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The map label for this gene is actII-2 [H]

Identifier: 120609434

GI number: 120609434

Start: 791334

End: 792800

Strand: Direct

Name: actII-2 [H]

Synonym: Aave_0738

Alternate gene names: 120609434

Gene position: 791334-792800 (Clockwise)

Preceding gene: 120609433

Following gene: 120609438

Centisome position: 14.78

GC content: 71.37

Gene sequence:

>1467_bases
ATGCCCGAAAGAATATTGTCCAGCCAGGGGACTCTCCTCGCAGAACCCGCAGCCTTGCCCCAGGGGCAGGCCGGAGCGGG
GATCCGTCCCGATGCGCGCCGCTGGATGGCGCTCGCCGTGCTGCTGACCGGTGCCCTGCTGCCCCCGCTGGATTTCTTCA
TCGTCAATGTCGCGCTGCCGGCCATGCGCGCCGACCTGGCGGCCAGTGCAGCCATGTCGCAAATGGTCATTTCCGTGTAT
GCCGCTGCGTATGCCGTCACGCTGATCCTGGGCGGCCGGCTCGGCGACCTGTACGGCCGCCGGCGCGTTTTCATCTGCGG
CATGCTGGGGTTCGGCGCGTCGTCGGTGCTGTGCGGGCTGGCCACGTCCCCCGGTGTGCTGGTGGTCGGCCGCCTGCTGC
AGGGGCTGACCGCCGCCGTCATGGCGCCGCAGCCGCTGGCAACGATCCACGCCCTTTTTCCCGCGCACGAGAAGAACCGC
GCTCTGGGCCTGTACGGGGCCGTCTTCGGGATGGCCGCCGTGGCAGGACAGGGCCTGGGGGGCGCACTGGTGGCCGCCGA
CTGGTTCGGCCTGGGCTGGCGCAGCGTTTTCCTGGTCAATCTACCCGTCGTCGCCCTGGCCGTGCCCGCCACGCTGATGC
TGGTGCGGGAGAGCCGCTCGGCACAGGCGATGCTGCTGGACGTGCGCGGCGCAGGCCTCCTGGCGGCCGGCCTGCTGGCG
CTGCTGATTCCCCTGATCGAAGGCCGCGAGCACGGATGGCCCTGGTGGTGCTTCGGGCTGCTGGTGGCATGTGTGCCGCT
GCTGCGGGCTTTCTGGCGTTTCGAACAGGGCCTGGAGCGTGCGGGTGGTGCGCCGCTGCTCGCGCCGTCGCTGCTGGCGC
AGCCGGGGCTGCGCCGCAGCCTGGCTGCCACGCTGTGCTTTTATTCCATCGCGCCGTTCTTCCTGATTTTCTCCATCTAC
CAGCAGGCGGGCCTGGGCCGTGGCCCTCTCGCCGCGGGGCTGGCGCTCATGCCGATGGGCGTGGGGTTCCTGTGCGGCTC
GCTGTGCAGCCGCGGGGCCGCCCTGCGGCTGGGCGCGGGAACGGCCACCTTCGGCATGGTGGTCGAGGTGCTGGGCATGC
TGAGCGCCTCGGCCCTGGCCGTGGCCCACCATGCGCCGTGGCTCGTCCTGCCGCTGTTCGCCATCGGCCTGGGCCAGGGC
ATGGCCATGCCGGCCCTGGTGCGCCTGAACATGGACCAGGTTGATGCCCGCTGGGCGGGGCTGTCCGCGGGCCTGGTCCA
CGCCACCCTGCAGATCGGCGCGGCGATTTCCGTGGCCGTCATCGGGGGGCTCTTTTTTGTCCTGGCGCCCCAGGGGGCGG
GTGCCGGGGCGGTGCAGGTCGGGTTCTCCGTCACCTCCGCCATCATCGGCGCGTGCCTTGCGGGCGCGGCCATGCTGGCA
TGGAAAGTCCGCCCCCGGGCGGACTGA

Upstream 100 bases:

>100_bases
ATCTCCGAACGTTCCAAGCCATAAGCGCCGCAGGCGTTTTCCACCGTATCGGGGCCTGAGGGCGCGCGGCTCCGCACTCT
GCAAGAAGGAGGGGTTTTGC

Downstream 100 bases:

>100_bases
TCGCCAGCGCTCCAGGGCTCGCTGCAGATTGCGGGCGCCCAAAGAAAAAAGCACCCGAAAAGGGTGCTTGGTTGATCCGG
GATGGAGGTGGGCCTCAGTG

Product: major facilitator superfamily transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MPERILSSQGTLLAEPAALPQGQAGAGIRPDARRWMALAVLLTGALLPPLDFFIVNVALPAMRADLAASAAMSQMVISVY
AAAYAVTLILGGRLGDLYGRRRVFICGMLGFGASSVLCGLATSPGVLVVGRLLQGLTAAVMAPQPLATIHALFPAHEKNR
ALGLYGAVFGMAAVAGQGLGGALVAADWFGLGWRSVFLVNLPVVALAVPATLMLVRESRSAQAMLLDVRGAGLLAAGLLA
LLIPLIEGREHGWPWWCFGLLVACVPLLRAFWRFEQGLERAGGAPLLAPSLLAQPGLRRSLAATLCFYSIAPFFLIFSIY
QQAGLGRGPLAAGLALMPMGVGFLCGSLCSRGAALRLGAGTATFGMVVEVLGMLSASALAVAHHAPWLVLPLFAIGLGQG
MAMPALVRLNMDQVDARWAGLSAGLVHATLQIGAAISVAVIGGLFFVLAPQGAGAGAVQVGFSVTSAIIGACLAGAAMLA
WKVRPRAD

Sequences:

>Translated_488_residues
MPERILSSQGTLLAEPAALPQGQAGAGIRPDARRWMALAVLLTGALLPPLDFFIVNVALPAMRADLAASAAMSQMVISVY
AAAYAVTLILGGRLGDLYGRRRVFICGMLGFGASSVLCGLATSPGVLVVGRLLQGLTAAVMAPQPLATIHALFPAHEKNR
ALGLYGAVFGMAAVAGQGLGGALVAADWFGLGWRSVFLVNLPVVALAVPATLMLVRESRSAQAMLLDVRGAGLLAAGLLA
LLIPLIEGREHGWPWWCFGLLVACVPLLRAFWRFEQGLERAGGAPLLAPSLLAQPGLRRSLAATLCFYSIAPFFLIFSIY
QQAGLGRGPLAAGLALMPMGVGFLCGSLCSRGAALRLGAGTATFGMVVEVLGMLSASALAVAHHAPWLVLPLFAIGLGQG
MAMPALVRLNMDQVDARWAGLSAGLVHATLQIGAAISVAVIGGLFFVLAPQGAGAGAVQVGFSVTSAIIGACLAGAAMLA
WKVRPRAD
>Mature_487_residues
PERILSSQGTLLAEPAALPQGQAGAGIRPDARRWMALAVLLTGALLPPLDFFIVNVALPAMRADLAASAAMSQMVISVYA
AAYAVTLILGGRLGDLYGRRRVFICGMLGFGASSVLCGLATSPGVLVVGRLLQGLTAAVMAPQPLATIHALFPAHEKNRA
LGLYGAVFGMAAVAGQGLGGALVAADWFGLGWRSVFLVNLPVVALAVPATLMLVRESRSAQAMLLDVRGAGLLAAGLLAL
LIPLIEGREHGWPWWCFGLLVACVPLLRAFWRFEQGLERAGGAPLLAPSLLAQPGLRRSLAATLCFYSIAPFFLIFSIYQ
QAGLGRGPLAAGLALMPMGVGFLCGSLCSRGAALRLGAGTATFGMVVEVLGMLSASALAVAHHAPWLVLPLFAIGLGQGM
AMPALVRLNMDQVDARWAGLSAGLVHATLQIGAAISVAVIGGLFFVLAPQGAGAGAVQVGFSVTSAIIGACLAGAAMLAW
KVRPRAD

Specific function: Promotes the efflux of actinorhodin [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI87081983, Length=392, Percent_Identity=27.5510204081633, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI1788392, Length=447, Percent_Identity=26.3982102908277, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788710, Length=316, Percent_Identity=27.8481012658228, Blast_Score=86, Evalue=6e-18,
Organism=Escherichia coli, GI1789042, Length=205, Percent_Identity=28.2926829268293, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1790195, Length=445, Percent_Identity=25.6179775280899, Blast_Score=71, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 50164; Mature: 50032

Theoretical pI: Translated: 10.06; Mature: 10.06

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPERILSSQGTLLAEPAALPQGQAGAGIRPDARRWMALAVLLTGALLPPLDFFIVNVALP
CCCCHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AMRADLAASAAMSQMVISVYAAAYAVTLILGGRLGDLYGRRRVFICGMLGFGASSVLCGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEEHHCCHHHHHHHC
ATSPGVLVVGRLLQGLTAAVMAPQPLATIHALFPAHEKNRALGLYGAVFGMAAVAGQGLG
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
GALVAADWFGLGWRSVFLVNLPVVALAVPATLMLVRESRSAQAMLLDVRGAGLLAAGLLA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHH
LLIPLIEGREHGWPWWCFGLLVACVPLLRAFWRFEQGLERAGGAPLLAPSLLAQPGLRRS
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHH
LAATLCFYSIAPFFLIFSIYQQAGLGRGPLAAGLALMPMGVGFLCGSLCSRGAALRLGAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
TATFGMVVEVLGMLSASALAVAHHAPWLVLPLFAIGLGQGMAMPALVRLNMDQVDARWAG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHEEECHHHHHHHHHC
LSAGLVHATLQIGAAISVAVIGGLFFVLAPQGAGAGAVQVGFSVTSAIIGACLAGAAMLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
WKVRPRAD
EECCCCCC
>Mature Secondary Structure 
PERILSSQGTLLAEPAALPQGQAGAGIRPDARRWMALAVLLTGALLPPLDFFIVNVALP
CCCHHCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AMRADLAASAAMSQMVISVYAAAYAVTLILGGRLGDLYGRRRVFICGMLGFGASSVLCGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCEEEEEEEHHCCHHHHHHHC
ATSPGVLVVGRLLQGLTAAVMAPQPLATIHALFPAHEKNRALGLYGAVFGMAAVAGQGLG
CCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCC
GALVAADWFGLGWRSVFLVNLPVVALAVPATLMLVRESRSAQAMLLDVRGAGLLAAGLLA
CHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHH
LLIPLIEGREHGWPWWCFGLLVACVPLLRAFWRFEQGLERAGGAPLLAPSLLAQPGLRRS
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCHHHH
LAATLCFYSIAPFFLIFSIYQQAGLGRGPLAAGLALMPMGVGFLCGSLCSRGAALRLGAG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
TATFGMVVEVLGMLSASALAVAHHAPWLVLPLFAIGLGQGMAMPALVRLNMDQVDARWAG
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHEEECHHHHHHHHHC
LSAGLVHATLQIGAAISVAVIGGLFFVLAPQGAGAGAVQVGFSVTSAIIGACLAGAAMLA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHH
WKVRPRAD
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1878971; 12000953 [H]