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The map label for this gene is fadE12 [H]

Identifier: 120608884

GI number: 120608884

Start: 196388

End: 197551

Strand: Reverse

Name: fadE12 [H]

Synonym: Aave_0176

Alternate gene names: 120608884

Gene position: 197551-196388 (Counterclockwise)

Preceding gene: 120608885

Following gene: 120608883

Centisome position: 3.69

GC content: 68.56

Gene sequence:

>1164_bases
ATGGACTTCGCCCTTTCGCCGGAACAGGAGCAGATCCGGGGCGCCATCGAGCGCGTCTGCGCGCCGTTCGATGCCGACTA
CTGGCTCGCGAAGGACCGCGAAGGCGGCTTTCCGCACGACTTCCACCAGGCGCTCGCAGATGCCGGCTGGCTGGGCATCG
CCATGCCCGAGGCCTATGGCGGCGCGGGCCTGGGCATCAGCGAAGCCGCGCTGATGATGCACGCCATCTCCGCCACGGGC
GCGGGCCTGTCGGGCGCCTCGGCCGTGCACATGAACATCTTCGGGCTGCACCCGGTGGTGGTGTTCGGCACCGAGGAACA
GAAGGCGCGCTGGCTGCCGCCGCTGATCCGGGGCCGCGACAAGGCCTGCTTCGGCGTGACCGAGCCCAACACGGGCCTGA
ACACGCTGGGGCTCAAGACCCGCGCCGTGCGGGAGGGCGACCACTACGTGGTGCACGGCCAGAAAGTGTGGATCAGCACC
GCGCAGGTGGCCAGCAAGATCCTGCTGCTCGCGCGCACCACGCCGCTGGAGGAATGCCGCGGCACCGAGGGCCTGAGCCT
CTTCTACACCGACCTGGACCGCAGCACGGTGGAAGTGCGCGAGATCGAGAAGCTCGGCCGCAAGTGCGTGGACTCCAACC
AGGTGTTCATCGACGGCCTGCGCATTCCCGTGGAAGACCGCGTGGGCGAGGAAGGCAAGGGCTTCCAGTACATCCTGCAC
GGACTCAACCCCGAACGCATCCTGATCGCGAGCGAGGCCGTGGGCCTGGGCCGCGCGGCACTGGCACGCGCGGCCGGCTA
TGCGCAGGAACGCGAAGTGTTCGGCCGCCCGATCGGGCAGAACCAGGGCATCCAGCATCCGCTGGCGCAGTCGTGGATGG
AGCTGGAGGCCGCGCACCTCATGGTGCAGAAGGCCGCCTGGCTCTACGACCGGCACCAGTCCTGCGGCGCCGAGGCCAAC
GCCGCCAAATACCTCGCGGCCGAGGCCTGCTACCACGCCTGCGAGCGCGCCATCCTGACCCATGGCGGCATGGGCTACGC
CAGGGAATACCACGTGGAGCGCTACCTGCGCGAATCGTGGATCCCCCGCCTCGCGCCCGTGAGCCCGCAGCTGATCCTGT
GTTTCATCGCGGAGAAAGTACTCGGCCTCCCGAAATCCTATTGA

Upstream 100 bases:

>100_bases
CCGTGACCAGCGACACGCCCGTGAAGCTCCTGGTGATCTACAGCCCGCCCTACGGCGAATCGCCCGACAAGGTGATCCGC
CCGGCCGGGAAAGGCGCGTG

Downstream 100 bases:

>100_bases
CCGCGGCCTGGGGCATCATCGCCCCCATGAAACTGCACCTGCTGCGCTACTTCACCGTGCTGGCCGAGGAGCTGCATTTC
GGCCGTGCGGCGGAGCGGCT

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MDFALSPEQEQIRGAIERVCAPFDADYWLAKDREGGFPHDFHQALADAGWLGIAMPEAYGGAGLGISEAALMMHAISATG
AGLSGASAVHMNIFGLHPVVVFGTEEQKARWLPPLIRGRDKACFGVTEPNTGLNTLGLKTRAVREGDHYVVHGQKVWIST
AQVASKILLLARTTPLEECRGTEGLSLFYTDLDRSTVEVREIEKLGRKCVDSNQVFIDGLRIPVEDRVGEEGKGFQYILH
GLNPERILIASEAVGLGRAALARAAGYAQEREVFGRPIGQNQGIQHPLAQSWMELEAAHLMVQKAAWLYDRHQSCGAEAN
AAKYLAAEACYHACERAILTHGGMGYAREYHVERYLRESWIPRLAPVSPQLILCFIAEKVLGLPKSY

Sequences:

>Translated_387_residues
MDFALSPEQEQIRGAIERVCAPFDADYWLAKDREGGFPHDFHQALADAGWLGIAMPEAYGGAGLGISEAALMMHAISATG
AGLSGASAVHMNIFGLHPVVVFGTEEQKARWLPPLIRGRDKACFGVTEPNTGLNTLGLKTRAVREGDHYVVHGQKVWIST
AQVASKILLLARTTPLEECRGTEGLSLFYTDLDRSTVEVREIEKLGRKCVDSNQVFIDGLRIPVEDRVGEEGKGFQYILH
GLNPERILIASEAVGLGRAALARAAGYAQEREVFGRPIGQNQGIQHPLAQSWMELEAAHLMVQKAAWLYDRHQSCGAEAN
AAKYLAAEACYHACERAILTHGGMGYAREYHVERYLRESWIPRLAPVSPQLILCFIAEKVLGLPKSY
>Mature_387_residues
MDFALSPEQEQIRGAIERVCAPFDADYWLAKDREGGFPHDFHQALADAGWLGIAMPEAYGGAGLGISEAALMMHAISATG
AGLSGASAVHMNIFGLHPVVVFGTEEQKARWLPPLIRGRDKACFGVTEPNTGLNTLGLKTRAVREGDHYVVHGQKVWIST
AQVASKILLLARTTPLEECRGTEGLSLFYTDLDRSTVEVREIEKLGRKCVDSNQVFIDGLRIPVEDRVGEEGKGFQYILH
GLNPERILIASEAVGLGRAALARAAGYAQEREVFGRPIGQNQGIQHPLAQSWMELEAAHLMVQKAAWLYDRHQSCGAEAN
AAKYLAAEACYHACERAILTHGGMGYAREYHVERYLRESWIPRLAPVSPQLILCFIAEKVLGLPKSY

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=334, Percent_Identity=33.8323353293413, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI187960098, Length=382, Percent_Identity=27.2251308900524, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI4557231, Length=382, Percent_Identity=27.2251308900524, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=28.8359788359788, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI7656849, Length=354, Percent_Identity=29.6610169491525, Blast_Score=162, Evalue=6e-40,
Organism=Homo sapiens, GI226958412, Length=358, Percent_Identity=28.4916201117318, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI21361497, Length=352, Percent_Identity=29.8295454545455, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI226958414, Length=322, Percent_Identity=28.5714285714286, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI76496475, Length=345, Percent_Identity=29.8550724637681, Blast_Score=150, Evalue=1e-36,
Organism=Homo sapiens, GI4557235, Length=345, Percent_Identity=29.8550724637681, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4501857, Length=381, Percent_Identity=25.4593175853018, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI211971008, Length=310, Percent_Identity=27.0967741935484, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI48976061, Length=310, Percent_Identity=27.0967741935484, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI7669494, Length=361, Percent_Identity=25.7617728531856, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI4503943, Length=361, Percent_Identity=25.7617728531856, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI38505218, Length=288, Percent_Identity=28.125, Blast_Score=92, Evalue=9e-19,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=28.9817232375979, Blast_Score=178, Evalue=4e-46,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=26.5625, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI87082384, Length=274, Percent_Identity=27.7372262773723, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=31.5789473684211, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17569725, Length=391, Percent_Identity=30.1790281329923, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17508101, Length=382, Percent_Identity=30.1047120418848, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17506239, Length=339, Percent_Identity=29.7935103244838, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17570075, Length=387, Percent_Identity=27.6485788113695, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17538396, Length=365, Percent_Identity=29.041095890411, Blast_Score=160, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI71985184, Length=384, Percent_Identity=29.4270833333333, Blast_Score=158, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI71990804, Length=282, Percent_Identity=32.2695035460993, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=30.8370044052863, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI71985192, Length=317, Percent_Identity=27.7602523659306, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17533517, Length=352, Percent_Identity=24.7159090909091, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17505929, Length=333, Percent_Identity=27.3273273273273, Blast_Score=117, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=246, Percent_Identity=30.0813008130081, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17551932, Length=333, Percent_Identity=25.5255255255255, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17534353, Length=315, Percent_Identity=26.3492063492064, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=28.9256198347107, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=255, Percent_Identity=27.0588235294118, Blast_Score=88, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI17531913, Length=161, Percent_Identity=28.5714285714286, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356377, Length=354, Percent_Identity=32.7683615819209, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=30.7277628032345, Blast_Score=168, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24660351, Length=383, Percent_Identity=28.7206266318538, Blast_Score=161, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=30.1333333333333, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI281363737, Length=388, Percent_Identity=26.8041237113402, Blast_Score=151, Evalue=8e-37,
Organism=Drosophila melanogaster, GI21355753, Length=326, Percent_Identity=28.2208588957055, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19920834, Length=300, Percent_Identity=27.6666666666667, Blast_Score=102, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42459; Mature: 42459

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFALSPEQEQIRGAIERVCAPFDADYWLAKDREGGFPHDFHQALADAGWLGIAMPEAYG
CCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCC
GAGLGISEAALMMHAISATGAGLSGASAVHMNIFGLHPVVVFGTEEQKARWLPPLIRGRD
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEECCCCCCCCCCCHHHCCCC
KACFGVTEPNTGLNTLGLKTRAVREGDHYVVHGQKVWISTAQVASKILLLARTTPLEECR
CEEEECCCCCCCCCCCCCCHHHEECCCEEEEECCEEEEEHHHHHHHHHHHHCCCCHHHHC
GTEGLSLFYTDLDRSTVEVREIEKLGRKCVDSNQVFIDGLRIPVEDRVGEEGKGFQYILH
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCHHHHEE
GLNPERILIASEAVGLGRAALARAAGYAQEREVFGRPIGQNQGIQHPLAQSWMELEAAHL
CCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
MVQKAAWLYDRHQSCGAEANAAKYLAAEACYHACERAILTHGGMGYAREYHVERYLRESW
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
IPRLAPVSPQLILCFIAEKVLGLPKSY
CCCCCCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDFALSPEQEQIRGAIERVCAPFDADYWLAKDREGGFPHDFHQALADAGWLGIAMPEAYG
CCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEECCCCCC
GAGLGISEAALMMHAISATGAGLSGASAVHMNIFGLHPVVVFGTEEQKARWLPPLIRGRD
CCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCEEEEECCCCCCCCCCCHHHCCCC
KACFGVTEPNTGLNTLGLKTRAVREGDHYVVHGQKVWISTAQVASKILLLARTTPLEECR
CEEEECCCCCCCCCCCCCCHHHEECCCEEEEECCEEEEEHHHHHHHHHHHHCCCCHHHHC
GTEGLSLFYTDLDRSTVEVREIEKLGRKCVDSNQVFIDGLRIPVEDRVGEEGKGFQYILH
CCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCCCCCCCHHHHEE
GLNPERILIASEAVGLGRAALARAAGYAQEREVFGRPIGQNQGIQHPLAQSWMELEAAHL
CCCCCEEEEECCCCCCCHHHHHHHHCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
MVQKAAWLYDRHQSCGAEANAAKYLAAEACYHACERAILTHGGMGYAREYHVERYLRESW
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHC
IPRLAPVSPQLILCFIAEKVLGLPKSY
CCCCCCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]