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The map label for this gene is fumC [H]

Identifier: 120610177

GI number: 120610177

Start: 1653683

End: 1655068

Strand: Direct

Name: fumC [H]

Synonym: Aave_1491

Alternate gene names: 120610177

Gene position: 1653683-1655068 (Clockwise)

Preceding gene: 120610171

Following gene: 120610185

Centisome position: 30.89

GC content: 68.76

Gene sequence:

>1386_bases
ATGACCACCCGTACGGAACGCGATACTTTCGGCCCCATCGAGGTCCCGGCCCACCGGCTCTGGGGCGCGCAGACGCAGCG
CTCGCTGCAGAACTTCGACATCTCCGGCGAGCGCCAGCCGCGCGAGATCCTCCATGCCCTGGCCCTGGTCAAGCGTGCCT
CGGCCAGCGTGAACCACGCCCTGGGCCTGCAGGACGCCAGGAAGACCGAGGCCATCATCGCCGCGGCCGACGAGGTGGCC
GCCGGCCGGCATCCGGACGAGTTCCCGCTCGTCGTCTGGCAGACCGGCTCGGGCACGCAGACCAACATGAACATGAACGA
GGTGCTGGCCAACCGGGCGAGCGAAATCCTCGGCGGCGAGCGCGGCGAGGGCCGGGCGGTCCATCCCAACGACGACGTGA
ACCGCAGCCAGTCCAGCAACGACGTGTTCCCCACGGCCATGCACGTGGCGGCCGTGGAGGCGCTCACCCACCGACTGCTG
CCCGCCATCGCGAAGCTGCGCGCCACCCTGGAGAAGAAGGCGGCGGAGTTCGACGGTATCGTGAAGATCGGGCGCACGCA
CCTGCAGGACGCGACCCCTCTCACGCTCGGCCAGGAAATCTCCGGCTGGGTGGCCCAGTTGGCGCACGGCGAAAAGCACG
TGTGCGACGCGCTGCCCCATCTCTGCGAACTGGCGCTGGGCGGCACCGCCGTGGGCACTGGGCTGAATGCGCCCAGGGGC
TACGCCGAGGGCGTGGCGAAGGAACTGGCCCGGCTGACGGGGCTGCCTTTCGTCACCTCGCCCAACAAGTTCGAGTCGCT
CGCCTCGTGCGACGCGCTGGTGCATGCCCATGGCGCGCTCAAGACGCTGGCGGCCAGCATGATGAAGATCGCCAACGACG
TGCGCTGGCTGGCGAGCGGCCCGCGCAGCGGCATCGGGGAGATCACGATTCCCGAGAACGAACCGGGCTCGTCGATCATG
CCCGGCAAGGTGAACCCCACGCAAAGCGAGGCCGTCACCATGCTGGCGGCGCAGGTCTTCGGCAACGACGTGGCCATCAA
CATCGGCGGCGCCTCCGGCAATTTCGAGCTGAACGTGTTCCGCCCGATGGTGGCCCACAACTTCCTGCAGAGCGTGCGCC
TGCTCGCCGACGGCATGGTGAGCTTCAACGACCACTGCGCCGTGGGCATCGAGCCCAACCGCGAGCGCATCGGCGAGCTG
GTGGAGCGTTCCCTGATGCTGGTGACGGCGCTCAATACCCACATCGGCTACGACAAGGCGGCCTTCATCGCCAAGAAGGC
CCACAAGGAAGGCACCTCGCTGCGCGAGGCGGCCGTGGCGTCGGGCCACGTGACGGGCGAGCAGTTCGACCAGTGGGTGG
TGCCCGGCAACATGGTGGGCCGCTGA

Upstream 100 bases:

>100_bases
TCGCCAGCGCGGCCCCGAAGAGAACGCGCCAGCCGTTGCCGGGGCGCATCCGCAGGGCATGCACCAGTCGTCACACCTTC
CATCCAGCGGAAATTCATCC

Downstream 100 bases:

>100_bases
CGCGGCAGCCGCTCAGGCCGCCGCCTTGCGGCGGGCGCGCCGGGCCGGCAGGGCAGGCCCGGCGGCGCGGGCTTTTCTTT
CGGCGCGCGCCCGGGCACGG

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTTRTERDTFGPIEVPAHRLWGAQTQRSLQNFDISGERQPREILHALALVKRASASVNHALGLQDARKTEAIIAAADEVA
AGRHPDEFPLVVWQTGSGTQTNMNMNEVLANRASEILGGERGEGRAVHPNDDVNRSQSSNDVFPTAMHVAAVEALTHRLL
PAIAKLRATLEKKAAEFDGIVKIGRTHLQDATPLTLGQEISGWVAQLAHGEKHVCDALPHLCELALGGTAVGTGLNAPRG
YAEGVAKELARLTGLPFVTSPNKFESLASCDALVHAHGALKTLAASMMKIANDVRWLASGPRSGIGEITIPENEPGSSIM
PGKVNPTQSEAVTMLAAQVFGNDVAINIGGASGNFELNVFRPMVAHNFLQSVRLLADGMVSFNDHCAVGIEPNRERIGEL
VERSLMLVTALNTHIGYDKAAFIAKKAHKEGTSLREAAVASGHVTGEQFDQWVVPGNMVGR

Sequences:

>Translated_461_residues
MTTRTERDTFGPIEVPAHRLWGAQTQRSLQNFDISGERQPREILHALALVKRASASVNHALGLQDARKTEAIIAAADEVA
AGRHPDEFPLVVWQTGSGTQTNMNMNEVLANRASEILGGERGEGRAVHPNDDVNRSQSSNDVFPTAMHVAAVEALTHRLL
PAIAKLRATLEKKAAEFDGIVKIGRTHLQDATPLTLGQEISGWVAQLAHGEKHVCDALPHLCELALGGTAVGTGLNAPRG
YAEGVAKELARLTGLPFVTSPNKFESLASCDALVHAHGALKTLAASMMKIANDVRWLASGPRSGIGEITIPENEPGSSIM
PGKVNPTQSEAVTMLAAQVFGNDVAINIGGASGNFELNVFRPMVAHNFLQSVRLLADGMVSFNDHCAVGIEPNRERIGEL
VERSLMLVTALNTHIGYDKAAFIAKKAHKEGTSLREAAVASGHVTGEQFDQWVVPGNMVGR
>Mature_460_residues
TTRTERDTFGPIEVPAHRLWGAQTQRSLQNFDISGERQPREILHALALVKRASASVNHALGLQDARKTEAIIAAADEVAA
GRHPDEFPLVVWQTGSGTQTNMNMNEVLANRASEILGGERGEGRAVHPNDDVNRSQSSNDVFPTAMHVAAVEALTHRLLP
AIAKLRATLEKKAAEFDGIVKIGRTHLQDATPLTLGQEISGWVAQLAHGEKHVCDALPHLCELALGGTAVGTGLNAPRGY
AEGVAKELARLTGLPFVTSPNKFESLASCDALVHAHGALKTLAASMMKIANDVRWLASGPRSGIGEITIPENEPGSSIMP
GKVNPTQSEAVTMLAAQVFGNDVAINIGGASGNFELNVFRPMVAHNFLQSVRLLADGMVSFNDHCAVGIEPNRERIGELV
ERSLMLVTALNTHIGYDKAAFIAKKAHKEGTSLREAAVASGHVTGEQFDQWVVPGNMVGR

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=459, Percent_Identity=61.0021786492375, Blast_Score=558, Evalue=1e-159,
Organism=Homo sapiens, GI266458395, Length=77, Percent_Identity=48.0519480519481, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1787896, Length=459, Percent_Identity=73.202614379085, Blast_Score=677, Evalue=0.0,
Organism=Escherichia coli, GI87082375, Length=459, Percent_Identity=40.3050108932462, Blast_Score=335, Evalue=3e-93,
Organism=Caenorhabditis elegans, GI17553882, Length=459, Percent_Identity=61.6557734204793, Blast_Score=576, Evalue=1e-164,
Organism=Caenorhabditis elegans, GI32565146, Length=325, Percent_Identity=63.3846153846154, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6324993, Length=459, Percent_Identity=56.8627450980392, Blast_Score=531, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24640179, Length=460, Percent_Identity=58.0434782608696, Blast_Score=560, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24640177, Length=460, Percent_Identity=58.0434782608696, Blast_Score=559, Evalue=1e-159,
Organism=Drosophila melanogaster, GI78710009, Length=461, Percent_Identity=57.9175704989154, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI24662684, Length=462, Percent_Identity=57.7922077922078, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI24583245, Length=462, Percent_Identity=51.5151515151515, Blast_Score=478, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 49242; Mature: 49111

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRTERDTFGPIEVPAHRLWGAQTQRSLQNFDISGERQPREILHALALVKRASASVNHA
CCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGLQDARKTEAIIAAADEVAAGRHPDEFPLVVWQTGSGTQTNMNMNEVLANRASEILGGE
HCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
RGEGRAVHPNDDVNRSQSSNDVFPTAMHVAAVEALTHRLLPAIAKLRATLEKKAAEFDGI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEISGWVAQLAHGEKHVCDALPHLCELALGGTAVGTGLNAPRG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
YAEGVAKELARLTGLPFVTSPNKFESLASCDALVHAHGALKTLAASMMKIANDVRWLASG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRSGIGEITIPENEPGSSIMPGKVNPTQSEAVTMLAAQVFGNDVAINIGGASGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEH
RPMVAHNFLQSVRLLADGMVSFNDHCAVGIEPNRERIGELVERSLMLVTALNTHIGYDKA
HHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
AFIAKKAHKEGTSLREAAVASGHVTGEQFDQWVVPGNMVGR
HHHHHHHHHCCCHHHHHHHHCCCCCHHHHHCEECCCCCCCC
>Mature Secondary Structure 
TTRTERDTFGPIEVPAHRLWGAQTQRSLQNFDISGERQPREILHALALVKRASASVNHA
CCCCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LGLQDARKTEAIIAAADEVAAGRHPDEFPLVVWQTGSGTQTNMNMNEVLANRASEILGGE
HCCCHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCC
RGEGRAVHPNDDVNRSQSSNDVFPTAMHVAAVEALTHRLLPAIAKLRATLEKKAAEFDGI
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKIGRTHLQDATPLTLGQEISGWVAQLAHGEKHVCDALPHLCELALGGTAVGTGLNAPRG
HHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
YAEGVAKELARLTGLPFVTSPNKFESLASCDALVHAHGALKTLAASMMKIANDVRWLASG
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PRSGIGEITIPENEPGSSIMPGKVNPTQSEAVTMLAAQVFGNDVAINIGGASGNFELNVF
CCCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEH
RPMVAHNFLQSVRLLADGMVSFNDHCAVGIEPNRERIGELVERSLMLVTALNTHIGYDKA
HHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
AFIAKKAHKEGTSLREAAVASGHVTGEQFDQWVVPGNMVGR
HHHHHHHHHCCCHHHHHHHHCCCCCHHHHHCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]