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The map label for this gene is glcD [H]

Identifier: 120608804

GI number: 120608804

Start: 100304

End: 101728

Strand: Reverse

Name: glcD [H]

Synonym: Aave_0095

Alternate gene names: 120608804

Gene position: 101728-100304 (Counterclockwise)

Preceding gene: 120608805

Following gene: 120608803

Centisome position: 1.9

GC content: 69.4

Gene sequence:

>1425_bases
ATGAACGCCCCCACCGCCACCGCCCACCTGCTGCCCGAGATCCGACTGCGCCCCGTGCCGCAGGCCTTCATGGACGCGTT
GCAGGCACGATTCGGCACCCAGTGCTCGCTGGCCCAGGCCGTGCGCGAGCAGCATGGGCGCGACGAAGGCTCGATGCAGG
CGCCGCCGCCCTCGGCCGTGGTCTTCGCCGAGAGCACGCAGGACGTGGCCGATGCCGTGCGCCTCGCCGCGCAGCACGAC
GTGCCCGTCATTCCGTACGGCGCGGGCTCCTCGCTCGAAGGCCACCTGCTCGCCATCCAGGGCGGCATCAGCATCGACGT
CTCGCGCATGAACCGCCTGCTGAGCGTGGATGCCGACGACCTTACCGTGACCGTGCAGCCGGGCATCACGCGCAAGCAGC
TCAACGAGGCGATCAAGGACACGGGCCTGTTCTTCCCCATCGACCCGGGCGCGGATGCCAGCATCGGCGGCATGGCCGCC
ACGCGCGCCAGCGGCACCAACGCCGTGCGCTACGGCACCATGCGCGAGAACGTGCTCGCGCTCGAAGTGGTGACCGCCGC
GGGCGAGGCCATCCGCACCGGCACCCGCGCCAAGAAGAGCGCCGCCGGCTACGACCTGACGCGCCTGCTGGTGGGCAGCG
AAGGCACGCTGGGCGTCATCACCGAAGTGACCCTGCGCCTTTACCCGCTGCCCGAGGCCGTGAGCGCCGCCATCTGCTCC
TTCCCGAGCATCGAGGCCGCCGTGCGCACCGTCATCCAGACCATCCAGCTGGGCGTGCCCATCGCCCGCGTGGAACTGAT
CGACGCGCACACCGTGCGCATGGTGAACGCCCACAGCAAGCTCGGCCTGCGCGAGGAACCCATGCTGCTGATGGAATTCC
ACGGCTCGCCCGCCGGCGTGCAGGAACAGGCCGAAACCGTGCAATCCATCGCACAGGAATGGAACGGCAACGCCTTCGAA
TGGGCCACCACACCCGAGGAACGCACGCGCCTGTGGACCGCGCGGCACAACGCCTACTTCGCCGCCGTGCAGAGCCGCCC
CGGCTGCCGCGCCATCAGCACCGACACCTGCGTGCCCATCAGCCGCCTGGCCGACTGCCTGCTCGATTCCGTGACCGAGG
CCGACGCCAGCGGCATCCCCTACTTCCTCGTCGGCCACGTGGGCGACGGCAACTTCCACTTCGGCTACCTGATCGACCCC
GACAGCGACGACGAGCGCATGGTGGCCGAGCGGCTCAACCACCAGCTCGTCGCACGGGCGCTGGCCATGGGCGGCACCTG
CACGGGCGAGCACGGCGTGGGCATCCACAAGATGGGGTTCCTGCTGGACGAGACCGGGCCGGGGGCCGTGGGGATGATGC
GGGCGATCAAGCAGGCGCTGGATCCGAAGAACATTTTGAATCCGGGGAAGATTTTCGAGATGTGA

Upstream 100 bases:

>100_bases
GCGCGCTCGCGAAACGCCATAAGCCACCGCTCCGGCCCGTGCCGGAATGCATGCGAACAGACGGATGCCTAGAATGGATC
TCCCCCAGGAGACAACCGCC

Downstream 100 bases:

>100_bases
CGAGCCAGGAGCGCGTCGCCCCATGCTTTTTCGCCGTCCTCTTCACCGACAGGCCCTACCAGGGTGACGTGCGGGCCGCA
CATCTCCAGGCGCACATTGC

Product: FAD linked oxidase domain-containing protein

Products: pyruvate; ferrocytochrome c

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MNAPTATAHLLPEIRLRPVPQAFMDALQARFGTQCSLAQAVREQHGRDEGSMQAPPPSAVVFAESTQDVADAVRLAAQHD
VPVIPYGAGSSLEGHLLAIQGGISIDVSRMNRLLSVDADDLTVTVQPGITRKQLNEAIKDTGLFFPIDPGADASIGGMAA
TRASGTNAVRYGTMRENVLALEVVTAAGEAIRTGTRAKKSAAGYDLTRLLVGSEGTLGVITEVTLRLYPLPEAVSAAICS
FPSIEAAVRTVIQTIQLGVPIARVELIDAHTVRMVNAHSKLGLREEPMLLMEFHGSPAGVQEQAETVQSIAQEWNGNAFE
WATTPEERTRLWTARHNAYFAAVQSRPGCRAISTDTCVPISRLADCLLDSVTEADASGIPYFLVGHVGDGNFHFGYLIDP
DSDDERMVAERLNHQLVARALAMGGTCTGEHGVGIHKMGFLLDETGPGAVGMMRAIKQALDPKNILNPGKIFEM

Sequences:

>Translated_474_residues
MNAPTATAHLLPEIRLRPVPQAFMDALQARFGTQCSLAQAVREQHGRDEGSMQAPPPSAVVFAESTQDVADAVRLAAQHD
VPVIPYGAGSSLEGHLLAIQGGISIDVSRMNRLLSVDADDLTVTVQPGITRKQLNEAIKDTGLFFPIDPGADASIGGMAA
TRASGTNAVRYGTMRENVLALEVVTAAGEAIRTGTRAKKSAAGYDLTRLLVGSEGTLGVITEVTLRLYPLPEAVSAAICS
FPSIEAAVRTVIQTIQLGVPIARVELIDAHTVRMVNAHSKLGLREEPMLLMEFHGSPAGVQEQAETVQSIAQEWNGNAFE
WATTPEERTRLWTARHNAYFAAVQSRPGCRAISTDTCVPISRLADCLLDSVTEADASGIPYFLVGHVGDGNFHFGYLIDP
DSDDERMVAERLNHQLVARALAMGGTCTGEHGVGIHKMGFLLDETGPGAVGMMRAIKQALDPKNILNPGKIFEM
>Mature_474_residues
MNAPTATAHLLPEIRLRPVPQAFMDALQARFGTQCSLAQAVREQHGRDEGSMQAPPPSAVVFAESTQDVADAVRLAAQHD
VPVIPYGAGSSLEGHLLAIQGGISIDVSRMNRLLSVDADDLTVTVQPGITRKQLNEAIKDTGLFFPIDPGADASIGGMAA
TRASGTNAVRYGTMRENVLALEVVTAAGEAIRTGTRAKKSAAGYDLTRLLVGSEGTLGVITEVTLRLYPLPEAVSAAICS
FPSIEAAVRTVIQTIQLGVPIARVELIDAHTVRMVNAHSKLGLREEPMLLMEFHGSPAGVQEQAETVQSIAQEWNGNAFE
WATTPEERTRLWTARHNAYFAAVQSRPGCRAISTDTCVPISRLADCLLDSVTEADASGIPYFLVGHVGDGNFHFGYLIDP
DSDDERMVAERLNHQLVARALAMGGTCTGEHGVGIHKMGFLLDETGPGAVGMMRAIKQALDPKNILNPGKIFEM

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=454, Percent_Identity=49.5594713656388, Blast_Score=463, Evalue=1e-130,
Organism=Homo sapiens, GI37595754, Length=477, Percent_Identity=47.1698113207547, Blast_Score=453, Evalue=1e-127,
Organism=Homo sapiens, GI119964728, Length=419, Percent_Identity=30.5489260143198, Blast_Score=168, Evalue=1e-41,
Organism=Homo sapiens, GI4501993, Length=463, Percent_Identity=26.3498920086393, Blast_Score=130, Evalue=3e-30,
Organism=Escherichia coli, GI1789351, Length=418, Percent_Identity=31.1004784688995, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1787977, Length=502, Percent_Identity=27.6892430278884, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI48994907, Length=459, Percent_Identity=23.3115468409586, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI48994914, Length=209, Percent_Identity=28.7081339712919, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71992373, Length=439, Percent_Identity=46.0136674259681, Blast_Score=409, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71992381, Length=439, Percent_Identity=44.874715261959, Blast_Score=391, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI71992392, Length=381, Percent_Identity=47.50656167979, Blast_Score=363, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI17534361, Length=447, Percent_Identity=25.7270693512304, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17556096, Length=462, Percent_Identity=25.1082251082251, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6320027, Length=428, Percent_Identity=37.6168224299065, Blast_Score=303, Evalue=5e-83,
Organism=Saccharomyces cerevisiae, GI6320023, Length=433, Percent_Identity=26.5588914549654, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6320764, Length=430, Percent_Identity=24.4186046511628, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI18921117, Length=425, Percent_Identity=27.2941176470588, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24639277, Length=425, Percent_Identity=27.2941176470588, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24639275, Length=425, Percent_Identity=27.2941176470588, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI24653753, Length=459, Percent_Identity=28.1045751633987, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.2.4

Molecular weight: Translated: 50617; Mature: 50617

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPTATAHLLPEIRLRPVPQAFMDALQARFGTQCSLAQAVREQHGRDEGSMQAPPPSAV
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
VFAESTQDVADAVRLAAQHDVPVIPYGAGSSLEGHLLAIQGGISIDVSRMNRLLSVDADD
EEECCHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCEEEHHHHHHHHCCCCCC
LTVTVQPGITRKQLNEAIKDTGLFFPIDPGADASIGGMAATRASGTNAVRYGTMRENVLA
EEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCEEEECCHHCCEEE
LEVVTAAGEAIRTGTRAKKSAAGYDLTRLLVGSEGTLGVITEVTLRLYPLPEAVSAAICS
EEEEHHCCHHHHCCCHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCHHHHHHHHC
FPSIEAAVRTVIQTIQLGVPIARVELIDAHTVRMVNAHSKLGLREEPMLLMEFHGSPAGV
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECHHHCCCCCCCEEEEEECCCCCCH
QEQAETVQSIAQEWNGNAFEWATTPEERTRLWTARHNAYFAAVQSRPGCRAISTDTCVPI
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHEEEEECCEEEEEECCCCCCCCCCCCCCCCH
SRLADCLLDSVTEADASGIPYFLVGHVGDGNFHFGYLIDPDSDDERMVAERLNHQLVARA
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
LAMGGTCTGEHGVGIHKMGFLLDETGPGAVGMMRAIKQALDPKNILNPGKIFEM
HHCCCCCCCCCCCCHHHHCEEEECCCCCHHHHHHHHHHHCCHHHCCCCCCCCCC
>Mature Secondary Structure
MNAPTATAHLLPEIRLRPVPQAFMDALQARFGTQCSLAQAVREQHGRDEGSMQAPPPSAV
CCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCEE
VFAESTQDVADAVRLAAQHDVPVIPYGAGSSLEGHLLAIQGGISIDVSRMNRLLSVDADD
EEECCHHHHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEECCCEEEHHHHHHHHCCCCCC
LTVTVQPGITRKQLNEAIKDTGLFFPIDPGADASIGGMAATRASGTNAVRYGTMRENVLA
EEEEECCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCEEECCCCCCEEEECCHHCCEEE
LEVVTAAGEAIRTGTRAKKSAAGYDLTRLLVGSEGTLGVITEVTLRLYPLPEAVSAAICS
EEEEHHCCHHHHCCCHHHHHCCCCCEEEEEECCCCCEEEEEEEEEEEECCCHHHHHHHHC
FPSIEAAVRTVIQTIQLGVPIARVELIDAHTVRMVNAHSKLGLREEPMLLMEFHGSPAGV
CCCHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEEECHHHCCCCCCCEEEEEECCCCCCH
QEQAETVQSIAQEWNGNAFEWATTPEERTRLWTARHNAYFAAVQSRPGCRAISTDTCVPI
HHHHHHHHHHHHHHCCCEEEECCCCHHHHHEEEEECCEEEEEECCCCCCCCCCCCCCCCH
SRLADCLLDSVTEADASGIPYFLVGHVGDGNFHFGYLIDPDSDDERMVAERLNHQLVARA
HHHHHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHH
LAMGGTCTGEHGVGIHKMGFLLDETGPGAVGMMRAIKQALDPKNILNPGKIFEM
HHCCCCCCCCCCCCHHHHCEEEECCCCCHHHHHHHHHHHCCHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-lactate; ferricytochrome c

Specific reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]