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The map label for this gene is glcD [H]

Identifier: 120609345

GI number: 120609345

Start: 695371

End: 696906

Strand: Reverse

Name: glcD [H]

Synonym: Aave_0645

Alternate gene names: 120609345

Gene position: 696906-695371 (Counterclockwise)

Preceding gene: 120609346

Following gene: 120609343

Centisome position: 13.02

GC content: 70.83

Gene sequence:

>1536_bases
ATGAGCGCCGTCGCCCCCCTCCCCGCTGCGTCCCCCGGCCCCACGACCGCCAGCCCGCCCCCCGGTGCCACCGGGCGCGC
CGCCCGGCAGGCACAGGTCGTGCAGGCCCTGTCCGCGCACCTGCCCGCGCACATGCTGCTCTGGCATGCGGAAGACACTA
CACCCTACGAATGCGACGGCCTCACCGCCTACCGCCAGCGCCCGCTGGTGGTGTGCCTGCCCGAAACCGAGGCCCAGGTG
CAGGCCGTGCTGCGCACCTGCCACGCGCTGGGCGTGCCGGTGGTGGCGCGCGGCGCGGGCACGGGCCTGTCGGGCGGTGC
CATGCCGCATGCCCTCGGCGTCACGCTGTCGCTGGCGCGCTTCAACCGCATCCTGGGCATCGACCCGGTCAGCCGCACCG
CCCGCGTGCAGTGCGGCGTACGCAACCTGGCCATCAGCGAGGCCGCGGCGCCCTGGCAGCTCTACTACGCGCCCGACCCG
TCCAGCCAGATCGCCTGCACCATCGGCGGCAACATCGCCGAGAACTCGGGCGGCGTGCACTGCCTGAAATACGGCCTCAC
CGTCCACAACGTGCTGCGCGTGCGCGGCTTCACCGCCGAAGGCGAGCCGGTGGAGTTCGGCAGCGAGGCGCTGGACACGC
CCGGCTACGACCTGCTGGCCGCCGTGATCGGCAGCGAAGGCATGCTGGCCGTCACCACCGAGGCCACGGTGCGCCTCATC
CCCAGGCCCCAGCTGGCGCGCTGCATCATGGCCAGCTTCGACGACGTGCGCAAGGCCGGCGACGCGGTGGCCGCCGTCAT
CGCGGCCGGCATCATCCCGGCCGGGCTGGAGATGATGGACAAGCCCATGACCGCCGCCGTGGAAGACTTCGTCCAGGCCG
GCTACGACCTCGCGGCCGAGGCCATCCTGCTGTGCGAGAGCGACGGCACGCCCGAAGAGGTCGAGGAAGAGATCGGCCGC
ATGAGCGAGGTGCTGCGCGCGGCCGGCGCCACCGCCATCACCGTGAGCGAAAACGAGACCGAGCGCCTGCGCTTCTGGAG
CGGCCGCAAAAACGCCTTCCCCGCGAGCGGCCGCATCAGCCCCGACTACATGTGCCTGGACTCGACCATCCCCCGCAAGC
GCCTGGCCGACATCCTGCTGGCCATCCAGGAGATGGAGAAGAAATACGGCCTGCGCTGCTGCAACGTCTTCCATGCCGGC
GACGGCAACCTGCATCCGCTGGTGTTGTTCGACGCCAATGACCCCGACGAGCTGCACCGCTGCGAGCTCTTCGGCGCCGA
CATCCTGGAAACCAGCGTGGCCATGGGCGGCACCGTCTCGGGCGAGCACGGCGTGGGCGTGGAAAAATTGAACAGCATGT
GCACCCAGTTCACCACCGAGGAGAACGCGCAGATGTTCGCCCTCAAGGCCGCGTTCGACCCGGCCGGCCTGCTCAACCCG
GGCAAGGTCATCCCCACGGTGAGCCGCTGCGCGGAGTACGGAAAGATGCTGGTGCGCGGCGGGCAGATGCCGCACCCGGA
CCTGCCCCGGTTCTAG

Upstream 100 bases:

>100_bases
CGGGCCGGTGTGATCCCTCCGGCCGGTCATCCGGCCGATTCACGCGGCGCTGAAAGAAAACTCACGCACCCGCGGGCCAC
CTTCCTCTAAAGTCCAGGGC

Downstream 100 bases:

>100_bases
AGCCCGCCCGCCCGCTGTCTCGCGCCGTCGCAGCATGCTGTCGCACCCCGGGTACCGCCTGCGGCGATACCGTGCATCGC
CGGTGCGGCACCGAGGGGCC

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 511; Mature: 510

Protein sequence:

>511_residues
MSAVAPLPAASPGPTTASPPPGATGRAARQAQVVQALSAHLPAHMLLWHAEDTTPYECDGLTAYRQRPLVVCLPETEAQV
QAVLRTCHALGVPVVARGAGTGLSGGAMPHALGVTLSLARFNRILGIDPVSRTARVQCGVRNLAISEAAAPWQLYYAPDP
SSQIACTIGGNIAENSGGVHCLKYGLTVHNVLRVRGFTAEGEPVEFGSEALDTPGYDLLAAVIGSEGMLAVTTEATVRLI
PRPQLARCIMASFDDVRKAGDAVAAVIAAGIIPAGLEMMDKPMTAAVEDFVQAGYDLAAEAILLCESDGTPEEVEEEIGR
MSEVLRAAGATAITVSENETERLRFWSGRKNAFPASGRISPDYMCLDSTIPRKRLADILLAIQEMEKKYGLRCCNVFHAG
DGNLHPLVLFDANDPDELHRCELFGADILETSVAMGGTVSGEHGVGVEKLNSMCTQFTTEENAQMFALKAAFDPAGLLNP
GKVIPTVSRCAEYGKMLVRGGQMPHPDLPRF

Sequences:

>Translated_511_residues
MSAVAPLPAASPGPTTASPPPGATGRAARQAQVVQALSAHLPAHMLLWHAEDTTPYECDGLTAYRQRPLVVCLPETEAQV
QAVLRTCHALGVPVVARGAGTGLSGGAMPHALGVTLSLARFNRILGIDPVSRTARVQCGVRNLAISEAAAPWQLYYAPDP
SSQIACTIGGNIAENSGGVHCLKYGLTVHNVLRVRGFTAEGEPVEFGSEALDTPGYDLLAAVIGSEGMLAVTTEATVRLI
PRPQLARCIMASFDDVRKAGDAVAAVIAAGIIPAGLEMMDKPMTAAVEDFVQAGYDLAAEAILLCESDGTPEEVEEEIGR
MSEVLRAAGATAITVSENETERLRFWSGRKNAFPASGRISPDYMCLDSTIPRKRLADILLAIQEMEKKYGLRCCNVFHAG
DGNLHPLVLFDANDPDELHRCELFGADILETSVAMGGTVSGEHGVGVEKLNSMCTQFTTEENAQMFALKAAFDPAGLLNP
GKVIPTVSRCAEYGKMLVRGGQMPHPDLPRF
>Mature_510_residues
SAVAPLPAASPGPTTASPPPGATGRAARQAQVVQALSAHLPAHMLLWHAEDTTPYECDGLTAYRQRPLVVCLPETEAQVQ
AVLRTCHALGVPVVARGAGTGLSGGAMPHALGVTLSLARFNRILGIDPVSRTARVQCGVRNLAISEAAAPWQLYYAPDPS
SQIACTIGGNIAENSGGVHCLKYGLTVHNVLRVRGFTAEGEPVEFGSEALDTPGYDLLAAVIGSEGMLAVTTEATVRLIP
RPQLARCIMASFDDVRKAGDAVAAVIAAGIIPAGLEMMDKPMTAAVEDFVQAGYDLAAEAILLCESDGTPEEVEEEIGRM
SEVLRAAGATAITVSENETERLRFWSGRKNAFPASGRISPDYMCLDSTIPRKRLADILLAIQEMEKKYGLRCCNVFHAGD
GNLHPLVLFDANDPDELHRCELFGADILETSVAMGGTVSGEHGVGVEKLNSMCTQFTTEENAQMFALKAAFDPAGLLNPG
KVIPTVSRCAEYGKMLVRGGQMPHPDLPRF

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=442, Percent_Identity=28.7330316742081, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI37595754, Length=465, Percent_Identity=28.3870967741935, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI119964728, Length=439, Percent_Identity=28.9293849658314, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1789351, Length=482, Percent_Identity=60.3734439834025, Blast_Score=605, Evalue=1e-174,
Organism=Escherichia coli, GI1787977, Length=517, Percent_Identity=25.531914893617, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71992373, Length=429, Percent_Identity=27.7389277389277, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71992381, Length=429, Percent_Identity=26.1072261072261, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71992392, Length=374, Percent_Identity=26.2032085561497, Blast_Score=142, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI17534361, Length=452, Percent_Identity=25.8849557522124, Blast_Score=116, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6320023, Length=457, Percent_Identity=29.5404814004376, Blast_Score=156, Evalue=8e-39,
Organism=Saccharomyces cerevisiae, GI6320027, Length=433, Percent_Identity=24.9422632794457, Blast_Score=154, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6320764, Length=457, Percent_Identity=24.72647702407, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI18921117, Length=445, Percent_Identity=28.314606741573, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24639277, Length=445, Percent_Identity=28.314606741573, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24639275, Length=445, Percent_Identity=28.314606741573, Blast_Score=139, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 54108; Mature: 53976

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVAPLPAASPGPTTASPPPGATGRAARQAQVVQALSAHLPAHMLLWHAEDTTPYECDG
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
LTAYRQRPLVVCLPETEAQVQAVLRTCHALGVPVVARGAGTGLSGGAMPHALGVTLSLAR
CHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHH
FNRILGIDPVSRTARVQCGVRNLAISEAAAPWQLYYAPDPSSQIACTIGGNIAENSGGVH
HHHHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCEECCCCCEE
CLKYGLTVHNVLRVRGFTAEGEPVEFGSEALDTPGYDLLAAVIGSEGMLAVTTEATVRLI
EEEECCHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCEEEEECCCEEEEC
PRPQLARCIMASFDDVRKAGDAVAAVIAAGIIPAGLEMMDKPMTAAVEDFVQAGYDLAAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHEE
AILLCESDGTPEEVEEEIGRMSEVLRAAGATAITVSENETERLRFWSGRKNAFPASGRIS
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHEECCCCCCCCCCCCCC
PDYMCLDSTIPRKRLADILLAIQEMEKKYGLRCCNVFHAGDGNLHPLVLFDANDPDELHR
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCHHHHH
CELFGADILETSVAMGGTVSGEHGVGVEKLNSMCTQFTTEENAQMFALKAAFDPAGLLNP
HHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
GKVIPTVSRCAEYGKMLVRGGQMPHPDLPRF
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVAPLPAASPGPTTASPPPGATGRAARQAQVVQALSAHLPAHMLLWHAEDTTPYECDG
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCC
LTAYRQRPLVVCLPETEAQVQAVLRTCHALGVPVVARGAGTGLSGGAMPHALGVTLSLAR
CHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHH
FNRILGIDPVSRTARVQCGVRNLAISEAAAPWQLYYAPDPSSQIACTIGGNIAENSGGVH
HHHHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEECCCCCCCEEEEECCCEECCCCCEE
CLKYGLTVHNVLRVRGFTAEGEPVEFGSEALDTPGYDLLAAVIGSEGMLAVTTEATVRLI
EEEECCHHHHHHHHCCCCCCCCCCCCCCHHCCCCCHHHHHHHHCCCCEEEEECCCEEEEC
PRPQLARCIMASFDDVRKAGDAVAAVIAAGIIPAGLEMMDKPMTAAVEDFVQAGYDLAAE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHEE
AILLCESDGTPEEVEEEIGRMSEVLRAAGATAITVSENETERLRFWSGRKNAFPASGRIS
EEEEECCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHEECCCCCCCCCCCCCC
PDYMCLDSTIPRKRLADILLAIQEMEKKYGLRCCNVFHAGDGNLHPLVLFDANDPDELHR
CCEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCEEEEECCCCCHHHHH
CELFGADILETSVAMGGTVSGEHGVGVEKLNSMCTQFTTEENAQMFALKAAFDPAGLLNP
HHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
GKVIPTVSRCAEYGKMLVRGGQMPHPDLPRF
CCCCHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]