Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 120609469

GI number: 120609469

Start: 833223

End: 833930

Strand: Direct

Name: guaA [H]

Synonym: Aave_0775

Alternate gene names: 120609469

Gene position: 833223-833930 (Clockwise)

Preceding gene: 120609467

Following gene: 120609471

Centisome position: 15.57

GC content: 73.16

Gene sequence:

>708_bases
ATGCCCCATGACCCCATGCCGCCCGCGGCCGAACCGGCGCCCGCCGCGCCCGCCGCTCCCGAGCTGCCCGAAGGACTGTT
CGCGGATGCCCCGGGCGAGCCCGCGCGCTGCTTCTGGTGCCGCGCCACGCCGCTCTACCGCCACTACCACGACCATGAAT
GGGGCTTCCCGGTCAGCGACGACCGGCGCCTGTTCGAAAAGCTCTGCCTGGAGGGCTTCCAGGCGGGCCTGAGCTGGATC
ACCATCCTCAACAAGCGGGAGGCGTTCCGCGCGGGATTCGCGAACTTCGATGCCGAGCGCATGGCGGATTTCGGGGAGGC
CGAGGTGGCGCGCCTGCTGGCCGACCCGGGCATCGTGCGCCACCGCGGCAAGATCGAGTCGGCCATCCGCAATGCGCGCC
GCGTGCTGGAGCTGCGGCGCGAATTCGGCAGCCTGGCGCACTATGTGTGGCGCTTCGCGCCGGCCGCCGCCGAGGGACGC
CCGGAGCGGCTCACGCTGGCGGCCGCCAGGTCGCTCACCACCGCGCCGGCCGCCGTGGCCCTGTCGAAGGACCTGAAGAA
GCGCGGCTTCGGCTTCGTCGGGCCGACCACGATGTACGCCTTCATGCAGGCCATGGGCCTGGTCAACGACCACATCGAGG
GCTGCGCCACGCGCGAGGCGGCCCTGGCCGCGCGCGCCGCGTTCCAGGTGCCCGGGCCCGCGCGCTGA

Upstream 100 bases:

>100_bases
CAGGTCGGCGGGCGTGGAGGCGGGCGTGGGCAGGGCATGGGGCGGCACGCAGGAGCACGGTGGAGTGTACGGAGCGGCGG
CCGGTTCCTAGAATGCCGCC

Downstream 100 bases:

>100_bases
ACGGCCCCACGCAAAAAAGCCCTCGCGCAGGAGGGCTTCGGGGCGCAGGGCGGCCGCACGGGGCGCCGCCGCTGGAAAGG
GGGCTCAGCCGCCCTTCTTG

Product: DNA-3-methyladenine glycosylase I

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 235; Mature: 234

Protein sequence:

>235_residues
MPHDPMPPAAEPAPAAPAAPELPEGLFADAPGEPARCFWCRATPLYRHYHDHEWGFPVSDDRRLFEKLCLEGFQAGLSWI
TILNKREAFRAGFANFDAERMADFGEAEVARLLADPGIVRHRGKIESAIRNARRVLELRREFGSLAHYVWRFAPAAAEGR
PERLTLAAARSLTTAPAAVALSKDLKKRGFGFVGPTTMYAFMQAMGLVNDHIEGCATREAALAARAAFQVPGPAR

Sequences:

>Translated_235_residues
MPHDPMPPAAEPAPAAPAAPELPEGLFADAPGEPARCFWCRATPLYRHYHDHEWGFPVSDDRRLFEKLCLEGFQAGLSWI
TILNKREAFRAGFANFDAERMADFGEAEVARLLADPGIVRHRGKIESAIRNARRVLELRREFGSLAHYVWRFAPAAAEGR
PERLTLAAARSLTTAPAAVALSKDLKKRGFGFVGPTTMYAFMQAMGLVNDHIEGCATREAALAARAAFQVPGPAR
>Mature_234_residues
PHDPMPPAAEPAPAAPAAPELPEGLFADAPGEPARCFWCRATPLYRHYHDHEWGFPVSDDRRLFEKLCLEGFQAGLSWIT
ILNKREAFRAGFANFDAERMADFGEAEVARLLADPGIVRHRGKIESAIRNARRVLELRREFGSLAHYVWRFAPAAAEGRP
ERLTLAAARSLTTAPAAVALSKDLKKRGFGFVGPTTMYAFMQAMGLVNDHIEGCATREAALAARAAFQVPGPAR

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG2818

COG function: function code L; 3-methyladenine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 N-acetyltransferase domains [H]

Homologues:

Organism=Escherichia coli, GI1789971, Length=183, Percent_Identity=50.2732240437158, Blast_Score=186, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR005019
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011257
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF03352 Adenine_glyco; PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 25822; Mature: 25691

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHDPMPPAAEPAPAAPAAPELPEGLFADAPGEPARCFWCRATPLYRHYHDHEWGFPVSD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCH
DRRLFEKLCLEGFQAGLSWITILNKREAFRAGFANFDAERMADFGEAEVARLLADPGIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCHHH
HRGKIESAIRNARRVLELRREFGSLAHYVWRFAPAAAEGRPERLTLAAARSLTTAPAAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHH
LSKDLKKRGFGFVGPTTMYAFMQAMGLVNDHIEGCATREAALAARAAFQVPGPAR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PHDPMPPAAEPAPAAPAAPELPEGLFADAPGEPARCFWCRATPLYRHYHDHEWGFPVSD
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHCCCCCCCCCCH
DRRLFEKLCLEGFQAGLSWITILNKREAFRAGFANFDAERMADFGEAEVARLLADPGIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHCCCHHH
HRGKIESAIRNARRVLELRREFGSLAHYVWRFAPAAAEGRPERLTLAAARSLTTAPAAVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCHHHHHHHHHHHHHHHHHH
LSKDLKKRGFGFVGPTTMYAFMQAMGLVNDHIEGCATREAALAARAAFQVPGPAR
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954 [H]