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The map label for this gene is ppiB [H]

Identifier: 120599061

GI number: 120599061

Start: 2606356

End: 2606850

Strand: Direct

Name: ppiB [H]

Synonym: Sputw3181_2257

Alternate gene names: 120599061

Gene position: 2606356-2606850 (Clockwise)

Preceding gene: 120599060

Following gene: 120599064

Centisome position: 55.36

GC content: 44.85

Gene sequence:

>495_bases
ATGATTATTTTCACTACCAATGTCGGGGATATCAGCATCGAACTCGATTTTGAGCGAGCGCCTGTCACTGCCAAAAACTT
TCTCCGTTATTGTGAAGAAGGGTTTTATGAGCACACTATTTTTCATCGCGTGATCAAAGGCTTTATGATCCAAGGTGGTG
GTTTTACCGCCAAGATGAAAGAAAAACCGACCCACGACCCCATAGTCAACGAAGCCAATAAAGGTCTTTCCAATACCTTA
GGCACGATTGCCATGGCACGGACTGACGCCCCACATTCCGCCACGGCGCAGTTTTTTATCAATACCTCGAATAATGATTT
TCTCGATCATACGGCCACAACAAACAACGGTTGGGGTTATGCCGTATTTGGTAAAGTGGTCGCGGGACTTGAGGTAGTAC
AGCAAATTGAAAAGGTCAAAACCACTAAAGTCGCAGGCCATGAAGATGTACCGCGCGAACCTATTATTATCGAAAAAGTA
ACCATTACAGGGTAA

Upstream 100 bases:

>100_bases
GGCAGAGGGAAGTCCAAAACAACAGGACAGTGGTGCCCCTTTTAATCCATGGGCCAGCGGACCTAAAACCAAGTAATTCA
ATCGAATAGAAGCTAATACT

Downstream 100 bases:

>100_bases
TTTTCACGGAATAAGGTGGGTAAAAAAACAAAGGGAGCTTATCGCTCCCTTTGTTTTTCATCGTGGGTCAATCAATATCC
TTGAGCGGCCACAACACGAT

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin type

Products: NA

Alternate protein names: PPIase B; Rotamase B [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MIIFTTNVGDISIELDFERAPVTAKNFLRYCEEGFYEHTIFHRVIKGFMIQGGGFTAKMKEKPTHDPIVNEANKGLSNTL
GTIAMARTDAPHSATAQFFINTSNNDFLDHTATTNNGWGYAVFGKVVAGLEVVQQIEKVKTTKVAGHEDVPREPIIIEKV
TITG

Sequences:

>Translated_164_residues
MIIFTTNVGDISIELDFERAPVTAKNFLRYCEEGFYEHTIFHRVIKGFMIQGGGFTAKMKEKPTHDPIVNEANKGLSNTL
GTIAMARTDAPHSATAQFFINTSNNDFLDHTATTNNGWGYAVFGKVVAGLEVVQQIEKVKTTKVAGHEDVPREPIIIEKV
TITG
>Mature_164_residues
MIIFTTNVGDISIELDFERAPVTAKNFLRYCEEGFYEHTIFHRVIKGFMIQGGGFTAKMKEKPTHDPIVNEANKGLSNTL
GTIAMARTDAPHSATAQFFINTSNNDFLDHTATTNNGWGYAVFGKVVAGLEVVQQIEKVKTTKVAGHEDVPREPIIIEKV
TITG

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI22547212, Length=160, Percent_Identity=35, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI7657473, Length=160, Percent_Identity=35, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI22547215, Length=160, Percent_Identity=35, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI19557636, Length=141, Percent_Identity=36.8794326241135, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI5454154, Length=164, Percent_Identity=34.1463414634146, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI64276486, Length=128, Percent_Identity=35.9375, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI7706339, Length=166, Percent_Identity=31.3253012048193, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI310110104, Length=136, Percent_Identity=36.7647058823529, Blast_Score=70, Evalue=7e-13,
Organism=Homo sapiens, GI10863927, Length=137, Percent_Identity=35.7664233576642, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310129267, Length=136, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI310120620, Length=136, Percent_Identity=35.2941176470588, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI24308049, Length=177, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI6631100, Length=147, Percent_Identity=32.6530612244898, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1786736, Length=163, Percent_Identity=60.1226993865031, Blast_Score=204, Evalue=2e-54,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=53.2051282051282, Blast_Score=176, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI71980594, Length=162, Percent_Identity=32.7160493827161, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=140, Percent_Identity=39.2857142857143, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=32.7160493827161, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=142, Percent_Identity=35.2112676056338, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=163, Percent_Identity=33.7423312883436, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=168, Percent_Identity=29.7619047619048, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532643, Length=163, Percent_Identity=33.1288343558282, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71997782, Length=101, Percent_Identity=34.6534653465347, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=166, Percent_Identity=33.1325301204819, Blast_Score=63, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17986117, Length=164, Percent_Identity=32.3170731707317, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19922376, Length=164, Percent_Identity=30.4878048780488, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI17647301, Length=157, Percent_Identity=34.3949044585987, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45549139, Length=136, Percent_Identity=38.9705882352941, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24586038, Length=167, Percent_Identity=31.1377245508982, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24664125, Length=136, Percent_Identity=36.0294117647059, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21357783, Length=136, Percent_Identity=36.0294117647059, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24652460, Length=141, Percent_Identity=29.7872340425532, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI19922912, Length=150, Percent_Identity=31.3333333333333, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18102; Mature: 18102

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIFTTNVGDISIELDFERAPVTAKNFLRYCEEGFYEHTIFHRVIKGFMIQGGGFTAKMK
CEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCEEEEEC
EKPTHDPIVNEANKGLSNTLGTIAMARTDAPHSATAQFFINTSNNDFLDHTATTNNGWGY
CCCCCCCCHHHHCCCHHHHHHHEEEEECCCCCCCEEEEEEECCCCCEECCCCCCCCCCCH
AVFGKVVAGLEVVQQIEKVKTTKVAGHEDVPREPIIIEKVTITG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECC
>Mature Secondary Structure
MIIFTTNVGDISIELDFERAPVTAKNFLRYCEEGFYEHTIFHRVIKGFMIQGGGFTAKMK
CEEEEECCCEEEEEEECCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHEECCCCEEEEEC
EKPTHDPIVNEANKGLSNTLGTIAMARTDAPHSATAQFFINTSNNDFLDHTATTNNGWGY
CCCCCCCCHHHHCCCHHHHHHHEEEEECCCCCCCEEEEEEECCCCCEECCCCCCCCCCCH
AVFGKVVAGLEVVQQIEKVKTTKVAGHEDVPREPIIIEKVTITG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]