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The map label for this gene is yegE [H]

Identifier: 120609500

GI number: 120609500

Start: 870515

End: 871906

Strand: Reverse

Name: yegE [H]

Synonym: Aave_0806

Alternate gene names: 120609500

Gene position: 871906-870515 (Counterclockwise)

Preceding gene: 120609524

Following gene: 120609497

Centisome position: 16.29

GC content: 70.69

Gene sequence:

>1392_bases
ATGGATTTCGAACTGACCGCCACGCTCCTGGATTCGCTGGGCATCGCCATGTGCGTGTTCGATGCCGAGGAGCGTACCGT
TGTGTGGAATGCCTCGTTTCTCCGCTTCTTCCCGGAGCACGAAGGCCACGTGCATGCCGGCGAACCCTATGCCGACAACC
TGCGGCGCTTCTACCAGGGCCGCCTGCCGCCCGAAGACCTGCCCCATATCGACCGCTTCATCGCCGATGGGCTGATGCGC
AACCGCCTGCAGACGCGCCCCTACGTCTTCCAGCACCTGGGACGCTGGCTGCGCGTGGCCGCGGTGCCGGTGCAGGGCGG
CCACCGCATCCGCGTCTGGCAGCACGTGGCGCACACGGACGGCGACCCCGGCGTGCCGGCCGCGGAAATCCAGCCGGTGC
TGCCGGCCTCGGGCACCCGGCAGATGCTGGAAGACCTGGGCGAAGCCGCGGCCGTGCTGGACGACGAAGGGCGCATCCTG
TATGCCAACGACCTGTTCGTGACGATGCACGGGCTTGCCTCCAGGGAAGCGCTGGCGCAGCGCACCTATGTGCAGATCGT
CCGGCAGCTCTGGGATGCATCGCCCGATGCCCACGAGCGCCTGCGGCGGGCCCAGGACGTGGCCGCGGCCCTGCACGATG
CCGCCTTCTTCGAGGGCGCCCCCTTCGAGGTCCCCCTGCCCGGCGGCCGCTGGATGCGCGTGACCATGAACCGCAGCGCC
GGCGGGCAGAACTACGCGCTGCACACGGACATCTCCGCAGTGAAGCGCAACGAAAGCGAACTGCGCGCGGCCGAGCTGCG
CGCGCGTGAAAGCGAGGAGCAACTGCGCGTGCTGGCCGAGCAACTGCGCACCGAAACGCACCACGATGTGCTGACCGGCC
TGCCCAACCGCCGCACGCTCGGAGCGAAGGTCCAGGAACTCTCCGCCCAGCCCGGCTCGCACGCGCTGCTGTTCATCGAC
CTGGACGGATTCAAGGCCGTGAACGACGAGGCCGGCCATGCGGCCGGCGACGACGTGCTCTGCCAGGTGGCGGACCGGCT
GCGCCGGTGCGTGCGCGGAGACGACGTGCTCGTGCGGCTGGGCGGCGACGAGTTCGTGGTGCTTCTGCGGCACTGCGACC
GGCAGAAGGCCCTGGGCACCGGCCTGCAGATCGTCGATACCCTGCGCGGCGAGCCGTTCCACTCGGCGGGACGCGCCTTC
CGGATCGGCGCGAGCGTCGGCGTGCGGCTTTTCGGGACCGCGCAGGAGCCCGTGGAAAAGCTCATGGCCGATGCGGACGC
GGCCTGCTACGCCGCCAAGCGCGGCGGCCGCGGGCGCGTCGAGATGGCCGGCGCAGGCAGCGGCCCGCAGGCGCCCGTCA
CGCTGCCTTGCGCATCACCGCCAGGCCCTTGA

Upstream 100 bases:

>100_bases
CTTTTCCCCGGTTGGCGCGCGGGGAAATGCGCTACATTGATTTTCCGGATTTTTGTCCCGACAGCCCTTCCGAGCCGTTC
CTCCAGCTCCTTTCCAGGCC

Downstream 100 bases:

>100_bases
GGTATTCGCCCTCCGGGAATTCCAGGGTCATGGGATGGTCGGGCGCGCCGCCCAGGCGCTCGAGGATGTAGCCGTCCACG
CCCGCGTCGGCGCCGGCCGA

Product: PAS/PAC sensor-containing diguanylate cyclase

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MDFELTATLLDSLGIAMCVFDAEERTVVWNASFLRFFPEHEGHVHAGEPYADNLRRFYQGRLPPEDLPHIDRFIADGLMR
NRLQTRPYVFQHLGRWLRVAAVPVQGGHRIRVWQHVAHTDGDPGVPAAEIQPVLPASGTRQMLEDLGEAAAVLDDEGRIL
YANDLFVTMHGLASREALAQRTYVQIVRQLWDASPDAHERLRRAQDVAAALHDAAFFEGAPFEVPLPGGRWMRVTMNRSA
GGQNYALHTDISAVKRNESELRAAELRARESEEQLRVLAEQLRTETHHDVLTGLPNRRTLGAKVQELSAQPGSHALLFID
LDGFKAVNDEAGHAAGDDVLCQVADRLRRCVRGDDVLVRLGGDEFVVLLRHCDRQKALGTGLQIVDTLRGEPFHSAGRAF
RIGASVGVRLFGTAQEPVEKLMADADAACYAAKRGGRGRVEMAGAGSGPQAPVTLPCASPPGP

Sequences:

>Translated_463_residues
MDFELTATLLDSLGIAMCVFDAEERTVVWNASFLRFFPEHEGHVHAGEPYADNLRRFYQGRLPPEDLPHIDRFIADGLMR
NRLQTRPYVFQHLGRWLRVAAVPVQGGHRIRVWQHVAHTDGDPGVPAAEIQPVLPASGTRQMLEDLGEAAAVLDDEGRIL
YANDLFVTMHGLASREALAQRTYVQIVRQLWDASPDAHERLRRAQDVAAALHDAAFFEGAPFEVPLPGGRWMRVTMNRSA
GGQNYALHTDISAVKRNESELRAAELRARESEEQLRVLAEQLRTETHHDVLTGLPNRRTLGAKVQELSAQPGSHALLFID
LDGFKAVNDEAGHAAGDDVLCQVADRLRRCVRGDDVLVRLGGDEFVVLLRHCDRQKALGTGLQIVDTLRGEPFHSAGRAF
RIGASVGVRLFGTAQEPVEKLMADADAACYAAKRGGRGRVEMAGAGSGPQAPVTLPCASPPGP
>Mature_463_residues
MDFELTATLLDSLGIAMCVFDAEERTVVWNASFLRFFPEHEGHVHAGEPYADNLRRFYQGRLPPEDLPHIDRFIADGLMR
NRLQTRPYVFQHLGRWLRVAAVPVQGGHRIRVWQHVAHTDGDPGVPAAEIQPVLPASGTRQMLEDLGEAAAVLDDEGRIL
YANDLFVTMHGLASREALAQRTYVQIVRQLWDASPDAHERLRRAQDVAAALHDAAFFEGAPFEVPLPGGRWMRVTMNRSA
GGQNYALHTDISAVKRNESELRAAELRARESEEQLRVLAEQLRTETHHDVLTGLPNRRTLGAKVQELSAQPGSHALLFID
LDGFKAVNDEAGHAAGDDVLCQVADRLRRCVRGDDVLVRLGGDEFVVLLRHCDRQKALGTGLQIVDTLRGEPFHSAGRAF
RIGASVGVRLFGTAQEPVEKLMADADAACYAAKRGGRGRVEMAGAGSGPQAPVTLPCASPPGP

Specific function: Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains [H]

Homologues:

Organism=Escherichia coli, GI1788381, Length=302, Percent_Identity=32.7814569536424, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI87081881, Length=174, Percent_Identity=39.6551724137931, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI145693134, Length=178, Percent_Identity=35.3932584269663, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1787541, Length=321, Percent_Identity=28.3489096573209, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1787816, Length=162, Percent_Identity=35.1851851851852, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI87082007, Length=178, Percent_Identity=35.3932584269663, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI87081977, Length=164, Percent_Identity=35.9756097560976, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786584, Length=171, Percent_Identity=32.1637426900585, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1787262, Length=173, Percent_Identity=34.1040462427746, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787802, Length=174, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788956, Length=172, Percent_Identity=33.7209302325581, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788085, Length=167, Percent_Identity=28.7425149700599, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081974, Length=96, Percent_Identity=34.375, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR001633
- InterPro:   IPR007895
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013656
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00563 EAL; PF00990 GGDEF; PF05231 MASE1; PF08447 PAS_3; PF08448 PAS_4 [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 50838; Mature: 50838

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50112 PAS ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFELTATLLDSLGIAMCVFDAEERTVVWNASFLRFFPEHEGHVHAGEPYADNLRRFYQG
CCCCHHHHHHHHCCEEEEEECCCCCEEEEEHHHHHHCCCCCCCEECCCCHHHHHHHHHCC
RLPPEDLPHIDRFIADGLMRNRLQTRPYVFQHLGRWLRVAAVPVQGGHRIRVWQHVAHTD
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEEECCCCEEEEEEHHHHCC
GDPGVPAAEIQPVLPASGTRQMLEDLGEAAAVLDDEGRILYANDLFVTMHGLASREALAQ
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEHHHHHHHHHHH
RTYVQIVRQLWDASPDAHERLRRAQDVAAALHDAAFFEGAPFEVPLPGGRWMRVTMNRSA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCC
GGQNYALHTDISAVKRNESELRAAELRARESEEQLRVLAEQLRTETHHDVLTGLPNRRTL
CCCCEEEECCHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
GAKVQELSAQPGSHALLFIDLDGFKAVNDEAGHAAGDDVLCQVADRLRRCVRGDDVLVRL
HHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
GGDEFVVLLRHCDRQKALGTGLQIVDTLRGEPFHSAGRAFRIGASVGVRLFGTAQEPVEK
CCCCEEHHHHHCCHHHHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCHHHHHH
LMADADAACYAAKRGGRGRVEMAGAGSGPQAPVTLPCASPPGP
HHHCCCHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure
MDFELTATLLDSLGIAMCVFDAEERTVVWNASFLRFFPEHEGHVHAGEPYADNLRRFYQG
CCCCHHHHHHHHCCEEEEEECCCCCEEEEEHHHHHHCCCCCCCEECCCCHHHHHHHHHCC
RLPPEDLPHIDRFIADGLMRNRLQTRPYVFQHLGRWLRVAAVPVQGGHRIRVWQHVAHTD
CCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHEEEEEEECCCCEEEEEEHHHHCC
GDPGVPAAEIQPVLPASGTRQMLEDLGEAAAVLDDEGRILYANDLFVTMHGLASREALAQ
CCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCEEEEEHHHHHHHHHHH
RTYVQIVRQLWDASPDAHERLRRAQDVAAALHDAAFFEGAPFEVPLPGGRWMRVTMNRSA
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEECCC
GGQNYALHTDISAVKRNESELRAAELRARESEEQLRVLAEQLRTETHHDVLTGLPNRRTL
CCCCEEEECCHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
GAKVQELSAQPGSHALLFIDLDGFKAVNDEAGHAAGDDVLCQVADRLRRCVRGDDVLVRL
HHHHHHHCCCCCCCEEEEEECCCCEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEE
GGDEFVVLLRHCDRQKALGTGLQIVDTLRGEPFHSAGRAFRIGASVGVRLFGTAQEPVEK
CCCCEEHHHHHCCHHHHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCEEEEECCHHHHHH
LMADADAACYAAKRGGRGRVEMAGAGSGPQAPVTLPCASPPGP
HHHCCCHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 6094528; 7984428 [H]