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The map label for this gene is argH [H]

Identifier: 120610625

GI number: 120610625

Start: 2106482

End: 2108083

Strand: Reverse

Name: argH [H]

Synonym: Aave_1945

Alternate gene names: 120610625

Gene position: 2108083-2106482 (Counterclockwise)

Preceding gene: 120610627

Following gene: 120610622

Centisome position: 39.38

GC content: 71.29

Gene sequence:

>1602_bases
ATGACGATTCCACGAGAACGCCCCCGGAAACATCCCCGGATGCGCACCGCGCTGCACGCCCTCGCCTGCGCCGCCGCGCT
CTGCGCTGGCGCCGCGCCAGCGCAGCCGGCCTCTCCGGCCTCTCCGGCGTCGGCCGCCAGCGCACCCTCCGCAGCGCCGG
TCCGGCCGGCCCCTGCCCCGCCGCGCGACGAATTCTTCTGGCTCGGGGAGATCAACAAGGCATCTGCCGTCATCAACATC
GACCAGGGCCTGCTCGACAAGTCCCTGGCGCCGCTGGTCCACGGCGGCATCAGCAAGGTGCTGGCCGACGGCAACCGGCC
CGGCGGCAAGCGGCCCAGGCTGGTGATCACTTTCGAGCCCCTGCTCATCGAGGCCGCGGGCCCGCAGATCACGCTGCTGC
ACGCCGGCCGCTCCAGCCAGGACATGCTCTCCACCGTGCGCGCGGCCATGCTGCGCGACCAGATGTTGCAACTGGCCGAG
GCGCTGAACCAGACGACGGCCACGATGGTCCGGCTGGCCGACAGGCACCAGGCCACCGTGGTGCCCAACTACACGAACGG
CGTGGCCGCGCAGCCCAACAGCTACGGCCACTATCTGCTGGGCCTGGCCAGCGGCCTGGACCGCGATGCGCAGCGCATCC
GCGAGGCCTATGCCCGCATCGACCGCTCGCCCATGGGCACCACGGTGCTCAACGGCACGAGCTGGCCGCTCGACCGCCAG
CGCATGGCGGACTACCTGGGCTTTTCCGCCACGGTGGACAATGCCTACGACGCCGCGCAGGTTTCGGCCGTGGACCAGCC
GGTGGAGGCCGGCGCCATCGTCATGGCGATCGCCCTGCACGCCGGCTCCTTCATCGAGGACGTGATGACGCAGTACGCGC
AGCCCCGCCCGTGGATCCTGCTGCAGGAAGGCGGCGGCAACACCTACGTGTCGAGCGCGATGCCGCAAAAGCGCAACCCC
GGCCTGCTCAACGCCACGCGCCGCGACGCCTCGCAGGCCCTGACGCTGGGCATGGGCGCGGCCATCCAGGCGCACAACAT
CCCGCCGGGCATGCAGGACCCGAAGGAAGCGCGCAACAACACCGCCATGGTGCAGAGCGCGATCGACGTGCTGCGCCAGT
GGGACCGCATCCTGGGCGCGCTGGTCATCGACCCGCAGCGCGCGCTCGAGGAATTGAACAGTGACTGGACCGCCTCGCAG
GAACTGGCCGACGTGCTGATGCGCAAGTACCGGCTGCCCTTCCGCGTGGGCCACCATTTCGCGTCGGAGGCGGTCGGCTA
CGCCAAGGCCAAGGACATCAAGCCGCTGGACTTCCCCTACGCCGAGGCCCGCCGCATCTATGCGGAATCGGTGCACGGCT
CGGAATTCCCCGCGCAACTGCCCATGGACGAGGCCGAGTTCCGCGCCACGCTGGACCCGGTGGCCATCGTCCGCCACCGC
GCGACGGCCGGCGGCCCCCAGCCGGCGGAAATGGCCCGCATGCTCAAGGCCGCCCAGGCCCGCGTGGAGCAGCAATCGGC
CTGGATAGCCGCGCAGCGCGCCCGCATCGGCGGCAGCCTCGCCCGCCTGGACCGCGACTTCGACCGCCTGGCCCCCCGCT
GA

Upstream 100 bases:

>100_bases
AGGCTGCGCGGCGGTGAGTCAACCCGTTCAGTGGCCAAGGCCGGCCGGCCTGCCTTGACGACTGAAGTTTGAACCAACTG
AGACATATAAGGAGACAGAC

Downstream 100 bases:

>100_bases
CCGCCGGGCCGCGCCGCGGGCAAGCGCGGCCCAGGCCAGCAGCAGCCAAGCAAGGGCCCCCCGCAGCGAGGGCTGCGTCC
CCCCGCCCGCCATGCGCAGC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 533; Mature: 532

Protein sequence:

>533_residues
MTIPRERPRKHPRMRTALHALACAAALCAGAAPAQPASPASPASAASAPSAAPVRPAPAPPRDEFFWLGEINKASAVINI
DQGLLDKSLAPLVHGGISKVLADGNRPGGKRPRLVITFEPLLIEAAGPQITLLHAGRSSQDMLSTVRAAMLRDQMLQLAE
ALNQTTATMVRLADRHQATVVPNYTNGVAAQPNSYGHYLLGLASGLDRDAQRIREAYARIDRSPMGTTVLNGTSWPLDRQ
RMADYLGFSATVDNAYDAAQVSAVDQPVEAGAIVMAIALHAGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNP
GLLNATRRDASQALTLGMGAAIQAHNIPPGMQDPKEARNNTAMVQSAIDVLRQWDRILGALVIDPQRALEELNSDWTASQ
ELADVLMRKYRLPFRVGHHFASEAVGYAKAKDIKPLDFPYAEARRIYAESVHGSEFPAQLPMDEAEFRATLDPVAIVRHR
ATAGGPQPAEMARMLKAAQARVEQQSAWIAAQRARIGGSLARLDRDFDRLAPR

Sequences:

>Translated_533_residues
MTIPRERPRKHPRMRTALHALACAAALCAGAAPAQPASPASPASAASAPSAAPVRPAPAPPRDEFFWLGEINKASAVINI
DQGLLDKSLAPLVHGGISKVLADGNRPGGKRPRLVITFEPLLIEAAGPQITLLHAGRSSQDMLSTVRAAMLRDQMLQLAE
ALNQTTATMVRLADRHQATVVPNYTNGVAAQPNSYGHYLLGLASGLDRDAQRIREAYARIDRSPMGTTVLNGTSWPLDRQ
RMADYLGFSATVDNAYDAAQVSAVDQPVEAGAIVMAIALHAGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNP
GLLNATRRDASQALTLGMGAAIQAHNIPPGMQDPKEARNNTAMVQSAIDVLRQWDRILGALVIDPQRALEELNSDWTASQ
ELADVLMRKYRLPFRVGHHFASEAVGYAKAKDIKPLDFPYAEARRIYAESVHGSEFPAQLPMDEAEFRATLDPVAIVRHR
ATAGGPQPAEMARMLKAAQARVEQQSAWIAAQRARIGGSLARLDRDFDRLAPR
>Mature_532_residues
TIPRERPRKHPRMRTALHALACAAALCAGAAPAQPASPASPASAASAPSAAPVRPAPAPPRDEFFWLGEINKASAVINID
QGLLDKSLAPLVHGGISKVLADGNRPGGKRPRLVITFEPLLIEAAGPQITLLHAGRSSQDMLSTVRAAMLRDQMLQLAEA
LNQTTATMVRLADRHQATVVPNYTNGVAAQPNSYGHYLLGLASGLDRDAQRIREAYARIDRSPMGTTVLNGTSWPLDRQR
MADYLGFSATVDNAYDAAQVSAVDQPVEAGAIVMAIALHAGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNPG
LLNATRRDASQALTLGMGAAIQAHNIPPGMQDPKEARNNTAMVQSAIDVLRQWDRILGALVIDPQRALEELNSDWTASQE
LADVLMRKYRLPFRVGHHFASEAVGYAKAKDIKPLDFPYAEARRIYAESVHGSEFPAQLPMDEAEFRATLDPVAIVRHRA
TAGGPQPAEMARMLKAAQARVEQQSAWIAAQRARIGGSLARLDRDFDRLAPR

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=320, Percent_Identity=28.125, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI68303542, Length=320, Percent_Identity=28.125, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI68303547, Length=316, Percent_Identity=28.1645569620253, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1790398, Length=392, Percent_Identity=29.8469387755102, Blast_Score=137, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6321806, Length=314, Percent_Identity=27.3885350318471, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221473854, Length=332, Percent_Identity=27.710843373494, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI78706858, Length=332, Percent_Identity=27.710843373494, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 57619; Mature: 57488

Theoretical pI: Translated: 9.54; Mature: 9.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIPRERPRKHPRMRTALHALACAAALCAGAAPAQPASPASPASAASAPSAAPVRPAPAP
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PRDEFFWLGEINKASAVINIDQGLLDKSLAPLVHGGISKVLADGNRPGGKRPRLVITFEP
CCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
LLIEAAGPQITLLHAGRSSQDMLSTVRAAMLRDQMLQLAEALNQTTATMVRLADRHQATV
EEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VPNYTNGVAAQPNSYGHYLLGLASGLDRDAQRIREAYARIDRSPMGTTVLNGTSWPLDRQ
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHH
RMADYLGFSATVDNAYDAAQVSAVDQPVEAGAIVMAIALHAGSFIEDVMTQYAQPRPWIL
HHHHHHCCCCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LQEGGGNTYVSSAMPQKRNPGLLNATRRDASQALTLGMGAAIQAHNIPPGMQDPKEARNN
EECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHH
TAMVQSAIDVLRQWDRILGALVIDPQRALEELNSDWTASQELADVLMRKYRLPFRVGHHF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ASEAVGYAKAKDIKPLDFPYAEARRIYAESVHGSEFPAQLPMDEAEFRATLDPVAIVRHR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHH
ATAGGPQPAEMARMLKAAQARVEQQSAWIAAQRARIGGSLARLDRDFDRLAPR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TIPRERPRKHPRMRTALHALACAAALCAGAAPAQPASPASPASAASAPSAAPVRPAPAP
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
PRDEFFWLGEINKASAVINIDQGLLDKSLAPLVHGGISKVLADGNRPGGKRPRLVITFEP
CCCCEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECC
LLIEAAGPQITLLHAGRSSQDMLSTVRAAMLRDQMLQLAEALNQTTATMVRLADRHQATV
EEEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VPNYTNGVAAQPNSYGHYLLGLASGLDRDAQRIREAYARIDRSPMGTTVLNGTSWPLDRQ
CCCCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHH
RMADYLGFSATVDNAYDAAQVSAVDQPVEAGAIVMAIALHAGSFIEDVMTQYAQPRPWIL
HHHHHHCCCCCCCCCHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
LQEGGGNTYVSSAMPQKRNPGLLNATRRDASQALTLGMGAAIQAHNIPPGMQDPKEARNN
EECCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHH
TAMVQSAIDVLRQWDRILGALVIDPQRALEELNSDWTASQELADVLMRKYRLPFRVGHHF
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHH
ASEAVGYAKAKDIKPLDFPYAEARRIYAESVHGSEFPAQLPMDEAEFRATLDPVAIVRHR
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCHHHHHHHH
ATAGGPQPAEMARMLKAAQARVEQQSAWIAAQRARIGGSLARLDRDFDRLAPR
HCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA