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The map label for this gene is tdcB [H]

Identifier: 120608850

GI number: 120608850

Start: 152775

End: 153983

Strand: Reverse

Name: tdcB [H]

Synonym: Aave_0142

Alternate gene names: 120608850

Gene position: 153983-152775 (Counterclockwise)

Preceding gene: 120608851

Following gene: 120608849

Centisome position: 2.88

GC content: 70.89

Gene sequence:

>1209_bases
ATGGCGCACATGCTGACCCTCCCCGACATCCAGGCCGCCGCCGCCCGCCTCCAGGGCCAGGTGCTCGACACCCCCTGCGT
CGAATCGCGCACGCTCTCGCAGATCGTGGGCGCGCAGGTGTTCCTCAAGTTCGAGAACCTGCAGTTCACCGCCTCCTTCA
AGGAGCGTGGTGCCTGCAACAAGCTGAGCCAGCTTTCGCCCGAGGAGCAGCGGCGCGGCGTGATCGCCATGAGCGCCGGC
AACCATGCCCAGGGCGTGGCCTACCACGCGCAGCGCCTGGGCCTGGCCGCCGTGATCGTGATGCCGCGCTTCACGCCCGG
CGTGAAGGTGGAGCGCACGCGCGGCTTCGGCGCCGAGGTCGTGCTGCACGGCGACACGCTGGAGGAGGCTCGCGCGCATG
CCTATGCCCTGGCCGAGGAGCGGGGGCTCACTTTCGTGCATCCCTACGACGACGAGGCCGTCGCCGCAGGCCAGGGCACC
GTCGGCCTGGAGATGCTGCAGGCGGTGCCGGACCTGGACTGCCTGGCCATCGCCGTGGGCGGAGGCGGCCTGATCGCGGG
CATCGCCACCGCGGCCAAGGCCCTGAAACCGGGCATCGAGATCATCGGCGTGCAGACCTCGCGCTTCCCGGCCATGGTCA
ACGCGGTCAAGGGCACGCAGCACCCGCAGGGCACCTCCACCATCGCCGAGGGCATCGCCGTGGGCACGCCCGGCCAGGTG
ACCCGCGAGGTGATCGCGCGGCTCGTGGACGACCTGCTGCTCGTGGACGAGGGCGACATCGAGCAGGCCGTGCTCATGCT
GCTGGAAATCGAGAAGACCCTCGTCGAGGGCGCCGGCGCCGCCGGCCTGGCAGCGCTGCTTCGGCACCCGGAGCGCTTCC
GCGGCAAGCGGGTGGGCCTGGTGCTGTGCGGCGGCAACATCGACCCCTTGCTGCTGGCGGCCATCATCGAGCGCGGCATG
GTGCGCTCCGGGCGCCTGGCGCGCGTCAAGGTGAGTGCGCGCGACATCCCGGGCGTGCTCGCGCGCATCACGGCCACGGT
GGCCGAAGCGGGCGCCAACATCGAGGAAGTCCACCACCAGCGCGCCTTCACCATGCTGGCCGCCCAGAACGTGGAGATCG
AACTCGTGCTGCAGACGCGGGGCCGCGAGCATGTGCAGCAGGTACTGGCCTGCCTCCGCCAAGCGTCCATGGAAGCCGAA
CTCCTGTGA

Upstream 100 bases:

>100_bases
CCAGCGCCGCGGGCGCTAGGAAACGAAGGACCGCGGGGAAGCGACAGGAATGCCATCGGGATGAACGGCGCGTGACGCGC
AGCGGACCGCACGCGCCACA

Downstream 100 bases:

>100_bases
TCCGGTGGCCTTCCGCGCTGTAGGACTGGAGCGGCTTTTGCGGCCAATGCCCACAGAGTCACACGGCGTTGCATCACCGC
CGCGTCGTTTTCGGCACACT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 402; Mature: 401

Protein sequence:

>402_residues
MAHMLTLPDIQAAAARLQGQVLDTPCVESRTLSQIVGAQVFLKFENLQFTASFKERGACNKLSQLSPEEQRRGVIAMSAG
NHAQGVAYHAQRLGLAAVIVMPRFTPGVKVERTRGFGAEVVLHGDTLEEARAHAYALAEERGLTFVHPYDDEAVAAGQGT
VGLEMLQAVPDLDCLAIAVGGGGLIAGIATAAKALKPGIEIIGVQTSRFPAMVNAVKGTQHPQGTSTIAEGIAVGTPGQV
TREVIARLVDDLLLVDEGDIEQAVLMLLEIEKTLVEGAGAAGLAALLRHPERFRGKRVGLVLCGGNIDPLLLAAIIERGM
VRSGRLARVKVSARDIPGVLARITATVAEAGANIEEVHHQRAFTMLAAQNVEIELVLQTRGREHVQQVLACLRQASMEAE
LL

Sequences:

>Translated_402_residues
MAHMLTLPDIQAAAARLQGQVLDTPCVESRTLSQIVGAQVFLKFENLQFTASFKERGACNKLSQLSPEEQRRGVIAMSAG
NHAQGVAYHAQRLGLAAVIVMPRFTPGVKVERTRGFGAEVVLHGDTLEEARAHAYALAEERGLTFVHPYDDEAVAAGQGT
VGLEMLQAVPDLDCLAIAVGGGGLIAGIATAAKALKPGIEIIGVQTSRFPAMVNAVKGTQHPQGTSTIAEGIAVGTPGQV
TREVIARLVDDLLLVDEGDIEQAVLMLLEIEKTLVEGAGAAGLAALLRHPERFRGKRVGLVLCGGNIDPLLLAAIIERGM
VRSGRLARVKVSARDIPGVLARITATVAEAGANIEEVHHQRAFTMLAAQNVEIELVLQTRGREHVQQVLACLRQASMEAE
LL
>Mature_401_residues
AHMLTLPDIQAAAARLQGQVLDTPCVESRTLSQIVGAQVFLKFENLQFTASFKERGACNKLSQLSPEEQRRGVIAMSAGN
HAQGVAYHAQRLGLAAVIVMPRFTPGVKVERTRGFGAEVVLHGDTLEEARAHAYALAEERGLTFVHPYDDEAVAAGQGTV
GLEMLQAVPDLDCLAIAVGGGGLIAGIATAAKALKPGIEIIGVQTSRFPAMVNAVKGTQHPQGTSTIAEGIAVGTPGQVT
REVIARLVDDLLLVDEGDIEQAVLMLLEIEKTLVEGAGAAGLAALLRHPERFRGKRVGLVLCGGNIDPLLLAAIIERGMV
RSGRLARVKVSARDIPGVLARITATVAEAGANIEEVHHQRAFTMLAAQNVEIELVLQTRGREHVQQVLACLRQASMEAEL
L

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=35.0157728706625, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI19923959, Length=301, Percent_Identity=32.890365448505, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI33469958, Length=277, Percent_Identity=30.3249097472924, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789505, Length=309, Percent_Identity=41.1003236245955, Blast_Score=204, Evalue=6e-54,
Organism=Escherichia coli, GI1790207, Length=376, Percent_Identity=35.3723404255319, Blast_Score=169, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71991565, Length=394, Percent_Identity=42.1319796954315, Blast_Score=282, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI17537387, Length=392, Percent_Identity=36.734693877551, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=31.2101910828025, Blast_Score=140, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6322631, Length=320, Percent_Identity=38.4375, Blast_Score=182, Evalue=1e-46,
Organism=Saccharomyces cerevisiae, GI6320930, Length=393, Percent_Identity=34.3511450381679, Blast_Score=174, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=269, Percent_Identity=26.7657992565056, Blast_Score=80, Evalue=8e-16,
Organism=Drosophila melanogaster, GI21355833, Length=393, Percent_Identity=38.4223918575064, Blast_Score=237, Evalue=9e-63,
Organism=Drosophila melanogaster, GI24645328, Length=297, Percent_Identity=37.037037037037, Blast_Score=159, Evalue=3e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 42622; Mature: 42491

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHMLTLPDIQAAAARLQGQVLDTPCVESRTLSQIVGAQVFLKFENLQFTASFKERGACN
CCCEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCEEEEEEECEEEEECHHHCCCHH
KLSQLSPEEQRRGVIAMSAGNHAQGVAYHAQRLGLAAVIVMPRFTPGVKVERTRGFGAEV
HHHHCCCHHHHCCEEEEECCCCCCHHHHHHHHHCEEEEEEECCCCCCCEEEECCCCCEEE
VLHGDTLEEARAHAYALAEERGLTFVHPYDDEAVAAGQGTVGLEMLQAVPDLDCLAIAVG
EEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCHHHHHHHHCCCCCEEEEEEC
GGGLIAGIATAAKALKPGIEIIGVQTSRFPAMVNAVKGTQHPQGTSTIAEGIAVGTPGQV
CCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHH
TREVIARLVDDLLLVDEGDIEQAVLMLLEIEKTLVEGAGAAGLAALLRHPERFRGKRVGL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHCCCEEEE
VLCGGNIDPLLLAAIIERGMVRSGRLARVKVSARDIPGVLARITATVAEAGANIEEVHHQ
EEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH
RAFTMLAAQNVEIELVLQTRGREHVQQVLACLRQASMEAELL
HHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AHMLTLPDIQAAAARLQGQVLDTPCVESRTLSQIVGAQVFLKFENLQFTASFKERGACN
CCEECCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCEEEEEEECEEEEECHHHCCCHH
KLSQLSPEEQRRGVIAMSAGNHAQGVAYHAQRLGLAAVIVMPRFTPGVKVERTRGFGAEV
HHHHCCCHHHHCCEEEEECCCCCCHHHHHHHHHCEEEEEEECCCCCCCEEEECCCCCEEE
VLHGDTLEEARAHAYALAEERGLTFVHPYDDEAVAAGQGTVGLEMLQAVPDLDCLAIAVG
EEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCEECCCCCHHHHHHHHCCCCCEEEEEEC
GGGLIAGIATAAKALKPGIEIIGVQTSRFPAMVNAVKGTQHPQGTSTIAEGIAVGTPGQV
CCHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHH
TREVIARLVDDLLLVDEGDIEQAVLMLLEIEKTLVEGAGAAGLAALLRHPERFRGKRVGL
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCHHHHCCCEEEE
VLCGGNIDPLLLAAIIERGMVRSGRLARVKVSARDIPGVLARITATVAEAGANIEEVHHQ
EEECCCCCHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCHHHHHHH
RAFTMLAAQNVEIELVLQTRGREHVQQVLACLRQASMEAELL
HHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA