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The map label for this gene is acsA [H]

Identifier: 120610185

GI number: 120610185

Start: 1663925

End: 1665919

Strand: Direct

Name: acsA [H]

Synonym: Aave_1499

Alternate gene names: 120610185

Gene position: 1663925-1665919 (Clockwise)

Preceding gene: 120610177

Following gene: 120610186

Centisome position: 31.09

GC content: 68.32

Gene sequence:

>1995_bases
ATGAGTGCGTCATCGTCCACGATCGAATCCGTGCTGGTGGAAAACCGCGTGTTCCCCCCGCCCGCCGCCTGCGAGCAAGC
CGCCCGCGTGTCCGGCATGGCCGGCTACGAGGCCCTGTGCTCCGAGGCCGAGCGTGATTTCGAGGGCTTCTGGGCGCGCC
TGGCGCGCGAGAACGTGCAGTGGACCAGGCCCTTCACCCGCACGCTCGACGAGTCCAACGCCCCGTTCTTCCAGTGGTTC
GCCGACGGCGAGCTGAACGCCAGCGCCAACTGCCTGGACCGCCACATCGGCACGCCGGTCGAGAACAAGACCGCGATCGT
CTTCGAGGCCGACGACGGGGCCGTGACGAAGGTCACCTACAGGGAACTGCTGGAGCGCGTGGGCCGCTTCGCCAACGCCC
TCCAGGCCGAGGGCGTGAAGAAGGGCGACCGCGTGCTGATCTACATGCCCATGACCATCGAGGGCGTGGTGGCCATGCAG
GCCTGCGCGCGCATCGGCGCCACCCACAGCGTGGTGTTCGGCGGCTTCTCGGCCAAGGCGCTGCAGGAGCGCATCATCGA
CGCGGGCGCGGTGGCCGTGATCACCGCCAACTACCAGATGCGCGGCGGCAAGGAGTTGCCGCTGAAGGCCATCGTGGACG
AAGGCATCGCCATGGGCGGCTGCGAGTCGATCCGCAGCATCCTCGTCTTCCAGCGCACGCCCACGGCCTGCAACATGGTG
GCGGGCCGCGACAAGACCTTCGATGAAGCGCTGGCCGGCCAGGGGGCCGAGTGCGCCCCCGTGCCCGTGGGCGCGGAGCA
CCCGCTCTTCATCCTCTACACCAGCGGTTCGACCGGCAAGCCCAAGGGCGTGCAGCATTCCACCGGCGGCTACCTGCTGT
GGGCCAGGCTCACGATGGACTGGACTTTCGACCTCAAGCCCGAGGACGTGTTCTGGTGCACGGCCGACATCGGCTGGATC
ACCGGCCACACCTACGTGGCGTACGGCCCGCTCGCCGCCGGCGCCACGCAGGTCGTGTTCGAGGGCGTGCCCACCTACCC
GGACGCCGGCCGCTTCTGGCAGATGATCGAGCGCCACAAGGTCTCGATCTTCTACACCGCGCCCACGGCCATCCGCTCCC
TCATCAAGGCGGCCGATTCGGACGAGAAGGTGCATCCGAAGAACTGGGACCTCTCGAGCCTGCGCATCCTGGGCAGCGTG
GGCGAACCCATCAATCCGGAGGCCTGGATGTGGTACCACCGGAACGTGGGCGGCGAGCGCTGCCCCATCGTGGACACCTT
CTGGCAGACCGAAACCGGCGGCCATGTCATCACCCCGCTGCCGGGTGCCACGCCGCTGGTGCCGGGCTCCTGCACGCTGC
CGCTGCCCGGCATCACCGCCGCCATCGTCGATGAATCCGGCAACGACATCCCCAACGGCACGGGCGGGATCCTGGTCATC
AAGCGCCCCTGGCCCAGCATGATCCGCACCATCTGGAACGATCCGGAGCGCTTCAAGAAGAGCTACTTCCCCGAAGAGCT
CAAGGGCTACTACCTGGCGGGCGACGGCGCGGTGCGCTCGGCCGACCGTGGCTACTTCCGCATCACCGGCCGCATCGACG
ACGTGCTGAACGTCTCGGGCCACCGCATGGGCACGATGGAGATCGAATCGGCCCTGGTCGCCAAGACCGACCTCGTGGCC
GAGGCCGCCGTGGTGGGCCGCCCCGACGACCTGACCGGCGAGGCCATCTGCGCCTTCGTCGTCTTGAAGCGACCGCGCCC
CACCGGCGACGAGGCCAAAGCGATCGCCAAGGAACTGCGCGACTGGGTGGCCAGGGAGATCGGCCCGATCGCCAAGCCGA
AGGACATCCGCTTCGGCGACAACCTGCCCAAGACCCGCAGCGGCAAGATCATGCGCCGCCTGCTGCGCTCCATCGCCAAG
GGGGAGGCGATCACGCAGGACACCAGCACGCTTGAGAATCCGGCGATCCTGGATCAGCTGGCCCAGGCCAACTGA

Upstream 100 bases:

>100_bases
GGGCTGCGGCCGCATGCGGGCATGCGTCAGTGGCATGTAAGTGGGCCCCCTGAAAGTACGGCGAAAACCTGTTCCAACGA
TTCCCAGGAGACACAAGCAA

Downstream 100 bases:

>100_bases
TCCGGGGACTGGCGCATCCTGTAGGACGGAATCTGTTTCGCCGGCCCCGCGCCGGCGGGACGGCCATGGCCGGGTTACAA
CCGGGTGCCAACGCCGCCGC

Product: acetyl-coenzyme A synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 664; Mature: 663

Protein sequence:

>664_residues
MSASSSTIESVLVENRVFPPPAACEQAARVSGMAGYEALCSEAERDFEGFWARLARENVQWTRPFTRTLDESNAPFFQWF
ADGELNASANCLDRHIGTPVENKTAIVFEADDGAVTKVTYRELLERVGRFANALQAEGVKKGDRVLIYMPMTIEGVVAMQ
ACARIGATHSVVFGGFSAKALQERIIDAGAVAVITANYQMRGGKELPLKAIVDEGIAMGGCESIRSILVFQRTPTACNMV
AGRDKTFDEALAGQGAECAPVPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWARLTMDWTFDLKPEDVFWCTADIGWI
TGHTYVAYGPLAAGATQVVFEGVPTYPDAGRFWQMIERHKVSIFYTAPTAIRSLIKAADSDEKVHPKNWDLSSLRILGSV
GEPINPEAWMWYHRNVGGERCPIVDTFWQTETGGHVITPLPGATPLVPGSCTLPLPGITAAIVDESGNDIPNGTGGILVI
KRPWPSMIRTIWNDPERFKKSYFPEELKGYYLAGDGAVRSADRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLVA
EAAVVGRPDDLTGEAICAFVVLKRPRPTGDEAKAIAKELRDWVAREIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAK
GEAITQDTSTLENPAILDQLAQAN

Sequences:

>Translated_664_residues
MSASSSTIESVLVENRVFPPPAACEQAARVSGMAGYEALCSEAERDFEGFWARLARENVQWTRPFTRTLDESNAPFFQWF
ADGELNASANCLDRHIGTPVENKTAIVFEADDGAVTKVTYRELLERVGRFANALQAEGVKKGDRVLIYMPMTIEGVVAMQ
ACARIGATHSVVFGGFSAKALQERIIDAGAVAVITANYQMRGGKELPLKAIVDEGIAMGGCESIRSILVFQRTPTACNMV
AGRDKTFDEALAGQGAECAPVPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWARLTMDWTFDLKPEDVFWCTADIGWI
TGHTYVAYGPLAAGATQVVFEGVPTYPDAGRFWQMIERHKVSIFYTAPTAIRSLIKAADSDEKVHPKNWDLSSLRILGSV
GEPINPEAWMWYHRNVGGERCPIVDTFWQTETGGHVITPLPGATPLVPGSCTLPLPGITAAIVDESGNDIPNGTGGILVI
KRPWPSMIRTIWNDPERFKKSYFPEELKGYYLAGDGAVRSADRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLVA
EAAVVGRPDDLTGEAICAFVVLKRPRPTGDEAKAIAKELRDWVAREIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAK
GEAITQDTSTLENPAILDQLAQAN
>Mature_663_residues
SASSSTIESVLVENRVFPPPAACEQAARVSGMAGYEALCSEAERDFEGFWARLARENVQWTRPFTRTLDESNAPFFQWFA
DGELNASANCLDRHIGTPVENKTAIVFEADDGAVTKVTYRELLERVGRFANALQAEGVKKGDRVLIYMPMTIEGVVAMQA
CARIGATHSVVFGGFSAKALQERIIDAGAVAVITANYQMRGGKELPLKAIVDEGIAMGGCESIRSILVFQRTPTACNMVA
GRDKTFDEALAGQGAECAPVPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWARLTMDWTFDLKPEDVFWCTADIGWIT
GHTYVAYGPLAAGATQVVFEGVPTYPDAGRFWQMIERHKVSIFYTAPTAIRSLIKAADSDEKVHPKNWDLSSLRILGSVG
EPINPEAWMWYHRNVGGERCPIVDTFWQTETGGHVITPLPGATPLVPGSCTLPLPGITAAIVDESGNDIPNGTGGILVIK
RPWPSMIRTIWNDPERFKKSYFPEELKGYYLAGDGAVRSADRGYFRITGRIDDVLNVSGHRMGTMEIESALVAKTDLVAE
AAVVGRPDDLTGEAICAFVVLKRPRPTGDEAKAIAKELRDWVAREIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKG
EAITQDTSTLENPAILDQLAQAN

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=679, Percent_Identity=46.5390279823269, Blast_Score=571, Evalue=1e-163,
Organism=Homo sapiens, GI253970489, Length=692, Percent_Identity=45.6647398843931, Blast_Score=568, Evalue=1e-162,
Organism=Homo sapiens, GI28416953, Length=631, Percent_Identity=47.70206022187, Blast_Score=560, Evalue=1e-159,
Organism=Homo sapiens, GI13375727, Length=651, Percent_Identity=37.173579109063, Blast_Score=395, Evalue=1e-110,
Organism=Homo sapiens, GI38505220, Length=537, Percent_Identity=29.9813780260708, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI42544132, Length=534, Percent_Identity=29.4007490636704, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI122937307, Length=599, Percent_Identity=28.5475792988314, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI31982927, Length=655, Percent_Identity=25.4961832061069, Blast_Score=174, Evalue=3e-43,
Organism=Homo sapiens, GI58082049, Length=526, Percent_Identity=28.7072243346008, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI115511026, Length=594, Percent_Identity=27.1043771043771, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI157311624, Length=526, Percent_Identity=27.9467680608365, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI157311622, Length=526, Percent_Identity=27.9467680608365, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI187761345, Length=406, Percent_Identity=27.0935960591133, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI187761343, Length=406, Percent_Identity=27.0935960591133, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI156151445, Length=587, Percent_Identity=23.1686541737649, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790505, Length=634, Percent_Identity=50.3154574132492, Blast_Score=609, Evalue=1e-175,
Organism=Escherichia coli, GI1786529, Length=624, Percent_Identity=38.7820512820513, Blast_Score=405, Evalue=1e-114,
Organism=Escherichia coli, GI1788107, Length=575, Percent_Identity=26.0869565217391, Blast_Score=115, Evalue=1e-26,
Organism=Escherichia coli, GI145693145, Length=542, Percent_Identity=24.169741697417, Blast_Score=114, Evalue=3e-26,
Organism=Escherichia coli, GI1786810, Length=529, Percent_Identity=22.117202268431, Blast_Score=93, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71982997, Length=667, Percent_Identity=42.2788605697151, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI71983001, Length=664, Percent_Identity=42.4698795180723, Blast_Score=482, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17569507, Length=645, Percent_Identity=24.8062015503876, Blast_Score=143, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17560308, Length=566, Percent_Identity=26.678445229682, Blast_Score=92, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI71994703, Length=592, Percent_Identity=24.3243243243243, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994690, Length=592, Percent_Identity=24.3243243243243, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI71994694, Length=592, Percent_Identity=24.3243243243243, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI71985884, Length=589, Percent_Identity=23.7691001697793, Blast_Score=88, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17531443, Length=386, Percent_Identity=26.6839378238342, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=654, Percent_Identity=48.3180428134557, Blast_Score=578, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6319264, Length=659, Percent_Identity=47.1927162367223, Blast_Score=561, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319699, Length=554, Percent_Identity=23.1046931407942, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667955, Length=673, Percent_Identity=46.2109955423477, Blast_Score=568, Evalue=1e-162,
Organism=Drosophila melanogaster, GI62472339, Length=560, Percent_Identity=51.0714285714286, Blast_Score=538, Evalue=1e-153,
Organism=Drosophila melanogaster, GI24667959, Length=529, Percent_Identity=50.2835538752363, Blast_Score=496, Evalue=1e-140,
Organism=Drosophila melanogaster, GI21355225, Length=656, Percent_Identity=33.3841463414634, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI21355181, Length=532, Percent_Identity=24.2481203007519, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24648260, Length=411, Percent_Identity=25.7907542579075, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24656500, Length=542, Percent_Identity=23.8007380073801, Blast_Score=83, Evalue=8e-16,
Organism=Drosophila melanogaster, GI18859661, Length=395, Percent_Identity=26.3291139240506, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24581924, Length=537, Percent_Identity=24.2085661080074, Blast_Score=76, Evalue=9e-14,
Organism=Drosophila melanogaster, GI21356947, Length=391, Percent_Identity=24.5524296675192, Blast_Score=70, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72336; Mature: 72205

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASSSTIESVLVENRVFPPPAACEQAARVSGMAGYEALCSEAERDFEGFWARLARENVQ
CCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
WTRPFTRTLDESNAPFFQWFADGELNASANCLDRHIGTPVENKTAIVFEADDGAVTKVTY
CCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCEEHHHH
RELLERVGRFANALQAEGVKKGDRVLIYMPMTIEGVVAMQACARIGATHSVVFGGFSAKA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
LQERIIDAGAVAVITANYQMRGGKELPLKAIVDEGIAMGGCESIRSILVFQRTPTACNMV
HHHHHHCCCEEEEEEECEEECCCCCCCHHHHHHCCCCCCCHHHHHHHEEECCCCCHHHHC
AGRDKTFDEALAGQGAECAPVPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWARLTMD
CCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDLKPEDVFWCTADIGWITGHTYVAYGPLAAGATQVVFEGVPTYPDAGRFWQMIERHK
EEECCCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCC
VSIFYTAPTAIRSLIKAADSDEKVHPKNWDLSSLRILGSVGEPINPEAWMWYHRNVGGER
EEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
CPIVDTFWQTETGGHVITPLPGATPLVPGSCTLPLPGITAAIVDESGNDIPNGTGGILVI
CCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEE
KRPWPSMIRTIWNDPERFKKSYFPEELKGYYLAGDGAVRSADRGYFRITGRIDDVLNVSG
ECCCHHHHHHHCCCHHHHHHHCCCHHHCCEEEECCCCCCCCCCCEEEEECCCCHHHCCCC
HRMGTMEIESALVAKTDLVAEAAVVGRPDDLTGEAICAFVVLKRPRPTGDEAKAIAKELR
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEEECCCCCCHHHHHHHHHHH
DWVAREIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEAITQDTSTLENPAILDQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHH
AQAN
HHCC
>Mature Secondary Structure 
SASSSTIESVLVENRVFPPPAACEQAARVSGMAGYEALCSEAERDFEGFWARLARENVQ
CCCHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
WTRPFTRTLDESNAPFFQWFADGELNASANCLDRHIGTPVENKTAIVFEADDGAVTKVTY
CCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCEEHHHH
RELLERVGRFANALQAEGVKKGDRVLIYMPMTIEGVVAMQACARIGATHSVVFGGFSAKA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHH
LQERIIDAGAVAVITANYQMRGGKELPLKAIVDEGIAMGGCESIRSILVFQRTPTACNMV
HHHHHHCCCEEEEEEECEEECCCCCCCHHHHHHCCCCCCCHHHHHHHEEECCCCCHHHHC
AGRDKTFDEALAGQGAECAPVPVGAEHPLFILYTSGSTGKPKGVQHSTGGYLLWARLTMD
CCCCCCHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEECCCCEEEEEEEEEE
WTFDLKPEDVFWCTADIGWITGHTYVAYGPLAAGATQVVFEGVPTYPDAGRFWQMIERHK
EEECCCCCCEEEEECCCCEEECCCEEEECCCCCCCHHHHCCCCCCCCCCHHHHHHHHHCC
VSIFYTAPTAIRSLIKAADSDEKVHPKNWDLSSLRILGSVGEPINPEAWMWYHRNVGGER
EEEEEECHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEECCCCCCC
CPIVDTFWQTETGGHVITPLPGATPLVPGSCTLPLPGITAAIVDESGNDIPNGTGGILVI
CCEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEE
KRPWPSMIRTIWNDPERFKKSYFPEELKGYYLAGDGAVRSADRGYFRITGRIDDVLNVSG
ECCCHHHHHHHCCCHHHHHHHCCCHHHCCEEEECCCCCCCCCCCEEEEECCCCHHHCCCC
HRMGTMEIESALVAKTDLVAEAAVVGRPDDLTGEAICAFVVLKRPRPTGDEAKAIAKELR
CEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHEEEEEEEECCCCCCHHHHHHHHHHH
DWVAREIGPIAKPKDIRFGDNLPKTRSGKIMRRLLRSIAKGEAITQDTSTLENPAILDQL
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHCCCHHHHHHH
AQAN
HHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA