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The map label for this gene is purM [H]

Identifier: 120610650

GI number: 120610650

Start: 2139565

End: 2140623

Strand: Reverse

Name: purM [H]

Synonym: Aave_1970

Alternate gene names: 120610650

Gene position: 2140623-2139565 (Counterclockwise)

Preceding gene: 120610655

Following gene: 120610649

Centisome position: 39.99

GC content: 69.69

Gene sequence:

>1059_bases
ATGAGTTCCTCCGCTTCCTCCACTCCCATTTCGTACAAAGACGCCGGCGTCGACATCGACGCGGGCGACGCGCTGGTCGA
GCGCATCAAGCCGCTGGCGAAGAAGACGATGCGCGAAGGCGTGCTGGCCGGCATCGGCGGCTTCGGCGCGCTGTTCGAGG
TGCCCAAGCGCTACAAGGAGCCGGTGCTGGTTTCCGGCACCGACGGCGTGGGCACCAAGCTCAAGCTGGCCTTCGAGTGG
AACATGCACGATACGGTAGGCATCGACCTCGTGGCCATGAGCGTGAACGACGTGCTGGTGCAGGGCGCCGAGCCGCTCTT
CTTCCTGGACTACTTCGCCTGCGGCAAGCTCCATGTGGACACCGCCGCCGCGGTGGTGGGCGGCATCGCCCGCGGCTGCG
AGCTGTCGGGCTGCGCGCTGATCGGCGGCGAGACCGCCGAGATGCCCGGCATGTACCCGGACGGCGAATACGACCTCGCG
GGCTTCGCCGTGGGCGCGGTCGAGAAGTCGAAGATCCTCACCGGCCGCGAAGTGGCTGCCGGCGACGTGGTGCTGGGCCT
GGCCTCCGCCGGCGTGCACTCCAATGGCTTCAGCCTGGTGCGCAAGTGCATCGAGCGCGCCGGAGACTCCGCCCCCGCCA
CGCTGGACGGCAAGCCCTTCAGGCAGGCCATCATGGAACCCACGCGCCTGTACGTGAAGAACGTGCTGGCCGCGCTGGCG
CAGCACCCCGCCGACGCTGGCGGCATCAAGGCCCTGGCCCACATCACGGGCGGCGGCCTGCTGGAGAACATCCCGCGCGT
GCTGCCCGAAGGCCTCGCCGCCCACCTCAAGGCCGGCAGCTGGCCGCAGACCGAACTGTTCGCCTGGCTGCAGAAGACGG
CCGGCATCGACGACATCGAGATGAACCGCACCTTCAACAACGGCATCGGCATGGCGGTGGTGGTGTCCGCCGCCCAGGCC
GAGGCCGTCGCCGCCACGCTGCGCGCGCAGGGCGAATCCGTGCACGCCATCGGCGTGATCGCCGAGCGCGGTACGGGCGC
CCCGGTCGTGGTCGCCTGA

Upstream 100 bases:

>100_bases
CGTGCACGGCCGAGGGGGCATTGGGCCGCGATGCCGGCGCGGCCTTAGAATCCGCGCGATCCGGCCCGCCCCGCGGCCCC
CGCACCACACCATCGAGCCC

Downstream 100 bases:

>100_bases
TCCGCCAGCACATCCCACATCCCTTTTCGCGCCATCCCATGGAGCCGCTTCCGACGGCCGACCCGGCCCCCGCCGCGCCG
ACGCGCGGCGTGCGTACCGC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSSSASSTPISYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLKLAFEW
NMHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLHVDTAAAVVGGIARGCELSGCALIGGETAEMPGMYPDGEYDLA
GFAVGAVEKSKILTGREVAAGDVVLGLASAGVHSNGFSLVRKCIERAGDSAPATLDGKPFRQAIMEPTRLYVKNVLAALA
QHPADAGGIKALAHITGGGLLENIPRVLPEGLAAHLKAGSWPQTELFAWLQKTAGIDDIEMNRTFNNGIGMAVVVSAAQA
EAVAATLRAQGESVHAIGVIAERGTGAPVVVA

Sequences:

>Translated_352_residues
MSSSASSTPISYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLKLAFEW
NMHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLHVDTAAAVVGGIARGCELSGCALIGGETAEMPGMYPDGEYDLA
GFAVGAVEKSKILTGREVAAGDVVLGLASAGVHSNGFSLVRKCIERAGDSAPATLDGKPFRQAIMEPTRLYVKNVLAALA
QHPADAGGIKALAHITGGGLLENIPRVLPEGLAAHLKAGSWPQTELFAWLQKTAGIDDIEMNRTFNNGIGMAVVVSAAQA
EAVAATLRAQGESVHAIGVIAERGTGAPVVVA
>Mature_351_residues
SSSASSTPISYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKEPVLVSGTDGVGTKLKLAFEWN
MHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLHVDTAAAVVGGIARGCELSGCALIGGETAEMPGMYPDGEYDLAG
FAVGAVEKSKILTGREVAAGDVVLGLASAGVHSNGFSLVRKCIERAGDSAPATLDGKPFRQAIMEPTRLYVKNVLAALAQ
HPADAGGIKALAHITGGGLLENIPRVLPEGLAAHLKAGSWPQTELFAWLQKTAGIDDIEMNRTFNNGIGMAVVVSAAQAE
AVAATLRAQGESVHAIGVIAERGTGAPVVVA

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=347, Percent_Identity=51.8731988472622, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI209869995, Length=347, Percent_Identity=51.8731988472622, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI209869993, Length=347, Percent_Identity=51.8731988472622, Blast_Score=349, Evalue=2e-96,
Organism=Escherichia coli, GI1788845, Length=348, Percent_Identity=55.4597701149425, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17567511, Length=352, Percent_Identity=44.0340909090909, Blast_Score=254, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6321203, Length=355, Percent_Identity=48.4507042253521, Blast_Score=324, Evalue=1e-89,
Organism=Drosophila melanogaster, GI24582400, Length=359, Percent_Identity=42.0612813370474, Blast_Score=241, Evalue=7e-64,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36320; Mature: 36189

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSASSTPISYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKE
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PVLVSGTDGVGTKLKLAFEWNMHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLHVD
CEEEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCEEEEHHHHCCCEEHH
TAAAVVGGIARGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKILTGREVAA
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCCCCCCCCC
GDVVLGLASAGVHSNGFSLVRKCIERAGDSAPATLDGKPFRQAIMEPTRLYVKNVLAALA
CCEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QHPADAGGIKALAHITGGGLLENIPRVLPEGLAAHLKAGSWPQTELFAWLQKTAGIDDIE
HCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEE
MNRTFNNGIGMAVVVSAAQAEAVAATLRAQGESVHAIGVIAERGTGAPVVVA
ECCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEC
>Mature Secondary Structure 
SSSASSTPISYKDAGVDIDAGDALVERIKPLAKKTMREGVLAGIGGFGALFEVPKRYKE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
PVLVSGTDGVGTKLKLAFEWNMHDTVGIDLVAMSVNDVLVQGAEPLFFLDYFACGKLHVD
CEEEECCCCCCCEEEEEEEECCCCCCCEEEEEEEHHHHHHCCCCCEEEEHHHHCCCEEHH
TAAAVVGGIARGCELSGCALIGGETAEMPGMYPDGEYDLAGFAVGAVEKSKILTGREVAA
HHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEECCCHHHHCCCCCCCCC
GDVVLGLASAGVHSNGFSLVRKCIERAGDSAPATLDGKPFRQAIMEPTRLYVKNVLAALA
CCEEEEHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
QHPADAGGIKALAHITGGGLLENIPRVLPEGLAAHLKAGSWPQTELFAWLQKTAGIDDIE
HCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEE
MNRTFNNGIGMAVVVSAAQAEAVAATLRAQGESVHAIGVIAERGTGAPVVVA
ECCCCCCCCCEEEEEEHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA