGCTTCGACCCCGTGGCGATTCTCGCCTTTCCGCACGCCCATATCGGGGTTTTCGGCATCAAAACGATGGAAGCGATA
TTGGAAAGCGCTCCCCCTGAAAAGCGGCGGGTGGTGGAACTGCTCCGCCGCGAGATCTCGGCGCCGGCCCGGCTGGCGGA
GAAAGGCCTCGTCACGGAAGTGATCGACCCTGCAGACACGCGGGAAAGAATCCTGCACTACCTCGCCCCCTATCTGACGA
CAGAGGCCGCGCCGGGGCAGCCTGGGGCACGCGCCAGGAACCCGACCCCTATGCGCAAGCGTGCATGA

Upstream 100 bases:

>100_bases
ATACAAATTAGTTAATCGCCGCAGAAATTAAATTTCTCTTCGCCTCAAATTCTCGAGAATTATTTACATAACAATTCCGA
CAAAACACGAGGAGAAACCC

Downstream 100 bases:

>100_bases
CCCGCAAAGCCGCCCGCCCGGCATCCCCGAATCCCCTGGAAAATGAAAACACTGCACCGATGAAATCCTGGATCTTCGAA
CAATTCAACGTTTCCGCTGA

Product: propionyl-CoA carboxylase

Products: ADP; phosphate; (S)-methylmalonyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSISAARTRSIFDTGTFTETQPSIESHFICGKGLVDSRTVFLIMNRGRDCEFDDRLQRNTAPHIIRTVEQAAQAGAPLLY
VQDQLGDPDRGFDTTRVITADLSTLLLSPSGMGRVSACLARFAEQHLMVSAVLGPTSGPLALPLMLADLVLMTRKGALCM
GRPDMVRAMLGQECDLQSLGGAQVHSDAGSAQLVFDDEQALFACARKLIRLDSRQAPRRPARGPRPRPMDIGSLIPHDPG
RPYDAHALVEAVADAGSLVEISPRHAPEVLTGFATVGKHPMALIANNPRHQSGAIQGPSARKMVRAIRIADKLRIPIVFF
ADVPGFMIGREAERSGIFSAAAELFSAHVRSTVPKILIVVRKAFTGGLYAMHGPGFDPVAILAFPHAHIGVFGIKTMEAI
LESAPPEKRRVVELLRREISAPARLAEKGLVTEVIDPADTRERILHYLAPYLTTEAAPGQPGARARNPTPMRKRA

Sequences:

>Translated_475_residues
MSISAARTRSIFDTGTFTETQPSIESHFICGKGLVDSRTVFLIMNRGRDCEFDDRLQRNTAPHIIRTVEQAAQAGAPLLY
VQDQLGDPDRGFDTTRVITADLSTLLLSPSGMGRVSACLARFAEQHLMVSAVLGPTSGPLALPLMLADLVLMTRKGALCM
GRPDMVRAMLGQECDLQSLGGAQVHSDAGSAQLVFDDEQALFACARKLIRLDSRQAPRRPARGPRPRPMDIGSLIPHDPG
RPYDAHALVEAVADAGSLVEISPRHAPEVLTGFATVGKHPMALIANNPRHQSGAIQGPSARKMVRAIRIADKLRIPIVFF
ADVPGFMIGREAERSGIFSAAAELFSAHVRSTVPKILIVVRKAFTGGLYAMHGPGFDPVAILAFPHAHIGVFGIKTMEAI
LESAPPEKRRVVELLRREISAPARLAEKGLVTEVIDPADTRERILHYLAPYLTTEAAPGQPGARARNPTPMRKRA
>Mature_474_residues
SISAARTRSIFDTGTFTETQPSIESHFICGKGLVDSRTVFLIMNRGRDCEFDDRLQRNTAPHIIRTVEQAAQAGAPLLYV
QDQLGDPDRGFDTTRVITADLSTLLLSPSGMGRVSACLARFAEQHLMVSAVLGPTSGPLALPLMLADLVLMTRKGALCMG
RPDMVRAMLGQECDLQSLGGAQVHSDAGSAQLVFDDEQALFACARKLIRLDSRQAPRRPARGPRPRPMDIGSLIPHDPGR
PYDAHALVEAVADAGSLVEISPRHAPEVLTGFATVGKHPMALIANNPRHQSGAIQGPSARKMVRAIRIADKLRIPIVFFA
DVPGFMIGREAERSGIFSAAAELFSAHVRSTVPKILIVVRKAFTGGLYAMHGPGFDPVAILAFPHAHIGVFGIKTMEAIL
ESAPPEKRRVVELLRREISAPARLAEKGLVTEVIDPADTRERILHYLAPYLTTEAAPGQPGARARNPTPMRKRA

Specific function: Unknown

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=464, Percent_Identity=25.2155172413793, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI295821216, Length=401, Percent_Identity=26.4339152119701, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI11545863, Length=340, Percent_Identity=24.7058823529412, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25147359, Length=455, Percent_Identity=28.1318681318681, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI25147362, Length=455, Percent_Identity=28.1318681318681, Blast_Score=163, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17552936, Length=340, Percent_Identity=27.0588235294118, Blast_Score=131, Evalue=9e-31,
Organism=Drosophila melanogaster, GI24586065, Length=375, Percent_Identity=23.7333333333333, Blast_Score=125, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: 6.4.1.3

Molecular weight: Translated: 51383; Mature: 51252

Theoretical pI: Translated: 9.71; Mature: 9.71

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISAARTRSIFDTGTFTETQPSIESHFICGKGLVDSRTVFLIMNRGRDCEFDDRLQRNT
CCCCHHHHHHHHCCCCCCCCCCCHHHCEEECCCCCCCCEEEEEEECCCCCCHHHHHHHCC
APHIIRTVEQAAQAGAPLLYVQDQLGDPDRGFDTTRVITADLSTLLLSPSGMGRVSACLA
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHH
RFAEQHLMVSAVLGPTSGPLALPLMLADLVLMTRKGALCMGRPDMVRAMLGQECDLQSLG
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCHHHCC
GAQVHSDAGSAQLVFDDEQALFACARKLIRLDSRQAPRRPARGPRPRPMDIGSLIPHDPG
CCEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RPYDAHALVEAVADAGSLVEISPRHAPEVLTGFATVGKHPMALIANNPRHQSGAIQGPSA
CCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHH
RKMVRAIRIADKLRIPIVFFADVPGFMIGREAERSGIFSAAAELFSAHVRSTVPKILIVV
HHHHHHHHHHHHHCCCEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKAFTGGLYAMHGPGFDPVAILAFPHAHIGVFGIKTMEAILESAPPEKRRVVELLRREIS
HHHHCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
APARLAEKGLVTEVIDPADTRERILHYLAPYLTTEAAPGQPGARARNPTPMRKRA
CHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SISAARTRSIFDTGTFTETQPSIESHFICGKGLVDSRTVFLIMNRGRDCEFDDRLQRNT
CCCHHHHHHHHCCCCCCCCCCCHHHCEEECCCCCCCCEEEEEEECCCCCCHHHHHHHCC
APHIIRTVEQAAQAGAPLLYVQDQLGDPDRGFDTTRVITADLSTLLLSPSGMGRVSACLA
CHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEHHHHHHHHHCCCCCCHHHHHHHH
RFAEQHLMVSAVLGPTSGPLALPLMLADLVLMTRKGALCMGRPDMVRAMLGQECDLQSLG
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHCCCCCHHHCC
GAQVHSDAGSAQLVFDDEQALFACARKLIRLDSRQAPRRPARGPRPRPMDIGSLIPHDPG
CCEEECCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RPYDAHALVEAVADAGSLVEISPRHAPEVLTGFATVGKHPMALIANNPRHQSGAIQGPSA
CCCHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHH
RKMVRAIRIADKLRIPIVFFADVPGFMIGREAERSGIFSAAAELFSAHVRSTVPKILIVV
HHHHHHHHHHHHHCCCEEEEECCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RKAFTGGLYAMHGPGFDPVAILAFPHAHIGVFGIKTMEAILESAPPEKRRVVELLRREIS
HHHHCCCEEEECCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
APARLAEKGLVTEVIDPADTRERILHYLAPYLTTEAAPGQPGARARNPTPMRKRA
CHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; propanoyl-CoA; HCO3-

Specific reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 9387222 [H]