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The map label for this gene is proC [H]

Identifier: 120609301

GI number: 120609301

Start: 657919

End: 658761

Strand: Reverse

Name: proC [H]

Synonym: Aave_0601

Alternate gene names: 120609301

Gene position: 658761-657919 (Counterclockwise)

Preceding gene: 120609302

Following gene: 120609300

Centisome position: 12.31

GC content: 72.72

Gene sequence:

>843_bases
ATGACGCCCGATACCCCCTCCCCCGCATCCGAGCAACCCGCGATCGCCTTCATCGGCGGCGGCAACATGGCCAGCGCCAT
CATCGGAGGGCTGATCCGGCAGGGCATGCCGGCCTCCGGCATCGAGGTGGTCGAGCCCTGGGAGGAAGCGCGGGCCGCCC
TGCGCGCGCACCACGGAATCGAGGCCCTGCCGGAGGCCGGGACGGCACTGGAGCGCGCCGGCGTGGTGGTGTGGGCGGTC
AAGCCCCAGACGTTCAAGGAGGCGGCGCAGCAGGCACGCGCCCATACGGCGAATGCGGTGCACCTCAGCGTGGCCGCCGG
CATCCGGTCGGACAGTATCGCCGCCTGGCTGGGCTCGGATTGCGTGGTGCGCGCCATGCCGAACACGCCCGCGCTGATCG
GGCGCGGCATGACGGCGCTCTATGCCCGCCCGCAGGTCAGCCCCGCGCAGCGCGCGGCCGTGCAGCAGGTGCTGTCGTCC
ACGGGCGAACTGCTCTGGGTGGACGAGGAGCCACAGCTCGACGCCGTGACCGCGCTGTCGGGATCCGGCCCGGCCTATGT
CTTCCTGTTCCTGGAGGCGATGGCGCGCGCGGGGGTGGAAATGGGCCTGGCGCCCGAGCAGGCGCACCAGCTGGCGGTGG
GTACGTTCACGGGGGCGTCGGAACTGGCGCGCCGCTCGGACGAGTCGCCCGCGGTGCTGCGCCAGCGTGTGACCTCCAAG
GGCGGCACGACCTTCGCGGCGGTGCAGGCGATGGAACAGGCGGGCGTGCCGGAGCATTTCATCCGGGCGATGAAGGCCGC
GCAGGCGCGGGCCCGGGAACTGGGGGACGAGTTCGGAAGGTGA

Upstream 100 bases:

>100_bases
GAGGAAGCGCTACCATCCGGTGCCGCGGCCCGCGGCGGCGCGTCCGTCGCGGGCCTTCCCTTCTTCCACGGCCGCCCGCC
GGCCCCGCCCTTTCGCACGC

Downstream 100 bases:

>100_bases
TACCGGCAGGGCGTTGCAACTTTTACAATCGCAGGTCCTTTTGCCTGCGCCTGCCACGCCCGCCTGCATGCCCATCGCCA
CCACCGCACCGTCCAGCATT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MTPDTPSPASEQPAIAFIGGGNMASAIIGGLIRQGMPASGIEVVEPWEEARAALRAHHGIEALPEAGTALERAGVVVWAV
KPQTFKEAAQQARAHTANAVHLSVAAGIRSDSIAAWLGSDCVVRAMPNTPALIGRGMTALYARPQVSPAQRAAVQQVLSS
TGELLWVDEEPQLDAVTALSGSGPAYVFLFLEAMARAGVEMGLAPEQAHQLAVGTFTGASELARRSDESPAVLRQRVTSK
GGTTFAAVQAMEQAGVPEHFIRAMKAAQARARELGDEFGR

Sequences:

>Translated_280_residues
MTPDTPSPASEQPAIAFIGGGNMASAIIGGLIRQGMPASGIEVVEPWEEARAALRAHHGIEALPEAGTALERAGVVVWAV
KPQTFKEAAQQARAHTANAVHLSVAAGIRSDSIAAWLGSDCVVRAMPNTPALIGRGMTALYARPQVSPAQRAAVQQVLSS
TGELLWVDEEPQLDAVTALSGSGPAYVFLFLEAMARAGVEMGLAPEQAHQLAVGTFTGASELARRSDESPAVLRQRVTSK
GGTTFAAVQAMEQAGVPEHFIRAMKAAQARARELGDEFGR
>Mature_279_residues
TPDTPSPASEQPAIAFIGGGNMASAIIGGLIRQGMPASGIEVVEPWEEARAALRAHHGIEALPEAGTALERAGVVVWAVK
PQTFKEAAQQARAHTANAVHLSVAAGIRSDSIAAWLGSDCVVRAMPNTPALIGRGMTALYARPQVSPAQRAAVQQVLSST
GELLWVDEEPQLDAVTALSGSGPAYVFLFLEAMARAGVEMGLAPEQAHQLAVGTFTGASELARRSDESPAVLRQRVTSKG
GTTFAAVQAMEQAGVPEHFIRAMKAAQARARELGDEFGR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI24797097, Length=269, Percent_Identity=32.7137546468402, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI24797095, Length=269, Percent_Identity=32.7137546468402, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI198041662, Length=272, Percent_Identity=31.9852941176471, Blast_Score=111, Evalue=6e-25,
Organism=Homo sapiens, GI21361454, Length=270, Percent_Identity=31.8518518518519, Blast_Score=108, Evalue=6e-24,
Organism=Escherichia coli, GI1786585, Length=263, Percent_Identity=37.6425855513308, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=32.5842696629214, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17540664, Length=305, Percent_Identity=28.8524590163934, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320861, Length=240, Percent_Identity=29.1666666666667, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358587, Length=263, Percent_Identity=34.9809885931559, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24648116, Length=275, Percent_Identity=33.4545454545455, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24647700, Length=153, Percent_Identity=39.8692810457516, Blast_Score=102, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29250; Mature: 29118

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPDTPSPASEQPAIAFIGGGNMASAIIGGLIRQGMPASGIEVVEPWEEARAALRAHHGI
CCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHCCC
EALPEAGTALERAGVVVWAVKPQTFKEAAQQARAHTANAVHLSVAAGIRSDSIAAWLGSD
HHCCCCCHHHHHCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHCCC
CVVRAMPNTPALIGRGMTALYARPQVSPAQRAAVQQVLSSTGELLWVDEEPQLDAVTALS
CEEEECCCCCHHHHCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHEEEC
GSGPAYVFLFLEAMARAGVEMGLAPEQAHQLAVGTFTGASELARRSDESPAVLRQRVTSK
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCHHHHHHCCCCCHHHHHHHHHHC
GGTTFAAVQAMEQAGVPEHFIRAMKAAQARARELGDEFGR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TPDTPSPASEQPAIAFIGGGNMASAIIGGLIRQGMPASGIEVVEPWEEARAALRAHHGI
CCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCCCCCCCCHHCCCHHHHHHHHHHHCCC
EALPEAGTALERAGVVVWAVKPQTFKEAAQQARAHTANAVHLSVAAGIRSDSIAAWLGSD
HHCCCCCHHHHHCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHHHHCCC
CVVRAMPNTPALIGRGMTALYARPQVSPAQRAAVQQVLSSTGELLWVDEEPQLDAVTALS
CEEEECCCCCHHHHCCHHHHHCCCCCCHHHHHHHHHHHHCCCCEEEECCCCCCCHHEEEC
GSGPAYVFLFLEAMARAGVEMGLAPEQAHQLAVGTFTGASELARRSDESPAVLRQRVTSK
CCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHEECCCCHHHHHHCCCCCHHHHHHHHHHC
GGTTFAAVQAMEQAGVPEHFIRAMKAAQARARELGDEFGR
CCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2107123; 10984043; 1676385 [H]