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The map label for this gene is argG [H]

Identifier: 120610536

GI number: 120610536

Start: 2011519

End: 2012862

Strand: Reverse

Name: argG [H]

Synonym: Aave_1856

Alternate gene names: 120610536

Gene position: 2012862-2011519 (Counterclockwise)

Preceding gene: 120610537

Following gene: 120610534

Centisome position: 37.6

GC content: 66.82

Gene sequence:

>1344_bases
ATGGCGACCATCCTCCAGAACCTCCCCGCCGGCCAGAAGGTCGGCATCGCCTTCTCCGGCGGCCTCGACACCAGCGCGGC
CCTGCGCTGGATGAAGAACAAGGGCGCCCTGCCTTACGCCTACACCGCCAACCTGGGCCAGCCCGACGAGCCCGACTACG
ACGCCATCCCGCGCAAGGCCATGGAATACGGCGCCGAGAAGGCCCGCCTGATCGACTGCCGCACGCAGCTGGCCCACGAA
GGTATCGCAGCCCTCCAGGCCGGCGCCTTCCACGTGCGCACCGCCGGCGCCACCTACTTCAACACCACGCCGCTGGGCCG
CGCCGTCACGGGCACGATGCTGGTGGCCGCCATGAAGGAAGACGACGTCCACATCTGGGGCGACGGCTCGACCTTCAAGG
GCAACGACATCGAGCGCTTCTACCGCTACGGCCTGCTGACCAACCCGTCGCTCAAGATCTACAAGCCTTGGCTGGATCAG
CTCTTCATCGACGAGCTGGGCGGCCGCGCCGAGATGTCGGCCTTCATGACGAAGGAAGGCTTCGGCTACAAGATGAGCGC
CGAGAAGGCCTACTCCACCGACTCCAACATGCTCGGCGCCACGCACGAGGCCAAGGACCTGGAGTTCCTGAACAGCGGCA
TGCGCATCGTGAACCCGATCATGGGCGTCGCGTTCTGGAAGGACGACGTGGTCGTCAAGGCCGAGGAAGTCTCGGTGCGC
TTCGAGGAAGGCCAGCCGGTGGCCCTGAACGGCGTCGAGTTCAACGACCCGGTGGAACTGTTCCTGGAAGCCAACCGCAT
CGGCGGCCGCCACGGCCTGGGGATGTGCGACCAGATCGAGAACCGCATCATCGAGGCCAAGAGCCGCGGCATCTACGAAG
CCCCCGGCCTGGCGCTGCTGCACATCGCCTACGAACGCCTGGTGAGCGGCATCCACAACGAGGACACGATCGAGCAGTAC
CGCATGAACGGCCTGAAGCTCGGCCGCCTGCTCTACCAGGGCCGCTGGTTCGACCCGCAGGCCATCATGCTGCGCGAGAC
CGCCCAGCGCTGGGTGGCCCGCGCCGTCACCGGCACCGTGACGCTCGAGCTGCGCCGCGGCAACGACTACTCCATCCTGA
ACACCGAATCGCCCAACCTGACCTACGCGCCGGAGCGCCTGTCGATGGAAAAAGTGGAAGACGCGCCGTTCAGCCCCGCC
GACCGCATCGGCCAGCTGACCATGCGCAACCTGGACATCGTGGACACGCGCGACAAGCTCGGCGTCTATGCGCAGGCGGG
CCTGCTGTCGCTGGGCGGCAATGCCGCGCTGGCGCAGCTGGGCGACGACAGCAGCCGCAAATAA

Upstream 100 bases:

>100_bases
GCGTGACCGAGGCCTACCACTACATCTGCCACTTCGGCTGATCCACGGCCGAGACCGCTCCACTGCCGCACCGACGCACC
CGACACGACCCGAGATTTCC

Downstream 100 bases:

>100_bases
GGCCGCGGCCCTGCCGTCCGCGGCAGGCACGCTCCCGGAGAAACCGCTCCGCCGCAAGGCCGGGCGGTTTTTTCACGTCC
GGCGGCCCGGACCTCGCGGC

Product: argininosuccinate synthase

Products: NA

Alternate protein names: Citrulline--aspartate ligase [H]

Number of amino acids: Translated: 447; Mature: 446

Protein sequence:

>447_residues
MATILQNLPAGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEPDYDAIPRKAMEYGAEKARLIDCRTQLAHE
GIAALQAGAFHVRTAGATYFNTTPLGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPSLKIYKPWLDQ
LFIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEFLNSGMRIVNPIMGVAFWKDDVVVKAEEVSVR
FEEGQPVALNGVEFNDPVELFLEANRIGGRHGLGMCDQIENRIIEAKSRGIYEAPGLALLHIAYERLVSGIHNEDTIEQY
RMNGLKLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPA
DRIGQLTMRNLDIVDTRDKLGVYAQAGLLSLGGNAALAQLGDDSSRK

Sequences:

>Translated_447_residues
MATILQNLPAGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEPDYDAIPRKAMEYGAEKARLIDCRTQLAHE
GIAALQAGAFHVRTAGATYFNTTPLGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPSLKIYKPWLDQ
LFIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEFLNSGMRIVNPIMGVAFWKDDVVVKAEEVSVR
FEEGQPVALNGVEFNDPVELFLEANRIGGRHGLGMCDQIENRIIEAKSRGIYEAPGLALLHIAYERLVSGIHNEDTIEQY
RMNGLKLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPA
DRIGQLTMRNLDIVDTRDKLGVYAQAGLLSLGGNAALAQLGDDSSRK
>Mature_446_residues
ATILQNLPAGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEPDYDAIPRKAMEYGAEKARLIDCRTQLAHEG
IAALQAGAFHVRTAGATYFNTTPLGRAVTGTMLVAAMKEDDVHIWGDGSTFKGNDIERFYRYGLLTNPSLKIYKPWLDQL
FIDELGGRAEMSAFMTKEGFGYKMSAEKAYSTDSNMLGATHEAKDLEFLNSGMRIVNPIMGVAFWKDDVVVKAEEVSVRF
EEGQPVALNGVEFNDPVELFLEANRIGGRHGLGMCDQIENRIIEAKSRGIYEAPGLALLHIAYERLVSGIHNEDTIEQYR
MNGLKLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTVTLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPAD
RIGQLTMRNLDIVDTRDKLGVYAQAGLLSLGGNAALAQLGDDSSRK

Specific function: Arginine biosynthesis; seventh step. [C]

COG id: COG0137

COG function: function code E; Argininosuccinate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the argininosuccinate synthase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI53759107, Length=412, Percent_Identity=29.3689320388349, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI16950633, Length=412, Percent_Identity=29.3689320388349, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789563, Length=440, Percent_Identity=77.5, Blast_Score=708, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324514, Length=418, Percent_Identity=28.9473684210526, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21358151, Length=425, Percent_Identity=27.7647058823529, Blast_Score=153, Evalue=3e-37,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001518
- InterPro:   IPR018223
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00764 Arginosuc_synth [H]

EC number: =6.3.4.5 [H]

Molecular weight: Translated: 49376; Mature: 49245

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS00564 ARGININOSUCCIN_SYN_1 ; PS00565 ARGININOSUCCIN_SYN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATILQNLPAGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEPDYDAIPRKA
CCCHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHH
MEYGAEKARLIDCRTQLAHEGIAALQAGAFHVRTAGATYFNTTPLGRAVTGTMLVAAMKE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCHHHHHHHEEEEECC
DDVHIWGDGSTFKGNDIERFYRYGLLTNPSLKIYKPWLDQLFIDELGGRAEMSAFMTKEG
CCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCC
FGYKMSAEKAYSTDSNMLGATHEAKDLEFLNSGMRIVNPIMGVAFWKDDVVVKAEEVSVR
CCEEECCCHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHEEECCCEEEEEEEEEEE
FEEGQPVALNGVEFNDPVELFLEANRIGGRHGLGMCDQIENRIIEAKSRGIYEAPGLALL
EECCCEEEECCCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHH
HIAYERLVSGIHNEDTIEQYRMNGLKLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTV
HHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEE
TLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPADRIGQLTMRNLDIVDTRDKL
EEEEECCCCEEEEECCCCCCEECHHHCCHHHHCCCCCCCHHHHHHHHHCCCEEEECHHHC
GVYAQAGLLSLGGNAALAQLGDDSSRK
CEEEECCEEEECCCEEEEECCCCCCCC
>Mature Secondary Structure 
ATILQNLPAGQKVGIAFSGGLDTSAALRWMKNKGALPYAYTANLGQPDEPDYDAIPRKA
CCHHHHCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCHHH
MEYGAEKARLIDCRTQLAHEGIAALQAGAFHVRTAGATYFNTTPLGRAVTGTMLVAAMKE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCHHHHHHHEEEEECC
DDVHIWGDGSTFKGNDIERFYRYGLLTNPSLKIYKPWLDQLFIDELGGRAEMSAFMTKEG
CCEEEEECCCCCCCCCHHHHHHHCCCCCCCCEEEHHHHHHHHHHHCCCHHHHHHHHHCCC
FGYKMSAEKAYSTDSNMLGATHEAKDLEFLNSGMRIVNPIMGVAFWKDDVVVKAEEVSVR
CCEEECCCHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHEEECCCEEEEEEEEEEE
FEEGQPVALNGVEFNDPVELFLEANRIGGRHGLGMCDQIENRIIEAKSRGIYEAPGLALL
EECCCEEEECCCCCCCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHH
HIAYERLVSGIHNEDTIEQYRMNGLKLGRLLYQGRWFDPQAIMLRETAQRWVARAVTGTV
HHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEE
TLELRRGNDYSILNTESPNLTYAPERLSMEKVEDAPFSPADRIGQLTMRNLDIVDTRDKL
EEEEECCCCEEEEECCCCCCEECHHHCCHHHHCCCCCCCHHHHHHHHHCCCEEEECHHHC
GVYAQAGLLSLGGNAALAQLGDDSSRK
CEEEECCEEEECCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA