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The map label for this gene is alsR [H]

Identifier: 120608883

GI number: 120608883

Start: 195453

End: 196361

Strand: Reverse

Name: alsR [H]

Synonym: Aave_0175

Alternate gene names: 120608883

Gene position: 196361-195453 (Counterclockwise)

Preceding gene: 120608884

Following gene: 120608882

Centisome position: 3.67

GC content: 72.61

Gene sequence:

>909_bases
ATGAAACTGCACCTGCTGCGCTACTTCACCGTGCTGGCCGAGGAGCTGCATTTCGGCCGTGCGGCGGAGCGGCTGGCCAT
CACGCAGCCGCCGCTCAGCTCGGGCATCAAGGCGCTGGAGGACGAGCTGGGCGTGAAGCTCTTCGACCGCAGCAGCAAGC
ACGTGGCGCTCACGCCCGCGGGCGCGGCCTACCTCGCGGAGGCGCGCGTGGTGCTGGACCGCGTGGCGCGGGCGGGCGAC
ACGGCGCGGGCCGTCGCCGCCGGCCGGCGCGGCCGGCTGGACATCGGCTTCACCGGCTCCATGGTCTATCGCGACATGCC
GGCCATCGTGCGGGCCTTCGGCGAACGCGCCCCGGGCATCGAGGTGCACCTGCGCGAGATGTCCTCGGGCGAGCAGACCG
AAGCATTGCTGCACCGCCAGCTGCATGCCGGCTTCATCAACGCCAGCGTGGTGCCCGCGCCCCTGCGCTGCCTGCCGCTG
GCGCACGACCACTTCGTGGCCTGCCTGCCCCAGGGGCATGCCCTGGCCGGCACGGCGCCGGTGGACCTGCACGCCCTGGC
CGGGGAAACCTTCGTGATGTTCGCGCGCGACGTGGCGCCGGCCAACCACGACAACGTCATCGCACTCTTCCACCGCGCCG
GCATCCATCCGCACACGCGCCACGCCGCGCGCCAGTGGCTGACGGTGGTGGCGCTGGTCGCCATGCGCATGGGCGTGGCA
CTGGTGCCGGCCTCGATGGCGCAGGCCGCCGTGCAGGGCGTGCGCTTCGTGCCCATCGCCCACCTGGAGCACCCCACGGT
GGGGGTGCTGGCCTGGCATGAAGAGGGCACGAATCCGGCGCTGCAGGCGTTCCTGGACGTGGCATCTGCCGCTTCGCAGC
AGCACCGCCCGGCCTCCGAGGGTTCCTGA

Upstream 100 bases:

>100_bases
TCGCGCCCGTGAGCCCGCAGCTGATCCTGTGTTTCATCGCGGAGAAAGTACTCGGCCTCCCGAAATCCTATTGACCGCGG
CCTGGGGCATCATCGCCCCC

Downstream 100 bases:

>100_bases
CAGACGGCGTCCGCTCCCCGCGCCAGGATCACCGGCAGTTGCCGACACGCCTGAACCGGTGGTTGTGCAAAGCCATGGCG
GAGTCAGGAGCAAAGGGGCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MKLHLLRYFTVLAEELHFGRAAERLAITQPPLSSGIKALEDELGVKLFDRSSKHVALTPAGAAYLAEARVVLDRVARAGD
TARAVAAGRRGRLDIGFTGSMVYRDMPAIVRAFGERAPGIEVHLREMSSGEQTEALLHRQLHAGFINASVVPAPLRCLPL
AHDHFVACLPQGHALAGTAPVDLHALAGETFVMFARDVAPANHDNVIALFHRAGIHPHTRHAARQWLTVVALVAMRMGVA
LVPASMAQAAVQGVRFVPIAHLEHPTVGVLAWHEEGTNPALQAFLDVASAASQQHRPASEGS

Sequences:

>Translated_302_residues
MKLHLLRYFTVLAEELHFGRAAERLAITQPPLSSGIKALEDELGVKLFDRSSKHVALTPAGAAYLAEARVVLDRVARAGD
TARAVAAGRRGRLDIGFTGSMVYRDMPAIVRAFGERAPGIEVHLREMSSGEQTEALLHRQLHAGFINASVVPAPLRCLPL
AHDHFVACLPQGHALAGTAPVDLHALAGETFVMFARDVAPANHDNVIALFHRAGIHPHTRHAARQWLTVVALVAMRMGVA
LVPASMAQAAVQGVRFVPIAHLEHPTVGVLAWHEEGTNPALQAFLDVASAASQQHRPASEGS
>Mature_302_residues
MKLHLLRYFTVLAEELHFGRAAERLAITQPPLSSGIKALEDELGVKLFDRSSKHVALTPAGAAYLAEARVVLDRVARAGD
TARAVAAGRRGRLDIGFTGSMVYRDMPAIVRAFGERAPGIEVHLREMSSGEQTEALLHRQLHAGFINASVVPAPLRCLPL
AHDHFVACLPQGHALAGTAPVDLHALAGETFVMFARDVAPANHDNVIALFHRAGIHPHTRHAARQWLTVVALVAMRMGVA
LVPASMAQAAVQGVRFVPIAHLEHPTVGVLAWHEEGTNPALQAFLDVASAASQQHRPASEGS

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=288, Percent_Identity=35.4166666666667, Blast_Score=167, Evalue=6e-43,
Organism=Escherichia coli, GI2367136, Length=284, Percent_Identity=33.4507042253521, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1788887, Length=304, Percent_Identity=32.5657894736842, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI145693105, Length=191, Percent_Identity=29.8429319371728, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI157672245, Length=242, Percent_Identity=30.5785123966942, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1787806, Length=303, Percent_Identity=27.7227722772277, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1790399, Length=249, Percent_Identity=30.1204819277108, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787530, Length=252, Percent_Identity=29.3650793650794, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787601, Length=126, Percent_Identity=31.7460317460317, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=248, Percent_Identity=26.2096774193548, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1789173, Length=129, Percent_Identity=32.5581395348837, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1788296, Length=231, Percent_Identity=22.9437229437229, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32386; Mature: 32386

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLHLLRYFTVLAEELHFGRAAERLAITQPPLSSGIKALEDELGVKLFDRSSKHVALTPA
CEEHHHHHHHHHHHHHHHCHHHHHHEECCCCHHHHHHHHHHHHCEEEECCCCCEEEECCC
GAAYLAEARVVLDRVARAGDTARAVAAGRRGRLDIGFTGSMVYRDMPAIVRAFGERAPGI
CHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCC
EVHLREMSSGEQTEALLHRQLHAGFINASVVPAPLRCLPLAHDHFVACLPQGHALAGTAP
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCEEEECCCCCEECCCCC
VDLHALAGETFVMFARDVAPANHDNVIALFHRAGIHPHTRHAARQWLTVVALVAMRMGVA
CCHHHHCCCEEEEEEHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVPASMAQAAVQGVRFVPIAHLEHPTVGVLAWHEEGTNPALQAFLDVASAASQQHRPASE
HHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
GS
CC
>Mature Secondary Structure
MKLHLLRYFTVLAEELHFGRAAERLAITQPPLSSGIKALEDELGVKLFDRSSKHVALTPA
CEEHHHHHHHHHHHHHHHCHHHHHHEECCCCHHHHHHHHHHHHCEEEECCCCCEEEECCC
GAAYLAEARVVLDRVARAGDTARAVAAGRRGRLDIGFTGSMVYRDMPAIVRAFGERAPGI
CHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCC
EVHLREMSSGEQTEALLHRQLHAGFINASVVPAPLRCLPLAHDHFVACLPQGHALAGTAP
EEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHEECCCCCCEEEECCCCCEECCCCC
VDLHALAGETFVMFARDVAPANHDNVIALFHRAGIHPHTRHAARQWLTVVALVAMRMGVA
CCHHHHCCCEEEEEEHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LVPASMAQAAVQGVRFVPIAHLEHPTVGVLAWHEEGTNPALQAFLDVASAASQQHRPASE
HHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCC
GS
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]