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The map label for this gene is hemC [H]

Identifier: 120610679

GI number: 120610679

Start: 2171388

End: 2172344

Strand: Reverse

Name: hemC [H]

Synonym: Aave_1999

Alternate gene names: 120610679

Gene position: 2172344-2171388 (Counterclockwise)

Preceding gene: 120610682

Following gene: 120610678

Centisome position: 40.58

GC content: 74.4

Gene sequence:

>957_bases
ATGCATCCCTCTCCCCCCCCCACGACCTCCGCCGCCTCCGGCCTTCCTCCCATCGTCATCGCCACGCGCGAAAGCCGCCT
CGCGCTCTGGCAGGCCGAGCACGTGCAGGCCCTGCTGCGCGCGCGCGGCCACGCCGTCGAACTGCTCGGCATGACCACCC
AGGGCGACCGGATCCTCGACCGCACCCTGTCCAAGGTGGGCGGCAAGGGCCTCTTCGTGAAGGAACTGGAAGTCGCCCTG
GAGGAAGGCCGCGCCCACGTGGCCGTGCATTCGCTCAAGGACGTGCCCATGGAGCTGCCCGAGGGCTTCGAGCTGGCCTG
CGTGATGGAGCGCGAGGATCCGCGCGACGCGTTCGTCTCGCCCCGCCATGCCTGCCTCGCCGACCTCCCCCAGGGCGCCG
TGGTGGGCACCTCCAGCCTGCGCCGGCAGGTGCTGCTGCAGGCGCTGCGCCCCGACCTCGTCATCCAGCCGCTGCGCGGC
AACCTCGACACCCGCCTGCGCAAGCTCGACGAAGGCCAGTACGACGCCATCGTGCTGGCGGCCGCGGGCCTCAAGCGCCT
GGGCCTGGAAGGCCGCATCCGCGCCCTGTTCGAGCCCGACGAAATGCTGCCGGCCGCCGGCCAGGGCGCGCTGGGCCTGG
AGGTGCGATCCGAACGCCATGACCTGCTGCAGGCGGTGGCACCGCTCGCCCACCAGGCCACCTGGCTCTGCGTGGCCGCC
GAGCGCGCCGTGAGCCGCGCCCTGGGCGGCAGCTGCTCCGTGCCGCTGGCGGCCCATGGCCGCTGGACGGACGCCGGCAC
GCTGCGCCTGGACGGTGCCTGGGGCGACCCCGAAGGCATCCGCCCCCTGGTGCGGGTGCAGATATCCGCGCCGGTCGCCT
CCCTGCCCGAAGCCGAAGCGCTCGGCTCCGCCGTCGCGGCGCGGCTGCGCGCGGACGGCGCGCAGATCCCGGCCTGA

Upstream 100 bases:

>100_bases
TCCTGGGGCGCGCGCACGACGGGCAGGTGCTGCGGCGCAGCATGCTAGCATCCCCGCCAGGCCTGCCGAGCCTTCCGCCC
GCCCGGCCTGGAACACCGCG

Downstream 100 bases:

>100_bases
CCGCCGCGTCCGCACACCGAGCCCCATCCACCCCGTGCACCGCGCCCCCCCGCCTGCGGCCCCGCGCCGCGCCATCGTCA
CCCGCCCGGAGCGCGACGCC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MHPSPPPTTSAASGLPPIVIATRESRLALWQAEHVQALLRARGHAVELLGMTTQGDRILDRTLSKVGGKGLFVKELEVAL
EEGRAHVAVHSLKDVPMELPEGFELACVMEREDPRDAFVSPRHACLADLPQGAVVGTSSLRRQVLLQALRPDLVIQPLRG
NLDTRLRKLDEGQYDAIVLAAAGLKRLGLEGRIRALFEPDEMLPAAGQGALGLEVRSERHDLLQAVAPLAHQATWLCVAA
ERAVSRALGGSCSVPLAAHGRWTDAGTLRLDGAWGDPEGIRPLVRVQISAPVASLPEAEALGSAVAARLRADGAQIPA

Sequences:

>Translated_318_residues
MHPSPPPTTSAASGLPPIVIATRESRLALWQAEHVQALLRARGHAVELLGMTTQGDRILDRTLSKVGGKGLFVKELEVAL
EEGRAHVAVHSLKDVPMELPEGFELACVMEREDPRDAFVSPRHACLADLPQGAVVGTSSLRRQVLLQALRPDLVIQPLRG
NLDTRLRKLDEGQYDAIVLAAAGLKRLGLEGRIRALFEPDEMLPAAGQGALGLEVRSERHDLLQAVAPLAHQATWLCVAA
ERAVSRALGGSCSVPLAAHGRWTDAGTLRLDGAWGDPEGIRPLVRVQISAPVASLPEAEALGSAVAARLRADGAQIPA
>Mature_318_residues
MHPSPPPTTSAASGLPPIVIATRESRLALWQAEHVQALLRARGHAVELLGMTTQGDRILDRTLSKVGGKGLFVKELEVAL
EEGRAHVAVHSLKDVPMELPEGFELACVMEREDPRDAFVSPRHACLADLPQGAVVGTSSLRRQVLLQALRPDLVIQPLRG
NLDTRLRKLDEGQYDAIVLAAAGLKRLGLEGRIRALFEPDEMLPAAGQGALGLEVRSERHDLLQAVAPLAHQATWLCVAA
ERAVSRALGGSCSVPLAAHGRWTDAGTLRLDGAWGDPEGIRPLVRVQISAPVASLPEAEALGSAVAARLRADGAQIPA

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=282, Percent_Identity=45.3900709219858, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI66933009, Length=282, Percent_Identity=45.3900709219858, Blast_Score=215, Evalue=5e-56,
Organism=Escherichia coli, GI48994974, Length=298, Percent_Identity=53.0201342281879, Blast_Score=272, Evalue=2e-74,
Organism=Saccharomyces cerevisiae, GI6319996, Length=309, Percent_Identity=38.5113268608414, Blast_Score=196, Evalue=6e-51,
Organism=Drosophila melanogaster, GI20130425, Length=262, Percent_Identity=41.2213740458015, Blast_Score=185, Evalue=5e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33860; Mature: 33860

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPSPPPTTSAASGLPPIVIATRESRLALWQAEHVQALLRARGHAVELLGMTTQGDRILD
CCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHH
RTLSKVGGKGLFVKELEVALEEGRAHVAVHSLKDVPMELPEGFELACVMEREDPRDAFVS
HHHHHHCCCCEEHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCEEEEEEECCCCCHHHCC
PRHACLADLPQGAVVGTSSLRRQVLLQALRPDLVIQPLRGNLDTRLRKLDEGQYDAIVLA
CHHHHHHCCCCCCEECHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCEEEEE
AAGLKRLGLEGRIRALFEPDEMLPAAGQGALGLEVRSERHDLLQAVAPLAHQATWLCVAA
HHHHHHCCCCCCEEEEECCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
ERAVSRALGGSCSVPLAAHGRWTDAGTLRLDGAWGDPEGIRPLVRVQISAPVASLPEAEA
HHHHHHHCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCHHH
LGSAVAARLRADGAQIPA
HHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHPSPPPTTSAASGLPPIVIATRESRLALWQAEHVQALLRARGHAVELLGMTTQGDRILD
CCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHH
RTLSKVGGKGLFVKELEVALEEGRAHVAVHSLKDVPMELPEGFELACVMEREDPRDAFVS
HHHHHHCCCCEEHHHHHHHHHCCCCEEEEHHHHCCCCCCCCCCEEEEEEECCCCCHHHCC
PRHACLADLPQGAVVGTSSLRRQVLLQALRPDLVIQPLRGNLDTRLRKLDEGQYDAIVLA
CHHHHHHCCCCCCEECHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCCCCCCEEEEE
AAGLKRLGLEGRIRALFEPDEMLPAAGQGALGLEVRSERHDLLQAVAPLAHQATWLCVAA
HHHHHHCCCCCCEEEEECCHHHCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHH
ERAVSRALGGSCSVPLAAHGRWTDAGTLRLDGAWGDPEGIRPLVRVQISAPVASLPEAEA
HHHHHHHCCCCCCCCEECCCCCCCCCEEEECCCCCCCCCCCEEEEEEECCCCCCCCCHHH
LGSAVAARLRADGAQIPA
HHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA